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Elulookirjeldus (CV)
1.Eesnimi Meeme
2.Perekonnanimi Utt
3.Töökoht Tartu Ülikool
4.Ametikoht vanemteadur
5.Sünniaeg 08.05.1960 (päev.kuu.aasta)
6.Haridus kõrgem, Tartu Riiklik Ülikool 1983
7.Teenistuskäik 1983-1984 insener, TA Füüsika Instituut
1984-1985 nooremteadur, Keemilise Kineetika ja Katalüüsi Laboratoorium, TRÜ
1986-1989 aspirant, Orgaanilise keemia kateeder, TRÜ
1989-1990 nooremteadur, Orgaanilise keemia kateeder, TRÜ
1990-1992 teadur, Analüütilise Biokeemia Laboratoorium, TÜ
1992-1993 juhataja kt, Analüütilise Biokeemia Laboratoorium, TÜ
1994-1996 tegevdirektor, AS Bional
1997-1999 külalisteadur, Lundi Ülikool
1999-2002 doktorant, Lundi Ülikool
2002-2005 teadur, ÜMPI, TÜ
2005- vanemteadur, ÜMPI,TÜ
8.Teaduskraad PhD
9.Teaduskraadi välja
andnud asutus, aasta
Lundi Ülikool, 2002
10.Tunnustused
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus
12.Juhendamisel kaitstud
väitekirjad
13.Teadustöö põhisuunad 1. Immunogeensete valkude identifitseerimine proteoomika meetodite abil (2-DE, MALDI-TOF MS, bioinformaatika).
2. Antimikroobse toimega peptiidide uurimine.
3. Valkude interaktsioonid glükoosaminoglükaanidega
14.Jooksvad grandid ETF 5525
15.Teaduspublikatsioonid

K.E.Kisand, M.Utt, K.V.Kisand, T.Prükk, R.Uibo. Serological description of Estonian patients with Lyme disease, a comparison with control sera from endemic and non-endemic areas. Int J Med Microbiol. 2004 Suppl 37, 174-178

Oona M, Utt M, Nilsson I, Uibo O, Vorobjova T, Maaroos HI. Helicobacter pylori infection in children in Estonia: the decreasing seroprevalence during a 11-year period. Helicobacter, 2004, 9 (3), 233-241

I. Kornilovska, I. Nilsson, M.Utt, Å. Ljungh, T. Wadström. Immunogenic proteins of Helicobacter pullorum, Helicobacter bilis and Helicobacter hepaticus identified by two-dimensional gel-electrophoresis and immunoblotting. Proteomics, 2002, 2 (6), 775-783

Immunogenic cell surface proteins of Helicobacter pylori PCT WO 02/077022 A1 (3.10.2002) Ljungh Asa, Nilsson Ingrid, Utt Meeme, Wadström Torkel

I. Nilsson and M. Utt. 2002. Separation and surveys of proteins of Helicobacter pylori. J.Chromatography B, 771, 251–260

M. Utt, I. Nilsson, Å. Ljungh and T. Wadström Identification of novel immunogenic proteins of Helicobacter pylori by proteome technology. J.Immunol. Methods, 2002, 259(1-2), 1-10

Fallgren C., Utt M., Ljungh Å. Isolation and characterisation of a 17-kDa staphylococcal heparin-binding protein with broad specificity. J Medical Microbiology. 2001, 50(6), 547-558

Immunogenic cell surface proteins of Helicobacter pylori (April 2001)

Immunogenic proteins of Helicobacter pullorum, Helicobacter bilis and Helicobacter hepaticus (June 2001)

Meeme Utt, Bengt Danielsson and Torkel Wadström: H. pylori vacuolating cytotoxin binding to a putative cell surface receptor, heparan sulphate, studied by surface plasmon resonance. FEMS Immunology Med.Microbiol. 2001, 30, 109-113

Tamara Vorobjova, Olga Ananieva, Heidi-Ingrid Maaroos, Pentti Sipponen, Kaljo Villako, Meeme Utt, Ingrid Nilsson, Torkel Wadström and Raivo Uibo. Seropositivity to Helicobacter pylori heat shock protein 60 is strongly associated with intensity of chronic inflammation, particularly in antrum mucosa: an extension of an 18-year follow-up study of chronic gastritis in Saaremaa, Estonia FEMS Immunology Med.Microbiol.2001, 30, 143-149

Ingrid Nilsson, Meeme Utt, Hans-Olof Nilsson and Torkel Wadström: Two-dimentional electrophoretic and immunoblot analysis of cell surface proteins from spiral and coccoid forms of Helicobacter pylori type strain 17874. Electophoresis, 2000, 21(13), 2670-2677

Chmiela M, Paziak-Domanska B, Hirmo S, Rudnicka W, Utt M, Wadström T. 1998. Helicobacter pylori - interactions with phagocytes. In: Helicobacter pylori. Basic mechanisms to clinical cure 1999 (Hunt RH, Tytgat GNJ, Eds), pp. 90- 100. Kluwer Academic Publishers, Dordrecht, Boston, London.

Fallgren C., Utt M., Petersson AC., Ljungh A., Wadstrom T.: In vitro anti-staphylococcal activity of heparinized biomaterials bonded with combinations of rifampicin. Zentralbl Bakteriol 1998, 287(1-2), 19-31

Hirmo S, Utt M, Wadström T. 1998. Sialylglycoconjugate- and proteoglycan-binding microbial lectins. In: Lectins: Biology, Biochemistry, Clinical Biochemistry (van Driessche E, Beekmans S, Bfg-Hansen TC, Eds.) Vol. 12, Textop, Hellerup, Denmark.

Hirmo S, Shumakov Y, Utt M, Wadström T. 1997. Genetic heterogeneity ofHelicobacter pylori and strain typing. In: Pathogenesis and Host Response in Helicobacter pylori Infections (Moran AP, O´Morain CA, Eds.), pp. 199-205, Normed Verlag, Bad Hamburg-Englewood, N.J.

M. Utt and T. Wadström: Identification of heparan sulphate binding surface proteins of Helicobacter pylori: inhibition of heparan sulphate binding with sulphated carbohydrates polymers. J.Med. Microbiol. 1997, 46, 541-546

Siiri Hirmo, Meeme Utt and Torkel Wadström. Sialylglycoconjugate- and proteoglycan-binding microbial lectins http://plab.ku.dk/tcbh/Lectins12/Hirmo/paper.htm The Electronic Lectin Journal: Lectins, Biology, Biochemistry, ClinicalBiochemistry , Volume 12 , Accepted 18 december 1997, Editors Edilbert van Driessche, Sonia Beeckmans, Thorkild C. Bøg-Hansen

Torkel Wadström, Siiri Hirmo, Hajdi Novak, Antonio Guzman, Martina Ringer-Pantzer, Meeme Utt, Pär Aleljung: Sulfatides inhibit binding of Helicobacter pylori to the gastric cancer Kato III cell line. Current Microbiology: 1997, 34, 267-272

Siiri Hirmo, Meeme Utt, Martina Ringer and Torkel Wadström: Inhibition of heparan sulphate and other glycosaminoglycans to Helicobacter pylori by various polysulphated carbohydrates. FEMS Immunology and Medical Microbiology: 1995, 10, 301-306

T. Wadström, F.Ascencio, Å.Ljungh, J.Lelwala-Guruge, M.Ringer, M.Utt, K.Valkonen Helicobacter pylori adhesins. European Journal of Gastroenterology and Hepatology: 1993, 5 (suppl 2) S 12-15,

viimati muudetud: 12.10.2005

Curriculum Vitae (CV)
1.First Name Meeme
2.Surname Utt
3.Institution University of Tartu
4.Position senior research fellow
5.Date of birth 08.05.1960 (day.month.year)
6.Education higher, Tartu State University 1983
7.Research and
professional experience
1983-1984 Engineer at Institute of Physics
1984-1985 Junior researcher at Tartu State University, Laboratory of Chemical Kinetics and Catalysis
1989-1990 Junior researcher at Department of Organic Chemistry
1990-1992 Research associate Laboratory of Analytical Biochemistry
1992 -1993 Head of Laboratory of Analytical Biochemistry, University of Tartu
1994 Researcher at Institute of Organic Chemistry
1994-1996 Managing Director at Bional Ltd
1997-1999 Visiting researcher at Lund, University, Sweden
1999-2002 PhD student, Lund University
2002-2005 researcher, University of Tartu
2005- senior reseacher, University of Tartu
8.Academic degree PhD
9.Dates and sites of
earning the degrees
University of Lund, 2002
10.Honours/awards
11.Research-administrative
experience
12.Supervised dissertations
13.Current research program 1. Identification of immunogenic proteins using methods of proteomics (2-DE, MALDI-TOF MS, bioinformatics)
2. Antimicrobial peptides
3. Protein interactions with glycosaminoglycans
14.Current grant funding EstSF 5525
15.List of most important publications

K.E.Kisand, M.Utt, K.V.Kisand, T.Prükk, R.Uibo. Serological description of Estonian patients with Lyme disease, a comparison with control sera from endemic and non-endemic areas. Int J Med Microbiol. 2004 Suppl 37, 174-178

Oona M, Utt M, Nilsson I, Uibo O, Vorobjova T, Maaroos HI. Helicobacter pylori infection in children in Estonia: the decreasing seroprevalence during a 11-year period. Helicobacter, 2004, 9 (3), 233-241

I. Kornilovska, I. Nilsson, M.Utt, Å. Ljungh, T. Wadström. Immunogenic proteins of Helicobacter pullorum, Helicobacter bilis and Helicobacter hepaticus identified by two-dimensional gel-electrophoresis and immunoblotting. Proteomics, 2002, 2 (6), 775-783

Immunogenic cell surface proteins of Helicobacter pylori PCT WO 02/077022 A1 (3.10.2002) Ljungh Asa, Nilsson Ingrid, Utt Meeme, Wadström Torkel

I. Nilsson and M. Utt. 2002. Separation and surveys of proteins of Helicobacter pylori. J.Chromatography B, 771, 251–260

M. Utt, I. Nilsson, Å. Ljungh and T. Wadström Identification of novel immunogenic proteins of Helicobacter pylori by proteome technology. J.Immunol. Methods, 2002, 259(1-2), 1-10

Fallgren C., Utt M., Ljungh Å. Isolation and characterisation of a 17-kDa staphylococcal heparin-binding protein with broad specificity. J Medical Microbiology. 2001, 50(6), 547-558

Immunogenic cell surface proteins of Helicobacter pylori (April 2001)

Immunogenic proteins of Helicobacter pullorum, Helicobacter bilis and Helicobacter hepaticus (June 2001)

Meeme Utt, Bengt Danielsson and Torkel Wadström: H. pylori vacuolating cytotoxin binding to a putative cell surface receptor, heparan sulphate, studied by surface plasmon resonance. FEMS Immunology Med.Microbiol. 2001, 30, 109-113

Tamara Vorobjova, Olga Ananieva, Heidi-Ingrid Maaroos, Pentti Sipponen, Kaljo Villako, Meeme Utt, Ingrid Nilsson, Torkel Wadström and Raivo Uibo. Seropositivity to Helicobacter pylori heat shock protein 60 is strongly associated with intensity of chronic inflammation, particularly in antrum mucosa: an extension of an 18-year follow-up study of chronic gastritis in Saaremaa, Estonia FEMS Immunology Med.Microbiol.2001, 30, 143-149

Ingrid Nilsson, Meeme Utt, Hans-Olof Nilsson and Torkel Wadström: Two-dimentional electrophoretic and immunoblot analysis of cell surface proteins from spiral and coccoid forms of Helicobacter pylori type strain 17874. Electophoresis, 2000, 21(13), 2670-2677

Chmiela M, Paziak-Domanska B, Hirmo S, Rudnicka W, Utt M, Wadström T. 1998. Helicobacter pylori - interactions with phagocytes. In: Helicobacter pylori. Basic mechanisms to clinical cure 1999 (Hunt RH, Tytgat GNJ, Eds), pp. 90- 100. Kluwer Academic Publishers, Dordrecht, Boston, London.

Fallgren C., Utt M., Petersson AC., Ljungh A., Wadstrom T.: In vitro anti-staphylococcal activity of heparinized biomaterials bonded with combinations of rifampicin. Zentralbl Bakteriol 1998, 287(1-2), 19-31

Hirmo S, Utt M, Wadström T. 1998. Sialylglycoconjugate- and proteoglycan-binding microbial lectins. In: Lectins: Biology, Biochemistry, Clinical Biochemistry (van Driessche E, Beekmans S, Bfg-Hansen TC, Eds.) Vol. 12, Textop, Hellerup, Denmark.

Hirmo S, Shumakov Y, Utt M, Wadström T. 1997. Genetic heterogeneity ofHelicobacter pylori and strain typing. In: Pathogenesis and Host Response in Helicobacter pylori Infections (Moran AP, O´Morain CA, Eds.), pp. 199-205, Normed Verlag, Bad Hamburg-Englewood, N.J.

M. Utt and T. Wadström: Identification of heparan sulphate binding surface proteins of Helicobacter pylori: inhibition of heparan sulphate binding with sulphated carbohydrates polymers. J.Med. Microbiol. 1997, 46, 541-546

Siiri Hirmo, Meeme Utt and Torkel Wadström. Sialylglycoconjugate- and proteoglycan-binding microbial lectins http://plab.ku.dk/tcbh/Lectins12/Hirmo/paper.htm The Electronic Lectin Journal: Lectins, Biology, Biochemistry, ClinicalBiochemistry , Volume 12 , Accepted 18 december 1997, Editors Edilbert van Driessche, Sonia Beeckmans, Thorkild C. Bøg-Hansen

Torkel Wadström, Siiri Hirmo, Hajdi Novak, Antonio Guzman, Martina Ringer-Pantzer, Meeme Utt, Pär Aleljung: Sulfatides inhibit binding of Helicobacter pylori to the gastric cancer Kato III cell line. Current Microbiology: 1997, 34, 267-272

Siiri Hirmo, Meeme Utt, Martina Ringer and Torkel Wadström: Inhibition of heparan sulphate and other glycosaminoglycans to Helicobacter pylori by various polysulphated carbohydrates. FEMS Immunology and Medical Microbiology: 1995, 10, 301-306

T. Wadström, F.Ascencio, Å.Ljungh, J.Lelwala-Guruge, M.Ringer, M.Utt, K.Valkonen Helicobacter pylori adhesins. European Journal of Gastroenterology and Hepatology: 1993, 5 (suppl 2) S 12-15,

last updated: 12.10.2005

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