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| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Ello |
| 2. | Perekonnanimi | Karelson |
| 3. | Töökoht | Tartu Ülikool, Biokeemia Instituut |
| 4. | Ametikoht | dotsent |
| 5. | Sünniaeg | 06.08.1946 (päev.kuu.aasta) |
| 6. | Haridus | TÜ Arstiteaduskond, 1972.a. TÜ Aspirantuur (biokeemia) 1977.a. |
| 7. | Teenistuskäik | 1972-1977 vanemlaborant, TÜ Biokeemia kateeder ja Sekretoorsete Protsesside Biokeemia Laboratoorium 1978-1979 nooremteadur, TÜ Sekretoorsete Protsesside Biokeemia Laboratoorium 1979-1989 vanemõpetaja, TÜ Biokeemia kateeder 1989-2005 dotsent, TÜ Biokeemia Inst. 1994-1996 TÜ Meditsiinilise Biokeemia Õppetooli hoidja |
| 8. | Teaduskraad | meditsiinikandidaat meditsiinidoktor |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Kõrgem Atestatsiooni Komisjon (Moskva), 1978 TÜ Arstiteaduskonna kraadinõukogu, 1999 |
| 10. | Tunnustused | Põhjamaade Minstrite Nõukogu Stipendiaat Turu Akadeemilises Ülikoolis (Soome), 1995 Rootsi Instituudi stipendiaat Stockholmi Ülikoolis 1998, 2000 Rootsi Kuningliku Akadeemia stipendiaat Stockholmi Ülikoolis,2002 Rahvusvahelise Wenner-Gren fondi stipendiaat Stockholmi Ülikoolis, 2003 Rootsi Dementsiafondi "DemensFonden" stipendiaat Stockholmi Ülikoolis ja Karolinska Instituudis, 2004 |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
1979 -1996 Eesti biokeemia Seltsi Tartu osakonna sekretär Rahvusvaliste konverentside orgkomiteede liige Kahe rahvusvahelise eelretsenseeritava zurnaali referent Mitmete bakalaureuse ja magistritööde retsensent Rahvuvaheline koostöö Karolinska Instituudi Huddinge Ülikooli Kliiniku Geriaatria osakonnaga (Rootsi) ja Stockholmi Ülikooli Neurokeemia Osakonnaga (Rootsi) |
| 12. | Juhendamisel kaitstud väitekirjad |
Riina Mahlapuu, MSc, 2000, juh. Ülo Langel, Ello Karelson, Uno Mäeorg. Amüloid beta-peptiidide efektid aju signaalülekandes. Tartu Ülikool Tanel Toomela, MSc, 1996, juh. Jaak Järv, Ello Karelson. Muskariinse retseptori agonisti anatgonistliku toime avaldumine ligandi kõrgel kontsentratsioonil. Tartu Ülikool Andres Valkna, MSc, 1995, juh. Ello Karelson, Mihkel Zilmer. Roti hipokampuse adenülaaditsüklaasi regulatsioon neuropeptiid galaniini ja tema analoogidega. Tartu Ülikool |
| 13. | Teadustöö põhisuunad | 1. Neuropeptiidide sh. amüloid-beeta peptiidide ja neuroprotektorite sh. östrogeenide ja isoflavonoidide molekulaarsed mehhanismid aju G-valk-vahendatud signaalradade tasandil normaalsel vananemisel ja neurodegeneratsiooni puhul 2. Aju ioon-pumbad neuropeptiidide, neurotoksiliste agensite ja neurodegeneratsiooni märklauana 3. Alzheimeri tõve molekulaarsed, sh. oksüdatiivsed mehhanismid postmortaalse inimaju tasandil |
| 14. | Jooksvad grandid | Eesti Teadusfondi grant Nr. 5222 "Fütoöstrogeenide ja östrogeenide neuroprotektiivne mehhanism inimaju füsiloogilisel vananemisel ja neurodegeneratsiooni puhul (postmortem uuring)", 2002-2005 |
| 15. | Teaduspublikatsioonid |
Karelson E, Fernaeus S, Reis K, Bogdanovic N, Land T. Stimulation of G-proteins in human control and Alzheimer's disease brain by FAD mutants of APP(714-723): implication of oxidative mechanisms. J Neurosci Res. 2005 Feb 1;79(3):368-74. PMID: 15614786 Mahlapuu R, Viht K, Balaspiri L, Bogdanovic N, Saar K, Soomets U, Land T, Zilmer M, Karelson E, Langel U. Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer's disease brain. Brain Res Mol Brain Res. 2003 Sep 10; 117(1):73-82. PMID: 14499483 Roots K, Koks S, Kairane C, Salum T, Karelson E, Vasar E, Zilmer M. Na-pump kinetic properties are differently altered in the brain regions of the cholecystokinin(2)receptor-deficient mice. Ann N Y Acad Sci. 2003 Apr;986:644-645. PMID: 12763910 Jefremov V, Rakitin A, Mahlapuu R, Karelson E, Zilmer M, Bogdanovic N. Antioxidant mechanism of estrogens: relevance to modulation of hippocampal G-proteins in Alzheimer's disease. Neurobiol of Aging. 23(1):S334-S334 1239 Suppl.1, Jul-Aug 2002. ISSN: 0197-4580 Kairane C, Roots K, Uusma T, Bogdanovic N, Karelson E, Koks S, Zilmer M. Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: difference from the age-matched control but similarity to the rat model. FEBS Lett. 2002 Nov 6;531(2):241-4 PMID: 12417319 Karelson E, Mahlapuu R, Zilmer M, Soomets U, Bogdanovic N, Langel U. Possible signaling by glutathione and its novel analogue through potent stimulation of frontocortical G-proteins in normal aging and in Alzheimer's disease. Ann N Y Acad Sci. 2002 Nov;973:537-40. PMID: 12485924 Bogdanovic N, Zilmer M, Zilmer K, Rehema A, Karelson E; The Swedish APP670/671 Alzheimer's disease mutation: the first evidence for strikingly increased oxidative injury in the temporal inferior cortex. Dement Geriatr Cogn Disord. 2001 Nov-Dec;12(6):364-70. PMID: 11598307 Karelson E, Bogdanovic N, Garlind A, Winblad B, Zilmer K, Kullisaar T, Vihalemm T, Kairane C, Zilmer M. The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defence. Neurochem Res. 2001 Apr;26(4):353-61. PMID: 11495345 Saar K, Mahlapuu R, Laidmäe E, Valkna A, Kahl U, Karelson E. Langel U. Characterization of a new chimeric ligand for galanin receptors:galanin(1-13)-[D-Trp32)]-neuropeptideY(25-36)amide. Regul Pept. 2001 Oct 15;102(1):15-9. PMID: 11600206 |
viimati muudetud: 16.08.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Ello |
| 2. | Surname | Karelson |
| 3. | Institution | Deapartment of Biochemistry Univesrity of Tartu |
| 4. | Position | Associate Professor (docent) |
| 5. | Date of birth | 06.08.1946 (day.month.year) |
| 6. | Education | Faculty of Medicine, University of Tartu, 1972 University of Tartu, Postgraduate studentship (biochemistry),1977 |
| 7. | Research and professional experience |
1972-1977 Senior Research Assistant, Department of Biochemistry and Laboratory of Biochemistry of Secretory Processes, University of Tartu 1978-1979 Junior Researcher, Laboratory of Biochemistry of Secretory Processes, University of Tartu 1979-1989 Senior Assistant (lecturer), Department of Biochemistry, University of Tartu 1989-2005 Associate Professor (docent),University of Tartu 1994-1996 Curator of Chair of Medical Bichemistry, University of Tartu |
| 8. | Academic degree | Doctor of Philosphy (Candidate of Medicine) Doctor of Medicinae |
| 9. | Dates and sites of earning the degrees |
Higher Atestation Commision (Moscow), 1978 Council of the Faculty of Medicinae, University of Tartu |
| 10. | Honours/awards | Scholar of Nordic Council of Ministers in Abo Academy University (Finland), 1995 Scholar of Swedish Institute in University of Stockholm, 1998, 2000 Scholar of Royal Swedish Academy of Sciences in University of Stockholm, 2002 Scholar of International Wenner-Gren Foundation in University of Stockholm, 2003 Scolar of Swedish "DemensFonden" in University of Stockholm and in Karolinska Institute, 2004 |
| 11. | Research-administrative experience |
1979 -1996 Secretary of Estonian Biochemical Society (Section of Tartu) The member of Organizing Committees of International Conferences Reviewer of two international peer-reviewd journals Reviewer of many Baccalaureate and Master thesis International Collaboration with Geraitric Department of Huddinge University Hospital at Karolinska Institute (Sweden) and Department of Neurochemistry at University of Stockholm |
| 12. | Supervised dissertations |
Riina Mahlapuu, MSc, 2000, superv. Ülo Langel, Ello Karelson, Uno Mäeorg. Amüloid beta-peptiidide efektid aju signaalülekandes. Tartu Ülikool Tanel Toomela, MSc, 1996, superv. Jaak Järv, Ello Karelson. Muskariinse retseptori agonisti anatgonistliku toime avaldumine ligandi kõrgel kontsentratsioonil. Tartu Ülikool Andres Valkna, MSc, 1995, superv. Ello Karelson, Mihkel Zilmer. Roti hipokampuse adenülaaditsüklaasi regulatsioon neuropeptiid galaniini ja tema analoogidega. Tartu Ülikool |
| 13. | Current research program | 1. Molecular mecanisms of neuropeptides, incl. amyloid-beta peptides, and neuroprotectors, incl. estrogens and isoflavonoids, at the level of brain G-protein-mediated signalling pathways in normal aging and in neurodegeneration 2. Brain ion-pumps as a target of neuropeptides, neurotoxic agents and neurodegeneration 3. Molecular (incl. oxidative) mechanisms of Alzheimer's disease at the level of postmortal human brain |
| 14. | Current grant funding | Estonian Scientific Foundation Grant No. 5222 " Neuroprotective mechanism of phytoestrogens and estrogens in physiological aging of human brain and in neurodegeneration", 2002 -2005. |
| 15. | List of most important publications |
Karelson E, Fernaeus S, Reis K, Bogdanovic N, Land T. Stimulation of G-proteins in human control and Alzheimer's disease brain by FAD mutants of APP(714-723): implication of oxidative mechanisms. J Neurosci Res. 2005 Feb 1;79(3):368-74. PMID: 15614786 Mahlapuu R, Viht K, Balaspiri L, Bogdanovic N, Saar K, Soomets U, Land T, Zilmer M, Karelson E, Langel U. Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer's disease brain. Brain Res Mol Brain Res. 2003 Sep 10; 117(1):73-82. PMID: 14499483 Roots K, Koks S, Kairane C, Salum T, Karelson E, Vasar E, Zilmer M. Na-pump kinetic properties are differently altered in the brain regions of the cholecystokinin(2)receptor-deficient mice. Ann N Y Acad Sci. 2003 Apr;986:644-645. PMID: 12763910 Jefremov V, Rakitin A, Mahlapuu R, Karelson E, Zilmer M, Bogdanovic N. Antioxidant mechanism of estrogens: relevance to modulation of hippocampal G-proteins in Alzheimer's disease. Neurobiol of Aging. 23(1):S334-S334 1239 Suppl.1, Jul-Aug 2002. ISSN: 0197-4580 Kairane C, Roots K, Uusma T, Bogdanovic N, Karelson E, Koks S, Zilmer M. Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: difference from the age-matched control but similarity to the rat model. FEBS Lett. 2002 Nov 6;531(2):241-4 PMID: 12417319 Karelson E, Mahlapuu R, Zilmer M, Soomets U, Bogdanovic N, Langel U. Possible signaling by glutathione and its novel analogue through potent stimulation of frontocortical G-proteins in normal aging and in Alzheimer's disease. Ann N Y Acad Sci. 2002 Nov;973:537-40. PMID: 12485924 Bogdanovic N, Zilmer M, Zilmer K, Rehema A, Karelson E; The Swedish APP670/671 Alzheimer's disease mutation: the first evidence for strikingly increased oxidative injury in the temporal inferior cortex. Dement Geriatr Cogn Disord. 2001 Nov-Dec;12(6):364-70. PMID: 11598307 Karelson E, Bogdanovic N, Garlind A, Winblad B, Zilmer K, Kullisaar T, Vihalemm T, Kairane C, Zilmer M. The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defence. Neurochem Res. 2001 Apr;26(4):353-61. PMID: 11495345 Saar K, Mahlapuu R, Laidmäe E, Valkna A, Kahl U, Karelson E. Langel U. Characterization of a new chimeric ligand for galanin receptors:galanin(1-13)-[D-Trp32)]-neuropeptideY(25-36)amide. Regul Pept. 2001 Oct 15;102(1):15-9. PMID: 11600206 |
last updated: 16.08.2005
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