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Elulookirjeldus (CV)
1.Eesnimi Ivar
2.Perekonnanimi Järving
3.Töökoht TTÜ keemiainstituut
4.Ametikoht vanemteadur
5.Sünniaeg 13.07.1957 (päev.kuu.aasta)
6.Haridus Tallinna Tehnikaülikool 1980.a. keemiatööstuse protsesside ja keemiaküberneetika eriala, keemiatehnoloogiainsener.
7.Teenistuskäik 1980-1981 stazeerimine Moskva Riiklikus Ülikoolis.
1981-1990 töötanud vaneminseneri ja nooremteaduri ametikohal tollases TA Keemia Instituudis.
Alates 1991.a. TA Keemia Instituudi bioorgaanilise keemia osakonna vanemteadur (alates 1997 TTÜ keemiainstituut).
8.Teaduskraad keemiakandidaat
9.Teaduskraadi välja
andnud asutus, aasta		 Eesti NSV TA Keemia Instituut 1991
10.Tunnustused Üleliiduline Leninliku Komsomoli preemia teaduse ja tehnika ala 1986.a.
Riiklik Teaduspreemia keemia ja molekulaarbioloogia alal tööde tsükli “Prostaglandiinide biosüntees korallides" eest 2002.a.
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus
12.Juhendamisel kaitstud
väitekirjad

Helike Lõhelaid, MSc, 2003, juh. Ivar Järving, Nigulas Samel. 8R-lipoksügenaas-alleenoksiidsüntetaas liitvalk korallist Gersemia fruticosa. TTÜ

Reet Järving, PhD, 2001, juh. Ivar Järving, Nigulas Samel. Novel Fatty Acid Dioxygenases from the Corals Plexaura homomalla and Gersemia fruticosa. TTÜ

Karin Valmsen, MSc, 1999, juh. Ivar Järving, Raivo Vilu. Prostaglandiin süntetaas korallist Plexaura homomalla. TTÜ

Siret Kristjuhan, MSc, 1994, juh. Ivar Järving, Ülo Lille. E-prostaglandiinide teke. TTÜ
13.Teadustöö põhisuunad Olen osalenud preparatiivsete meetodite välja töötamisel looduslike prostaglandiinide saamiseks bio- või poolkeemilise sünteesi teel. Olen tegelenud looduslike ühendite eraldamise ja identifitseerimisega.
Hetkel uute dioksügenaaside identifitseerimine ja dioksügenaaside katalüüsimehhanismi uurimine.
14.Jooksvad grandid Rasvhappe dioksügenaasid ja eikosanoidhormoonid
sihtfinantseerimine: SF0142499s03, teema juht: N.Samel
kestus: 01.01.2003 - 31.12.2007

Uute tsüklookügenaaside mehhanismiuuringud
ETF Grant: 5639, granti hoidja: N.Samel
kestus: 01.01.2003 - 31.12.2006.

Enantiomeerselt puhaste monohüdroperoksühapete preparatiivne biokatalüütiline süntees rekombinantsete lipoksügenaasidega
ETF Grant: 5100, granti hoidja: I.Järving
kestus: 01.01.2002 - 31.12.2005.

Arahidoonhappe oksüdatsioonimehhanisnid
3 R01 GM-53638; Granti hoidja: A.Brash;
NIH (USA Tervishoiuministeerium);
kestus: 01.04.2002-31.08.2005
15.Teaduspublikatsioonid

Mortimer, M., Järving, R., Brash, A., Samel, N., Järving, I. (2006) Identification and characterization of an arachidonate 11R-lipoxygenase. Archives of Biochemistry and Biophysics, 445, 147-155.

Vallikivi, I., Fransson, L., Hult, K., Järving, I., Pehk, T., Samel, N., Tõugu, V., Villo, L., Parve, O. (2005) The modelling and kinetic investigation of the lipase-catalysed acetylation of stereoisomeric prostaglandins. Journal of Molecular Catalysis B: Enzymatic, 35, 62-69.

Järving R., Järving I., Kurg R., Brash A.R., Samel N. (2004) On the Evolutionary origin of Cyclooxygenase (COX) Isozymes: Characterization of Marine Invertebrate COX Genes Points to Independent duplicationEvents in Vertebrate and Invertebrate Lineages. J. Biol. Chem., 279, 13624-13633.

Vallikivi, I., Järving, I., Samel, N., Tõugu, V., Pehk, T. and Parve, O. (2004) NMR Monitoring of Lipase-catalysed reactions of prostaglandins; preliminary estimation of reaction velocities. Journal of Molecular Catalysis B: Enzymatic, 32, 15-19

Valmsen K., Boeglin W.E., Järving I., Schneider C., Varvas K., Brash A.R., Samel N. (2004) Structural and Functional Comparison of 15S- and 15R-specific Cyclooxygenases from the Coral Plexaura homomalla. Eur. J. Biochem., 271, 3533-3538.

Jäälaid R, Järving I, Pehk T, Parve O, Lille Ü, (2001) Short synthesis of novel 9,11-secosterols, Nat Prod Lett., 15(4), 221-8

Kobzar G, Mardla V, Järving I, Samel N (2001) Comparison of anti-aggregatory effects of PGI2, PGI3 and iloprost on human and rabbit platelets. Cell Physiol Biochem. 11(5), 279-84

Koljak, R., Järving, I., Kurg, R., Boeglin, W. E., Varvas, K., Valmsen, K., Ustav, M., Brash, A. R., & Samel, N. (2001). The Basis of Prostaglandin Synthesis in Coral - Molecular Cloning and Expression of a Cyclooxygenase From the Arctic Soft Coral Gersemia Fruticosa. Journal of Biological Chemistry, 276(10), 7033-7040.

Valmsen, K., Järving, I., Boeglin, W. E., Varvas, K., Koljak, R., Pehk, T., Brash, A. R., & Samel, N. (2001). The Origin of 15r-Prostaglandins in the Caribbean Coral Plexaura Homomalla: Molecular Cloning and Expression of a Novel Cyclooxygenase. Proceedings of the National Academy of Sciences of the United States of America, 98(14), 7700-7705.

Parve O, Järving I, Martin I, Metsala A, Vallikivi I, Aidnik M, Pehk T, Samel N. (1999) Lipase-catalysed acylation of prostanoids, Bioorg Med Chem Lett. 9(13),1853-8

Varvas K, Järving I, Koljak R, Valmsen K, Brash AR, Samel N. (1999) Evidence of a cyclooxygenase-related prostaglandin synthesis in coral. The allene oxide pathway is not involved in prostaglandin biosynthesis, J Biol Chem. 274(15), 9923-9

viimati muudetud: 12.08.2005

Curriculum Vitae (CV)
1.First Name Ivar
2.Surname Järving
3.Institution Department of Chemistry, TUT
4.Position senior research scientist
5.Date of birth 13.07.1957 (day.month.year)
6.Education Faculty of Chemistry, TTU; Graduated as a Dipl. Chemical Engineer,1980
7.Research and
professional experience		 1980-1981 Research Fellow, Moscow State University
1982-1990 Research Scientist, Department of Bioorganic Chemistry, Institute of Chemistry at the Estonian Academy of Sciences
1991-present Senior Research Scientist, Laboratory of bioorganic Chemistry, Institute of Chemistry, Estonian Academy of Sciences (since 1997 Department of Chemistry, Tallinn University of Technology).
8.Academic degree candidate of sciences
9.Dates and sites of
earning the degrees		 Estonian Academy of Sciences, Institute of Chemistry, 1991
10.Honours/awards All-Union Prize for Leninsky Komsomol for Science and Technology in 1986.
National Prize for Chemistry and Molecular Biology in 2002: “The pathway of prostaglandin biosynthesis in invertebrates”, member of the research team
11.Research-administrative
experience
12.Supervised dissertations

Helike Lõhelaid, MSc, 2003, superv. Ivar Järving, Nigulas Samel. 8R-lipoksügenaas-alleenoksiidsüntetaas liitvalk korallist Gersemia fruticosa. TTÜ

Reet Järving, PhD, 2001, superv. Ivar Järving, Nigulas Samel. Novel Fatty Acid Dioxygenases from the Corals Plexaura homomalla and Gersemia fruticosa. TTÜ

Karin Valmsen, MSc, 1999, superv. Ivar Järving, Raivo Vilu. Prostaglandiin süntetaas korallist Plexaura homomalla. TTÜ

Siret Kristjuhan, MSc, 1994, superv. Ivar Järving, Ülo Lille. E-prostaglandiinide teke. TTÜ
13.Current research program I have studied preparative bio- and semisynthetic methods for production of natural prostaglandins. I have been engaged in separation, structure elucidation and bioassay of novel bioactive natural products (eicosanoids, steroids).
The current topic is molecular cloning of novel dioxygenases and characterization of the mechanism of catalysis.
14.Current grant funding SF0142499s03; Samel (PI); 1/01/03-12/31/07
Ministry of Education and Science, Estonia
Fatty Acid Dioxygenases and Eicosanoid Hormones;

ESF-5639; Samel (PI); 1/01/03-12/31/06
ESF (Estonian Science Foundation)
Mechanistic Studies of Novel Cyclooxygenases

ESF-5100; Järving (PI); 1/01/02-12/31/05
ESF (Estonian Science Foundation);
Preparative biocatalytic preparation of enantiomerically pure monohydroperoxy acids with recombinant lipoxygenases

3 R01 GM-53638 Brash (PI); 4/01/02-8/31/05
NIH (USA) Novel Oxygenations of Arachidonic Acid
15.List of most important publications

Mortimer, M., Järving, R., Brash, A., Samel, N., Järving, I. (2006) Identification and characterization of an arachidonate 11R-lipoxygenase. Archives of Biochemistry and Biophysics, 445, 147-155.

Vallikivi, I., Fransson, L., Hult, K., Järving, I., Pehk, T., Samel, N., Tõugu, V., Villo, L., Parve, O. (2005) The modelling and kinetic investigation of the lipase-catalysed acetylation of stereoisomeric prostaglandins. Journal of Molecular Catalysis B: Enzymatic, 35, 62-69.

Järving R., Järving I., Kurg R., Brash A.R., Samel N. (2004) On the Evolutionary origin of Cyclooxygenase (COX) Isozymes: Characterization of Marine Invertebrate COX Genes Points to Independent duplicationEvents in Vertebrate and Invertebrate Lineages. J. Biol. Chem., 279, 13624-13633.

Vallikivi, I., Järving, I., Samel, N., Tõugu, V., Pehk, T. and Parve, O. (2004) NMR Monitoring of Lipase-catalysed reactions of prostaglandins; preliminary estimation of reaction velocities. Journal of Molecular Catalysis B: Enzymatic, 32, 15-19

Valmsen K., Boeglin W.E., Järving I., Schneider C., Varvas K., Brash A.R., Samel N. (2004) Structural and Functional Comparison of 15S- and 15R-specific Cyclooxygenases from the Coral Plexaura homomalla. Eur. J. Biochem., 271, 3533-3538.

Jäälaid R, Järving I, Pehk T, Parve O, Lille Ü, (2001) Short synthesis of novel 9,11-secosterols, Nat Prod Lett., 15(4), 221-8

Kobzar G, Mardla V, Järving I, Samel N (2001) Comparison of anti-aggregatory effects of PGI2, PGI3 and iloprost on human and rabbit platelets. Cell Physiol Biochem. 11(5), 279-84

Koljak, R., Järving, I., Kurg, R., Boeglin, W. E., Varvas, K., Valmsen, K., Ustav, M., Brash, A. R., & Samel, N. (2001). The Basis of Prostaglandin Synthesis in Coral - Molecular Cloning and Expression of a Cyclooxygenase From the Arctic Soft Coral Gersemia Fruticosa. Journal of Biological Chemistry, 276(10), 7033-7040.

Valmsen, K., Järving, I., Boeglin, W. E., Varvas, K., Koljak, R., Pehk, T., Brash, A. R., & Samel, N. (2001). The Origin of 15r-Prostaglandins in the Caribbean Coral Plexaura Homomalla: Molecular Cloning and Expression of a Novel Cyclooxygenase. Proceedings of the National Academy of Sciences of the United States of America, 98(14), 7700-7705.

Parve O, Järving I, Martin I, Metsala A, Vallikivi I, Aidnik M, Pehk T, Samel N. (1999) Lipase-catalysed acylation of prostanoids, Bioorg Med Chem Lett. 9(13),1853-8

Varvas K, Järving I, Koljak R, Valmsen K, Brash AR, Samel N. (1999) Evidence of a cyclooxygenase-related prostaglandin synthesis in coral. The allene oxide pathway is not involved in prostaglandin biosynthesis, J Biol Chem. 274(15), 9923-9

last updated: 12.08.2005

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