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Elulookirjeldus (CV)
1.Eesnimi Külliki
2.Perekonnanimi Varvas
3.Töökoht Tallinna Tehnikaülikool (TTÜ) matemaatika-loodusteaduskond, keemiainstituut, bioorgaanilise keemia õppetool
4.Ametikoht vanemteadur
5.Sünniaeg 18.10.1959 (päev.kuu.aasta)
6.Haridus 1992-1996 TTÜ doktorant
1983 diplom orgaaniline keemia erialal
1978-1983 Tartu Riiklik Ülikool keemia erala
7.Teenistuskäik 1999- tänaseni vanemteadur TTÜ keemiainstituudis
1996-1999 teadur TTÜ Keemia Instituudi Bioorgaanilise keemia osakonnas
1989-1996 nooremteadur Eesti TA Keemia Instituudis
1983-1989 insener ja vaneminsener Eesti TA Keemia Instituudis
8.Teaduskraad Ph.D. loodusteaduste alal
9.Teaduskraadi välja
andnud asutus, aasta		 Tallinna Tehnikaülikool, 1999
10.Tunnustused Eesti Vabariigi Teaduspreemia keemia ja molekulaarbioloogia alal, “Prostaglandiinide biosüntees korallides" eest 2002.a. (teaduskollektiivi liige)
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus		 Eesti Keemia seltsi juhatuse liige
Eesti Biokeemia Seltsi liige
12.Juhendamisel kaitstud
väitekirjad
13.Teadustöö põhisuunad Uute bioaktiivsete looduslike ühendite (oksülipiinid, steroidid) eraldamine ja identifitseerimine. Eikosanoidide biosünteesi ja metabolismiradade uuringud korrallides. Uute tsükloosügenaaside otsing selgrootutes (putukad) ja vetikates ning rasvhapete metabolismiradade uurimine nimetatud organismides.
14.Jooksvad grandid Grandihoidja ETF Grant nr 6197 (2005- 2008)
Põhitäitja ETF Grant nr 5639 (2003-2006, (grandihoidja N.Samel) ja NIH grant 2001-2005 (Eesti poolne garndihoidja N.Samel).
15.Teaduspublikatsioonid

Valmsen K., Boeglin W.E., Järving I., Schneider C., Varvas K., Brash A.R., Samel N. Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla. Eur. J. Biochem., 2004, 271, 3533-3538.

Koljak R., Järving I., Kurg R., Boeglin W.E., Varvas K., Valmsen K., Ustav M., Brash, A.R., Samel N. The Basis of Prostaglandin synthesis in Coral: Molecular Cloning and Expression of a Cyclooxygenase from the Arctic Soft Coral Gersemia fruticosa. J. Biol. Chem, 2001, 276, 7033-7040.

Valmsen K., Järving I., Boeglin W.E., Varvas K., Koljak R., Pehk T., Brash A.R., Samel N. The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: Molecular cloning and expression of a novel cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A., 2001, 98, 7700-7705.

Varvas K., Järving I., Koljak R., Valmsen K., Brash A.R. and Samel N. Evidence of a Cyclooxygenase-related Prostaglandin Synthesis in Coral: The Allene Oxide Pathway is not Involved in Prostaglandin Biosynthesis, J.Biol.Chem., 1999, 274, 9923-9929.

R. Koljak, A. Lopp, T. Pehk, K. Varvas, A.-M. Müürisepp, I. Järving, N. Samel.(1998) New Cytotoxic Sterols from the Soft Coral Gersemia fruticosa, Tetrahedron 54, 179-186

Varvas, K., Järving, I., Valmsen, K., Koljak, R., and Samel, N. Effect of Selective Inhibitors on Arachidonic Acid Metabolism in the Soft Coral Gersemia fruticosa. 10th International Conference on Prostaglandins and Related Compounds, Vienna, Austria, 1996. In: Prostaglandins Leukotrienes and Essential Fatty Acids 55, Supplement 1, p.82

Varvas, K., Koljak, R., Järving, I., Pehk, T., and Samel, N. (1994) Endoperoxide pathway in Prostaglandin Biosynthesis in the soft coral Gersemia fruticosa. Tetrahedron Lett. 35, 8267-8270

R.Koljak, T.Pehk, I.Järving, M.Liiv, A.Lopp, K.Varvas, Ü.Lille, N.Samel. (1993) New Antiproliferative 9,11-Secosterol from the Soft Coral Gersemia fruticosa, Tetrahedron Lett. 34, 1985-1986

Varvas, K., Järving, I., Koljak, R., Vahemets, A., Pehk, T., Müürisepp, A.-M., Lille, Ü., and Samel, N. (1993) In vitro Biosynthesis of Prostaglandins in the White Sea Soft Coral Gersemia Fruticosa: Formation of Optically Active PGD2, PGE2,PGF2a and 15-keto- PGF2a from Aracidonic Acid. Tetrahedron Lett. 34, 643-3646

viimati muudetud: 28.09.2005

Curriculum Vitae (CV)
1.First Name Külliki
2.Surname Varvas
3.Institution Chair of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Tallinn University of Technology (TTU)
4.Position Senior Research Scientist
5.Date of birth 18.10.1959 (day.month.year)
6.Education 1992-1996 Ph.D. student at TTU
1978-1983 Faculty of Chemistry, Tartu State University
1983 graduated as a Dipl. chemist in organic chemistry
7.Research and
professional experience		 1999- at present: Senior research scientist, Institute of Chemistry, TTU
1996-1999 Research scientist, Institute of Chemistry, TTU
1989-1996 Junior Research scientist,Institute of Chemistry, Estonian Academy of Sciences
1983-1989 Research Engineer, Institute of Chemistry, Estonian Academy of Sciences
8.Academic degree Ph.D. in Natural Sciences
9.Dates and sites of
earning the degrees		 Tallinn Technical University, 1999
10.Honours/awards National Prize for Chemistry and Molecular Biology in 2002, "Biosynthesis of Prostaglandins in Invertebrates"
(member of the scientific group)
11.Research-administrative
experience		 Board Member of the Estonian Chemical Society
Membrer of the Estonian Biochemical Society
12.Supervised dissertations
13.Current research program Separation and structure elucidation of novel bioactive natural products (oxylipins, steroids) in lower organisms. Studies of eicosanoid biosynthesis pathways in corals. Search for novel cyclooxygenases in invertebrates (insects) and algae. Investigation of fatty acid metabolism in these organisms.
14.Current grant funding Ppincipal investigator ESF grant nr 6197 (2005-2008)
Investigator, ESF grant No. 5639 (2003-2006, P.I.- N.Samel);
Suppl. (N.Samel) of NIH (USA) grant GM-53638 (P.I. A.R.Brash) "Novel Oxygenations of Fatty Acids" (2001-2005).
15.List of most important publications

Valmsen K., Boeglin W.E., Järving I., Schneider C., Varvas K., Brash A.R., Samel N. Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla. Eur. J. Biochem., 2004, 271, 3533-3538.

Koljak R., Järving I., Kurg R., Boeglin W.E., Varvas K., Valmsen K., Ustav M., Brash, A.R., Samel N. The Basis of Prostaglandin synthesis in Coral: Molecular Cloning and Expression of a Cyclooxygenase from the Arctic Soft Coral Gersemia fruticosa. J. Biol. Chem, 2001, 276, 7033-7040.

Valmsen K., Järving I., Boeglin W.E., Varvas K., Koljak R., Pehk T., Brash A.R., Samel N. The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: Molecular cloning and expression of a novel cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A., 2001, 98, 7700-7705.

Varvas K., Järving I., Koljak R., Valmsen K., Brash A.R. and Samel N. Evidence of a Cyclooxygenase-related Prostaglandin Synthesis in Coral: The Allene Oxide Pathway is not Involved in Prostaglandin Biosynthesis, J.Biol.Chem., 1999, 274, 9923-9929.

R. Koljak, A. Lopp, T. Pehk, K. Varvas, A.-M. Müürisepp, I. Järving, N. Samel.(1998) New Cytotoxic Sterols from the Soft Coral Gersemia fruticosa, Tetrahedron 54, 179-186

Varvas, K., Järving, I., Valmsen, K., Koljak, R., and Samel, N. Effect of Selective Inhibitors on Arachidonic Acid Metabolism in the Soft Coral Gersemia fruticosa. 10th International Conference on Prostaglandins and Related Compounds, Vienna, Austria, 1996. In: Prostaglandins Leukotrienes and Essential Fatty Acids 55, Supplement 1, p.82

Varvas, K., Koljak, R., Järving, I., Pehk, T., and Samel, N. (1994) Endoperoxide pathway in Prostaglandin Biosynthesis in the soft coral Gersemia fruticosa. Tetrahedron Lett. 35, 8267-8270

R.Koljak, T.Pehk, I.Järving, M.Liiv, A.Lopp, K.Varvas, Ü.Lille, N.Samel. (1993) New Antiproliferative 9,11-Secosterol from the Soft Coral Gersemia fruticosa, Tetrahedron Lett. 34, 1985-1986

Varvas, K., Järving, I., Koljak, R., Vahemets, A., Pehk, T., Müürisepp, A.-M., Lille, Ü., and Samel, N. (1993) In vitro Biosynthesis of Prostaglandins in the White Sea Soft Coral Gersemia Fruticosa: Formation of Optically Active PGD2, PGE2,PGF2a and 15-keto- PGF2a from Aracidonic Acid. Tetrahedron Lett. 34, 643-3646

last updated: 28.09.2005

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