[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Anne |
| 2. | Perekonnanimi | Kahru |
| 3. | Töökoht | Keemilise ja Bioloogilise Füüsika Instituut (KBFI) |
| 4. | Ametikoht | Molekulaargeneetika laboratooriumi juhataja k.t., vanemteadur |
| 5. | Sünniaeg | 17.02.1955 (päev.kuu.aasta) |
| 6. | Haridus | 1973-1978 - Tartu Ülikool, Bioloogia-Geograafia Teaduskond, cum laude diplom (bioloog-mikrobioloog), 1978 Täienduskoolitus: - 1992 uurimistöö firmas BioOrbit (Soome) uute fotobakteriaalsete toksilisuse testide välja töötamiseks - 1996 Rahvusvaheline ToxKit treeningukursus FITA II, RECETOX centre, Brno. - 1997 - Rahvusvaheline uute ökotoksikoloogiliste testide kursus, Institute of Botany, Brno, Czech Republic. Organiseerija: National Water Research Institute, Burlington, Canada - 25. 01.-07.02. 2004 EU Center of Excellence in Environmental Health, Institute of Preventive and Clinical Medicine, Bratislava) täienduskoolitus Comet Assay metoodikas - 22.12. 2004 & 20.-21. 01.2004 - Projektijuhtide koolitus. Esko Koolitus AS |
| 7. | Teenistuskäik | 1978 – 1980 insener Küberneetika Instituudis 1980 – 1983 insener KBFI-s 1983 – 1987 nooremteadur KBFI-s 1987-1996 teadur KBFI-s 1996 – vanemteadur KBFI-s 2001 - KBFI Molekulaargeneetika Laboratooriumi Juhataja asetäitja 2005 - KBFI Molekulaargeneetika Laboratooriumi Juhataja k.t. |
| 8. | Teaduskraad | Bioloogiakandidaat, biokeemia, kood 03.00.04 |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Ülikool, 1986 |
| 10. | Tunnustused | - ISF-i (G. Soros) preemia avaldatud tööde eest, 1993 - "Viron Säätiö" stipendium (1994) - EU Mobility grant BMH1-CT-920038, 1994-1996 - EU grant CT92-0104/ERBCI-PD-930020, 1994-1995 - USA National Research Council, Board on Science and Technology for International, stipendium, 1994-1995. - IUTOX stipendium osalemiseks konverentsil ICT VIII, Pariis, 5-9.juuli 1998 - RSS (Research Support Scheme via Open Estonian Foundation) grant 430/1999, 2000-2001 - Eesti-Prantsuse teadlasvahetuse programmi (Parroti programm) grant, 2005-2006 |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
- KBFI Teadusnõukogu liige, 2005 - - Journal of Soils and Sediments, toimetuskolleegiumi liige, 2001— - Eesti Haridusministeeriumi poolt 2001.a. moodustatud toksikoloogia-alase koolituse arendamise komisjoni liige - Eesti esindaja EL ekspertide seminaril “Alternative Methods for Regulatory Toxicity Testing”, mida organiseerisid ECVAM (European Centre for the Validation of Alternative Methods)ja ESTIV (European Society of Toxicology in Vitro), November 26-28, 2001, Ispra, Itaalia - Soome Akadeemia keskkonnateaduste projektide rahvusvahelise evaluaatorite paneeli liige, 2003 - ECETOC ekspertrühma liige "Alternative testing approaches in environmental assessment", Crecy-la-Chapelle, July 7-9, 2004, Prantsusmaa - rahvusvahelise teaduskonverentsi SSCT-ETS 98 korraldus- ja teaduskomiteede esimees, Tallinn, 1998 - ekspertpaneeli “Toward common references for risk assessment of contaminated sites in Europe”, mille organiseerisid DG-JRC ja DG-ENV, Ispra, Italy, 3-4 veebr. 2005 - paneeli liige - Konverentside ISTA10 (Aug. 26-31, 2001, Quebec City, Canada), ISTA 11 (Vilnius, Lithuania, June 1-6, 2003) ja ISTA12 (12-17. June 2005, Skiathos, Greece) - rahvusvahelise teaduskomitee liige - Ülemaailmse teaduskongressi 5th World Congress (WC5 )on Alternatives and Animal use in the Life Sciences, Berlin, August 21-25, 2005 - rahvusvahelise korralduskomitee liige - USA keskkonnaagentuuri (US EPA) teadusprojekti retsensent - 2005 - Rahvusvahelise SSCT-ETS teaduskonverentsi “Chemicals, human, environment”, 20.-23.Oct. 2005, Toila, Estonia - korraldus- ja teaduskomiteede esimees Osalemine teadusühingutes ja – seltsides: - Eesti Toksikoloogia Seltsi looja (1997) ja Juhatuse esimees, 1997 - - Eesti Mikrobioloogide Ühenduse liige - Skandinaavia Rakutoksikoloogia Seltsi liige, 1993- - SETAC-i (Ülemaailmne keskkonnatoksikoloogia ja –keemia Selts) liige Muu teadusadministratiivne tegevus (sh koolitustegevus): - erinevate rahvusvaheliste teadusajakirjadesse esitatud artiklite retsensent - ETF-st taotletavate projektide ja aruannete retsensent -2001 - lepinguline lektor Tallinna Pedagoogikaülikoolis (2.0 AP kursus "Ökotoksikoloogia ja tervisekaitse" - Rahvusvahelise ökotoksikoloogia-teemalise kursuse "For Greener Grass" akadeemiline kordinaator, Tallinn, 26.06-10.07.2005. - lektor Tallinna Tehnikaülikoolis Keskkonnatehnika Õppetoolis (2.0 AP loeng "Keskkonnariski hindamine ja ökotoksikoloogia", 2005 - - lektor NATO-rahastatud keskkonnatemaatilistel kursustel (2000, 2003) - lektor rahvusvahelistel üliõpilaste koolitusel "Management and treatment of polluted soils in Europe" (Socrates Intensive Programme 2001-2005). - KBFI BioSPinno projekti teaduskoordinaator, 2004 - |
| 12. | Juhendamisel kaitstud väitekirjad |
Lee Põllumaa, DSc, 2005, juh. Anne Kahru. "Evaluation of ecotoxicological effects related to oil shale industry". Tallinna Tehnikaülikool (Tallinn University of Technology) Villem Aruoja, MSc, 2004, juh. Anne Kahru. "Toxicity testing of heavy metal polluted soils with algae Selenastrum capricornutum: a soil suspension-test" ("Raskemetallidega saastatud muldade toksilisuse testimine vetikatega Selenastrum capricornutum: mullasuspensiooni-test"). Tallinna Tehnikaülikool (Tallinn University of Technology) Alla Maloverjan, MSc, 2001, juh. Anne Kahru. "Application of microbiological, ecotoxicological and chemical methods for environmental risk assessment of polluted soils, sediments and solid wastes" (“Mikrobioloogiliste, ökotoksikoloogiliste ja keemiliste meetodite kasutamine saastatud muldade, setete ja tahkete jäätmete keskkonnaohtlikkuse hindamisel “. Tallinna Tehnikaülikool (Tallinn Technical University) Angela Ivask, MSc, 2001, juh. Anne Kahru, Marko Virta. Construction and use of luminescent recombinant bacterial sensors for the detection of heavy metals" (“Luminestseeruvad rekombinantsed sensorbakterid raskemetallide detekteerimiseks: konstrueerimine ja kasutamine “). Tallinna Tehnikaülikool (Tallinn Technical University) |
| 13. | Teadustöö põhisuunad | - inimesele oluliste (keskkonna)toksikantide mõju uurimine erineval bioloogilise organisatsiooni tasemel:molekulidest selgrootute organismideni (in vitro) - in vitro testpatareide välja töötamine kemikaalide (sh inimese tervist ohustavate mürgiste kemikaalide) toksilisuse hindamiseks ja toksilisuse mehhanismide uurimiseks - ökotoksikoloogiliste testide rakendamine eeluuringute tasemel uute kemikaalide (sh ravimikandidaatide ja nanoosakeste) toksilisuse hindamiseks: 3R strateegia (loomkatsete osakaalu vähendamine in vitro testimismeetodite laialdasema kasutamise teel). - rekombinantsete sensorbakterite (bioreporterite) konstrueerimine, modifitseerimine ja rakendamine toksikantide mõjumehhanismide uurimisel. - rekombinantsete sensorbakterite mehhanismipõhine modifitseerimine nende tundlikkuse ja spetsiifilisuse suurendamiseks. Sensorbakterite kasutamine toksikantide biokättesaadavuse ja selle mehhanismide uurimiseks. - toksikantide, rakkude ja keskkonnamaatriksi vaheliste interaktsioonide uurimine (sh. sorptsioon, desorptsioon), bioloogiline kättesaadavus ja seda modifitseerivad faktorid. Toksikantide biokontsentreerumine ja -võimendumine piki bioloogilist toiduahelat. - ökotoksikoloogia ja keskkonnariski hindamine |
| 14. | Jooksvad grandid | “Toksikoloogilise riski hindamine in vitro” - sihtfinantseerimise grant nr. 0222601Bs03 (2003-2007) - juht “Keskkonnaohtlike ainete toksilisus, biokättesaadavus ja liikuvus mullas, setetes ja tahketes jäätmetes”. ETF grant nr. 5551 (2003-2006)- juht - Rekombinantsed luminestseeruvad biosensorid - keskkonnarealistlikud mudelorganismid toksiliste raskemetallide biokättesaadavuse määramiseks - Eesti-Prantsuse teadlastevahetuse (Parroti projekti) grant - 2005-2006 - Juht - BioSpinno 2 projekt (2004-2006), KBFI alaprojekti juht " Study of the ecotoxicity of the polluted soils" (2000-2005). Uurimispartner: ISA (Institut Supérieur d'Agriculture, Lille, Prantsusmaa), Koostööpartnerid: Dr. Francis Douay & Prof. H.C. Dubourguier (ISA, Lille, Prantsusmaa). Juht -Risk based environmental site assessment of waste from the oil shale industry′. (2002-2003). Koordinaator: Dr. J.-E. Sorlie, Norwegian Geotechnical Institute, Oslo, Norway – Alaprojekti juht "Analysis of bioavailable heavy metals and organic compounds in the Baltic Sea by using sensor bacteria. (2001-2004). Maj and Tor Nessling Fondi projekt, koordinaator: Dr. M. Virta, Turu Ülikool, Soome. Alaprojekti juht. NATO ühisgrant "Evaluation of composting and fungal treatment technology for remediation of PAH contaminated soil" EST CLG No 978297. Koordinaator: Dr. T. Eggen, Jordforsk-Centre, Aas, Norra, (2002-2003). Alaprojekti juht |
| 15. | Teaduspublikatsioonid |
Kahru, A. (2006) Ecotoxicological Tests in Non-Ecotoxicological Research: Contribution to the Three Rs. ALTEX, in press Kahru, A. & Põllumaa, L. (2006)Environmental hazard of the waste streams of the Estonian oil-shale industry: an ecotoxicological review. Oil Shale, Vol. 23, No. 1 pp. 53–93 Leedjärv, A., Ivask, A. Virta, M., Kahru, A. (2006)Analysis of bioavailable phenols from natural samples by recombinant luminescent bacterial sensors CHEMOSPHERE, in press Bernaus, A., Gaona, X., Ivask, A., Kahru, A., Valiente, M. (2005) Analysis of sorption and bioavailability of different species of mercury on model soil components using XAS techniques and sensor bacteria – Analytical and Bioanalytical Chemistry, Volume 382, Number 7, Pages: 1541 - 1548 Kahru, A., Drews, M., Põllumaa, L., Kasemets, K., Veidebaum, T., Kogerman, P. (2005) Toxicity of nanoscale cationic polymers in vitro and in vivo - ALTEX, Vol. 22, Special Issue, p. 302 Kahru, A., Ivask, A., Kasemets, A., Põllumaa, L., Kurvet, I., Francois, M., Dubourguier, HC. (2005) Biotests and biosensors in ecotoxicological risk assessment of field soils polluted with zinc, lead and cadmium – Environmental Toxicology & Chemistry, Vol. 24, No. 11, pp. 2973-2982 Aruoja, V., Kurvet, I., Dubourguier, H.C., Kahru, A. (2004) Toxicity Testing of heavy Metal Polluted Soils with Algae Selenastrum capricornutum: a Soil Suspension Assay. –Environmental Toxicology. Volume 19, Issue 4, p. 396 – 402. Ivask, A., François, M. Kahru, A., Dubourguier, H.C., Virta, M., Douay, F. (2004). Recombinant luminescent bacterial sensors for the measurement of bioavailability of cadmium and lead in soils polluted by metal smelters. – Chemosphere, 55: 147-156. Põllumaa L, Kahru A, Manusadzianas L (2004): Biotest- and Chemistry-Based Hazard Assessment of Soils, Sediments and Solid Wastes. JSS - J Soils & Sediments, Vol. 4 (4): 267-275 Sørlie, J.-E., Bityukova, L., Sæther, O.-M., Rudolph-Lund, K., Kahru, A., Vallner, L., Petersell, V., Razgonjajev, A., Põllumaa, L. 2004. Estonia, the oil shale industry. Risk based environmental site assessment of landfills. Report. Reg. No FS 32989. NGI, 216pp. Sørlie, J.-E., Bityukova, L., Sæther, O.-M., Rudolph-Lund, K., Kahru, A., Vallner, L., Petersell, V., Razgonjajev, A., Põllumaa, L. 2004. Estonia, the oil shale industry. Risk based environmental site assessment of landfills. Report. Reg. No FS 32989. NGI, 216pp. L. Põllumaa & A. Kahru (2003) Ecotoxicological hazard assessment of solid-phase samples. In: "The Utilization of Bioremediation to Reduce Soil Contamination: Problems and Solutions", ed. by V. Sasek, J.A. Glaser and Ph. Baveye. NATO Science Series IV: Earth and Environmental Sciences. Voil. 19. Kluwer Academic Publishers, Dordrecht/Boston/London, p. 217-220. ISBN 1-4020-1145-5. Manusadžianas, L, Balkelytė, L., Sadauskas, K., Blinova, I., Põllumaa, L., Kahru, A. (2003)Ecotoxicological study of Lithuanian and Estonian wastewaters: selection of the biotests, and correspondence between toxicity and chemical-based indices. –Aquatic Toxicology, Vol. 63, 1, p. 27-41. Ivask, A., Kahru, A., Kunttu, K., Virta, M., Douay, F., Dubourguier, H.-C. (2002) Bioanalysis of heavy metals from soils and sediments using recombinant luminescent bacterial sensors. Toxicology Letters 135, S101 Ivask, A., Virta, M., Kahru, A. (2002) Construction and use of specific luminescent recombinant bacterial sensors for the assessment of bioavailable fraction of cadmium, zinc, mercury and chromium in the soil – Soil Biol. & Biochem., 34: 1439-1447. Kahru, A., Maloverjan, A., Sillak, H., Põllumaa, L. (2002). Toxicity and fate of phenolic pollutants in the contaminated soils associated with the oil-shale industry. Environmental Science and Pollution Research, Special Issue 1, 27-33. Kahru, A., Põllumaa, L. (2001) Application of the ecotoxicological test batteries for the study of environmental pollution. – Pharmacology & Toxicology. Vol. 88, supplement I, p. 19. Põllumaa, L., Maloveryan, A., Trapido, M., Sillak, H., Kahru, A. (2001) Study of the Environmental Hazard Caused by the Oil-Shale Industry Solid Waste– ATLA, 29, p. 259-267.. Kahru, A., Põllumaa, L., Reiman, R. and Rätsep, A. (2000) Microbiotests for the evaluation of the pollution from the oil-shale industry. In: New Microbiotests for Routine Toxicity Testing and Biomonitoring. KLUWER ACADEMIC/PLENUM PUBLISHERS. Eds. Persoone, G., Janssen, C., De Coen, W. , p. 357-365. Kahru, A., Põllumaa, L., Reiman, R., Rätsep, A., Liiders, M. and Maloveryan, A. (2000) The toxicity and biodegradability of eight main phenolic compounds characteristic to the oil-shale industry wastewaters: a test battery approach. – Environmental Toxicology, Vol. 15, Nr. 2, 431-442. Pôllumaa L., Kahru A. , Eisenträger A., Reiman R. , Maloveryan A. , Rätsep A (2000) Toxicological investigation of soil with the solid-phase flash assay: comparison with other ecotoxicological tests. –ATLA, Vol. 28, p. 461-472. Kahru, A., Põllumaa, L., Reiman, R. and Rätsep, A. (1999) Predicting the toxicity of oil-shale industry wastewater by its phenolic composition - ATLA, Vol. 27, p. 359-366. Rozkov, A., Vassiljeva, I., Kurvet, M., Kahru A., Preis, S., Kharchenko, A., Krichevskaja, M., Liiv, M., Käärd, A., Vilu, R. (1999) Laboratory Study of Bioremediation of Rocket Fuel-Polluted Groundwater. - Water Research, Vol. 33, p.1303-1313. Shugart, L., Cibulka, J., Boruvka, L., Curdova, E., Holsbeek, L., Kahru, A., Kotelevtsev, S., Kratz, W., Kubiznakova, J., and Walker, C. (1999)Report of the working group on Northern Bohemia. - In: Biomarkers: A Pragmatic Basis for Remediation of Severe Pollution in Eastern Europe. Ed. by D.B. Peakall, C.H. Walker and P. Migula. NATO Science Series. 2. Environmental Security - Vol. 54, Kluwer Academic Publishers, 1999. Dordrecht/Boston/London, pp. 229-279. Clemedson, C., Andersson, M., Aoki, Y., Barile, F.A., Bassi, A.M., Calleja, M.C., Castano, A., Clothier, R., Dierickx, P., Enwall, B., Ferro, M., Fiskesjö, G., Garza-Ocanas, L., Gómez-Lechón, Gülden, M., Hall, T., Imai, K., Isomaa, B.,Kahru, A., Kerszman, G., Kjellstrand, P., Kristen, U., Kunimoto, M., Kärenlampi, S., Lewan, L., Lilius, H., Loukianov, A., Monaco, F., Ohno, T., Persoone, G., Romert, L., Sandberg, M., Sawer, T., Segner, H., Seibert, H., Shrivastava, R., Sjöström, M. Stammati, A.,Tanaka, N., Thuvander, A., Torres-Alanis, O., Valentino, M., Wakuri, S., Walum, E., Wang, X., Wieslander, A., Zucco, F. & Ekwall, B. (1998) MEIC evaluation of acute systemic toxicity toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis. - ATLA, 26, p. 131-183. Clemedson, C., Barile, F.A., Ekwall, B., Gómez-Lechón, M.J., Hall, T., Imai, K., Kahru, A., Logemann, P., Monaco, F., Ohno, T., Segner, H., Sjöström, M. , Valentino, M., Walum, E., Wang, X., Ekwall, B. (1998) MEIC evaluation of acute systemic toxicity. Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. - ATLA, 26, p. 93-129. Ekwall, B., Barile, F.A., Castano, A., Clemedson, C., Clothier, R., Dierickx, P., Ekwall, B., Ferro, M., Fiskesjö, G., Garza-Ocanas, L., Gómez-Lechón, Gülden, M., Hall, T., Isomaa, B.,Kahru, A., Kerszman, G., Kristen, U., Kunimoto, M., Kärenlampi, S., Lewan, L., Loukianov, A., Ohno, T., Persoone, G., Romert, L., Sawer, T., Shrivastava, R., Segner, H., Stammati, A.,Tanaka, N., Valentino, M., Walum, Zucco, F. (1998) MEIC evaluation of acute systemic toxicity toxicity. Part VI. The prediction of human toxicity by rodent LD50 values and results from 61 in vitro methods. - ATLA, 26, p. 617-658. Kahru, A., Põllumaa, L., Blinova, I., Reiman, R. and Rätsep, A. (1998) Chemical versus toxicological analysis in characterization of phenolic pollution: a test battery approach - Toxicology Letters, Supplement 1/95, p. 237 Kahru, A., Põllumaa, L., Blinova, I., Reiman, R. and Rätsep, A. (1998) Chemical versus toxicological analysis in characterization of phenolic pollution: a test battery approach - Toxicology Letters, Supplement 1/95, p. 237 Kahru, A. , Reiman, R. and Rätsep, A. (1998) The efficiency of different phenol-degrading bacteria and activated sludges in detoxification of phenolic leachates - CHEMOSPHERE, Vol. 37, No. 2, p. 301-318 Kahru, A., Kurvet, M. and Kurvet, I. (1997) Study of the toxicological impact of different components of ash-heap water. - Oil Shale, Vol. 14, Nr. 4 SPECIAL, p. 469-475. Kahru, A., Kurvet, M., Kurvet, I., Reiman, R., Rätsep, A. (1997) The toxcity of ash-heap water (sulfur-rich phenolic leachate) and the efficiency of different phenol-utilising bacterial strains in its biopurification/detoxification. - Human and Experimental Toxicology, Vol., 16, Nr. 10., p. 617. Paalme, T., Elken, R., Kahru, A., Vanatalu, K. and Vilu, R. (1997) The growth rate control in Escherichia coli at near to maximum growth rates: the A-stat approach - Antonie van Leeuwenhoek, 71: 217-230. Shevchuk, I., Chekulayev, V., Chekulayeva, L., Kahru, A. (1997) Phototoxicity of lonidamine, and antitumour agent, towards mammary cells. – Human and Experimental Toxicology, Vol., 16, Nr. 10., p. 623. V. Chekulayev, I. Shevchuk, L. Chekulayeva, A. Kahru (1997) Study of the photochemical and phototoxic properties of lonidamine [1-(2,4-dichlorobenzyl)-1H-indazol-3-carboxylic acid], J. Photochem. Photobiol, B: Biology, v.41, no.1-2, pp. 11-21. Chekulayev, V., Shevchuk, I., Chekulayeva, L. and Kahru, A. (1996) Increasing the efficiency of photosensitized damage of Erlich ascites carcinoma cells using haematoporphyrin derivative or chlorin-e6 in combination with lonidamine - Proc. Estonian Acad. Aci. Biol., 45, Nr. 3-4, p. 102-127. Clemedson, C., McFarlane-Abdulla, E., Andersson, M., Barile, F.A., Calleja, M.C., Chesné, C., Clothier, R., Cottin, M., Curren, R., Dierickx, P., Ferro, M., Fiskesjö, G., Garza-Ocanas, L., Gómez-Lechón, Gülden, M., Isomaa, B., Janus, J., Judge, P., Kahru, A., Kemp, R.B., Kerszman, G., Kristen, U., Kunimoto, M., Kärenlampi, S., Lavrijsen, K.,Lewan, L., Lilius, H., Malmsten, A., Ohno, T., Persoone, G., Petterson, R., Roguet, R., Romert, L., Sandberg, M., Sawer, T., Seibert, H., Shrivastava, R., Sjöström, M. Stammati, A.,Tanaka, N., Torres ALanis, O.Voss, J.-U., Wakuri, S., Walum, E., Wang, X., Zucco, F. & Ekwal, B. MEIC evaluation of acute systemic toxicity toxicity. Part I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals (1996) - ATLA, Supplement 1, p. 251-272. Clemedson, C., McFarlane-Abdulla, E., Andersson, M., Barile, F.A., Calleja, M.C., Chesné, C., Clothier, R., Cottin, M., Curren, R., Dierickx, P., Ferro, M., Fiskesjö, G., Garza-Ocanas, L., Gómez-Lechón, Gülden, M., Isomaa, B., Janus, J., Judge, P., Kahru, A., Kemp, R.B., Kerszman, G., Kristen, U., Kunimoto, M., Kärenlampi, S., Lavrijsen, K.,Lewan, L., Lilius, H., Malmsten, A., Ohno, T., Persoone, G., Petterson, R., Roguet, R., Romert, L., Sandberg, M., Sawer, T., Seibert, H., Shrivastava, R., Sjöström, M. Stammati, A.,Tanaka, N., Torres ALanis, O.Voss, J.-U., Wakuri, S., Walum, E., Wang, X., Zucco, F. & Ekwall, B. MEIC evaluation of acute systemic toxicity toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis (1996) - ATLA, Supplement 1, p. 273-311. Kahru, K. Tomson, T. Pall and I. Külm. (1996) Study of toxicity of pesticides using luminescent bacteria Photobacterium phosphoreum - Wat. Sci. &Tech., Vol. 33, Nr. 6, p. 147-154. Kahru, M. Kurvet and I. Külm (1996) Toxicity of phenolic wastewater to luminescent bacteria Photobacterium phosphoreum. - Wat. Sci. &Tech. 1996, Vol. 33, Nr. 6, 139-146. Paalme, T., Kahru, A., Elken, R., Vanatalu, K.,Tiisma, K. and Vilu, R. (1995). The Computer- Controlled Continuous Culture of Escherichia coli with Smooth Change of Dilution rate. A-stat. “J. Microbiol. Methods”, 24, 145-153. Kahru, A. and Borchardt, B. (1994) Toxicity of 39 MEIC Chemicals to Bioluminescent Photobacteria (The BiotoxTM Test): Correlation with Other Test Systems" - ATLA, 22, 147-160. Kahru, A. (1993) In vitro toxicity testing using marine luminescent bacteria Photobacterium phosphoreum:The BiotoxTM test - ATLA, Vol. 21, Nr 2, p. 210-215. Pruul, R., Kahn, H. and Kahru, A. (1993) Application of the Ames genotoxicity assay and the bioluminescent toxicity assay in the testing of urine samples. - ATLA, Vol. 21, Nr. 2, p. 225-232. Kahru A. and Vilu, R. (1991). The ATP bioluminescence technique in evaluating the bacteriological quality of dried milk. - In: Bioluminescence and Chemiluminescence. Current Status. Ed. by P.E. Stanley & L.J. Kricka. John Wiley & Sons, 1991, p. 495-498. Kahru, A. Pelkonen, M. Vilu, R. (1991). Application of ATP bioluminescent method of rapid determination of microbial biomass in environmental samples: trial of the assay in enumeration of bacteria in soil and activated sludge. - "Med. Fac. Landbouww. Rijksuniv. Gent", Vol. 56 (4a), p. 1585-1587. Kahru, A. and Vilu, R. (1990). The role of the adenine nucleotides in the regulation of bacterial energy metabolism: theoretical problems and experimental pitfalls. - "Microbios", Vol. 62, p. 83-92. Paalme, T., Tiisma, K., Kahru, A., Vanatalu, K, Vilu, R. (1990) Glucose-limited fed-batch cultivation of Escherichia coli with computer-controlled fixed growth rate. - "Biotechnol. Bioeng.", Vol. 35, p. 312-319. Kahru, A. Vilu, R. (1988) Use of the luciferin-luciferase assay of ATP for measuring the bacterial growth: application to Escherichia coli. - "Acta Biotechnol.", Vol. 8, p. 92-98. Kahru, A. Paalme, T. Vilu, R. (1987) Effect of temperature on the ATP pool and adenylate energy charge of Escherichia coli . - "FEMS Microbiol. Lett.", Vol. 41 (3), p. 305-308. Kahru, A. Vilu, R. (1983) On characterization of the growth of Escherichia coli in batch culture. - "Arch. Microbiol.", Vol. 135 (1), p. 12-15. Kahru, A. Liiders, M., Vanatalu, K., Vilu, R. (1982) Adenylate energy charge during batch culture of Thermoactinomyces vulgaris. - "Arch. Microbiol.", Vol. 133 (2), p. 142-144. |
viimati muudetud: 09.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Anne |
| 2. | Surname | Kahru |
| 3. | Institution | National Institute of Chemical Physics and Biophysics (NICPB), Tallinn, Estonia |
| 4. | Position | Head of the Laboratory of Molecular Genetics, senior research scietist |
| 5. | Date of birth | 17.02.1955 (day.month.year) |
| 6. | Education | 1973-1978 - Tartu University, Dept. of Biology-Geography, graduated cum laude as biologist-microbiologist, 1978 Additional professional training: - 1992 research in biotechnology company BioOrbit (Finland) on elaboration of the new photobacterial toxicity test - 1996 International ToxKit training course FITA II in RECETOX centre, Brno. - 1997 International Training on ecotoxicological bioassays, Institute of Botany, Brno, Czech Republic. Organized by National Water Research Institute, Burlington, Canada - 25. 01.-07.02. 2004 EU Center of Excellence in Environmental Health, Institute of Preventive and Clinical Medicine, Bratislava) professional training courses on Comet Assay techniques - 22.12. 2004 & 20.-21. 01.2004 - Training for project management. Esko Koolitus AS |
| 7. | Research and professional experience |
1978 – 1980 engineer, Institute of Cybernetics, Estonia 1980 – 1983 engineer in National Institute of Chemical Physics and Biophysics (NICPB), Estonia 1983 – 1987 junior research scientist in NICPB 1987-1996 research scientist in NICPB 1996 – senior research scientist in NICPB 2001 - Vice head of Laboratory of Molecular Genetics, NICPB, Estonia 2005 - Head of Laboratory of Molecular Genetics, NICPB, Estonia |
| 8. | Academic degree | Candidate of Biological Sciences (biochemistry), equivalent of PhD |
| 9. | Dates and sites of earning the degrees |
Tartu University (Estonia), 1986 |
| 10. | Honours/awards | - ISF-i (G. Soros) award for scientific publications (1993) - Scolarship of Finnish Foundation "Viron Säätiö" (1994) - EC Mobility grant BMH1-CT-920038, 1994-1996 - Grant from EC CT92-0104/ERBCI-PD-930020, 1994-1995 - USA National Research Council, Board on Science and Technology for International, fellowship, 1994-1995. - IUTOX mobility grant for ICT VIII, Paris, 5-9.07.1998 - RSS (Research Support Scheme via Open Estonian Foundation) grant 430/1999, 2000-2001 - Estonian-French mobility programme (Parrot programme) grant, 2005-2006 |
| 11. | Research-administrative experience |
Membership of Editorial, Scientific and Advisory Boards: - Member of the Scientific Council of National Institute of Chemical Physics and Biophysics, Estonia. 2005 - - member of the editorial board of Journal of Soils and Sediments, 2001— - member of the Commission on the Education in Toxicology in Estonia at the Estonian Ministry of Education, 2001 - Representative of Estonia in the EC-funded workshop organized by ECVAM (European Centre for the Validation of Alternative Methods) and ESTIV (European Society of Toxicology in Vitro) workshop “Alternative Methods for Regulatory Toxicity Testing”. November 26-28, 2001, Ispra, Italy - member of the International Evaluation Panel of Experts for research applications on environmental sciences presented to Finnish Academy of Sciences, 2003. - member of the ECETOC task force on alternative testing approaches in environmental assessment, Crecy-la-Chapelle, July 7-9, 2004, France -Chair-person of the organizing and scientific committees of the SSCT-ETS International Conference in Tallinn, Estonia (1998) - member of the expert meeting “Toward common references for risk assessment of contaminated sites in Europe” organized by DG-JRC and DG-ENV, Ispra, Italy, 3-4 February 2005 - Member of the Scientific Committees of ISTA10 (Aug. 26-31, 2001, Quebec City, Canada), ISTA 11 (Vilnius, Lithuania, June 1-6, 2003) and ISTA12 (12-17. June 2005, Skiathos, Greece) - member of the International Organizing Committee of 5th World Congress (WC5 )on Alternatives and Animal use in the Life Sciences, Berlin, August 21-25, 2005 - expert referee for US Environmental Protection Agency, 2005 - Chair-person of the organizing and scientific committees of the International SSCT-ETS conference “Chemicals, human, environment”, 20.-23.Oct. 2005, Toila, Estonia. Membership of professional societies: - Founder and Chair-person of Estonian Society of Toxicology (created at 1997). - member Estonian Society for Microbiology, Scandinavian Society of Cell Toxicology, Society of Environmental Toxicology and Ecotoxicology (SETAC) Other administrative tasks (e.g., teaching): - referee for several international scientific Journals - referee for scientiic projects of Estonian Science Foundation -2001 - lecturer of 2.0 credit course ”Ecotoxicology and environmental health” in Tallinn Pedagogical University - organiser of the academic part of international BEST course on ecotoxicology "For Greener Grass", Tallinn, 26.06-10.07.2005. - Lecturer of 2.0 credit course ”Environmental risk assessment and ecotoxicology” in Tallinn University of Technology (TTÜ, 2005 - - invited lecturer on international education courses "Management and treatment of polluted soils in Europe" (Socrates Intensive Programme 2001-2005. - invited lecturer on NATO-funded training courses (2000, 2003) - scientific coordinator of BioSpinno project in NICPB, 2004 - |
| 12. | Supervised dissertations |
Lee Põllumaa, DSc, 2005, superv. Anne Kahru. "Evaluation of ecotoxicological effects related to oil shale industry". Tallinna Tehnikaülikool (Tallinn University of Technology) Villem Aruoja, MSc, 2004, superv. Anne Kahru. "Toxicity testing of heavy metal polluted soils with algae Selenastrum capricornutum: a soil suspension-test" ("Raskemetallidega saastatud muldade toksilisuse testimine vetikatega Selenastrum capricornutum: mullasuspensiooni-test"). Tallinna Tehnikaülikool (Tallinn University of Technology) Alla Maloverjan, MSc, 2001, superv. Anne Kahru. "Application of microbiological, ecotoxicological and chemical methods for environmental risk assessment of polluted soils, sediments and solid wastes" (“Mikrobioloogiliste, ökotoksikoloogiliste ja keemiliste meetodite kasutamine saastatud muldade, setete ja tahkete jäätmete keskkonnaohtlikkuse hindamisel “. Tallinna Tehnikaülikool (Tallinn Technical University) Angela Ivask, MSc, 2001, superv. Anne Kahru, Marko Virta. Construction and use of luminescent recombinant bacterial sensors for the detection of heavy metals" (“Luminestseeruvad rekombinantsed sensorbakterid raskemetallide detekteerimiseks: konstrueerimine ja kasutamine “). Tallinna Tehnikaülikool (Tallinn Technical University) |
| 13. | Current research program | - study of the priority (environmental) toxicants and their adverse effects on different levels of biological organisation in vitro: from molecular level till invertebrates - combination of in vitro toxicity tests for the study of adverse effects and mechanisms of toxic action of chemicals on environment and human health - applicability of ecotoxicological tests in toxicity screening of new chemicals, e.g potential drug candidates and nanoparticles: 3R (reduction, replacement, refinement) strategy - a worldwide acknowledged and EU-level prioritized strategy for the reduction of the use of laboratory animals in scientific studies as well as in the legislature-driven research - Construction, modification and use of recombinant sensor bacteria (bioreporters) for the study of bioavailability of toxicants and toxicity mechanisms - mechanism-based modification of recombinant sensor bacteria in order to increase their sensitivity towards target analytes and specificity (Pb, Hg, Zn, phenol etc). Application of modified sensor bacteria for the study of bioavailability of toxicants and mechanisms of bioavailability. - study of the interactions of toxcicants, cells and environmental matrices (e.g., sorption & desorption), bioavailablity and its modifying factors. Transfer of toxicants via food web. - ecotoxicological evaluation of environmental hazard |
| 14. | Current grant funding | "Toxicological risk assessment in vitro" - basic funding grant nr. 0222601Bs03 (2003-2007) - PI "Bioavailability, toxicity and mobility of main industrial and urban pollutants in soil, sediments and solid wastes.", Estonian Science Foundation grant N5. 5551 (2003-2006)- PI - Bioavailability of toxic heavy metals: recombinant luminescent biosensors and environmental reality", Estonian-French science cooperation (Parrot project) grant, 2005-2006 – leader - BioSpinno 2 project (2004-2006), leader of the NICPB project -"Study of the ecotoxicity of the polluted soils′ (2000-2005): Scientific cooperation project with ISA (Lille, France), Dr. F. Douay. H. C. Dubourguier, Dr. A. Kahru -Risk based environmental site assessment of waste from the oil shale industry. Funded by Norwegian Government and Norwegian Ministry of Foreign Affairs under the Integration Program for EU Candidate Countries (2002-2003). Coordinator: Dr. J.-E. Sorlie, Norwegian Geotechnical Institute, Oslo, Norway - leader of NICPB project -NATO Collaborate Linkage Grant ′Evaluation of composting and fungal treatment technology for remediation of PAH contaminated soil′ (2002-2003). Coordinator: Dr. T. Eggen, Jordforsk-Centre, Aas, Norway – leader of the Estonian project -"Analysis of bioavailable heavy metals and organic compounds in the Baltic Sea by using sensor bacteria". (2001-2003). Maj and Tor Nessling Foundation project. Coordinator: Dr. M. Virta, University of Turku - leader of the Estonian project |
| 15. | List of most important publications |
Kahru, A. (2006) Ecotoxicological Tests in Non-Ecotoxicological Research: Contribution to the Three Rs. ALTEX, in press Kahru, A. & Põllumaa, L. (2006)Environmental hazard of the waste streams of the Estonian oil-shale industry: an ecotoxicological review. Oil Shale, Vol. 23, No. 1 pp. 53–93 Leedjärv, A., Ivask, A. Virta, M., Kahru, A. (2006)Analysis of bioavailable phenols from natural samples by recombinant luminescent bacterial sensors CHEMOSPHERE, in press Bernaus, A., Gaona, X., Ivask, A., Kahru, A., Valiente, M. (2005) Analysis of sorption and bioavailability of different species of mercury on model soil components using XAS techniques and sensor bacteria – Analytical and Bioanalytical Chemistry, Volume 382, Number 7, Pages: 1541 - 1548 Kahru, A., Drews, M., Põllumaa, L., Kasemets, K., Veidebaum, T., Kogerman, P. (2005) Toxicity of nanoscale cationic polymers in vitro and in vivo - ALTEX, Vol. 22, Special Issue, p. 302 Kahru, A., Ivask, A., Kasemets, A., Põllumaa, L., Kurvet, I., Francois, M., Dubourguier, HC. (2005) Biotests and biosensors in ecotoxicological risk assessment of field soils polluted with zinc, lead and cadmium – Environmental Toxicology & Chemistry, Vol. 24, No. 11, pp. 2973-2982 Aruoja, V., Kurvet, I., Dubourguier, H.C., Kahru, A. (2004) Toxicity Testing of heavy Metal Polluted Soils with Algae Selenastrum capricornutum: a Soil Suspension Assay. –Environmental Toxicology. Volume 19, Issue 4, p. 396 – 402. Ivask, A., François, M. Kahru, A., Dubourguier, H.C., Virta, M., Douay, F. (2004). Recombinant luminescent bacterial sensors for the measurement of bioavailability of cadmium and lead in soils polluted by metal smelters. – Chemosphere, 55: 147-156. Põllumaa L, Kahru A, Manusadzianas L (2004): Biotest- and Chemistry-Based Hazard Assessment of Soils, Sediments and Solid Wastes. JSS - J Soils & Sediments, Vol. 4 (4): 267-275 Sørlie, J.-E., Bityukova, L., Sæther, O.-M., Rudolph-Lund, K., Kahru, A., Vallner, L., Petersell, V., Razgonjajev, A., Põllumaa, L. 2004. Estonia, the oil shale industry. Risk based environmental site assessment of landfills. Report. Reg. No FS 32989. NGI, 216pp. Sørlie, J.-E., Bityukova, L., Sæther, O.-M., Rudolph-Lund, K., Kahru, A., Vallner, L., Petersell, V., Razgonjajev, A., Põllumaa, L. 2004. Estonia, the oil shale industry. Risk based environmental site assessment of landfills. Report. Reg. No FS 32989. NGI, 216pp. L. Põllumaa & A. Kahru (2003) Ecotoxicological hazard assessment of solid-phase samples. In: "The Utilization of Bioremediation to Reduce Soil Contamination: Problems and Solutions", ed. by V. Sasek, J.A. Glaser and Ph. Baveye. NATO Science Series IV: Earth and Environmental Sciences. Voil. 19. Kluwer Academic Publishers, Dordrecht/Boston/London, p. 217-220. ISBN 1-4020-1145-5. Manusadžianas, L, Balkelytė, L., Sadauskas, K., Blinova, I., Põllumaa, L., Kahru, A. (2003)Ecotoxicological study of Lithuanian and Estonian wastewaters: selection of the biotests, and correspondence between toxicity and chemical-based indices. –Aquatic Toxicology, Vol. 63, 1, p. 27-41. Ivask, A., Kahru, A., Kunttu, K., Virta, M., Douay, F., Dubourguier, H.-C. (2002) Bioanalysis of heavy metals from soils and sediments using recombinant luminescent bacterial sensors. Toxicology Letters 135, S101 Ivask, A., Virta, M., Kahru, A. (2002) Construction and use of specific luminescent recombinant bacterial sensors for the assessment of bioavailable fraction of cadmium, zinc, mercury and chromium in the soil – Soil Biol. & Biochem., 34: 1439-1447. Kahru, A., Maloverjan, A., Sillak, H., Põllumaa, L. (2002). Toxicity and fate of phenolic pollutants in the contaminated soils associated with the oil-shale industry. Environmental Science and Pollution Research, Special Issue 1, 27-33. Kahru, A., Põllumaa, L. (2001) Application of the ecotoxicological test batteries for the study of environmental pollution. – Pharmacology & Toxicology. Vol. 88, supplement I, p. 19. Põllumaa, L., Maloveryan, A., Trapido, M., Sillak, H., Kahru, A. (2001) Study of the Environmental Hazard Caused by the Oil-Shale Industry Solid Waste– ATLA, 29, p. 259-267.. Kahru, A., Põllumaa, L., Reiman, R. and Rätsep, A. (2000) Microbiotests for the evaluation of the pollution from the oil-shale industry. In: New Microbiotests for Routine Toxicity Testing and Biomonitoring. KLUWER ACADEMIC/PLENUM PUBLISHERS. Eds. Persoone, G., Janssen, C., De Coen, W. , p. 357-365. Kahru, A., Põllumaa, L., Reiman, R., Rätsep, A., Liiders, M. and Maloveryan, A. (2000) The toxicity and biodegradability of eight main phenolic compounds characteristic to the oil-shale industry wastewaters: a test battery approach. – Environmental Toxicology, Vol. 15, Nr. 2, 431-442. Pôllumaa L., Kahru A. , Eisenträger A., Reiman R. , Maloveryan A. , Rätsep A (2000) Toxicological investigation of soil with the solid-phase flash assay: comparison with other ecotoxicological tests. –ATLA, Vol. 28, p. 461-472. Kahru, A., Põllumaa, L., Reiman, R. and Rätsep, A. (1999) Predicting the toxicity of oil-shale industry wastewater by its phenolic composition - ATLA, Vol. 27, p. 359-366. Rozkov, A., Vassiljeva, I., Kurvet, M., Kahru A., Preis, S., Kharchenko, A., Krichevskaja, M., Liiv, M., Käärd, A., Vilu, R. (1999) Laboratory Study of Bioremediation of Rocket Fuel-Polluted Groundwater. - Water Research, Vol. 33, p.1303-1313. Shugart, L., Cibulka, J., Boruvka, L., Curdova, E., Holsbeek, L., Kahru, A., Kotelevtsev, S., Kratz, W., Kubiznakova, J., and Walker, C. (1999)Report of the working group on Northern Bohemia. - In: Biomarkers: A Pragmatic Basis for Remediation of Severe Pollution in Eastern Europe. Ed. by D.B. Peakall, C.H. Walker and P. Migula. NATO Science Series. 2. Environmental Security - Vol. 54, Kluwer Academic Publishers, 1999. Dordrecht/Boston/London, pp. 229-279. Clemedson, C., Andersson, M., Aoki, Y., Barile, F.A., Bassi, A.M., Calleja, M.C., Castano, A., Clothier, R., Dierickx, P., Enwall, B., Ferro, M., Fiskesjö, G., Garza-Ocanas, L., Gómez-Lechón, Gülden, M., Hall, T., Imai, K., Isomaa, B.,Kahru, A., Kerszman, G., Kjellstrand, P., Kristen, U., Kunimoto, M., Kärenlampi, S., Lewan, L., Lilius, H., Loukianov, A., Monaco, F., Ohno, T., Persoone, G., Romert, L., Sandberg, M., Sawer, T., Segner, H., Seibert, H., Shrivastava, R., Sjöström, M. Stammati, A.,Tanaka, N., Thuvander, A., Torres-Alanis, O., Valentino, M., Wakuri, S., Walum, E., Wang, X., Wieslander, A., Zucco, F. & Ekwall, B. (1998) MEIC evaluation of acute systemic toxicity toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis. - ATLA, 26, p. 131-183. Clemedson, C., Barile, F.A., Ekwall, B., Gómez-Lechón, M.J., Hall, T., Imai, K., Kahru, A., Logemann, P., Monaco, F., Ohno, T., Segner, H., Sjöström, M. , Valentino, M., Walum, E., Wang, X., Ekwall, B. (1998) MEIC evaluation of acute systemic toxicity. Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. - ATLA, 26, p. 93-129. Ekwall, B., Barile, F.A., Castano, A., Clemedson, C., Clothier, R., Dierickx, P., Ekwall, B., Ferro, M., Fiskesjö, G., Garza-Ocanas, L., Gómez-Lechón, Gülden, M., Hall, T., Isomaa, B.,Kahru, A., Kerszman, G., Kristen, U., Kunimoto, M., Kärenlampi, S., Lewan, L., Loukianov, A., Ohno, T., Persoone, G., Romert, L., Sawer, T., Shrivastava, R., Segner, H., Stammati, A.,Tanaka, N., Valentino, M., Walum, Zucco, F. (1998) MEIC evaluation of acute systemic toxicity toxicity. Part VI. The prediction of human toxicity by rodent LD50 values and results from 61 in vitro methods. - ATLA, 26, p. 617-658. Kahru, A., Põllumaa, L., Blinova, I., Reiman, R. and Rätsep, A. (1998) Chemical versus toxicological analysis in characterization of phenolic pollution: a test battery approach - Toxicology Letters, Supplement 1/95, p. 237 Kahru, A., Põllumaa, L., Blinova, I., Reiman, R. and Rätsep, A. (1998) Chemical versus toxicological analysis in characterization of phenolic pollution: a test battery approach - Toxicology Letters, Supplement 1/95, p. 237 Kahru, A. , Reiman, R. and Rätsep, A. (1998) The efficiency of different phenol-degrading bacteria and activated sludges in detoxification of phenolic leachates - CHEMOSPHERE, Vol. 37, No. 2, p. 301-318 Kahru, A., Kurvet, M. and Kurvet, I. (1997) Study of the toxicological impact of different components of ash-heap water. - Oil Shale, Vol. 14, Nr. 4 SPECIAL, p. 469-475. Kahru, A., Kurvet, M., Kurvet, I., Reiman, R., Rätsep, A. (1997) The toxcity of ash-heap water (sulfur-rich phenolic leachate) and the efficiency of different phenol-utilising bacterial strains in its biopurification/detoxification. - Human and Experimental Toxicology, Vol., 16, Nr. 10., p. 617. Paalme, T., Elken, R., Kahru, A., Vanatalu, K. and Vilu, R. (1997) The growth rate control in Escherichia coli at near to maximum growth rates: the A-stat approach - Antonie van Leeuwenhoek, 71: 217-230. Shevchuk, I., Chekulayev, V., Chekulayeva, L., Kahru, A. (1997) Phototoxicity of lonidamine, and antitumour agent, towards mammary cells. – Human and Experimental Toxicology, Vol., 16, Nr. 10., p. 623. V. Chekulayev, I. Shevchuk, L. Chekulayeva, A. Kahru (1997) Study of the photochemical and phototoxic properties of lonidamine [1-(2,4-dichlorobenzyl)-1H-indazol-3-carboxylic acid], J. Photochem. Photobiol, B: Biology, v.41, no.1-2, pp. 11-21. Chekulayev, V., Shevchuk, I., Chekulayeva, L. and Kahru, A. (1996) Increasing the efficiency of photosensitized damage of Erlich ascites carcinoma cells using haematoporphyrin derivative or chlorin-e6 in combination with lonidamine - Proc. Estonian Acad. Aci. Biol., 45, Nr. 3-4, p. 102-127. Clemedson, C., McFarlane-Abdulla, E., Andersson, M., Barile, F.A., Calleja, M.C., Chesné, C., Clothier, R., Cottin, M., Curren, R., Dierickx, P., Ferro, M., Fiskesjö, G., Garza-Ocanas, L., Gómez-Lechón, Gülden, M., Isomaa, B., Janus, J., Judge, P., Kahru, A., Kemp, R.B., Kerszman, G., Kristen, U., Kunimoto, M., Kärenlampi, S., Lavrijsen, K.,Lewan, L., Lilius, H., Malmsten, A., Ohno, T., Persoone, G., Petterson, R., Roguet, R., Romert, L., Sandberg, M., Sawer, T., Seibert, H., Shrivastava, R., Sjöström, M. Stammati, A.,Tanaka, N., Torres ALanis, O.Voss, J.-U., Wakuri, S., Walum, E., Wang, X., Zucco, F. & Ekwal, B. MEIC evaluation of acute systemic toxicity toxicity. Part I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals (1996) - ATLA, Supplement 1, p. 251-272. Clemedson, C., McFarlane-Abdulla, E., Andersson, M., Barile, F.A., Calleja, M.C., Chesné, C., Clothier, R., Cottin, M., Curren, R., Dierickx, P., Ferro, M., Fiskesjö, G., Garza-Ocanas, L., Gómez-Lechón, Gülden, M., Isomaa, B., Janus, J., Judge, P., Kahru, A., Kemp, R.B., Kerszman, G., Kristen, U., Kunimoto, M., Kärenlampi, S., Lavrijsen, K.,Lewan, L., Lilius, H., Malmsten, A., Ohno, T., Persoone, G., Petterson, R., Roguet, R., Romert, L., Sandberg, M., Sawer, T., Seibert, H., Shrivastava, R., Sjöström, M. Stammati, A.,Tanaka, N., Torres ALanis, O.Voss, J.-U., Wakuri, S., Walum, E., Wang, X., Zucco, F. & Ekwall, B. MEIC evaluation of acute systemic toxicity toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis (1996) - ATLA, Supplement 1, p. 273-311. Kahru, K. Tomson, T. Pall and I. Külm. (1996) Study of toxicity of pesticides using luminescent bacteria Photobacterium phosphoreum - Wat. Sci. &Tech., Vol. 33, Nr. 6, p. 147-154. Kahru, M. Kurvet and I. Külm (1996) Toxicity of phenolic wastewater to luminescent bacteria Photobacterium phosphoreum. - Wat. Sci. &Tech. 1996, Vol. 33, Nr. 6, 139-146. Paalme, T., Kahru, A., Elken, R., Vanatalu, K.,Tiisma, K. and Vilu, R. (1995). The Computer- Controlled Continuous Culture of Escherichia coli with Smooth Change of Dilution rate. A-stat. “J. Microbiol. Methods”, 24, 145-153. Kahru, A. and Borchardt, B. (1994) Toxicity of 39 MEIC Chemicals to Bioluminescent Photobacteria (The BiotoxTM Test): Correlation with Other Test Systems" - ATLA, 22, 147-160. Kahru, A. (1993) In vitro toxicity testing using marine luminescent bacteria Photobacterium phosphoreum:The BiotoxTM test - ATLA, Vol. 21, Nr 2, p. 210-215. Pruul, R., Kahn, H. and Kahru, A. (1993) Application of the Ames genotoxicity assay and the bioluminescent toxicity assay in the testing of urine samples. - ATLA, Vol. 21, Nr. 2, p. 225-232. Kahru A. and Vilu, R. (1991). The ATP bioluminescence technique in evaluating the bacteriological quality of dried milk. - In: Bioluminescence and Chemiluminescence. Current Status. Ed. by P.E. Stanley & L.J. Kricka. John Wiley & Sons, 1991, p. 495-498. Kahru, A. Pelkonen, M. Vilu, R. (1991). Application of ATP bioluminescent method of rapid determination of microbial biomass in environmental samples: trial of the assay in enumeration of bacteria in soil and activated sludge. - "Med. Fac. Landbouww. Rijksuniv. Gent", Vol. 56 (4a), p. 1585-1587. Kahru, A. and Vilu, R. (1990). The role of the adenine nucleotides in the regulation of bacterial energy metabolism: theoretical problems and experimental pitfalls. - "Microbios", Vol. 62, p. 83-92. Paalme, T., Tiisma, K., Kahru, A., Vanatalu, K, Vilu, R. (1990) Glucose-limited fed-batch cultivation of Escherichia coli with computer-controlled fixed growth rate. - "Biotechnol. Bioeng.", Vol. 35, p. 312-319. Kahru, A. Vilu, R. (1988) Use of the luciferin-luciferase assay of ATP for measuring the bacterial growth: application to Escherichia coli. - "Acta Biotechnol.", Vol. 8, p. 92-98. Kahru, A. Paalme, T. Vilu, R. (1987) Effect of temperature on the ATP pool and adenylate energy charge of Escherichia coli . - "FEMS Microbiol. Lett.", Vol. 41 (3), p. 305-308. Kahru, A. Vilu, R. (1983) On characterization of the growth of Escherichia coli in batch culture. - "Arch. Microbiol.", Vol. 135 (1), p. 12-15. Kahru, A. Liiders, M., Vanatalu, K., Vilu, R. (1982) Adenylate energy charge during batch culture of Thermoactinomyces vulgaris. - "Arch. Microbiol.", Vol. 133 (2), p. 142-144. |
last updated: 09.10.2005
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