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Elulookirjeldus (CV)
1.Eesnimi Jaak
2.Perekonnanimi Järv
3.Töökoht Tartu Ülikool
4.Ametikoht orgaanilise kemia professor
5.Sünniaeg 05.11.1948 (päev.kuu.aasta)
6.Haridus 1972 – Kiitusega diplom, keemiaosakond, Tartu Ülikool, eriala füüsikaline biokeemia
7.Teenistuskäik 1972–1973 nooremteadur, orgaanilise keemia kateeder, Tartu Ülikool,
1973–1976 aspirant, orgaanilise keemia kateeder, Tartu Ülikool,
1976–1977 nooremteadur, orgaanilise keemia kateeder, Tartu Ülikool,
1977–1982 vanemõpetaja, orgaanilise keemia kateeder, Tartu Ülikool,
1982–1983 dotsent, orgaanilise keemia kateeder, Tartu Ülikool,
1983–1991 teadusprorektori asetäitja, Tartu Ülikool.
1991-2001 bioorgaaanilise keemia korraline professor, Tartu Ülikool.
1998-2003 dekaan, füüsika –keemiateaduskond, Tartu Ülikool
2001-k.a. orgaanilise keemia korraline professor, Tartu Ülikool.
8.Teaduskraad Keemiakandidaat, dissertatsioon: "Kinetic Appearance of Acetylcholinesterase Active Center in Reactions with Acetic Esters and O,O–Diethylthiophosphates".
Keemiadoktor, dissertatsioon "Kinetic Mechanisms of Receptor Ligand Interaction. Muscarinic Acetylcholine Receptor".
9.Teaduskraadi välja
andnud asutus, aasta		 1976, ENSV TA Keemia Instituut
1990, Moskva Ülikool.
10.Tunnustused 1991 – Kuopio Ülikooli audoktor, Soome.
1996 – Uppsala Ülikooli audoktor, Rootsi
1997 – Eesti Teaduste Akadeemia akadeemik
2000 - Eesti Vabariigi Teaduspreemia
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus		 1983 - Ajakirja Bioorganic Chemistry (Elsevier) toimetuskolleegiumi liige,
1997-2001 - Euroopa Biokeemia Seltside Föderatsiooni kirjastuskomitee liige
2002-2006 - Euroopa Biokeemia Seltside Föderatsiooni stipendiumikomitee liige
1998-2003 ETF ekspert
2003 - k.a. TKN ekspert
2003 - k.a. Teadusinfrastruktuuride Komitee ekspert, EU DG XII
2004 - k.a. Eesti Biokeemia Seltsi president
12.Juhendamisel kaitstud
väitekirjad

Aldo Oras, PhD, 2004, juh. Jaak Järv. Kinetic aspects of dATP-alpha-S interaction with P2Y1 receptor. Tartu Ülikool

Meeri Sassian, PhD, 2003, juh. Jaak Järv, Ants Tuulmets. Reactions of partially solvated Grignard reagents. Tartu Ülikool

Boris Rogovoi, PhD, 2002, juh. Jaak Järv, Alan Katritzky. Synthesis of (benzotriazolyl)carboximidamides and their application in reactions with N- and S-nucleophiles.. Tartu Ülikool

Mart Loog, PhD, 2001, juh. Jaak Järv, Pia Ek. Studies on the differential specificity of protein kinases and its applications.. Uppsala Ülikool

Katrin Sak, PhD, 2000, juh. Jaak Järv. Some aspects of ligand specificityof P2Y receptors.. Tartu Ülikool

Martin Lepiku, PhD, 2000, juh. Jaak Järv, Ago Rinken. Kinetic aspects of dopüamine D2 receptor interactions with specific ligands.. Tartu Ülikool

Toonika Rinken, PhD, 2000, juh. Jaak Järv, Toomas Tenno. The modelling of amperometric biosensors based on oxidoreductases. Tartu Ülikool

Reet Toomik, PhD, 1997, juh. Jaak Järv, Lorentz Engström. Substrate specificity of protein kinases studied with synthetic peptides. Uppsala University

Armin Sepp, cand, 1990, juh. Jaak Järv. Specificity and catalytic properties of acetylcholinesterase, modified with N,N-dimethy-2-phenylaziridinium ion.. Tallinn, Keemia Instituut

Marika Eller, cand, 1989, juh. Jaak Järv. Kinetics regularities and mechanism of interaction of antagonists with muscarinic acetylcholine receptor. Tartu Ülikool

Ago Rinken, cand, 1987, juh. Jaak Järv. Muscarinic receptor:Solubilization and its influence on chemical modification of the receptor and ligand binding kinetics. Tallinn, Keemia Instituut

Rannar Sillard, cand, 1987, juh. Jaak Järv. Cooperativity of antagonist interaction with muscarinic receptor.. Tartu Ülikool

Peep Palumaa, cand, 1986, juh. Jaak Järv. Affinity modification of acetylcholinesterase by N,N-dimethyl-2-phenylaziridinium ion.. Tallinn, Keemia Instituut

Ülo Langel, cand, 1980, juh. Jaak Järv. Effects of structure and pH in reactions of cholinesterase. Tallinn, Keemia Instituut
13.Teadustöö põhisuunad Bioaktiivsete ühendite konstrueerimine ja süntees. Biomimetikud. Retseptorligandide süntees, sh märgismolekulid positron-emissioontomograafia tarbeks. Struktuur-aktiivsus sõltuvused ja bio-aktiivsuse kvantitatiivne iseloomustamine. Ligandide toimemehhanismid G-valkudega seotud retseptoritega. Ensüümkatalüüsi kineetika ja mehhanismid. Molekulaarne äratundmine ensüümkatalüüsil ja retseptorite sidumisel
14.Jooksvad grandid ETF grant: AGONISTI JA ANTAGONISTI ÜHEAEGSE SIDUMISE MEHHANISMI UURIMINE G VALGUGA KONJUGEERITUD RETSEPTORITE KORRAL. ATSETÜÜLKOLIINI MUSKARIINSET TÜÜPI RETSEPTOR JA P2Y1 PURINOTSEPTOR
15.Teaduspublikatsioonid

Jarv J, Oras A. Similar dynamics of G-protein coupled receptors molecules in response to antagonist binding. Neurosci Lett. 2005 Jan 10;373(2):150-2.

Loog M, Ek B, Oskolkov N, Narvanen A, Jarv J, Ek P. Screening for the optimal specificity profile of protein kinase C using electrospray mass-spectrometry. J Biomol Screen. 2005 Jun;10(4):320-8.

Loog M, Oskolkov N, O'Farrell F, Ek P, Jarv J. Comparison of cAMP-dependent protein kinase substrate specificity in reaction with proteins and synthetic peptides. Biochim Biophys Acta. 2005 Mar 14;1747(2):261-6.

Varfolomeyev S., Efremenko E., Beletskaya E., Bertini I., Blackburn G.M., Bogdanov A., Cunnin R., Eichler J., Galaev I., Gladyshev V., O’Haga D., Haertle T., Jarv J., Karyakin A., Kurochkin Y., Mickolajczyk M., Poroikov V., Sakharov I., Spener F., Voyer N., Wild J. Postgenomic Chemistry, Pure and Applied Chemistry, 2005 Sept: 77(9): 1641–1654.

Kuznetsov A, Uri A, Raidaru G, Jarv J. Kinetic analysis of inhibition of cAMP-dependent protein kinase catalytic subunit by the peptide-nucleoside conjugate AdcAhxArg6. Bioorg Chem. 2004 Dec;32(6):527-35.

Oras A, Jarv J. Kinetics of [35S]dATPalphaS interaction with P2Y1 purinoceptor in rat brain membranes.Neurosci Lett. 2004 Jan 23;355(1-2):9-12.

Tuulmets A, Nguyen BT, Panov D, Sassian M, Jarv J. Kinetics of the grignard reaction with silanes in diethyl ether and ether-toluene mixtures. J Org Chem. 2003 Dec 26;68(26):9933-7.

Lepiku M, Jarv J, Fuxe K, Rinken A. Reversible and irreversible components of [(3)H]-N-propylnorapomorphine interaction with rat striatal membranes.Neurosci Lett. 2002 Jun 7;325(2):111-4.

Oras A, Kilk K, Kunapuli S, Barnard EA, Jarv J. Kinetic analysis of [35S]dATP alpha S interaction with P2y(1) nucleotide receptor. Neurochem Int. 2002 Apr;40(5):381-6.

Sak K, Jarv J, Karelson M. 'Strain effect' descriptors for ATP and ADP derivatives with modified phosphate groups. Comput Chem. 2002 Jun;26(4):341-6.

Jolkkonen M, Oras A, Toomela T, Karlsson E, Jarv J, Akerman KE. Kinetic evidence for different mechanisms of interaction of black mamba toxins MT alpha and MT beta with muscarinic receptors. Toxicon. 2001 Feb-Mar;39(2-3):377-82.

Loog M, Toomik R, Sak K, Muszynska G, Jarv J, Ek P. Peptide phosphorylation by calcium-dependent protein kinase from maize seedlings.Eur J Biochem. 2000 Jan;267(2):337-43.

Loog M, Uri A, Jarv J, Ek P. Bi-substrate analogue ligands for affinity chromatography of protein kinases. FEBS Lett. 2000 Sep 1;480(2-3):244-8.

Sak K, Barnard EA, Jarv J. Dual effect of nucleotides on P2Y receptors. IUBMB Life. 2000 Aug;50(2):99-103.

Sak K, Jarv J. Adenosine triphosphate is full antagonist at human P2Y(1) purinoceptors. Neurosci Lett. 2000 Apr 28;284(3):179-81.

Sak K, Kreegipuu A, Jarv J. P2Y-receptor-ligand database.Trends Biochem Sci. 2000 Jan;25(1):35.

Sak K, Raidaru G, Webb TE, Jarv J. Phosphate-substituted ATP analogs are antagonists at human P2Y1 purinoceptors. Arch Biochem Biophys. 2000 Sep 1;381(1):171-2.

Sak K, Uri A, Enkvist E, Raidaru G, Subbi J, Kelve M, Jarv J. Adenosine-derived non-phosphate antagonists for P2Y(1) purinoceptors. Biochem Biophys Res Commun. 2000 Jun 7;272(2):327-31.

Loog M, Uri A, Raidaru G, Jarv J, Ek P. Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.

Oras A, Jarv J, Akerman KE. Influence of atropine on carbachol dual effect on Ca2+ mobilization in SH-SY5Y neuroblastoma cells. Biochem Mol Biol Int. 1999 May;47(5):743-7.

Sak K, Webb TE, Samuel K, Kelve M, Jarv J. Only pyrimidinoceptors are functionally expressed in mouse neuroblastoma cell lines.Mol Cell Biol Res Commun. 1999 Jun;1(3):203-8

Kreegipuu A, Blom N, Brunak S, Jarv J. Statistical analysis of protein kinase specificity determinants.FEBS Lett. 1998 Jun 23;430(1-2):45-50. Review.

Rinken T, Rinken A, Tenno T, Jarv J. Calibration of glucose biosensors by using pre-steady state kinetic data. Biosens Bioelectron. 1998 Oct 1;13(7-8):801-7.

Rosenthal K, Lember J, Karelson E, Jarv J. Activation of cAMP synthesis in rat brain cortical membranes by rubidium and cesium ions. Biochem Mol Biol Int. 1998 Jul;45(4):745-51

Sak K, Kelve M, Uri A, Jarv J. Pyrimidinoceptor potentiation by ATP in NG108-15 cells. FEBS Lett. 1998 Nov 13;439(1-2):107-9.

Lepiku M, Jarv J, Rinken A, Fuxe K. Mechanism of modulation of [3H]raclopride binding to dopaminergic receptors in rat striatal membranes by sodium ions.Neurochem Int. 1997 Jun;30(6):575-81.

Lepiku M, Rinken A, Jarv J, Fuxe K. Modulation of [3H]quinpirole binding to dopaminergic receptors by adenosine A2A receptors.Neurosci Lett. 1997 Dec 19;239(2-3):61-4.

Lepiku M, Rinken A, Jarv J, Fuxe K. Kinetic evidence for isomerization of the dopamine receptor-raclopride complex.Neurochem Int. 1996 May-Jun;28(5-6):591-5.

Jarv J. A model of non-exclusive binding of agonist and antagonist on G-protein coupled receptors.J Theor Biol. 1995 Aug 21;175(4):577-82.

Jarv J, Hautala R, Akerman KE. Dual effect of muscarinic receptor agonists on Ca2+ mobilization in SH-SY5Y neuroblastoma cells.Eur J Pharmacol. 1995 Sep 15;291(1):43-50.

viimati muudetud: 02.08.2005

Curriculum Vitae (CV)
1.First Name Jaak
2.Surname Järv
3.Institution University of Tartu
4.Position Professor of Organic Chemistry
5.Date of birth 05.11.1948 (day.month.year)
6.Education 1972 – Diploma with Honors in Physical Biochemistry, Chemistry Department, Tartu University
7.Research and
professional experience		 1972–1973 Research Fellow, Chair of Organic Chemistry, University of Tartu,
1973–1976 Doctoral student, Chair of Organic Chemistry, University of Tartu,
1976–1977 Research Fellow, Chair of Organic Chemistry, University of Tartu,
1977–1982 Senior Lecturer, Chair of Organic Chemistry, University of Tartu,
1982–1983 Docent, Chair of Organic Chemistry, University of Tartu,
1983–1991 Deputy Prorector on Research, University of Tartu,
1991-2001 Professor of Bioorganic Chemistry, University of Tartu,
1998-2003 Dean, Faculty of Physics and Chemistry, University of Tartu,
2001- present Professor of Organic Chemistry, University of Tartu,
8.Academic degree Candidate of Chemistry (=PhD), Thesis: "Kinetic Appearance of Acetylcholinesterase Active Center in Reactions with Acetic Esters and O,O–Diethylthiophosphates".
Doctor of Sciences (Chemistry), Thesis: "Kinetic Mechanisms of Receptor Ligand Interaction. Muscarinic Acetylcholine Receptor".
9.Dates and sites of
earning the degrees		 1976, Institute of Chemistry, Tallinn
1990, Moscow State University
10.Honours/awards 1991 – Doctor Honoris Causa, Kuopio University, Finland,
1996 – Honorary Doctor of Medical Sciences, Uppsala Ubiversity, Sweden,
1997 – Member of the Estonian Academy of Sciences,
2000 - Estonian Science Award
11.Research-administrative
experience		 1983–present - Editorial Board, Bioorganic Chemistry, Academic Press/elsevier, USA,
1997-2001 - Member, Publications Committee, Federation of European Biochemical Societies (FEBS)
2002-2006- Member, Fellowships Committee, Federation of European Biochemical Societies (FEBS)
1998-2003 Expert, Estonian Science Foundation
2003 - present, Expert, Estonian Council of scientific Expertise
2003 - present, Expert, Research Infrastructures Committee, EU DG XII
2004 - present, President, Estonian Biochemical Society,
12.Supervised dissertations

Aldo Oras, PhD, 2004, superv. Jaak Järv. Kinetic aspects of dATP-alpha-S interaction with P2Y1 receptor. Tartu Ülikool

Meeri Sassian, PhD, 2003, superv. Jaak Järv, Ants Tuulmets. Reactions of partially solvated Grignard reagents. Tartu Ülikool

Boris Rogovoi, PhD, 2002, superv. Jaak Järv, Alan Katritzky. Synthesis of (benzotriazolyl)carboximidamides and their application in reactions with N- and S-nucleophiles.. Tartu Ülikool

Mart Loog, PhD, 2001, superv. Jaak Järv, Pia Ek. Studies on the differential specificity of protein kinases and its applications.. Uppsala Ülikool

Katrin Sak, PhD, 2000, superv. Jaak Järv. Some aspects of ligand specificityof P2Y receptors.. Tartu Ülikool

Martin Lepiku, PhD, 2000, superv. Jaak Järv, Ago Rinken. Kinetic aspects of dopüamine D2 receptor interactions with specific ligands.. Tartu Ülikool

Toonika Rinken, PhD, 2000, superv. Jaak Järv, Toomas Tenno. The modelling of amperometric biosensors based on oxidoreductases. Tartu Ülikool

Reet Toomik, PhD, 1997, superv. Jaak Järv, Lorentz Engström. Substrate specificity of protein kinases studied with synthetic peptides. Uppsala University

Armin Sepp, cand, 1990, superv. Jaak Järv. Specificity and catalytic properties of acetylcholinesterase, modified with N,N-dimethy-2-phenylaziridinium ion.. Tallinn, Keemia Instituut

Marika Eller, cand, 1989, superv. Jaak Järv. Kinetics regularities and mechanism of interaction of antagonists with muscarinic acetylcholine receptor. Tartu Ülikool

Ago Rinken, cand, 1987, superv. Jaak Järv. Muscarinic receptor:Solubilization and its influence on chemical modification of the receptor and ligand binding kinetics. Tallinn, Keemia Instituut

Rannar Sillard, cand, 1987, superv. Jaak Järv. Cooperativity of antagonist interaction with muscarinic receptor.. Tartu Ülikool

Peep Palumaa, cand, 1986, superv. Jaak Järv. Affinity modification of acetylcholinesterase by N,N-dimethyl-2-phenylaziridinium ion.. Tallinn, Keemia Instituut

Ülo Langel, cand, 1980, superv. Jaak Järv. Effects of structure and pH in reactions of cholinesterase. Tallinn, Keemia Instituut
13.Current research program Design and chemical synthesis of bio-active compounds. Biomimetics. Synthesis of receptor ligands, including tracer molecules for PET (positron emission tomography). Structure-activity relationships and prognosis of activity of bio-active compounds. Mechanism of ligand interaction with G-protein coupled receptors and neurotransmitter transporters. Kinetics and mechanism of enzyme catalysis. Molecular recognition phenomena in enzyme catalysis and receptor binding.
14.Current grant funding ETF Grant:KINETIC STUDY OF AGONIST AND ANTAGONIST BINDING MECHANISM WITH 7TM RECEPTORS. MUSCARINIC ACETYLCHOLINE RECEPTOR AND P2Y1 PURINERGIC RECEPPTOR.
15.List of most important publications

Jarv J, Oras A. Similar dynamics of G-protein coupled receptors molecules in response to antagonist binding. Neurosci Lett. 2005 Jan 10;373(2):150-2.

Loog M, Ek B, Oskolkov N, Narvanen A, Jarv J, Ek P. Screening for the optimal specificity profile of protein kinase C using electrospray mass-spectrometry. J Biomol Screen. 2005 Jun;10(4):320-8.

Loog M, Oskolkov N, O'Farrell F, Ek P, Jarv J. Comparison of cAMP-dependent protein kinase substrate specificity in reaction with proteins and synthetic peptides. Biochim Biophys Acta. 2005 Mar 14;1747(2):261-6.

Varfolomeyev S., Efremenko E., Beletskaya E., Bertini I., Blackburn G.M., Bogdanov A., Cunnin R., Eichler J., Galaev I., Gladyshev V., O’Haga D., Haertle T., Jarv J., Karyakin A., Kurochkin Y., Mickolajczyk M., Poroikov V., Sakharov I., Spener F., Voyer N., Wild J. Postgenomic Chemistry, Pure and Applied Chemistry, 2005 Sept: 77(9): 1641–1654.

Kuznetsov A, Uri A, Raidaru G, Jarv J. Kinetic analysis of inhibition of cAMP-dependent protein kinase catalytic subunit by the peptide-nucleoside conjugate AdcAhxArg6. Bioorg Chem. 2004 Dec;32(6):527-35.

Oras A, Jarv J. Kinetics of [35S]dATPalphaS interaction with P2Y1 purinoceptor in rat brain membranes.Neurosci Lett. 2004 Jan 23;355(1-2):9-12.

Tuulmets A, Nguyen BT, Panov D, Sassian M, Jarv J. Kinetics of the grignard reaction with silanes in diethyl ether and ether-toluene mixtures. J Org Chem. 2003 Dec 26;68(26):9933-7.

Lepiku M, Jarv J, Fuxe K, Rinken A. Reversible and irreversible components of [(3)H]-N-propylnorapomorphine interaction with rat striatal membranes.Neurosci Lett. 2002 Jun 7;325(2):111-4.

Oras A, Kilk K, Kunapuli S, Barnard EA, Jarv J. Kinetic analysis of [35S]dATP alpha S interaction with P2y(1) nucleotide receptor. Neurochem Int. 2002 Apr;40(5):381-6.

Sak K, Jarv J, Karelson M. 'Strain effect' descriptors for ATP and ADP derivatives with modified phosphate groups. Comput Chem. 2002 Jun;26(4):341-6.

Jolkkonen M, Oras A, Toomela T, Karlsson E, Jarv J, Akerman KE. Kinetic evidence for different mechanisms of interaction of black mamba toxins MT alpha and MT beta with muscarinic receptors. Toxicon. 2001 Feb-Mar;39(2-3):377-82.

Loog M, Toomik R, Sak K, Muszynska G, Jarv J, Ek P. Peptide phosphorylation by calcium-dependent protein kinase from maize seedlings.Eur J Biochem. 2000 Jan;267(2):337-43.

Loog M, Uri A, Jarv J, Ek P. Bi-substrate analogue ligands for affinity chromatography of protein kinases. FEBS Lett. 2000 Sep 1;480(2-3):244-8.

Sak K, Barnard EA, Jarv J. Dual effect of nucleotides on P2Y receptors. IUBMB Life. 2000 Aug;50(2):99-103.

Sak K, Jarv J. Adenosine triphosphate is full antagonist at human P2Y(1) purinoceptors. Neurosci Lett. 2000 Apr 28;284(3):179-81.

Sak K, Kreegipuu A, Jarv J. P2Y-receptor-ligand database.Trends Biochem Sci. 2000 Jan;25(1):35.

Sak K, Raidaru G, Webb TE, Jarv J. Phosphate-substituted ATP analogs are antagonists at human P2Y1 purinoceptors. Arch Biochem Biophys. 2000 Sep 1;381(1):171-2.

Sak K, Uri A, Enkvist E, Raidaru G, Subbi J, Kelve M, Jarv J. Adenosine-derived non-phosphate antagonists for P2Y(1) purinoceptors. Biochem Biophys Res Commun. 2000 Jun 7;272(2):327-31.

Loog M, Uri A, Raidaru G, Jarv J, Ek P. Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.

Oras A, Jarv J, Akerman KE. Influence of atropine on carbachol dual effect on Ca2+ mobilization in SH-SY5Y neuroblastoma cells. Biochem Mol Biol Int. 1999 May;47(5):743-7.

Sak K, Webb TE, Samuel K, Kelve M, Jarv J. Only pyrimidinoceptors are functionally expressed in mouse neuroblastoma cell lines.Mol Cell Biol Res Commun. 1999 Jun;1(3):203-8

Kreegipuu A, Blom N, Brunak S, Jarv J. Statistical analysis of protein kinase specificity determinants.FEBS Lett. 1998 Jun 23;430(1-2):45-50. Review.

Rinken T, Rinken A, Tenno T, Jarv J. Calibration of glucose biosensors by using pre-steady state kinetic data. Biosens Bioelectron. 1998 Oct 1;13(7-8):801-7.

Rosenthal K, Lember J, Karelson E, Jarv J. Activation of cAMP synthesis in rat brain cortical membranes by rubidium and cesium ions. Biochem Mol Biol Int. 1998 Jul;45(4):745-51

Sak K, Kelve M, Uri A, Jarv J. Pyrimidinoceptor potentiation by ATP in NG108-15 cells. FEBS Lett. 1998 Nov 13;439(1-2):107-9.

Lepiku M, Jarv J, Rinken A, Fuxe K. Mechanism of modulation of [3H]raclopride binding to dopaminergic receptors in rat striatal membranes by sodium ions.Neurochem Int. 1997 Jun;30(6):575-81.

Lepiku M, Rinken A, Jarv J, Fuxe K. Modulation of [3H]quinpirole binding to dopaminergic receptors by adenosine A2A receptors.Neurosci Lett. 1997 Dec 19;239(2-3):61-4.

Lepiku M, Rinken A, Jarv J, Fuxe K. Kinetic evidence for isomerization of the dopamine receptor-raclopride complex.Neurochem Int. 1996 May-Jun;28(5-6):591-5.

Jarv J. A model of non-exclusive binding of agonist and antagonist on G-protein coupled receptors.J Theor Biol. 1995 Aug 21;175(4):577-82.

Jarv J, Hautala R, Akerman KE. Dual effect of muscarinic receptor agonists on Ca2+ mobilization in SH-SY5Y neuroblastoma cells.Eur J Pharmacol. 1995 Sep 15;291(1):43-50.

last updated: 02.08.2005

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