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| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Juhan |
| 2. | Perekonnanimi | Sedman |
| 3. | Töökoht | TArtu Ülikool |
| 4. | Ametikoht | Professor |
| 5. | Sünniaeg | 07.12.1958 (päev.kuu.aasta) |
| 6. | Haridus | Keemia (bioorgaaniline keemia), Tartu Riiklik Ülikool |
| 7. | Teenistuskäik | alates 09.2003 TÜMRI juhataja alates 09.2001 TÜMRI professor,üldise ja mikroobibiokeemia õppetooli juhataja 2000-2001 Tartu Ülikooli Molekulaar ja Rakubioloogia Instituudi erakorraline dotsent, üldise ja mikroobibiokeemia õppetooli hoidja 1998-2000 Eesti Biokeskuse venemteadur 1997-1998 Tartu Ülikooli Molekulaar ja Rakubioloogia Instituudi erakorraline vanemteadur, (repatriant finantseeritud PHARE programmi raames) 1993-1997 Järeldoktor Cold Spring Harbor Laboratooriumis, New York, USA aastani 1992 Aspirant, nooremteadur ja teadur Tartu Riiklikus Ülikoolis |
| 8. | Teaduskraad | Bioloogiateaduste kandidaat |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Riiklik Ülikool, 1990 |
| 10. | Tunnustused | |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
ETF ja TKN eriala ekspertkomisjonide liige TÜ strateegiakomisjoni liige |
| 12. | Juhendamisel kaitstud väitekirjad |
Dmitri Lubenets, MSc, 2005, juh. Juhan Sedman. In vivo studies of Saccharomyces cerevisiae Hmi1 helicase mitochondrial transport. Tartu Silja Kuusk, DSc, 2001, juh. Juhan Sedman. Pärmi Saccharomyces cerevisiae mitokondriaalne helikaas Hmi1. Tartu Priit Jõers, MSc, 2000, juh. Juhan Sedman. Eksperimentaalne süsteem Hmi1 valgu transportimise uurimiseks in vivo. Tartu Tiina Sedman, MSc, 2000, juh. Juhan Sedman. Identification of the novel mitochondrial DNA helicase Hmi1. Tartu |
| 13. | Teadustöö põhisuunad | DNA replikatsioon, valkude transport mitokondrisse |
| 14. | Jooksvad grandid | sihtfinantseeritav teema 0182129s02 Postgenoomiks: sekveneeritud genoomi biokeemiline ja geneetiline funktsionaalanalüüs ETF 5512 Mitokondriaalse DNA intaktsuse säilitamine: replikatsioon ja segregatsioon |
| 15. | Teaduspublikatsioonid |
Kuusk S, Sedman T, Joers P, Sedman J. (2005) Hmi1p from Saccharomyces cerevisiae mitochondria is a structure-specific DNA helicase. J. Biol. Chem.280, 24322-24329. Sedman T, Joers P, Kuusk S, Sedman J. (2005) Helicase Hmi1 stimulates the synthesis of concatemeric mitochondrial DNA molecules in yeast Saccharomyces cerevisiae. Curr. Genet. 47, 213-222. Kuusk, S., Sedman, T., Sedman, J. Yeast mitochondrial DNA helicases: purification and functional assays. In: Methods in Molecular Biology 197: Mitochondrial DNA. Copeland W.P ed. Humana Press 2002 pp. 303-316 Sedman T., Kuusk, S., Kivi, S., Sedman, J. (2000) A DNA helicase required for maintenance of the functional mitochondrial genome in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 20, 1816-1824 Lee, C.M., Sedman, J., Neupert, W., Stuart, R.A. (1999) The DNA helicase, Hmi1p, is transported into mitochondria by a C-terminal cleavable targeting signal. J. Biol. Chem. 274, 20937-20942 Sedman, J., Stenlund, A. (1998) The papillomavirus E1 protein forms a DNA-dependent hexameric complex with ATPase and DNA helicase activities. J. Virol. 72, 6893-6897 Sedman, T, J. Sedman and A. Stenlund (1997) Binding of the E1 and E2 proteins to the origin of replication of bovine papillomavirus. J. Virol. 71, 2887-2896 Sedman, J., Stenlund, A.(1996) The initiator protein E1 binds to the BPV origin of replication as a trimeric ring-like structure EMBO J. 15, 5085-50929 Melendy, T., Sedman, J., Stenlund, A. (1995) Cellular factors required for papillomavirus replication. J. Virol. 69, 7857-7867 Sedman, J., Stenlund, A., (1995) Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro. EMBO J. 14, 6218-6228 Felgengauer, P., Sedman, J., Shostak, N., Timofeeva, M., Lind, A., Bayev, A.(1990)The 5'-flanking sequence of the loach oocyte 5S rRNA gene contains a signal for effective transcription. Gene, 90, 243-248 Sedman, J., Shostak, N.G., Kuprijanova, N.S., Serenkova, T.I., Felgengauer, P.E., Gimalov, F., Lind, A.J., Timofeeva, M.J., Bajev, A.A. (1989) Intragenic polymorphism of the primary structure of 5S rRNA gene variants of the loach (Misgurnus fossilis L.) Molek. Biol. Mosk. 23, 1295-1308 Bergman, P, Ustav, M., Sedman, J., Moreno-Lopez, J., Vennstrom, B., Peterson, U. (1988) The E5 gene of bovine papillomavirus type 1 is sufficient for complete oncogenic transformation of mouse fibroblasts. Oncogene, 2, 453-459 Sedman, J., Felgengauer, P., Shostak, N.G., Timofeeva, M.J. (1988) The transcriptional efficiency of loach oocyte 5S rRNA genes depends on the region of 5'-flanking spacer. Dokl. Akad. Nauk SSSR, 303, 736-737 Sedman, J., Maimets, T., Ustav, M., Villems, R.(1981) The interaction of 5S rRNA and its large fragments with ribosomal proteins. FEBS Lett. 136, 251-254 |
viimati muudetud: 09.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Juhan |
| 2. | Surname | Sedman |
| 3. | Institution | University of Tartu |
| 4. | Position | Professor |
| 5. | Date of birth | 07.12.1958 (day.month.year) |
| 6. | Education | Chemistry (bioorganic chemistry), Tartu State University |
| 7. | Research and professional experience |
09.2003- Head of IMCB University of Tartu 09.2001- Professor, Dep. of Biochemistry, IMCB University of Tartu 2000-2001 Ass. Prof IMCB 1998-2000 senior research fellow EBC 1997-1998 senior research fellow, IMCB 1993-1997 postdoc Cold Spring Harbor Laboratory with Dr. Arne Stenlund -1992 junior research fellow, University of Tartu |
| 8. | Academic degree | Cand Sci (Biology) |
| 9. | Dates and sites of earning the degrees |
Tartu State University, 1990 |
| 10. | Honours/awards | |
| 11. | Research-administrative experience |
Expert in Molecular Biology for Estonian Science Foundation and Research Competency Council Member of Tartu University Strategy Comission |
| 12. | Supervised dissertations |
Dmitri Lubenets, MSc, 2005, superv. Juhan Sedman. In vivo studies of Saccharomyces cerevisiae Hmi1 helicase mitochondrial transport. Tartu Silja Kuusk, DSc, 2001, superv. Juhan Sedman. Pärmi Saccharomyces cerevisiae mitokondriaalne helikaas Hmi1. Tartu Priit Jõers, MSc, 2000, superv. Juhan Sedman. Eksperimentaalne süsteem Hmi1 valgu transportimise uurimiseks in vivo. Tartu Tiina Sedman, MSc, 2000, superv. Juhan Sedman. Identification of the novel mitochondrial DNA helicase Hmi1. Tartu |
| 13. | Current research program | DNA replication, mitochondrial protein transport |
| 14. | Current grant funding | 0182129s02 Postgenomics: functional analysis of the sequenced genome with the tools of biochemistry and genetics ETF5512 Maintenance of the mtDNA integrity: replication and segregation |
| 15. | List of most important publications |
Kuusk S, Sedman T, Joers P, Sedman J. (2005) Hmi1p from Saccharomyces cerevisiae mitochondria is a structure-specific DNA helicase. J. Biol. Chem.280, 24322-24329. Sedman T, Joers P, Kuusk S, Sedman J. (2005) Helicase Hmi1 stimulates the synthesis of concatemeric mitochondrial DNA molecules in yeast Saccharomyces cerevisiae. Curr. Genet. 47, 213-222. Kuusk, S., Sedman, T., Sedman, J. Yeast mitochondrial DNA helicases: purification and functional assays. In: Methods in Molecular Biology 197: Mitochondrial DNA. Copeland W.P ed. Humana Press 2002 pp. 303-316 Sedman T., Kuusk, S., Kivi, S., Sedman, J. (2000) A DNA helicase required for maintenance of the functional mitochondrial genome in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 20, 1816-1824 Lee, C.M., Sedman, J., Neupert, W., Stuart, R.A. (1999) The DNA helicase, Hmi1p, is transported into mitochondria by a C-terminal cleavable targeting signal. J. Biol. Chem. 274, 20937-20942 Sedman, J., Stenlund, A. (1998) The papillomavirus E1 protein forms a DNA-dependent hexameric complex with ATPase and DNA helicase activities. J. Virol. 72, 6893-6897 Sedman, T, J. Sedman and A. Stenlund (1997) Binding of the E1 and E2 proteins to the origin of replication of bovine papillomavirus. J. Virol. 71, 2887-2896 Sedman, J., Stenlund, A.(1996) The initiator protein E1 binds to the BPV origin of replication as a trimeric ring-like structure EMBO J. 15, 5085-50929 Melendy, T., Sedman, J., Stenlund, A. (1995) Cellular factors required for papillomavirus replication. J. Virol. 69, 7857-7867 Sedman, J., Stenlund, A., (1995) Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro. EMBO J. 14, 6218-6228 Felgengauer, P., Sedman, J., Shostak, N., Timofeeva, M., Lind, A., Bayev, A.(1990)The 5'-flanking sequence of the loach oocyte 5S rRNA gene contains a signal for effective transcription. Gene, 90, 243-248 Sedman, J., Shostak, N.G., Kuprijanova, N.S., Serenkova, T.I., Felgengauer, P.E., Gimalov, F., Lind, A.J., Timofeeva, M.J., Bajev, A.A. (1989) Intragenic polymorphism of the primary structure of 5S rRNA gene variants of the loach (Misgurnus fossilis L.) Molek. Biol. Mosk. 23, 1295-1308 Bergman, P, Ustav, M., Sedman, J., Moreno-Lopez, J., Vennstrom, B., Peterson, U. (1988) The E5 gene of bovine papillomavirus type 1 is sufficient for complete oncogenic transformation of mouse fibroblasts. Oncogene, 2, 453-459 Sedman, J., Felgengauer, P., Shostak, N.G., Timofeeva, M.J. (1988) The transcriptional efficiency of loach oocyte 5S rRNA genes depends on the region of 5'-flanking spacer. Dokl. Akad. Nauk SSSR, 303, 736-737 Sedman, J., Maimets, T., Ustav, M., Villems, R.(1981) The interaction of 5S rRNA and its large fragments with ribosomal proteins. FEBS Lett. 136, 251-254 |
last updated: 09.10.2005
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