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| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Vello |
| 2. | Perekonnanimi | Tõugu |
| 3. | Töökoht | Tallinna Tehnikaülikooli Geenitehnoloogia Instituut |
| 4. | Ametikoht | vanemteadur |
| 5. | Sünniaeg | 08.06.1957 (päev.kuu.aasta) |
| 6. | Haridus | Tartu Riiklik Ülikool 1980 keemik (orgaaniline keemia)/keemiaõpetaja TA Keemia Instituut 1991 kandidat nauk (orgaaniline keemia) |
| 7. | Teenistuskäik | 1980-82 TA Keemilise ja Bioloogilise Füüsika Instituudi Bioorgaanilise keemia laboratooriumi insener 1982-92 samas, nooremteadur 1992-95 samas, teadur 1995-2004 samas, vanemteadur 2005- TTÜ Geenitehnoloogia Instituut, vanemteadur |
| 8. | Teaduskraad | kandidat nauk (teaduste kandidaat, Ph.D kvalifikatsiooni nimetusele vastav kvalifikatsioon) |
| 9. | Teaduskraadi välja andnud asutus, aasta |
1991 Eesti TA Keemia Instituut/KAK |
| 10. | Tunnustused | |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
Eesti Biokeemia Seltsi juhatuse liige |
| 12. | Juhendamisel kaitstud väitekirjad |
|
| 13. | Teadustöö põhisuunad | Metalli-ioonide interaktsioonid valkude ja peptiidiga. Substraatide ja ligandide molekularne äratundmine ensüümide poolt ja ensüümide kasutamine keemilises sünteesis. |
| 14. | Jooksvad grandid | |
| 15. | Teaduspublikatsioonid |
Vallikivi, I., L. Fransson, K. Hult, I. Järving, T. Pehk, N. Samel, V. Tõugu, L. Villo, O. Parve, The modelling and kinetic investigation of the lipase-catalysed acetulation of stereoisomeric prostaglandins J. Mol. Cat. B: Enzymatic, 2005, 35, 62-69 Vallikivi, I., I. Järving, T. Pehk, N. Samel, V. Tõugu, O. Parve, NMR Monitoring of Lipase-catalysed Reactions of Prostaglandins: Preliminary Estimation of Reaction Velocities of Different Nucleophiles J. Mol. Cat. B: Enzymatic, 2004, 32, 15-19. Lookene, A., L. Zhang, V. Tougu, G. Olivecrona. – bis-ANS acts as an inhibitor of lipoprotein lipase and competes for binding with apolipoprotein CII, J. Biol. Chem. 2003, 278 (39), 37183-94 Vallikivi, I., Ü. Lille, A. Lõokene, A. Metsala, P. Sikk, V. Tõugu, H. Vija, L. Villo, O. Parve -Lipase action on some non-triglyceride substrates, J. Mol. Cat. B: Enzymatic, 2003, 22 (5-6), 279-298. Kesvatera, T., B. Jönsson, A. Telling, V. Tõugu, H. Vija, E. Thulin, S. Linse, S. - Calbindin D9k - A protein optimized for calcium binding at neutral pH - Biochemistry, 2001, 40(50), 15334-15340. Parve, O., T. Pehk, V. Tõugu, I. Vallikivi, L. Fransson, K. Hult, Synthetic, 1H NMR spectroscopic kinetic and MD modeling studies of lipase-catalysed reactions of prostanoids. Abstracts of Papers of the American Chemical Society 222:473-ORGN Part 2 2001 Tõugu, V. – Acetylcholinesterase: Mechanism of catalysis and inhibition. A review. – Curr. Med. Chem. – CNSA, 2001, 1 (2), 155-170 Tõugu, V., T. Kesvatera - Comparison of the salt effects on the reactions of acetylcholinesterase with cationic and anionic inhibitors - Biochim.Biophys. Acta, 2001, 1544, 189-195 |
viimati muudetud: 03.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Vello |
| 2. | Surname | Tõugu |
| 3. | Institution | Department of Gene Technology, Tallinn University of Technology |
| 4. | Position | senior research scientist |
| 5. | Date of birth | 08.06.1957 (day.month.year) |
| 6. | Education | Tartu State University 1980 chemist (organic chemistry)/ teacher of chemistry Institute of Chemistry of the Estonian Academy of Sciences 1991 Ph.D. (organic chemistry) |
| 7. | Research and professional experience |
1980-82 National Institute of Chemical Physics and Biophysics, Laboratory of bioorganic chemistry, engineer 1982-92 NICPB , research assistant 1992-95 NICPB, research scientist 1995-2004 NICPB, senior research scientist 2005 - Department of Gene Technology, Tallinn University of Technology, senior research scientist |
| 8. | Academic degree | Ph.D. |
| 9. | Dates and sites of earning the degrees |
1991 Institute of Chemistry of the Estonian Academy of Sciences/VAK |
| 10. | Honours/awards | |
| 11. | Research-administrative experience |
Estonian Biochemical Society, member of the board |
| 12. | Supervised dissertations | |
| 13. | Current research program | Interactions of metal ions with proteins and peptides. Molecular recognition of substrates and ligands by enzymes and application of enzymes in chemical synthesis, |
| 14. | Current grant funding | |
| 15. | List of most important publications |
Vallikivi, I., L. Fransson, K. Hult, I. Järving, T. Pehk, N. Samel, V. Tõugu, L. Villo, O. Parve, The modelling and kinetic investigation of the lipase-catalysed acetulation of stereoisomeric prostaglandins J. Mol. Cat. B: Enzymatic, 2005, 35, 62-69 Vallikivi, I., I. Järving, T. Pehk, N. Samel, V. Tõugu, O. Parve, NMR Monitoring of Lipase-catalysed Reactions of Prostaglandins: Preliminary Estimation of Reaction Velocities of Different Nucleophiles J. Mol. Cat. B: Enzymatic, 2004, 32, 15-19. Lookene, A., L. Zhang, V. Tougu, G. Olivecrona. – bis-ANS acts as an inhibitor of lipoprotein lipase and competes for binding with apolipoprotein CII, J. Biol. Chem. 2003, 278 (39), 37183-94 Vallikivi, I., Ü. Lille, A. Lõokene, A. Metsala, P. Sikk, V. Tõugu, H. Vija, L. Villo, O. Parve -Lipase action on some non-triglyceride substrates, J. Mol. Cat. B: Enzymatic, 2003, 22 (5-6), 279-298. Kesvatera, T., B. Jönsson, A. Telling, V. Tõugu, H. Vija, E. Thulin, S. Linse, S. - Calbindin D9k - A protein optimized for calcium binding at neutral pH - Biochemistry, 2001, 40(50), 15334-15340. Parve, O., T. Pehk, V. Tõugu, I. Vallikivi, L. Fransson, K. Hult, Synthetic, 1H NMR spectroscopic kinetic and MD modeling studies of lipase-catalysed reactions of prostanoids. Abstracts of Papers of the American Chemical Society 222:473-ORGN Part 2 2001 Tõugu, V. – Acetylcholinesterase: Mechanism of catalysis and inhibition. A review. – Curr. Med. Chem. – CNSA, 2001, 1 (2), 155-170 Tõugu, V., T. Kesvatera - Comparison of the salt effects on the reactions of acetylcholinesterase with cationic and anionic inhibitors - Biochim.Biophys. Acta, 2001, 1544, 189-195 |
last updated: 03.10.2005
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