[ sulge aken ]

Elulookirjeldus (CV)
1.Eesnimi Asko
2.Perekonnanimi Uri
3.Töökoht Tartu Ülikool, orgaanilise ja bioorgaanilise keemia instituut
4.Ametikoht juhtivteadur
5.Sünniaeg 03.12.1953 (päev.kuu.aasta)
6.Haridus Tartu Ülikool, diplom, keemia (orgaaniline keemia), 1977
7.Teenistuskäik TÜ orgaanilise keemia kateedri stazöör-uurija, 1977-1979;
TÜ orgaanilise keemia kateedri aspirant, 1979-1982;
TÜ keemilise kineetika ja katalüüsi labori nooremteadur, 1982-1985;
TÜ keemilise kineetika ja katalüüsi laboril vanemteadur, 1985-1993;
TÜ keemilise füüsika instituudi vanemteadur, 1993-1994;
TÜ keemilise füüsika instituudi keemik, 1994-1997;
TÜ keemilise füüsika instituudi teadur 1997-2000 ja vanemteadur, 2000-2001;
TÜ orgaanilise ja biorgaanilise keemia instituudi vanemteadur, 2001-2002;
Eesti TA uurija-professor Tartu Ülikooli juures, orgaanilise ja bioorgaanilise keemia instituut, 2002-2005;
TÜ orgaanilise ja biorgaanilise keemia insstituudi juhtivteadur (alates sept. 2005).
8.Teaduskraad keemiakandidaat (füüsikaine keemia)
9.Teaduskraadi välja
andnud asutus, aasta		 Tartu Ülikool, 1984
10.Tunnustused Eesti Teaduste Akadeemia uurija-professor, 2002
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus		 TÜ füüsika-keemiateaduskonna nõukogu liige;
Eesti biokeemia seltsi liige
12.Juhendamisel kaitstud
väitekirjad

Erki Enkvist, MSc, 2003, juh. Asko Uri. Synthesis of adenine nucleotide analogues containing carboxylate groups.. Tartu Ülikool

Kaido Viht, MSc, 2003, juh. Asko Uri. Liquid-phase synthesis of a pegylated inhibitor of protein kinase A. Tartu Ülikool
13.Teadustöö põhisuunad bioaktiivsete ainete disain ja arendus, nukleotiidretseptorite antagonistid,
proteiinkinaaside inhibiitorid; polümeerseotud reaktsioonid, sünteesid tahkel faasil, nukleosiid-peptiidkonjugaatide disaini- ja sünteesimeetodid; nukleosiidide ja nende lämmastikaluste modifitseerimine
14.Jooksvad grandid Eesti TA uurimistoetus uurija-professorile 2002-2005
15.Teaduspublikatsioonid

Viht, K., Vaasa, A., Raidaru, G., Enkvist, E. & Uri, A. (2005). Fluorometric TLC assay for evaluation of protein kinase inhibitors. Anal Biochem. 340(1), 165-170.

Kuznetsov, A., Uri, A., Raidaru, G., & Järv, J.(2004). Kinetic analysis of inhibition of cAMP-dependent protein kinase catalytic subunit by the peptide-nucleoside conjugate AdcAhxArg6.Bioorg Chem. 32(6), 527-535.

Vasiljev, K. S., Uri, A., & Laitinen, J. T. (2003). 2-Alkylthio-Substituted Platelet P2y(12) Receptor Antagonist Reveal Pharmacological Identity Between the Rat Brain G(I)- Linked Adp Receptors and P2y(12). Neuropharmacology, 45(1), 145-154.

Viht, K., Padari, K., Raidaru, G.-J., Subbi, J., Tammiste, I., Pooga, M., & Uri, A. (2003). Liquid-Phase Synthesis of a Pegylated Adenosine-Oligoarginine Conjugate, Cell-Permeable Inhibitor of Camp-Dependent Protein Kinase. Bioorganic & Medicinal Chemistry Letters, 13(18), 3035-3039.

Uri, A., Raidaru, G.-J., Subbi, J., Padari, K., & Pooga, M. (2002). Identification of the Ability of Highly Charged Nanomolar Inhibitors of Protein Kinases to Cross Plasma Membranes and Carry a Protein Into Cells. Bioorganic & Medicinal Chemistry Letters, 12(16), 2117-2120.

Laitinen, J. T., Uri, A., Raidaru, G.-J., & Miettinen, R. (2001). [S-35]Ctp Gamma S Autoradiography Reveals a Wide Distribution of G(I/O)-Linked Adp Receptors in the Nervous System: Close Similarities With the Platelet P2y(Adp) Receptor. Journal of Neurochemistry, 77(2), 505-518.

Loog, M., Uri, A., Järv, J., & Ek, P. (2000). Bi-Substrate Analogue Ligands for Affinity Chromatography of Protein Kinases. Febs Letters, 480(2-3), 244-248.

Sak, K., Uri, A., Enkvist, E., Raidaru, G.-J., Subbi, J., Kelve, M., & Järv, J. (2000). Adenosine-Derived Non-Phosphate Antagonists for P2y(1) Purinoceptors. Biochemical and Biophysical Research Communications, 272(2), 327-331

Loog, M., Uri, A., Raidaru, G.-J., Järv, J., & Ek, P. (1999). Adenosine-5 '-Carboxylic Acid Peptidyl Derivatives as Inhibitors of Protein Kinases. Bioorganic & Medicinal Chemistry Letters, 9(10), 1447-1452.

Pooga, M., Jureus, A., Rezaei, K., Hasanvan, H., Saar, K., Kask, K., Kjellen, P., Land, T., Halonen, J., Mäeorg, U., Uri, A., Solyom, S., Bartfai, T., & Langel, Ü. (1998). Novel Galanin Receptor Ligands. Journal of Peptide Research, 51(1), 65-74.

Sak, K., Kelve, M., Uri, A., & Järv, J. (1998). Pyrimidinoceptor Potentiation by Atp in Ng108-15 Cells. Febs Letters, 439(1-2), 107-109.

Pehk, T., & Uri, A. (1997). Synthesis and Structural Characterization of Conjugates of Adenosine and Tetra-Aspartate, Novel Analogs of ATP. Bioorganic & Medicinal Chemistry Letters, 7(17), 2159-2164

viimati muudetud: 05.10.2005

Curriculum Vitae (CV)
1.First Name Asko
2.Surname Uri
3.Institution University of Tartu, Institute of Organic and Bioorganic Chemistry
4.Position leading scientist
5.Date of birth 03.12.1953 (day.month.year)
6.Education Tartu University, diploma in chemistry (organic chemistry), 1977
7.Research and
professional experience		 University of Tartu (UT), Laboratory of Chemical Kinetics and Catalysis, research fellow 1982-1985;
UT, Laboratory of Chemical Kinetics and Catalysis, senior research fellow 1985-1993;
UT, Institute of Chemical Physics, senior research fellow, 1993-1994;
UT, Institute of Chemical Physics, chemist, 1994-1997;
UT, Institute of Chemical Physics, research fellow, 1997-2000, and senior research fellow, 2001-2002;
UT, Institute of Organic and Bioorganic Chemistry, senior research fellow, 2001-2002;
UT, Institute of Organic and Bioorganic Chemistry, research professor of the Estonian Academy of Sciences, 2002-2005
UT, Institute of Organic and Bioorganic Chemistry, leading scientist, starting from september 2005
8.Academic degree PhD in Chemistry (Candidate of Chemistry)
9.Dates and sites of
earning the degrees		 University of Tartu, 1984
10.Honours/awards Research professor of the Estonian Academy of Sciences, 2002
11.Research-administrative
experience		 Member of the government of the Faculty of Physics and Chemistry, University of Tartu; member of the Estonian Biochemistry Society
12.Supervised dissertations

Erki Enkvist, MSc, 2003, superv. Asko Uri. Synthesis of adenine nucleotide analogues containing carboxylate groups.. Tartu Ülikool

Kaido Viht, MSc, 2003, superv. Asko Uri. Liquid-phase synthesis of a pegylated inhibitor of protein kinase A. Tartu Ülikool
13.Current research program Design and development of bioactive compounds, antagonists of nucleotide receptors, inhibitors of protein kinases; reactions on polymeric carriers, design and development methods for nucleoside-peptide conjugates; modification of nucleosides and their nitrogen bases
14.Current grant funding Research grant from the Estonian Academy of Sciences to the research professor, 2002-2005
15.List of most important publications

Viht, K., Vaasa, A., Raidaru, G., Enkvist, E. & Uri, A. (2005). Fluorometric TLC assay for evaluation of protein kinase inhibitors. Anal Biochem. 340(1), 165-170.

Kuznetsov, A., Uri, A., Raidaru, G., & Järv, J.(2004). Kinetic analysis of inhibition of cAMP-dependent protein kinase catalytic subunit by the peptide-nucleoside conjugate AdcAhxArg6.Bioorg Chem. 32(6), 527-535.

Vasiljev, K. S., Uri, A., & Laitinen, J. T. (2003). 2-Alkylthio-Substituted Platelet P2y(12) Receptor Antagonist Reveal Pharmacological Identity Between the Rat Brain G(I)- Linked Adp Receptors and P2y(12). Neuropharmacology, 45(1), 145-154.

Viht, K., Padari, K., Raidaru, G.-J., Subbi, J., Tammiste, I., Pooga, M., & Uri, A. (2003). Liquid-Phase Synthesis of a Pegylated Adenosine-Oligoarginine Conjugate, Cell-Permeable Inhibitor of Camp-Dependent Protein Kinase. Bioorganic & Medicinal Chemistry Letters, 13(18), 3035-3039.

Uri, A., Raidaru, G.-J., Subbi, J., Padari, K., & Pooga, M. (2002). Identification of the Ability of Highly Charged Nanomolar Inhibitors of Protein Kinases to Cross Plasma Membranes and Carry a Protein Into Cells. Bioorganic & Medicinal Chemistry Letters, 12(16), 2117-2120.

Laitinen, J. T., Uri, A., Raidaru, G.-J., & Miettinen, R. (2001). [S-35]Ctp Gamma S Autoradiography Reveals a Wide Distribution of G(I/O)-Linked Adp Receptors in the Nervous System: Close Similarities With the Platelet P2y(Adp) Receptor. Journal of Neurochemistry, 77(2), 505-518.

Loog, M., Uri, A., Järv, J., & Ek, P. (2000). Bi-Substrate Analogue Ligands for Affinity Chromatography of Protein Kinases. Febs Letters, 480(2-3), 244-248.

Sak, K., Uri, A., Enkvist, E., Raidaru, G.-J., Subbi, J., Kelve, M., & Järv, J. (2000). Adenosine-Derived Non-Phosphate Antagonists for P2y(1) Purinoceptors. Biochemical and Biophysical Research Communications, 272(2), 327-331

Loog, M., Uri, A., Raidaru, G.-J., Järv, J., & Ek, P. (1999). Adenosine-5 '-Carboxylic Acid Peptidyl Derivatives as Inhibitors of Protein Kinases. Bioorganic & Medicinal Chemistry Letters, 9(10), 1447-1452.

Pooga, M., Jureus, A., Rezaei, K., Hasanvan, H., Saar, K., Kask, K., Kjellen, P., Land, T., Halonen, J., Mäeorg, U., Uri, A., Solyom, S., Bartfai, T., & Langel, Ü. (1998). Novel Galanin Receptor Ligands. Journal of Peptide Research, 51(1), 65-74.

Sak, K., Kelve, M., Uri, A., & Järv, J. (1998). Pyrimidinoceptor Potentiation by Atp in Ng108-15 Cells. Febs Letters, 439(1-2), 107-109.

Pehk, T., & Uri, A. (1997). Synthesis and Structural Characterization of Conjugates of Adenosine and Tetra-Aspartate, Novel Analogs of ATP. Bioorganic & Medicinal Chemistry Letters, 7(17), 2159-2164

last updated: 05.10.2005

[ sulge aken ]