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Elulookirjeldus (CV)
1.Eesnimi Ceslava
2.Perekonnanimi Kairane
3.Töökoht TÜ Biokeemia Instituut
4.Ametikoht dotsent
5.Sünniaeg 01.01.1950 (päev.kuu.aasta)
6.Haridus Riia meditsiini Instituut, 1973
7.Teenistuskäik 1973-1976 vanemlaborant, Riia meditsiini Instituut
1976-1981 aspirant, NSVL TA Füüsika Instituut (Moskva)
1981-1982 vanem-insener/uurija, Läti TA Orgaanilise Sünteesi Instituut
1982-1986 insner/uurija, Eesti TA Eksperimentaalbioloogia Instituut
1986-1990 teadur, TÜ TO Hormonaalregulatsiooni Laboratoorium
1990-1993 vanem-teadur, TÜ TO Ensümoloogia Laboratoorium
1993-1994 vanem-teadur, TÜ Arstiteaduskonna Biokeemia Instituut
1994-1995 0.5 k. vanemteadur/0.5 k vanemassistent TÜ Arstiteaduskonna Biokeemia Instituut
1996-2005 vanemassistent TÜ Arstiteaduskonna Biokeemia Instituut
2005-2010 dotsent TÜ Arstiteaduskonna Biokeemia Instituut
8.Teaduskraad bioloogiakandidaat (Ph.D.)
9.Teaduskraadi välja
andnud asutus, aasta
Kõrgem Atestatsiooni Komisjon (Moskva), 1983
10.Tunnustused
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus
Eesti Biokeemia Selts
Konverentside Organisatsioonikomiteede liige
Faramatseutlise kirjanduse referent
12.Juhendamisel kaitstud
väitekirjad
13.Teadustöö põhisuunad 1. Neuropeptiidide uurimine, nende toimemehhanism ja kasutamine kliinikus
2. Molekulaarmeditsiin ja oksüdatiivne stress, probiootikumid ja oksüdatiivne stress, koronaarhaigused ja oksüdatiivne stress
14.Jooksvad grandid
15.Teaduspublikatsioonid

Karu I, Loit R, Paapstel A, Kairane C, Zilmer M, Starkopf J. Early postoperative function of the heart after coronary artery bypass grafting is not predicted by myocardial necrosis and gluathione-associated oxidative stress. Cli Chim Acta. 2005 Sep; 359(1-2);195-202. PMID:15919071

Muda P,Kampus P,Zilmer M,Ristimäe T,Fischer K, Zilmer K, Kairane C, Teesalu R. Effect of antihypertensive treatment with candesartan or amilodipine on glutathione and its redox status, homocysteine and vitamin concentrations in patients with essential hypertension.J Hypertens. 2005 Jan;23 (1):105-12.PIMD:15643131

Pihl E, Zilmer K, Kullisaar T, Kairane C, Magi A, Zilmer M. Atherogenic infammatoty and oxidative stress markers in relation to overweight values in male former athletes. Int J Obes(Lond).20005 Sep 13; PMID:16158088

Eisen M,Kaur S,Rehema A, Kullisaar T, Vihalemm T,Zilmer K, Kairane C, Zilmer M.Allergic contact dermatitis is accompanied by severe abnormal changes in antioxidativity of blood.Biomed.Pharmacother.2004 May;58 (4):260-3.PMID:15183853

Muda P, Kampus P, Zilmer M, Kairane C, Ristimäe T, Ficher K, Teesalu R. Homocysteine and red blood cell glutathione as indices for middle-aged untreated essential hypertension patients. J. Hypertens. 2003, Dec; 21(12):2329-2333. PMID:14654754

Pihl E, Zilmer K,Kullisaar T, Kairane C, Pulges A, Zilmer M. High-sensitive C-reactive protein level and oxidtaive stress-related status in former athletes in realtion to traditional cardiovascular risk factors. Atherosclerosis. 2003 Dec; 171(2):321-6. PMID:14644403

Poder P,Pulges A, Kals J, Aavik A, Zilmer K, Kullisaar T, Kairane C, Zilmer M. Is elective abdominal aortic aneurysm repair accompanied by high grade oxidative stress? Scand J Surg. 2003; 92(3):206-9. PMID: 14582543

Roots K, Koks S, Kairane C, Salum T, Karelson E, Vasar E, Zilmer M. Na-pump kinetic properties are differently altered in the brain regions of the cholecystokinkn2 receptor-deficient mice. Ann N Y Acad Sci. 2003 Aprl; 986: 644-5.PMID:12763910

Kairane C, Roots K, Uusma T, Bogdanovic N, Karelson E, Koks S, Zilmer M. Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: difference from the age-matched control but similarity to the rat model. FEBS Lett. 2002 Nov 6;531(2):241-4 PMID:12417319

Kullisaar T,Zilmer M,Mikelsaar M,Vihalemm T, Annuk H, Kairane C, Kilk A. Two antioxidative lactobacilli strains as promising probiotics. Int J Food Microbiol. 2002 Feb 5; 72(3):215-24. PMID:11845820

Karelson E, Bogdanovic N, Garlind A, Winblad B, Zilmer K, Kullisaar T, Vihalemm T, Kairane C, Zilmer M. The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defence. Neurochem. Res. 2001 Apr;26(4):353-61. PMID:11495345

Tahepõld P, Valen G, Starkopf J, Kairane C, Zilmer M, Vaage J. Pretreating rats with hyperoxia attenuates ischemia-reperfusion injury of the heart. Life Sci. 2001 Feb 23; 68(14):1629-40. PMID:11263675

Vider J, Lehtmaa J, Kullisaar T, Vihalemm T, Zilmer K, Kairane C, Landor A, Karu T, Zilmer M. Acute immune response in respect to exercise-induced oxidative stress. Pathophysiology. 2001 Mar;7 (4):263-270. PMID:11228396

Valen G, Kawakami T, Tahepold P, Starkopf J, Kairane C, Dumitrescu A, Lowbeer C, Zilmer M, Vaage j.Pretreatment with methylprednisolone protects the isolated rat heart against ischemic and oxidative damage. Free Radic Res. 2000 Jul; 33(1):31-43. PMID:10826919

viimati muudetud: 04.09.2006

Curriculum Vitae (CV)
1.First Name Ceslava
2.Surname Kairane
3.Institution Department of Biochemistry, University of Tartu
4.Position associated professor
5.Date of birth 01.01.1950 (day.month.year)
6.Education Medical Institute of Riga, 1973
7.Research and
professional experience
1973-1976 sen.lab. assistant, Medical Institute of Riga
1976-1981 postgraduate student, Institute of Physics, USSR Academy of Sciences(Moscow)
1981-1982 sen. engineer/researcher, Institute of Organic Synthesis Latvian Academy of Sciences
1982-1986 engineer/researcher, Institute of Experimental Biology, Estonian Academy of Sciences
1986-1990 researcher, Laboratory of Hormonal Regulation, Tartu University
1990-1993 sen.researcher, Laboratory of Enzymology, Tartu University
1993-1994 sen.researcher, Department of Biochemistry, Tartu University

1994-1995 0.5 sen.researcher/0.5 sen. assistant, Department of Biochemistry, Tartu University
1996-2005 senior assistant Department of Biochemistry, Tartu University
2005-2010 associated professor Department of Biochemistry, Tartu University
8.Academic degree Ph.D. (Candidate of Biological Sciences)
9.Dates and sites of
earning the degrees
Higher Attestaion Commission
(Moscow), 1983
10.Honours/awards
11.Research-administrative
experience
Estonian Biochemical Society
Member of Organizing Committees of Conferences
Referent of pharmaceutical literature
12.Supervised dissertations
13.Current research program 1.Investigation of neuropeptides; their action mechanisms and clinical use
2. Molecular medicine and oxidative stress, probiotics and oxidative stress, coronary diseases and oxidative stress
14.Current grant funding
15.List of most important publications

Karu I, Loit R, Paapstel A, Kairane C, Zilmer M, Starkopf J. Early postoperative function of the heart after coronary artery bypass grafting is not predicted by myocardial necrosis and gluathione-associated oxidative stress. Cli Chim Acta. 2005 Sep; 359(1-2);195-202. PMID:15919071

Muda P,Kampus P,Zilmer M,Ristimäe T,Fischer K, Zilmer K, Kairane C, Teesalu R. Effect of antihypertensive treatment with candesartan or amilodipine on glutathione and its redox status, homocysteine and vitamin concentrations in patients with essential hypertension.J Hypertens. 2005 Jan;23 (1):105-12.PIMD:15643131

Pihl E, Zilmer K, Kullisaar T, Kairane C, Magi A, Zilmer M. Atherogenic infammatoty and oxidative stress markers in relation to overweight values in male former athletes. Int J Obes(Lond).20005 Sep 13; PMID:16158088

Eisen M,Kaur S,Rehema A, Kullisaar T, Vihalemm T,Zilmer K, Kairane C, Zilmer M.Allergic contact dermatitis is accompanied by severe abnormal changes in antioxidativity of blood.Biomed.Pharmacother.2004 May;58 (4):260-3.PMID:15183853

Muda P, Kampus P, Zilmer M, Kairane C, Ristimäe T, Ficher K, Teesalu R. Homocysteine and red blood cell glutathione as indices for middle-aged untreated essential hypertension patients. J. Hypertens. 2003, Dec; 21(12):2329-2333. PMID:14654754

Pihl E, Zilmer K,Kullisaar T, Kairane C, Pulges A, Zilmer M. High-sensitive C-reactive protein level and oxidtaive stress-related status in former athletes in realtion to traditional cardiovascular risk factors. Atherosclerosis. 2003 Dec; 171(2):321-6. PMID:14644403

Poder P,Pulges A, Kals J, Aavik A, Zilmer K, Kullisaar T, Kairane C, Zilmer M. Is elective abdominal aortic aneurysm repair accompanied by high grade oxidative stress? Scand J Surg. 2003; 92(3):206-9. PMID: 14582543

Roots K, Koks S, Kairane C, Salum T, Karelson E, Vasar E, Zilmer M. Na-pump kinetic properties are differently altered in the brain regions of the cholecystokinkn2 receptor-deficient mice. Ann N Y Acad Sci. 2003 Aprl; 986: 644-5.PMID:12763910

Kairane C, Roots K, Uusma T, Bogdanovic N, Karelson E, Koks S, Zilmer M. Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: difference from the age-matched control but similarity to the rat model. FEBS Lett. 2002 Nov 6;531(2):241-4 PMID:12417319

Kullisaar T,Zilmer M,Mikelsaar M,Vihalemm T, Annuk H, Kairane C, Kilk A. Two antioxidative lactobacilli strains as promising probiotics. Int J Food Microbiol. 2002 Feb 5; 72(3):215-24. PMID:11845820

Karelson E, Bogdanovic N, Garlind A, Winblad B, Zilmer K, Kullisaar T, Vihalemm T, Kairane C, Zilmer M. The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defence. Neurochem. Res. 2001 Apr;26(4):353-61. PMID:11495345

Tahepõld P, Valen G, Starkopf J, Kairane C, Zilmer M, Vaage J. Pretreating rats with hyperoxia attenuates ischemia-reperfusion injury of the heart. Life Sci. 2001 Feb 23; 68(14):1629-40. PMID:11263675

Vider J, Lehtmaa J, Kullisaar T, Vihalemm T, Zilmer K, Kairane C, Landor A, Karu T, Zilmer M. Acute immune response in respect to exercise-induced oxidative stress. Pathophysiology. 2001 Mar;7 (4):263-270. PMID:11228396

Valen G, Kawakami T, Tahepold P, Starkopf J, Kairane C, Dumitrescu A, Lowbeer C, Zilmer M, Vaage j.Pretreatment with methylprednisolone protects the isolated rat heart against ischemic and oxidative damage. Free Radic Res. 2000 Jul; 33(1):31-43. PMID:10826919

last updated: 04.09.2006

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