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| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Joel |
| 2. | Perekonnanimi | Starkopf |
| 3. | Töökoht | Tartu Ülikool, arstiteaduskond, anestesioloogia ja intensiivravi kliinik; Tartu Ülikooli Kliinikum, anestesioloogia ja intensiivravi kliinik |
| 4. | Ametikoht | professor; kliiniku juhataja |
| 5. | Sünniaeg | 08.02.1966 (päev.kuu.aasta) |
| 6. | Haridus | 1972 Tallinna 43. Keskkool 1991 Tartu Ülikool, arstiteaduskond 1997 Tartu Ülikool, meditsiiniteaduste doktor |
| 7. | Teenistuskäik | 1991-1992 Tartu Maarjamõisa Haigla, anestesioloogia internatuur 1992-1996 Tartu Ülikool, arstiteaduskond, biokeemia instituut, doktorant 1993-1999 Tartu Maarjamõisa Haigla, kardiokirurgia osakond, anestesioloog 1996-2001 Tartu Ülikool, arstiteaduskond, biokeemia instituut, assistent, vanemassistent 1996-2001 Tartu Ülikool, arstiteaduskond, anestesioloogia ja intensiivravi kliinik, assistent 1999-2001 Tartu Ülikooli Kliinikum, anestesioloogia ja intensiivravi kliinik, üldanestesioloogia osakond, arst-õppejõud 2001-2004 Tartu Ülikool, arstiteaduskond dotsent 2004- Tartu Ülikool, arstiteaduskond, professor 2001- Tartu Ülikool, Tartu Ülikooli Kliinikum, anestesioloogia ja intensiivravi kliiniku juhataja |
| 8. | Teaduskraad | meditsiiniteaduste doktor |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Ülikool, 1997 |
| 10. | Tunnustused | - |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
- Eesti Anestesioloogide Seltsi president; - EV Sotsiaalministeeriumi erialakomisjoni liige; - Euroopa Anestesiolooga Ühingu liige; - Euroopa Intensiivravi Seltsi liige; - Ajakirja Life Sciences referent. |
| 12. | Juhendamisel kaitstud väitekirjad |
Peeter Tähepõld, PhD, 2002, juh. Jarle Vaage, Guro Valen, Joel Starkopf. Myocardial protection with hyperoxia. Karolinska Haigla, Stockholm |
| 13. | Teadustöö põhisuunad | Kliinilised uuringud: - isheemia-reperfusiooni kahjustus, oksüdatiivne stress, võimalused isheemia-reperfusiooni kahjustuse vältimiseks erinevates kliinilistes situatsioonides (südamekirurgia kehavälise vereringe tingimustes, vaskulaarkirurgia, intensiivravi patsiendid). Hüperoksiline eelkohastumus südamekirurgias; - mitmeelundiline puudulikkus ja sepsis. Patogeneetilised mehhanismid, ravimite farmakokineetika sepsise puhul; Eksperimentaalsed uuringud: - müokardi isheemia-reperfusiooni kahjustus, patofüsioloogilised mehhanismid, uued võimalused müokardi protektsiooniks. Isheemiline eelkohastumus. Hüperoksia – uus võimalus südamelihase adaptatsiooniks isheemia-reperfusiooni kahjustusega; - neuroprotektiivsete interventsioonide uuringud aju globaalse isheemia mudelil. |
| 14. | Jooksvad grandid | ETF grant nr. 5304 (2002-2005) "Mitmeelundilise puudulikkuse preventsioon sepsise puhul: infusioonravi, mikrotsirkulatsioon, antibakteriaalne ravi ja plasmavahetus" grandihoidja ETF grant nr. 5327 (2002-2005) "Uudsete protektormolekulide disainimine ja uurimine in vitro ning loommudelitel" põhitäitja |
| 15. | Teaduspublikatsioonid |
Karjagin J, Pähkla R, Karki T, Starkopf J. Distribution of metronidazole in muscle tissue of patients with septic shock and its efficacy against Bacteroides fragilis in vitro. J Antimicrob Chemother. 2005 Mar;55(3):341-6. Karu I, Loit R, Paapstel A, Kairaine C, Zilmer M, Starkopf J. Early postoperative function of the heart after coronary artery bypass grafting is not predicted by myocardial necrosis and glutathione-associated oxidative stress. Clin Chim Acta. 2005 May 23; [Epub ahead of print] Karjagin J, Pähkla R, Starkopf J. Metronidazole in muscle tissue: a microdialysis study. European Journal of Pharmacology, 59 (11): 809-813, 2004 Põder P, Zilmer M, Starkopf J, Kals J, Talonpoika A, Pulges A, Langel Ü, Kullisaar T, Viirlaid S, Mahlapuu R, Žarkovski A, Arend A, Soomets U. An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. Neurosci Lett, 370(1):45-50, 2004 Angdin M, Settergren G, Starkopf J, Zilmer M, Zilmer K, Vaage J. Protective effect of antioxidants on pulmonary endothelial function after cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia, 17(3): 314-320, 2003 Tähepõld P, Vaage J, Starkopf J, Valen G. Hyperoxia elicits myocardial protection through a NFkB-dependent mechanism in the rat heart. J Thorac Cardiovasc Surg,125(3):650-660, 2003 Valen G, Tähepõld P. Starkopf J, Ruusalepp A, Vaage J. Adaptation to ischemia by in vivo exposure to hyperoxia – signalling through mitogen activated protein kinases and nuclear factor kappa B. In: Signal transduction and cardiac hypertrophy. Eds: NS Dhalla, LV Hryshko, E Kardami, PK Singal. Kluwer Academic Publishers, Boston, pp 461-477, 2003 Tähepõld P, Elfström P, Eha I, Kals J, Taal G, Talonpoika A, Valen G, Vaage J, Starkopf J.Exposure of rats to hyperoxia enhances relaxation of isolated aortic rings and reduces infarct size of isolated hearts. Acta Physiologica Scandinavica,175(4):271-277, 2002 Tähepõld P, Ruusalepp A, Li G, Vaage J, Starkopf J, Valen G. Cardioprotection by breathing hyperoxic gas – relation to oxygen concentration and exposure time in rats and mice. European Journal of Cardiothoracic Surgery,21:987-994, 2002 Tähepõld P, Valen G, Starkopf J, Kairane C, Zilmer M, Vaage J. Pretreating rats with hyperoxia attenuates ischaemia-reperfusion injury of the heart. Life Sciences, 68:1629-1640, 2001. Valen G, Kawakami T, Tähepõld P, Starkopf J, Kairane C, Dumitrescu A, Löwbeer C, Zilmer M, Vaage J. Pretreatment with methylprednisolone protects the isolated rat heart against ischaemic and oxidative damage. Free Radicals Research, 33:31-43, 2000 Starkopf J, Andreasen T, Bugge E, Ytrehus K. Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart. Cardiovascular Research, 37:66-75, 1998 Valen G, Starkopf J, Takeshima S, Kullisaar T, Vihalemm T, Kengsepp A-T, Löwbeer C, Vaage J, Zilmer M. Preconditioning with hydrogen peroxide (H2O2) or ischemia in H2O2-induced cardiac dysfunction. Free Radicals Research, 29:235-245, 1998 Starkopf J, Bugge E, Ytrehus K. Preischemic bradykinin and ischemic preconditioning in functional and metabolic recovery of globally ischemic rat heart. Cardiovascular Research, 33:63-70, 1997 Starkopf J, Tamme K, Zilmer M, Talvik R, Samarütel J. The evidence of oxidative stress in cardiac surgery and septic patients - a comparative study. Clinica Chimica Acta, 262:77-88, 1997 Kokk K, Starkopf J, Sipria A, Zilmer M, Talvik R. Compared evidence of oxidative stress in SIRS and cardiac surgery patients. Proceedings of 8th European Congress of Intensive Care Medicine, Athens, pp. 69 – 73; 1995 Starkopf J, Zilmer K, Vihalemm T, Kullisaar T, Zilmer M, Samarütel J. Time course of oxidative stress during open-heart surgery. Scand J Thorac Cardiovasc Surg, 29(4):181-186, 1995 |
viimati muudetud: 01.08.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Joel |
| 2. | Surname | Starkopf |
| 3. | Institution | University of Tartu, Faculty of Medicine, Clinic of Anaesthesiology and Intensive Care; Tartu University Clinics, Clinic of Anaesthesiology and Intensive Care |
| 4. | Position | Professor; Head of the Clinic |
| 5. | Date of birth | 08.02.1966 (day.month.year) |
| 6. | Education | 1972 Tallinn Secondary School No. 43 1991 University of Tartu, Faculty of Medicine 1997 University of Tartu, Doctor of Medical Sciences |
| 7. | Research and professional experience |
1991-1992 Tartu Maarjamõisa Hospital, internship in anaesthesiology 1992-1996 University of Tartu, Faculty of Medicine, Institute of Biochemistry, research fellow 1993-1999 Tartu Maarjamõisa Hospital, Department of Cardiac Surgery, anaesthesiologist 1996-2001 University of Tartu, Faculty of Medicine, Institute of Biochemistry, assistant, senior assistant 1996-2001 University of Tartu, Faculty of Medicine, Clinic of Anaesthesiology and Intensive Care, assistant 1999-2001 Tartu University Clinics, Clinic of Anaesthesiology and Intensive Care, Department of Anaesthesiology, anaesthesiologist 2001-2004 University of Tartu, Faculty of Medicine, associate professor 2004- University of Tartu, Faculty of Medicine, professor 2001- University of Tartu, Tartu University Clinics, Clinic of Anaesthesiology and Intensive Care, head of the clinic |
| 8. | Academic degree | doctor of medical sciences |
| 9. | Dates and sites of earning the degrees |
University of Tartu, 1997 |
| 10. | Honours/awards | - |
| 11. | Research-administrative experience |
- President of Estonian Society of Anaesthesiologist; - Member of European Society of Anaesthesiology; - Member of European Society of Intensive Care; - Referee for scientific journal Life Sciences. |
| 12. | Supervised dissertations |
Peeter Tähepõld, PhD, 2002, superv. Jarle Vaage, Guro Valen, Joel Starkopf. Myocardial protection with hyperoxia. Karolinska Haigla, Stockholm |
| 13. | Current research program | Clinical studies: - Ischaemia-reperfusion injury, oxidative stress, organ protection from ischaemia-reperfusion injury in different clinical situations (open heart surgery, major vascular surgery, critically ill patients in intesive care). Preconditioning with hyperoxia in cardiac surgery; - Multiorgan failure and sepsis. Pathogenesis, farmakokinetics of antibiotic drugs used in sepsis; Experimental studies: - Myocardial ischaemia-reperfusion injury, patophysiology, myocardial protection. Ischaemic preconditioning. Myocardial preconditioning with hyperoxia; - Neuroprotective interventions in experimental model of brain global ishaemia. |
| 14. | Current grant funding | ETF grant no. 5304 (2002-2005) "Prevention of multiple organ failure in sepsis: infusion therapy, microcirculation, antibacterial treatment and plasma exchange" grant holder |
| 15. | List of most important publications |
Karjagin J, Pähkla R, Karki T, Starkopf J. Distribution of metronidazole in muscle tissue of patients with septic shock and its efficacy against Bacteroides fragilis in vitro. J Antimicrob Chemother. 2005 Mar;55(3):341-6. Karu I, Loit R, Paapstel A, Kairaine C, Zilmer M, Starkopf J. Early postoperative function of the heart after coronary artery bypass grafting is not predicted by myocardial necrosis and glutathione-associated oxidative stress. Clin Chim Acta. 2005 May 23; [Epub ahead of print] Karjagin J, Pähkla R, Starkopf J. Metronidazole in muscle tissue: a microdialysis study. European Journal of Pharmacology, 59 (11): 809-813, 2004 Põder P, Zilmer M, Starkopf J, Kals J, Talonpoika A, Pulges A, Langel Ü, Kullisaar T, Viirlaid S, Mahlapuu R, Žarkovski A, Arend A, Soomets U. An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. Neurosci Lett, 370(1):45-50, 2004 Angdin M, Settergren G, Starkopf J, Zilmer M, Zilmer K, Vaage J. Protective effect of antioxidants on pulmonary endothelial function after cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia, 17(3): 314-320, 2003 Tähepõld P, Vaage J, Starkopf J, Valen G. Hyperoxia elicits myocardial protection through a NFkB-dependent mechanism in the rat heart. J Thorac Cardiovasc Surg,125(3):650-660, 2003 Valen G, Tähepõld P. Starkopf J, Ruusalepp A, Vaage J. Adaptation to ischemia by in vivo exposure to hyperoxia – signalling through mitogen activated protein kinases and nuclear factor kappa B. In: Signal transduction and cardiac hypertrophy. Eds: NS Dhalla, LV Hryshko, E Kardami, PK Singal. Kluwer Academic Publishers, Boston, pp 461-477, 2003 Tähepõld P, Elfström P, Eha I, Kals J, Taal G, Talonpoika A, Valen G, Vaage J, Starkopf J.Exposure of rats to hyperoxia enhances relaxation of isolated aortic rings and reduces infarct size of isolated hearts. Acta Physiologica Scandinavica,175(4):271-277, 2002 Tähepõld P, Ruusalepp A, Li G, Vaage J, Starkopf J, Valen G. Cardioprotection by breathing hyperoxic gas – relation to oxygen concentration and exposure time in rats and mice. European Journal of Cardiothoracic Surgery,21:987-994, 2002 Tähepõld P, Valen G, Starkopf J, Kairane C, Zilmer M, Vaage J. Pretreating rats with hyperoxia attenuates ischaemia-reperfusion injury of the heart. Life Sciences, 68:1629-1640, 2001. Valen G, Kawakami T, Tähepõld P, Starkopf J, Kairane C, Dumitrescu A, Löwbeer C, Zilmer M, Vaage J. Pretreatment with methylprednisolone protects the isolated rat heart against ischaemic and oxidative damage. Free Radicals Research, 33:31-43, 2000 Starkopf J, Andreasen T, Bugge E, Ytrehus K. Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart. Cardiovascular Research, 37:66-75, 1998 Valen G, Starkopf J, Takeshima S, Kullisaar T, Vihalemm T, Kengsepp A-T, Löwbeer C, Vaage J, Zilmer M. Preconditioning with hydrogen peroxide (H2O2) or ischemia in H2O2-induced cardiac dysfunction. Free Radicals Research, 29:235-245, 1998 Starkopf J, Bugge E, Ytrehus K. Preischemic bradykinin and ischemic preconditioning in functional and metabolic recovery of globally ischemic rat heart. Cardiovascular Research, 33:63-70, 1997 Starkopf J, Tamme K, Zilmer M, Talvik R, Samarütel J. The evidence of oxidative stress in cardiac surgery and septic patients - a comparative study. Clinica Chimica Acta, 262:77-88, 1997 Kokk K, Starkopf J, Sipria A, Zilmer M, Talvik R. Compared evidence of oxidative stress in SIRS and cardiac surgery patients. Proceedings of 8th European Congress of Intensive Care Medicine, Athens, pp. 69 – 73; 1995 Starkopf J, Zilmer K, Vihalemm T, Kullisaar T, Zilmer M, Samarütel J. Time course of oxidative stress during open-heart surgery. Scand J Thorac Cardiovasc Surg, 29(4):181-186, 1995 |
last updated: 01.08.2005
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