[ sulge aken ]

Elulookirjeldus (CV)
1.Eesnimi Aavo-Valdur
2.Perekonnanimi Mikelsaar
3.Töökoht Üld-ja Molekulaarpatoloogia Instituut, Tartu Ülikool
4.Ametikoht juhataja
5.Sünniaeg 26.07.1941 (päev.kuu.aasta)
6.Haridus lõpetanud Tartu Ülikooli arstiteaduskonna, arst, 1959; aspirantuur Moskvas Teaduste Akadeemia Molekulaarbioloogia Instituudis 1967-1970; õpingud Viini ülikoolis, 1976-77; Tampere ülikoolis 1988 ja Lübeki Meditsiini ülikoolis, 1993
7.Teenistuskäik teadur Tartu ülikoolis, 1965-67; aspirant NSVL TA Molekulaarbioloogia Instituudis, 1967-70; teadur, vanemteadur, laborijuhatja Tartu ülikoolis, 1970-1987; TÜ ÜMPI direktor alates 1987 ja inimese bioloogia ja geneetika professor alates 1993
8.Teaduskraad meditsiinikandidaat; bioloogiadoktor
9.Teaduskraadi välja
andnud asutus, aasta		 meditsiinikandidaadi kraadi andis välja NSVL MTA, 1970; ja bioloogiadoktorikraadi sama asutus aastal 1980
10.Tunnustused Eesti Punase Risti III järgu orden, 2001
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus		 TÜ Üld-ja Molekulaarpatoloogia Instituudi juhataja alates 1987; juhendanud 4 teaduste kandidaati, 1 magister ja 3 teaduste doktorit
12.Juhendamisel kaitstud
väitekirjad

Gunnar Tasa, PhD, 2004, juh. Aavo-Valdur Mikelsaar. Polymorphic glutathione S-transferases - biology and role in modifying genetic susceptibility to senile cataract and primary open angle glaucoma.. Tartu ülikool

Ingrid Kalev, PhD, 2003, juh. Aavo-Valdur Mikelsaar. CC-chemokine receptor 5 (CCR5) gene polymorphism in Estonians and in patients with Type I and Type II diabetes mellitus.. Tartu ülikool

Andres Valdmann, PhD, 1999, juh. Ilmar Müürsepp, Aavo-Valdur Mikelsaar, Erik RopsatdAavo-Valdur Mikelsaar. Studies on progesterone in bovine milk. Immunoanalysis, distribution in the mammary gland, and influence at first insemination on fertility of dairy cows.. Tartu, EPMÜ

Andres Valdmann, MSc, 1997, juh. Ilmar Müürsepp ja Aavo-Valdur Mikelsaar. Piima progesteroonisisalduse määramismeetodite võrdlus ja kasutamine lehmade sigimisseisundi kindlakstegemiseks. Tartu, EPMÜ

Erkki Juronen, cand, 1988, juh. Aavo-Valdur Mikelsaar. Monoclonal antibodies against human myoglobin. Tartu ülikool

Sirje Kivi, cand, 1986, juh. Aavo-Valdur Mikelsaar. C-vöötide polümorfism rinna-ja munasarjavähi haigetel. Tartu ülikool

Tiina Talvik, cand, 1973, juh. Ernst Raudam ja Aavo-Valdur Mikelsaar. Vaimse maha jäämusega laste tsütogeneetiline uurimus. Tartu ülikool

Mari Lipping (Käosaar-Sitska), cand, 1972, juh. A.A.Prokofieva-Belgovskya ja Aavo-Valdur Mikelsaar. Korduvate spontaansete abortidega abielupaarid (vene k.). Tartu ülikool
13.Teadustöö põhisuunad multifaktoriaalsete haiguste uurimine geneetiliste, tsütoloogiliste ja molekulaarsete markeritega; antikehade saamine inimese närvirakkude vastu ja geenide ekspressiooni uurimine neuraalsetes tüvirakkudes.
14.Jooksvad grandid ETF-i grant no.5250 " Geenide ekspressiooni analüüs (proteoomika) neuraalsetes tüvirakkudes ja in vitro differentseerunud neuronites ja gliiarakkudes;
Sihtfinantseering TARMP0421: Geneetilised ja rakulised haiguste põhjused, rakkude diferentseerumine ja tüvirakud teraapias" 2003-2007
15.Teaduspublikatsioonid

Ingrid Kalev, Allen Kaasik, Aleksander Žarkovski and Aavo-Valdur Mikelsaar. Chemokine receptor CCR5 expression in in vitro differentiating human fetal neural stem/progenitor and glioblastoma cells. Neuroscience Letters, 2005, accepted

Kalev, I., Oselin, K., Pärlist, P., Zilmer, M., Rajasalu, T., Podar, T., & Mikelsaar, A.-V. (2003). Cc-Chemokine Receptor Ccr5-Del32 Mutation as a Modifying Pathogenetic Factor in Type I Diabetes. Journal of Diabetes and Its Complications, 17(6), 387-391.

Pärlist, P., Mikelsaar, A.-V., Tasa, G., & Beckman, L. (2001). The Frequency of C282y and H63d Mutations in Hemochromatosis Gene in Native Estonians. European Journal of Epidemiology, 17(3), 213-216.

Zerjal T, Beckman L, Beckman G, Mikelsaar AV, Krumina A, Kucinskas V, Hurles ME, Tyler-Smith C. Geographical, linguistic, and cultural influences on genetic diversity: Y-chromosomal distribution in Northern European populations. Mol Biol Evol. 2001 Jun;18(6):1077-87 .

Tasa, G., Kals, J., Muru, K., Juronen, E., Piirsoo, A., Veromann, S., Jänes, S., Mikelsaar, A.-V., & Lang, A. (2001). A Novel Mutation in the M1s1 Gene Responsible for Gelatinous Droplike Corneal Dystrophy. Investigative Ophthalmology & Visual Science, 42(12), 2762-2764.

Juronen, E., Tasa, G., Veromann, S., Parts, L., Tiidla, A., Pulges, R., Panov, A., Soovere, L., Koka, K., & Mikelsaar, A.-V. (2000). Polymorphic Glutathione S-Transferase M1 Is a Risk Factor of Primary Open-Angle Glaucoma Among Estonians. Experimental Eye Research, 71(5), 447-452.

Juronen E, Tasa G, Veromann S, Parts L, Tiidla A, Pulges R, Panov A, Soovere L, Koka K, Mikelsaar AV. Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. Invest Ophthalmol Vis Sci. 2000 Jul;41(8):2262-7.

Kalev I, Mikelsaar AV, Beckman L, Tasa G, Parlist P. High frequency of the HIV-1 protective CCR5 delta32 deletion in native Estonians. Eur J Epidemiol. 2000;16(12):1107-9.

Rosser, Z. H., Zerjal, T., Hurles, M. E., Adojaan, M., Alavantic, D., Amorim, A., Amos, W., Armenteros, M., Arroyo, E., Barbujani, G., Beckman, G., Beckman, L., Bertranpetit, J., Bosch, E., Bradley, D. G., Brede, G., Cooper, G., Corte-Real Hbsm, De Knijff, P., Decorte, R., Dubrova, Y. E., Evgrafov, O., Gilissen, A., Glisic, S., Golge, M., Hill, E. W., Jeziorowska, A., Kalaydjieva, L., Kayser, M., Kivisild, T., Kravchenko, S. A., Krumina, A., Kucinskas, V., Lavinha, J., Livshits, L. A., Malaspina, P., Maria, S., Mcelreavey, K., Meitinger, T. A., Mikelsaar, A.-V., Mitchell, R. J., Nafa, K., Nicholson, J., Norby, S., Pandya, A., Parik, J., Patsalis, P. C., Pereira, L., Peterlin, B., Pielberg, G., Prata, M. L., Previdere, C., Roewer, L., Rootsi, S., Rubinsztein, D. C., Saillard, J., Santos, F. R., Stefanescu, G., Sykes, B. C., Tolun, A., Villems, R., Tyler-Smith, C., & Jobling, M. A. (2000). Y-Chromosomal Diversity in Europe Is Clinal and Influenced Primarily by Geography, Rather Than by Language. American Journal of Human Genetics, 67(6), 1526-1543.

Beckman L, Sikstrom C, Mikelsaar A, Krumina A, Kucinskas V, Beckman G. alpha1-antitrypsin (PI) alleles as markers of Westeuropean influence in the Baltic Sea region.Hum Hered. 1999 Jan;49(1):52-5.

Beckman L, Sikstrom C, Mikelsaar AV, Krumina A, Ambrasiene D, Kucinskas V, Beckman G. Transferrin variants as markers of migrations and admixture between populations in the Baltic Sea region.Hum Hered. 1998 Jul-Aug;48(4):185-91.

Juronen E, Tasa G, Uuskula M, Pooga M, Mikelsaar AV.Production and characterization of monoclonal antibodies against class theta glutathione S-transferase T1-1. Hybridoma. 1996 Feb;15(1):77-82. P

Juronen E, Tasa G, Uuskula M, Pooga M, Mikelsaar AV. Purification, characterization and tissue distribution of human class theta glutathione S-transferase T1-1. Biochem Mol Biol Int. 1996 May;39(1):21-9.

Tasa G, Juronen E, Viikmaa M, Tiidla A, Parlist P, Uuskula M, Kalev I, Mikelsaar AV. Distribution of glutathione S-transferase T1 phenotypes in the Estonian population. Gene Geogr. 1996 Dec;10(3):181-9.

Talvik T, Haldre S, Soot A, Hamarik M, Piirsoo A, Mikelsaar AV. Creatine kinase isoenzyme BB concentrations in cerebrospinal fluid in asphyxiated preterm neonates.Acta Paediatr. 1995 Oct;84(10):1183-7.

Tasa G, Juronen E, Uuskula M, Viikmaa M, Mikelsaar AV. Phenotyping of glutathione S-transferase M1 in the Estonian population by ELISA using GSTM1a and GSTM1b specific monoclonal antibodies.Clin Chim Acta. 1995 Aug 14;239(2):191-6.

Juronen E, Tasa G, Uuskula M, Parik J, Mikelsaar AV.Allele-specific monoclonal antibodies against glutathione S-transferase Mu1-1.Hybridoma. 1994 Dec;13(6):477-84.

Mikelsaar AV, Tasa G, Parlist P, Uuskula M. Human glutathione S-transferase GSTM1 genetic polymorphism in Estonia.Hum Hered. 1994 Sep-Oct;44(5):248-51.

Sikut R, Veromann S, Piirsoo A, Mikelsaar AV, Saar H, Reintam MA. Ovarian carcinomas express a sperm acrosomal antigen, defined by monoclonal antibody 9H8. Tumour Biol. 1992;13(4):217-25.

Juronen EI, Viikmaa MH, Mikelsaar AV. Rapid, simple and sensitive antigen capture ELISA for the quantitation of myoglobin using monoclonal antibodies. J Immunol Methods. 1988 Jun 28;111(1):109-15.

Kivi S, Mikelsaar AV. C-band polymorphisms in lymphocytes of patients with ovarian or breast adenocarcinoma. Cancer Genet Cytogenet. 1987 Sep;28(1):77-85.

Kivi S, Mikelsaar AV. Polymorphism of Ag-stained nucleolus organizer regions in lymphocytes of patients with ovarian or breast adenocarcinoma. Hum Genet. 1985;69(4):350-2.

Mikelsaar AV, Schwarzacher HG. Clonal inheritance versus variability of rRNA gene activity in human fibroblasts.Hum Genet. 1984;66(4):372.

Kaosaar M, Mikelsaar AV. Partial short arm deletion of the X chromosome 46,X,del(X)(qter = to p21:).Hum Genet. 1980 Feb;53(2):275-7.

Kivi S, Mikelsaar AV. Q- and C-band polymorphisms in patients with ovarian or breast carcinoma.Hum Genet. 1980;56(1):111-4.

Mikelsaar AV, Ilus T. Populational polymorphisms in silver staining of nucleolus organizer regions (NORs) in human acrocentric chromosomes. Hum Genet. 1979 Oct 2;51(3):281-5.

Sigmund J, Schwarzacher HG, Mikelsaar AV. Satellite association frequency and number of nucleoli depend on cell cycle duration and NOR-activity. Studies on first, second, and third mitoses of lymphocyte cultures.Hum Genet. 1979;50(1):81-91.

Mikelsaar AV, Ilus T, Kivi S. Variant chromosome 3 (inv3) in normal newborns and their parents, and in children with mental retardation. Hum Genet. 1978 Feb 23;41(1):109-13.

Mikelsaar AV, Schwarzacher HG. Comparison of silver staining of nucleolus organizer regions in human lymphocytes and fibroblasts.Hum Genet. 1978 Jun 27;42(3):291-9.

Schwarzacher HG, Mikelsaar AV, Schnedl W. [Human nucleolus organizers] Verh Anat Ges. 1978;(72):367-8. German. No abstract available.

Schwarzacher HG, Mikelsaar AV, Schnedl W. The nature of the Ag-staining of nucleolus organizer regions. Electron- and light-microscopic studies on human cells in interphase, mitosis, and meiosis.Cytogenet Cell Genet. 1978;20(1-6):24-39.

Mikelsaar AV, Schmid M, Krone W, Schwarzacher HG, Schnedl W. Frequency of Ag-stained nucleolus organizer regions in the acrocentric chromosomes of man. Hum Genet. 1977 Jun 10;37(1):73-7.

Mikelsaar AV, Schwarzacher HG, Schnedl W, Wagenbichler P. Inheritance of Ag-stainability of nucleolus organizer regions. Investigations in 7 families with trisomy 21. Hum Genet. 1977 Sep 22;38(2):183-8.

Schnedl W, Mikelsaar AV, Breitenbach M, Dann O. DIPI and DAPI: fluorescence banding with only negliglible fading. Hum Genet. 1977 Apr 15;36(2):167-72.

Kaosaar ME, Mikelsaar AV, Talvik TA, Mikelsaar RV. A case of trisomy for the short arm of chromosome no. 9(+9(p)).Hum Genet. 1976 Sep 10;34(1):77-80.

Mikelsaar AV, Kaosaar ME, Tuur SJ, Viikmaa MH, Talvik TA, Laats J.Human karyotype polymorphism. III. Routine ank fluorescence microscopic investigation of chromosomes in normal adults and mentally retarded children. Humangenetik. 1975;26(1):1-23.

Mikelsaar AV, Viikmaa MH, Tuur SJ, Kaosaar ME. Human karyotype polymorphism. II. The distribution of individuals according to the presence of brilliant bands in chromosomes 3,4, and 13 in a normal adult population. Humangenetik. 1974 Jun 26;23(1):59-63. ]

Tuur S, Kaosaar M, Mikelsaar AV. 1q plus variants in a normal adult population (one with a pericentric inversion). Humangenetik. 1974;24(3):217-20.

Kaosaar ME, Mikelsaar AV. Chromosome investigation in married couples with repeated spontaneous abortions.Humangenetik. 1973;17(4):277-83.

Mikelsaar AV, Lazjuk GJ, Lurie JW, Tuur S, Kaosaar ME, Mikelsaar R, Loolaid VE. A 4p-syndrome. A case report.Humangenetik. 1973 Sep 20;19(3):345-7.

Mikelsaar AV, Tuur SJ, Kaosaar ME. Human karyotype polymorphism. I. Routine and fluorescence microscopic investigation of chromosomes in a normal adult population. Humangenetik. 1973;20(2):89-101.

Talvik T, Mikelsaar AV, Mikelsaar R, Kaosaar M, Tuur S. Inherited translocations in two families (t(14q+;10q-) and t(13q-;21q+)). Humangenetik. 1973 Sep 20;19(3):215-26.

Mikelsaar AV, Ananjev EV, Gindilis VM. Probable pericentric inversion in chromosome no. 1 in a female child (46,XX,inv(Ip+q-).Humangenetik. 1970;9(4):316-24.

Mikelsaar AV, Talvik TA.Partial deletion of the long arm of chromosome 18. Humangenetik. 1969;7(4):359-60.

viimati muudetud: 05.10.2005

Curriculum Vitae (CV)
1.First Name Aavo-Valdur
2.Surname Mikelsaar
3.Institution Institute of General and Molecular Pathology, Tartu University
4.Position director
5.Date of birth 26.07.1941 (day.month.year)
6.Education graduated from the Medical Faculty of Tartu University, 1965, physician; postgraduate studium in the Institute of Molecular Biology, Academy of Sciences, Moscow, 1967-1970; studium at University of Vienna 1976-77; studium in Tampere University, 1988; studium in Medical University of Luebeck, 1993
7.Research and
professional experience		 University of Tartu, reseacher, 1965-1967; postgraduate student, Moscow, 1967-1970; researcher, head of laboratory, Tartu University, 1970-87; porfessor of human biology and genetics, since 1993.
8.Academic degree cand.of medical science and doctor of biological sci.
9.Dates and sites of
earning the degrees		 1970, candidate of medical sciences, Academy of Medical Sciences, Moscow, and doctor of biological sciences, Academy of Medical Sciences, Moscow, 1980
10.Honours/awards The IIIrd class Order of the Estonian Red Cross, in 2001
11.Research-administrative
experience		 director of the Institute of General and Molecular Pathology, Tartu University, since 1987; 7 Ph.D. , 1 magister
12.Supervised dissertations

Gunnar Tasa, PhD, 2004, superv. Aavo-Valdur Mikelsaar. Polymorphic glutathione S-transferases - biology and role in modifying genetic susceptibility to senile cataract and primary open angle glaucoma.. Tartu ülikool

Ingrid Kalev, PhD, 2003, superv. Aavo-Valdur Mikelsaar. CC-chemokine receptor 5 (CCR5) gene polymorphism in Estonians and in patients with Type I and Type II diabetes mellitus.. Tartu ülikool

Andres Valdmann, PhD, 1999, superv. Ilmar Müürsepp, Aavo-Valdur Mikelsaar, Erik RopsatdAavo-Valdur Mikelsaar. Studies on progesterone in bovine milk. Immunoanalysis, distribution in the mammary gland, and influence at first insemination on fertility of dairy cows.. Tartu, EPMÜ

Andres Valdmann, MSc, 1997, superv. Ilmar Müürsepp ja Aavo-Valdur Mikelsaar. Piima progesteroonisisalduse määramismeetodite võrdlus ja kasutamine lehmade sigimisseisundi kindlakstegemiseks. Tartu, EPMÜ

Erkki Juronen, cand, 1988, superv. Aavo-Valdur Mikelsaar. Monoclonal antibodies against human myoglobin. Tartu ülikool

Sirje Kivi, cand, 1986, superv. Aavo-Valdur Mikelsaar. C-vöötide polümorfism rinna-ja munasarjavähi haigetel. Tartu ülikool

Tiina Talvik, cand, 1973, superv. Ernst Raudam ja Aavo-Valdur Mikelsaar. Vaimse maha jäämusega laste tsütogeneetiline uurimus. Tartu ülikool

Mari Lipping (Käosaar-Sitska), cand, 1972, superv. A.A.Prokofieva-Belgovskya ja Aavo-Valdur Mikelsaar. Korduvate spontaansete abortidega abielupaarid (vene k.). Tartu ülikool
13.Current research program The study of multifactorial diseases using genetic, cytological and molecular markers; producing monoclonal antibodies against human neural cells, and investigation of gene expression in neural stem cells.
14.Current grant funding ESF grant, no.5250: " The analysis of gene expression (proteomics) in neural stem cells and in vitro differentiated neurons and glial cells" ; target financing TARMP 0421:" Genetic and cellular causes of diseases, cellular differentiation and stem cells in therapy".
15.List of most important publications

Ingrid Kalev, Allen Kaasik, Aleksander Žarkovski and Aavo-Valdur Mikelsaar. Chemokine receptor CCR5 expression in in vitro differentiating human fetal neural stem/progenitor and glioblastoma cells. Neuroscience Letters, 2005, accepted

Kalev, I., Oselin, K., Pärlist, P., Zilmer, M., Rajasalu, T., Podar, T., & Mikelsaar, A.-V. (2003). Cc-Chemokine Receptor Ccr5-Del32 Mutation as a Modifying Pathogenetic Factor in Type I Diabetes. Journal of Diabetes and Its Complications, 17(6), 387-391.

Pärlist, P., Mikelsaar, A.-V., Tasa, G., & Beckman, L. (2001). The Frequency of C282y and H63d Mutations in Hemochromatosis Gene in Native Estonians. European Journal of Epidemiology, 17(3), 213-216.

Zerjal T, Beckman L, Beckman G, Mikelsaar AV, Krumina A, Kucinskas V, Hurles ME, Tyler-Smith C. Geographical, linguistic, and cultural influences on genetic diversity: Y-chromosomal distribution in Northern European populations. Mol Biol Evol. 2001 Jun;18(6):1077-87 .

Tasa, G., Kals, J., Muru, K., Juronen, E., Piirsoo, A., Veromann, S., Jänes, S., Mikelsaar, A.-V., & Lang, A. (2001). A Novel Mutation in the M1s1 Gene Responsible for Gelatinous Droplike Corneal Dystrophy. Investigative Ophthalmology & Visual Science, 42(12), 2762-2764.

Juronen, E., Tasa, G., Veromann, S., Parts, L., Tiidla, A., Pulges, R., Panov, A., Soovere, L., Koka, K., & Mikelsaar, A.-V. (2000). Polymorphic Glutathione S-Transferase M1 Is a Risk Factor of Primary Open-Angle Glaucoma Among Estonians. Experimental Eye Research, 71(5), 447-452.

Juronen E, Tasa G, Veromann S, Parts L, Tiidla A, Pulges R, Panov A, Soovere L, Koka K, Mikelsaar AV. Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. Invest Ophthalmol Vis Sci. 2000 Jul;41(8):2262-7.

Kalev I, Mikelsaar AV, Beckman L, Tasa G, Parlist P. High frequency of the HIV-1 protective CCR5 delta32 deletion in native Estonians. Eur J Epidemiol. 2000;16(12):1107-9.

Rosser, Z. H., Zerjal, T., Hurles, M. E., Adojaan, M., Alavantic, D., Amorim, A., Amos, W., Armenteros, M., Arroyo, E., Barbujani, G., Beckman, G., Beckman, L., Bertranpetit, J., Bosch, E., Bradley, D. G., Brede, G., Cooper, G., Corte-Real Hbsm, De Knijff, P., Decorte, R., Dubrova, Y. E., Evgrafov, O., Gilissen, A., Glisic, S., Golge, M., Hill, E. W., Jeziorowska, A., Kalaydjieva, L., Kayser, M., Kivisild, T., Kravchenko, S. A., Krumina, A., Kucinskas, V., Lavinha, J., Livshits, L. A., Malaspina, P., Maria, S., Mcelreavey, K., Meitinger, T. A., Mikelsaar, A.-V., Mitchell, R. J., Nafa, K., Nicholson, J., Norby, S., Pandya, A., Parik, J., Patsalis, P. C., Pereira, L., Peterlin, B., Pielberg, G., Prata, M. L., Previdere, C., Roewer, L., Rootsi, S., Rubinsztein, D. C., Saillard, J., Santos, F. R., Stefanescu, G., Sykes, B. C., Tolun, A., Villems, R., Tyler-Smith, C., & Jobling, M. A. (2000). Y-Chromosomal Diversity in Europe Is Clinal and Influenced Primarily by Geography, Rather Than by Language. American Journal of Human Genetics, 67(6), 1526-1543.

Beckman L, Sikstrom C, Mikelsaar A, Krumina A, Kucinskas V, Beckman G. alpha1-antitrypsin (PI) alleles as markers of Westeuropean influence in the Baltic Sea region.Hum Hered. 1999 Jan;49(1):52-5.

Beckman L, Sikstrom C, Mikelsaar AV, Krumina A, Ambrasiene D, Kucinskas V, Beckman G. Transferrin variants as markers of migrations and admixture between populations in the Baltic Sea region.Hum Hered. 1998 Jul-Aug;48(4):185-91.

Juronen E, Tasa G, Uuskula M, Pooga M, Mikelsaar AV.Production and characterization of monoclonal antibodies against class theta glutathione S-transferase T1-1. Hybridoma. 1996 Feb;15(1):77-82. P

Juronen E, Tasa G, Uuskula M, Pooga M, Mikelsaar AV. Purification, characterization and tissue distribution of human class theta glutathione S-transferase T1-1. Biochem Mol Biol Int. 1996 May;39(1):21-9.

Tasa G, Juronen E, Viikmaa M, Tiidla A, Parlist P, Uuskula M, Kalev I, Mikelsaar AV. Distribution of glutathione S-transferase T1 phenotypes in the Estonian population. Gene Geogr. 1996 Dec;10(3):181-9.

Talvik T, Haldre S, Soot A, Hamarik M, Piirsoo A, Mikelsaar AV. Creatine kinase isoenzyme BB concentrations in cerebrospinal fluid in asphyxiated preterm neonates.Acta Paediatr. 1995 Oct;84(10):1183-7.

Tasa G, Juronen E, Uuskula M, Viikmaa M, Mikelsaar AV. Phenotyping of glutathione S-transferase M1 in the Estonian population by ELISA using GSTM1a and GSTM1b specific monoclonal antibodies.Clin Chim Acta. 1995 Aug 14;239(2):191-6.

Juronen E, Tasa G, Uuskula M, Parik J, Mikelsaar AV.Allele-specific monoclonal antibodies against glutathione S-transferase Mu1-1.Hybridoma. 1994 Dec;13(6):477-84.

Mikelsaar AV, Tasa G, Parlist P, Uuskula M. Human glutathione S-transferase GSTM1 genetic polymorphism in Estonia.Hum Hered. 1994 Sep-Oct;44(5):248-51.

Sikut R, Veromann S, Piirsoo A, Mikelsaar AV, Saar H, Reintam MA. Ovarian carcinomas express a sperm acrosomal antigen, defined by monoclonal antibody 9H8. Tumour Biol. 1992;13(4):217-25.

Juronen EI, Viikmaa MH, Mikelsaar AV. Rapid, simple and sensitive antigen capture ELISA for the quantitation of myoglobin using monoclonal antibodies. J Immunol Methods. 1988 Jun 28;111(1):109-15.

Kivi S, Mikelsaar AV. C-band polymorphisms in lymphocytes of patients with ovarian or breast adenocarcinoma. Cancer Genet Cytogenet. 1987 Sep;28(1):77-85.

Kivi S, Mikelsaar AV. Polymorphism of Ag-stained nucleolus organizer regions in lymphocytes of patients with ovarian or breast adenocarcinoma. Hum Genet. 1985;69(4):350-2.

Mikelsaar AV, Schwarzacher HG. Clonal inheritance versus variability of rRNA gene activity in human fibroblasts.Hum Genet. 1984;66(4):372.

Kaosaar M, Mikelsaar AV. Partial short arm deletion of the X chromosome 46,X,del(X)(qter = to p21:).Hum Genet. 1980 Feb;53(2):275-7.

Kivi S, Mikelsaar AV. Q- and C-band polymorphisms in patients with ovarian or breast carcinoma.Hum Genet. 1980;56(1):111-4.

Mikelsaar AV, Ilus T. Populational polymorphisms in silver staining of nucleolus organizer regions (NORs) in human acrocentric chromosomes. Hum Genet. 1979 Oct 2;51(3):281-5.

Sigmund J, Schwarzacher HG, Mikelsaar AV. Satellite association frequency and number of nucleoli depend on cell cycle duration and NOR-activity. Studies on first, second, and third mitoses of lymphocyte cultures.Hum Genet. 1979;50(1):81-91.

Mikelsaar AV, Ilus T, Kivi S. Variant chromosome 3 (inv3) in normal newborns and their parents, and in children with mental retardation. Hum Genet. 1978 Feb 23;41(1):109-13.

Mikelsaar AV, Schwarzacher HG. Comparison of silver staining of nucleolus organizer regions in human lymphocytes and fibroblasts.Hum Genet. 1978 Jun 27;42(3):291-9.

Schwarzacher HG, Mikelsaar AV, Schnedl W. [Human nucleolus organizers] Verh Anat Ges. 1978;(72):367-8. German. No abstract available.

Schwarzacher HG, Mikelsaar AV, Schnedl W. The nature of the Ag-staining of nucleolus organizer regions. Electron- and light-microscopic studies on human cells in interphase, mitosis, and meiosis.Cytogenet Cell Genet. 1978;20(1-6):24-39.

Mikelsaar AV, Schmid M, Krone W, Schwarzacher HG, Schnedl W. Frequency of Ag-stained nucleolus organizer regions in the acrocentric chromosomes of man. Hum Genet. 1977 Jun 10;37(1):73-7.

Mikelsaar AV, Schwarzacher HG, Schnedl W, Wagenbichler P. Inheritance of Ag-stainability of nucleolus organizer regions. Investigations in 7 families with trisomy 21. Hum Genet. 1977 Sep 22;38(2):183-8.

Schnedl W, Mikelsaar AV, Breitenbach M, Dann O. DIPI and DAPI: fluorescence banding with only negliglible fading. Hum Genet. 1977 Apr 15;36(2):167-72.

Kaosaar ME, Mikelsaar AV, Talvik TA, Mikelsaar RV. A case of trisomy for the short arm of chromosome no. 9(+9(p)).Hum Genet. 1976 Sep 10;34(1):77-80.

Mikelsaar AV, Kaosaar ME, Tuur SJ, Viikmaa MH, Talvik TA, Laats J.Human karyotype polymorphism. III. Routine ank fluorescence microscopic investigation of chromosomes in normal adults and mentally retarded children. Humangenetik. 1975;26(1):1-23.

Mikelsaar AV, Viikmaa MH, Tuur SJ, Kaosaar ME. Human karyotype polymorphism. II. The distribution of individuals according to the presence of brilliant bands in chromosomes 3,4, and 13 in a normal adult population. Humangenetik. 1974 Jun 26;23(1):59-63. ]

Tuur S, Kaosaar M, Mikelsaar AV. 1q plus variants in a normal adult population (one with a pericentric inversion). Humangenetik. 1974;24(3):217-20.

Kaosaar ME, Mikelsaar AV. Chromosome investigation in married couples with repeated spontaneous abortions.Humangenetik. 1973;17(4):277-83.

Mikelsaar AV, Lazjuk GJ, Lurie JW, Tuur S, Kaosaar ME, Mikelsaar R, Loolaid VE. A 4p-syndrome. A case report.Humangenetik. 1973 Sep 20;19(3):345-7.

Mikelsaar AV, Tuur SJ, Kaosaar ME. Human karyotype polymorphism. I. Routine and fluorescence microscopic investigation of chromosomes in a normal adult population. Humangenetik. 1973;20(2):89-101.

Talvik T, Mikelsaar AV, Mikelsaar R, Kaosaar M, Tuur S. Inherited translocations in two families (t(14q+;10q-) and t(13q-;21q+)). Humangenetik. 1973 Sep 20;19(3):215-26.

Mikelsaar AV, Ananjev EV, Gindilis VM. Probable pericentric inversion in chromosome no. 1 in a female child (46,XX,inv(Ip+q-).Humangenetik. 1970;9(4):316-24.

Mikelsaar AV, Talvik TA.Partial deletion of the long arm of chromosome 18. Humangenetik. 1969;7(4):359-60.

last updated: 05.10.2005

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