ERIS - Eesti teadus- ja arendustegevuse infosüsteem

Elulookirjeldus (CV)
1.	Eesnimi	Riina
2.	Perekonnanimi	Mahlapuu
3.	Töökoht	Tartu Ülikool, Arstiteaduskond, Biokeemia Instituut
4.	Ametikoht	vanemteadur
5.	Sünniaeg	09.07.1951 (päev.kuu.aasta)
6.	Haridus	kõrgharidus
7.	Teenistuskäik	1974-1976 Kadrina Keskkool, keemiaõpetaja; 1976-1979 TÜ orgaanilise keemia Instituudi vaneminsener;1979-1983 TÜ orgaanilise keemia Instituudi nooremteadur; 1983-1988 TÜ orgaanilise keemia Instituudi vanemteadur; 1988-1991 TÜ orgaanilise keemia Instituudi teadur; 1991-1996 TÜ orgaanilise keemia Instituudi nooremteadur; 1996-2000 TÜ Biokeemia Instituudi vanemlaborant; 2000-2004 teadur, 2004 - vanemteadur
8.	Teaduskraad	PhD
9.	Teaduskraadi välja andnud asutus, aasta	Tartu Ülikool, 2004
10.	Tunnustused
11.	Teadusorganisatsiooniline ja –administratiivne tegevus	Biokeemia Seltsi liige
12.	Juhendamisel kaitstud väitekirjad
13.	Teadustöö põhisuunad	Signaalsüsteemide uurimine ajukoes Alzheimeri tõve korral. Antioksüdantsete peptiidide disainimine, süntees ja omaduste uurimine.
14.	Jooksvad grandid	ETF grantide 6503 ja 5327 põhitäitja
15.	Teaduspublikatsioonid	P. Põder, M. Zilmer, J. Starkopf, J. Kals, A. Talonpoika, A. Pulges, Ü. Langel, T. Kullisaar, S. Viirlaid, R. Mahlapuu, A. Zarkovski, A.Arend, U. Soomets, An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischaemia, Neuroscience Letters 370 (2004) 45-50. Mahlapuu,R., Viht,K., Balaspiri,L., Bogdanovic,N., Saar,K., Soomets,U., Land,T., Zilmer, M., Karelson,E. and Langel,Ü (2003). Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer’s disease brain. Mol. Brain Res. 117, 73-82 Karelson E., Mahlapuu R., Zilmer M., Soomets U., Bogdanovic N. and Langel Ü. Possible signalling by glutathione and its novel analogue through potent stimulation of frontocortical G-proteins in normal aging and in Alzheimer’s disease. Ann. N.-Y. Ac. Sci. (2002). Saar,K., Mazarati,A., Mahlapuu,R., Halnemo,G., Soomets,U., Kilk,K., Hellberg,S., Pooga,M., Tolf,B.-R., Shi,T.S., Hökfelt,T., Wasterlain,C., Bartfai,T. and Langel,Ü (2002). Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc. Natl. Acad. Sci. USA, 99(10), 7136-7141. Saar,K., Mahlapuu,R., Laidmäe,E., Valkna,A., Kahl,U., Karelson,E. and Langel,Ü. Characterisation of a new chimeric ligand for galanin receptors: galanin(1-13)-[D-Trp32]-neuropeptideY(25-36)amide. Regulatory Peptides 102 (2001) 15-19.P. U.Soomets, R. Mahlapuu, R. Tehranian, J. Jarvet, E. Karelson, M. Zilmer, K. Iverfeldt, M. Zorko, A. Gräslund, Ü. Langel, Regulation of GTPase and adenylate cyclase activity by amyloid b-peptide and its fragments in rat brain tissue, Brain Res. (1999) 850, 179-188. U. Soomets, R. Mahlapuu, E. Karelson, M. Zilmer, M. Zorko, Ü. Langel, Regulation of activity of GTPase and adenylate cyclase in the rat ventral hippocampus by fragments of b-amyloid peptide, Clinical Neuroscience (Hungary) (1998) 51, 59-60.

viimati muudetud: 03.10.2005

Curriculum Vitae (CV)
1.	First Name	Riina
2.	Surname	Mahlapuu
3.	Institution	Tartu University, Medical Faculty, Department of Biochemistry
4.	Position	senior researcher
5.	Date of birth	09.07.1951 (day.month.year)
6.	Education	Tartu University, 1969-1974, chemist
7.	Research and professional experience	1974-1976 Kadrina Secondary School, teacher; 1976-1979 TÜ Dept. of Organic Chemistry, senior engineer; 1979-1983 TÜ Dept. of Organic Chemistry, junior scientist; 1983-1988 TÜ Dept. of Organic Chemistry, senior scientist; 1988-1991 TÜ Dept. of Organic Chemistry scientist; 1991-1996 TÜ Dept. of Organic Chemistry junior scientist; 1996-2000 TÜ Dept. of Biochemistry, senior assistant; 2000-2004 researcher, 2004- senior researcher
8.	Academic degree	PhD biochemistry
9.	Dates and sites of earning the degrees	PhD - 2004 Tartu University
10.	Honours/awards
11.	Research-administrative experience
12.	Supervised dissertations
13.	Current research program	Affected cellular signal transduction in brain tissues of Alzheimer's disease patientsPeptidic and non-peptidic galanin receptor ligands. Synthesis novel antioxidants and study antioxidative properties
14.	Current grant funding	ESF grants 6503 and 5327 senior personnel
15.	List of most important publications	P. Põder, M. Zilmer, J. Starkopf, J. Kals, A. Talonpoika, A. Pulges, Ü. Langel, T. Kullisaar, S. Viirlaid, R. Mahlapuu, A. Zarkovski, A.Arend, U. Soomets, An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischaemia, Neuroscience Letters 370 (2004) 45-50. Mahlapuu,R., Viht,K., Balaspiri,L., Bogdanovic,N., Saar,K., Soomets,U., Land,T., Zilmer, M., Karelson,E. and Langel,Ü (2003). Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer’s disease brain. Mol. Brain Res. 117, 73-82 Karelson E., Mahlapuu R., Zilmer M., Soomets U., Bogdanovic N. and Langel Ü. Possible signalling by glutathione and its novel analogue through potent stimulation of frontocortical G-proteins in normal aging and in Alzheimer’s disease. Ann. N.-Y. Ac. Sci. (2002). Saar,K., Mazarati,A., Mahlapuu,R., Halnemo,G., Soomets,U., Kilk,K., Hellberg,S., Pooga,M., Tolf,B.-R., Shi,T.S., Hökfelt,T., Wasterlain,C., Bartfai,T. and Langel,Ü (2002). Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc. Natl. Acad. Sci. USA, 99(10), 7136-7141. Saar,K., Mahlapuu,R., Laidmäe,E., Valkna,A., Kahl,U., Karelson,E. and Langel,Ü. Characterisation of a new chimeric ligand for galanin receptors: galanin(1-13)-[D-Trp32]-neuropeptideY(25-36)amide. Regulatory Peptides 102 (2001) 15-19.P. U.Soomets, R. Mahlapuu, R. Tehranian, J. Jarvet, E. Karelson, M. Zilmer, K. Iverfeldt, M. Zorko, A. Gräslund, Ü. Langel, Regulation of GTPase and adenylate cyclase activity by amyloid b-peptide and its fragments in rat brain tissue, Brain Res. (1999) 850, 179-188. U. Soomets, R. Mahlapuu, E. Karelson, M. Zilmer, M. Zorko, Ü. Langel, Regulation of activity of GTPase and adenylate cyclase in the rat ventral hippocampus by fragments of b-amyloid peptide, Clinical Neuroscience (Hungary) (1998) 51, 59-60.

last updated: 03.10.2005