[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Siiri |
| 2. | Perekonnanimi | Altraja, (sünd. Hirmo) |
| 3. | Töökoht | Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut |
| 4. | Ametikoht | Vanemteadur |
| 5. | Sünniaeg | 15.06.1965 (päev.kuu.aasta) |
| 6. | Haridus | Kõrgem 1983-88: Füüsika-Keemiateaduskond; eriala: biokeemia, Tartu Ülikool, Eesti; 1991-93: Magistrantuur, Tartu Ülikool, Eesti; 1996-2000: Doktorantuur, Infektsioonhaiguste ja Meditsiinilise Mikrobioloogia Instituut, Lundi Ülikool, Rootsi |
| 7. | Teenistuskäik | 1988-91: nooremteadur, Immunoloogia Labor, Tartu Ülikool, Eesti; 1991-93: Magistrantuur, Tartu Ülikool, Eesti; 1993-96: külalisuurija, Meditsiinilise Mikrobioloogia Instituut, Lundi Ülikool, Rootsi; 1996-2000: Doktorantuur, Infektsioonhaiguste ja Meditsiinilise Mikrobioloogia Instituut, Lundi Ülikool, Rootsi. Alates 2001: Eesti Biokeskus, vanemteadur, alates 2002: Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, vanemteadur Lisaks teadustöö: 1) Biokeemia Instituut, Kieli Ülikool, Saksamaa 6 korral alates märts 1994 kokku 8 kuud; 2). Kaitsejõudude Uurimisinstituut, Umeå, Rootsi ja Odontoloogia kateeder, Umeå Ülikool, Rootsi alates nov. 1996, kokku 5 kuud; 3). Meditsiinilise Biokeemia Instituut, Göteborgi Ülikool, Rootsi (sügis 1999); 4) Proteoomika Keskus, Aberdeeni Ülikool, Suurbritannia (sept. 2001) |
| 8. | Teaduskraad | Ph.D (meditsiin) |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Lundi Ülikool, Rootsi; 2000 |
| 10. | Tunnustused | Vabariigi Presidendi Kultuurirahastu "Noore teadlase preemia" konkursil äramärkimist väärinud teadustöö, 2000. a. |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
1) Täienduskursuse "Microbial Adhesion and Virulence", 14.-23.04.1999 (Kopenhaagen/ Lund) organiseerimiskomitee liige 2) Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituudi teadussekretär alates 2002 3) Alates 2003: Ekspert EU grantide hindamiskomisjonis 4) Euroopa Kopsuarstide Assotsiatsiooni liige alates 01.2003 |
| 12. | Juhendamisel kaitstud väitekirjad |
Martin Kadai, MSc, 2005, juh. Siiri Altraja. "The effect of proinflammatory mediators on the expression of tenascin and laminin by bronchial epithelial cells with special respect to cysteinyl leukotrienes". Tartu Ülikool |
| 13. | Teadustöö põhisuunad | 1. Helicobacter pylori raku pinna proteiinid; 2. Eukarüootsete rakkude ribosoom- assotsieerunud valgud ja neile vastavad geenid 3. Obstruktiivsete kopsuhaiguste puhuse hingamisteede remodelleerumise uurimine ja haigusmarkerite leidmine |
| 14. | Jooksvad grandid | 1) ETF grant nr. 5011 (2002-2005) "Ekstratsellulaarse maatriksi proteiinide ekspressioon inimese hingamisteede struktuursetes rakkudes: oksüdatiivse stressi mõju ja põletikumediaatorite moduleeriv toime", grandihoidja 2) HM Sihtfinantseeritud teadusteema "Inimese genoom II", Reg. Nr. 0182582s03, teema juht Andres Metspalu |
| 15. | Teaduspublikatsioonid |
Altraja S, Kadai M, Altraja A. Expression of the cysteinyl leukotriene receptors CysLT1 and CysLT2 in the airway structural cells. Eur Respir J 2005; 26(Suppl. 49): 346s. Altraja S, Rekker E, Altraja A. Cysteinyl leukotrienes enhance expression of tenascin and laminin beta2 chain by human lung fibroblasts. Proc Am Thoracic Soc 2005; 2: A76. Altraja A, Kadai M, Altraja S. Cysteinyl leukotrienes increase tenascin expression by human bronchial epithelial cells. Am J Respir Crit Care Med 2004; 169(Suppl.): A454. Altraja S, Kadai M, Altraja A. Oxidative stress in bronchial epithelial cells: relations to extracellular matrix synthesis. Eur Respir J 2004; 24(Suppl. 48): 106s. Altraja S, Kadai M, Altraja A. Leukotriene E4 increases tenascin production by human bronchial epithelial cells. Eur Respir J 2003; 22(Suppl. 45): 36s. Mahdavi J, Sonden B, Hurtig M, Olfat FO, Forsberg L, Roche N, Angstrom J, Larsson T, Teneberg S, Karlsson KA, Altraja S, Wadstrom T, Kersulyte D, Berg DE, Dubois A, Petersson C, Magnusson KE, Norberg T, Lindh F, Lundskog BB, Arnqvist A, Hammarstrom L, Boren T. 2002. Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science 297, 573-578. Annuk H, Hynes SO, Hirmo S, Mikelsaar M, Wadström T. 2001. Characterisation and differentiation of lactobacilli by lectin typing. J Med Microbiol. 50:1069-1074. Arnqvist A, Ilver D, Ögren J, Hirmo S, Wadström T, Borén T. 2001. Adherence of Helicobacter pylori: Mechanisms and Relevance to Pathogenesis. In: Helicobacter 2001: Past, Present and Future (Moran AP, Ed.) Normed Verlag Inc, Englewood, NJ, USA. Gerhard M, Hirmo S, Wadström T, Miller-Podraza H, Teneberg S, Karlsson K- A, Appelmelk B, Odenbreit S, Haas R, Arnqvist A, Borén T. 2001. H.pylori, an adherent pain in the stomach. In: Helicobacter pylori: Molecular and Cellular Biology (Achtman M, Suerbaum S, Eds.) Horizon Scientific Press, Norfolk, U.K. Chapter 12. Wang X, Hirmo S, Willén R, Wadström T. 2001. Inhibition of Helicobacter pylori infection by bovine milk glycoconjugates in a Balb/cA mouse model. J Med Microbiol 50: 430-435. Wang X, Hirmo S, Willen R, Wadström, T Inhibition of H-pylori infection by bovine milk glycoconjugates in a mouse model. Gut 2000; 47(Suppl):A60 Annuk H, Hirmo S, Türi E, Mikelsaar M, Arak E, Wadström T. 1999. Effect on cell surface hydrophobicity and susceptibility of Helicobacter pylori to medicinal plant extracts. FEMS Microbiol. Lett. 172: 41-45. Chmiela M, Paziak-Domanska B, Hirmo S, Rudnicka W, Utt M, Wadström T. 1998. Helicobacter pylori - interactions with phagocytes. In: Helicobacter pylori. Basic mechanisms to clinical cure 1999 (Hunt RH, Tytgat GNJ, Eds), pp. 90- 100. Kluwer Academic Publishers, Dordrecht, Boston, London. Hirmo S, Artursson E, Puu G, Wadström T, Nilsson B. 1999. Helicobacter pylori interactions with human gastric mucin studied with a resonant mirror biosensor. J Microbiol Meth. 37, 177-182. Hynes SO, Hirmo S, Wadström T, Moran AP. 1999. Differentiation of Helicobacter pylori isolates based on lectin binding of cell extracts in an agglutination assay. J Clin Microbiol. 37: 1994-1998. Hirmo S, Artursson E, Puu G, Wadström T, Nilsson B. 1998. Characterization of Helicobacter pylori interactions with sialylglycoconjugates using a resonant mirror biosensor. Anal Biochem 257, 63-66. Hirmo S, Kelm S, Iwersen M, Hotta K, Goso Y, Ishihara K, Suguri T, Morita M, Wadström T, Schauer R. 1998. Inhibition of Helicobacter pylori sialic acid-specific haemagglutination by human gastrointestinal mucins and milk glycoproteins. FEMS Immunol Med Microbiol. 20, 275-281. Hirmo S, Utt M, Wadström T. 1998. Sialylglycoconjugate- and proteoglycan-binding microbial lectins. In: Lectins: Biology, Biochemistry, Clinical Biochemistry (van Driessche E, Beekmans S, B?g-Hansen TC, Eds.) Vol. 12, Textop, Hellerup, Denmark. Hirmo S, Kelm S, Wadström T, Schauer R. 1997. Lack of evidence for sialidase activity in Helicobacter pylori. FEMS Immunol Med Microbiol; 17:67-72. Hirmo S, Shumakov Y, Utt M, Wadström T. 1997. Genetic heterogeneity of Helicobacter pylori and strain typing. In: Pathogenesis and Host Response in Helicobacter pylori Infections (Moran AP, O´Morain CA, Eds.), pp. 199-205, Normed Verlag, Bad Hamburg-Englewood, N.J. Wadstrom T, Hirmo S, Kelm S, Nilsson B, Schauer R, Utt M Sialylglycoconjugate and heparin binding surface proteins of Helicobacter pylori Eur J Cell Biol 1997;74(Suppl.46):106 Wadström T, Hirmo S, Nilsson B. 1997. Biochemical aspects of H.pylori adhesion. J Physiol Pharmacol; 48:325-331. Wadström T, Hirmo S, Novak H, Guzman A, Ringnér-Pantzar M, Utt M, Aleljung P. 1997 Sulfatides inhibit binding of Helicobacter pylori to the gastric cancer Kato III cell line. Current Microbiol; 34:267-272. Pascu C, Hirmo S, Ljungh Å, Wadström T. 1996. A particle agglutination assay for rapid identification of heparin binding to coagulase-negative staphylococci. J Med Microbiol; 45:263-269. Pascu C, Hirmo S, Ljungh Å, Wadström T. 1996. Inhibition of extracellular matrix and serum proteins binding to Staphylococcus aureus by heparin and various polysulphated agents. Med Microbiol Lett; 4:397-405. Wadström T, Hirmo S. 1996. IV.Bacterial pathogenesis. Helicobacter pylori: An Atlas (Eds. Malfertheiner P, Michetti P, Price A) Science press, UK Wadström T, Hirmo S, Borén T. 1996. Biochemical aspects of Helicobacter pylori colonization of the human gastric mucosa. Aliment Pharmacol Ther; 10(Suppl.1):17-27. Hirmo S, Kelm S, Schauer R, Nilsson B, Wadström T. 1996. Adhesion of Helicobacter pylori strains to a-2,3-linked sialic acids. Glycoconjug J; 13:1005-1011. Hirmo S, Utt M, Ringner M, Wadström T. 1995. Inhibition of heparan sulphate and other glycosaminoglycans binding to Helicobacter pylori by various polysulphated carbohydrates. FEMS Immunol Med Microbiol; 10:301-306. |
viimati muudetud: 06.08.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Siiri |
| 2. | Surname | Altraja, (sünd. Hirmo) |
| 3. | Institution | Institute of Molecular and Cell Biology, University of Tartu |
| 4. | Position | Senior Research Associate |
| 5. | Date of birth | 15.06.1965 (day.month.year) |
| 6. | Education | University Degree, Ph.D. 1983-88: Graduate student, Dept. of Chemistry, University of Tartu, Estonia. Narrower speciality – biochemistry; 1991-93: Post-graduate student for a degree of M.Sc, University of Tartu, Estonia; 1996-2000: Full-time PhD student, Dept. of Infectious Diseases and Medical Microbiology, University of Lund, Sweden. |
| 7. | Research and professional experience |
1988-91: Junior research fellow, Lab. of Immunology, University of Tartu, Estonia; 1991-93: Post-graduate student for degree of M.Sc., University of Tartu, Estonia; 1993-96: Guest researcher, Dept. of Medical Microbiology, University of Lund, Sweden; 1996-2000: PhD studies, Dept. of Infectious Diseases and Medical Microbiology, University of Lund, Sweden; From 2001: senior research associate, Estonian Biocentre From 2002: senior research associate, Institute of Molecular and Cell Biology, University of Tartu Additional research experience: 1) Inst. of Biochemistry, University of Kiel, Germany, since March 1994 a total of 8 months; 2). Dept. of NBC Defence at the National Defence Research Establishment, Umeå, Sweden and Dept. of Odontology, University of Umeå, Sweden since Nov. 1996, a total of 5 months; 3). Inst. of Medical Biochemistry, University of Gothenburg, Sweden (autumn 1999); Aberdeen Proteome Facility, Univerisyt of Aberdeen, UK (September 2001) |
| 8. | Academic degree | Ph.D (Medicine) |
| 9. | Dates and sites of earning the degrees |
University of Lund, Sweden; 2000 |
| 10. | Honours/awards | Awarded position in the competition for a "Young Scientist Award" from the President's Culture Fund of Estonia, 2000. |
| 11. | Research-administrative experience |
1) Member of the organisation and teaching staff in PhD course "Microbial Adhesion and Virulence", 14. - 23.04. 1999 (Copenhagen/Lund) 2) Scientific secretary of the Institute of Molecular and Cell Biology, University of Tartu since 2002 3) From 2003: Expert in the evaluation of the EU grant proposals 4) Member of the European Respiratory Society since 01.2003 |
| 12. | Supervised dissertations |
Martin Kadai, MSc, 2005, superv. Siiri Altraja. "The effect of proinflammatory mediators on the expression of tenascin and laminin by bronchial epithelial cells with special respect to cysteinyl leukotrienes". Tartu Ülikool |
| 13. | Current research program | 1. Helicobacter pylori cell surface proteins; 2. Ribosome-associated proteins of eucaryotic cells and the respective genes 3. Airway remodeling and disease markers in obstructive pulmonary diseases |
| 14. | Current grant funding | 1) A research grant from the Estonian Science Foundation No. 5011: "Expression of Extracellular Matrix Proteins by Human Airway Structural Cells: the Effect of Oxidative Stress and Modulation by Inflammatory Mediators" 2002-2005, grant holder 2) Grant funding from the Ministry of Education "Human genome II", Reg. No. 0182582s03, lead by Andres Metspalu |
| 15. | List of most important publications |
Altraja S, Kadai M, Altraja A. Expression of the cysteinyl leukotriene receptors CysLT1 and CysLT2 in the airway structural cells. Eur Respir J 2005; 26(Suppl. 49): 346s. Altraja S, Rekker E, Altraja A. Cysteinyl leukotrienes enhance expression of tenascin and laminin beta2 chain by human lung fibroblasts. Proc Am Thoracic Soc 2005; 2: A76. Altraja A, Kadai M, Altraja S. Cysteinyl leukotrienes increase tenascin expression by human bronchial epithelial cells. Am J Respir Crit Care Med 2004; 169(Suppl.): A454. Altraja S, Kadai M, Altraja A. Oxidative stress in bronchial epithelial cells: relations to extracellular matrix synthesis. Eur Respir J 2004; 24(Suppl. 48): 106s. Altraja S, Kadai M, Altraja A. Leukotriene E4 increases tenascin production by human bronchial epithelial cells. Eur Respir J 2003; 22(Suppl. 45): 36s. Mahdavi J, Sonden B, Hurtig M, Olfat FO, Forsberg L, Roche N, Angstrom J, Larsson T, Teneberg S, Karlsson KA, Altraja S, Wadstrom T, Kersulyte D, Berg DE, Dubois A, Petersson C, Magnusson KE, Norberg T, Lindh F, Lundskog BB, Arnqvist A, Hammarstrom L, Boren T. 2002. Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science 297, 573-578. Annuk H, Hynes SO, Hirmo S, Mikelsaar M, Wadström T. 2001. Characterisation and differentiation of lactobacilli by lectin typing. J Med Microbiol. 50:1069-1074. Arnqvist A, Ilver D, Ögren J, Hirmo S, Wadström T, Borén T. 2001. Adherence of Helicobacter pylori: Mechanisms and Relevance to Pathogenesis. In: Helicobacter 2001: Past, Present and Future (Moran AP, Ed.) Normed Verlag Inc, Englewood, NJ, USA. Gerhard M, Hirmo S, Wadström T, Miller-Podraza H, Teneberg S, Karlsson K- A, Appelmelk B, Odenbreit S, Haas R, Arnqvist A, Borén T. 2001. H.pylori, an adherent pain in the stomach. In: Helicobacter pylori: Molecular and Cellular Biology (Achtman M, Suerbaum S, Eds.) Horizon Scientific Press, Norfolk, U.K. Chapter 12. Wang X, Hirmo S, Willén R, Wadström T. 2001. Inhibition of Helicobacter pylori infection by bovine milk glycoconjugates in a Balb/cA mouse model. J Med Microbiol 50: 430-435. Wang X, Hirmo S, Willen R, Wadström, T Inhibition of H-pylori infection by bovine milk glycoconjugates in a mouse model. Gut 2000; 47(Suppl):A60 Annuk H, Hirmo S, Türi E, Mikelsaar M, Arak E, Wadström T. 1999. Effect on cell surface hydrophobicity and susceptibility of Helicobacter pylori to medicinal plant extracts. FEMS Microbiol. Lett. 172: 41-45. Chmiela M, Paziak-Domanska B, Hirmo S, Rudnicka W, Utt M, Wadström T. 1998. Helicobacter pylori - interactions with phagocytes. In: Helicobacter pylori. Basic mechanisms to clinical cure 1999 (Hunt RH, Tytgat GNJ, Eds), pp. 90- 100. Kluwer Academic Publishers, Dordrecht, Boston, London. Hirmo S, Artursson E, Puu G, Wadström T, Nilsson B. 1999. Helicobacter pylori interactions with human gastric mucin studied with a resonant mirror biosensor. J Microbiol Meth. 37, 177-182. Hynes SO, Hirmo S, Wadström T, Moran AP. 1999. Differentiation of Helicobacter pylori isolates based on lectin binding of cell extracts in an agglutination assay. J Clin Microbiol. 37: 1994-1998. Hirmo S, Artursson E, Puu G, Wadström T, Nilsson B. 1998. Characterization of Helicobacter pylori interactions with sialylglycoconjugates using a resonant mirror biosensor. Anal Biochem 257, 63-66. Hirmo S, Kelm S, Iwersen M, Hotta K, Goso Y, Ishihara K, Suguri T, Morita M, Wadström T, Schauer R. 1998. Inhibition of Helicobacter pylori sialic acid-specific haemagglutination by human gastrointestinal mucins and milk glycoproteins. FEMS Immunol Med Microbiol. 20, 275-281. Hirmo S, Utt M, Wadström T. 1998. Sialylglycoconjugate- and proteoglycan-binding microbial lectins. In: Lectins: Biology, Biochemistry, Clinical Biochemistry (van Driessche E, Beekmans S, B?g-Hansen TC, Eds.) Vol. 12, Textop, Hellerup, Denmark. Hirmo S, Kelm S, Wadström T, Schauer R. 1997. Lack of evidence for sialidase activity in Helicobacter pylori. FEMS Immunol Med Microbiol; 17:67-72. Hirmo S, Shumakov Y, Utt M, Wadström T. 1997. Genetic heterogeneity of Helicobacter pylori and strain typing. In: Pathogenesis and Host Response in Helicobacter pylori Infections (Moran AP, O´Morain CA, Eds.), pp. 199-205, Normed Verlag, Bad Hamburg-Englewood, N.J. Wadstrom T, Hirmo S, Kelm S, Nilsson B, Schauer R, Utt M Sialylglycoconjugate and heparin binding surface proteins of Helicobacter pylori Eur J Cell Biol 1997;74(Suppl.46):106 Wadström T, Hirmo S, Nilsson B. 1997. Biochemical aspects of H.pylori adhesion. J Physiol Pharmacol; 48:325-331. Wadström T, Hirmo S, Novak H, Guzman A, Ringnér-Pantzar M, Utt M, Aleljung P. 1997 Sulfatides inhibit binding of Helicobacter pylori to the gastric cancer Kato III cell line. Current Microbiol; 34:267-272. Pascu C, Hirmo S, Ljungh Å, Wadström T. 1996. A particle agglutination assay for rapid identification of heparin binding to coagulase-negative staphylococci. J Med Microbiol; 45:263-269. Pascu C, Hirmo S, Ljungh Å, Wadström T. 1996. Inhibition of extracellular matrix and serum proteins binding to Staphylococcus aureus by heparin and various polysulphated agents. Med Microbiol Lett; 4:397-405. Wadström T, Hirmo S. 1996. IV.Bacterial pathogenesis. Helicobacter pylori: An Atlas (Eds. Malfertheiner P, Michetti P, Price A) Science press, UK Wadström T, Hirmo S, Borén T. 1996. Biochemical aspects of Helicobacter pylori colonization of the human gastric mucosa. Aliment Pharmacol Ther; 10(Suppl.1):17-27. Hirmo S, Kelm S, Schauer R, Nilsson B, Wadström T. 1996. Adhesion of Helicobacter pylori strains to a-2,3-linked sialic acids. Glycoconjug J; 13:1005-1011. Hirmo S, Utt M, Ringner M, Wadström T. 1995. Inhibition of heparan sulphate and other glycosaminoglycans binding to Helicobacter pylori by various polysulphated carbohydrates. FEMS Immunol Med Microbiol; 10:301-306. |
last updated: 06.08.2005
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