Ulla Aapola, PhD, 2004, juh. Pärt Peterson. Characterisation and Functional Studies of the DNA Cytosine-5-Methyltransferase 3-like Gene (DNMT3L-geenin karakterisointi ja toiminta). Tampere Ülikool

Maarit Heino, PhD, 2001, juh. Pärt Peterson, Kai Krohn. Identification of the Autoimmune Regulator Gene, its mutation pattern in APECED patients and Localisation of the Gene Expression (Autoimmune Regulator-geenin identifiointi, mutaatiot APECED potilailla ja geenin ilmentymisprofiili ). Tampere Ülikool

Pitkänen J, Rebane A, Rowell J, Murumägi A, Ströbel P, Möll K, Saare M, Heikkila J, Doucas V, Marx A, Peterson P. (2005) Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochem Biophys Res Commun. 2005 333:944-953

Tuomela M, Malm M, Wallen M, Stanescu I, Krohn K and Peterson P. (2005) Biodistribution and general safety of a naked DNA plasmid, GTU®-MULTIHIV, in a rat, using a quantitative PCR method. Vaccine 23: 890-896.

Webster KE, O'Bryan MK, Fletcher S, Crewther PE, Aapola U, Craig J, Harrison DK, Aung H, Phutikanit N, Lyle R, Meachem SJ, Antonarakis SE, de Kretser DM, Hedger MP, Peterson P, Carroll BJ, Scott HS (2005) Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci USA 102: 4068-4073

Aapola U, Mäenpää K, Kaipia A, Peterson P. (2004) Epigenetic modifications affect Dnmt3L expression. Biochem J. 380: 705-713

Akiyoshi H, Hatakeyama S, Pitkänen J, Mouri Y, Doucas V, Kudoh J, Tsurugaya K, Uchida D, Matsushima A, Oshikawa K, Nakayama KI, Shimizu N, Peterson P, Matsumoto M. (2004) Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. Journal of Biological Chemistry 279: 33984-33991

Krohn K and Peterson P. (2004) The central role of AIRE in thymic induction of tolerance to self antigens. Current Opinion in Endocrinology and Diabetes. 11: 26-30.

Peterson P, Pitkänen J, Sillanpää N, Krohn K. (2004) APECED: a model disease to study molecular aspects of endocrine autoimmunity. Clinical and Experimental Immunology 135: 348-357.

Sillanpää N, Magureanu CM, Murumägi A, Reinikainen A, Manninen A, Heino M, Ranki A, Saksela K, Krohn, Lahesmaa R and Peterson P. (2004) Autoimmune regulator induced changes in the gene expression profile of monocyte-dendritic cell –lineage. Molecular Immunology, 41: 1185-1198

Stjernberg-Salmela S, Pettersson T, Karenko L, Blazevic V, Nevala H, Pitkänen S, Peterson P, Ranki A. (2004) A novel tumour necrosis factor receptor mutation in a Finnish family with periodic fever syndrome. Scandinavian Journal of Rheumatology. 33: 140-144

Ströbel P, Baiersdorf N, Kerkau T, Murumägi A, Sillanpää N, Peterson P, Hummel V, Rieckmann P, Gold R, Schalke B, Nix W, Kiefer R, Powrie F, Müller-Hermelink HK and Marx A. (2004) Selective loss of CD4+ CD25+ regulatory T cells in thymomas. Annals of Neurology 56: 901-904

Chin RK, Lo JC, Kim O, Blink SE, Christiansen PA, Peterson P, Wang Y, Ware C, Fu YX. (2003) Lymphotoxin pathway directs thymic Aire expression. Nature Immunology 4: 1121-1127

Murumägi A, Vähämurto P, Peterson P. (2003) Characterization of regulatory elements and methylation pattern of AIRE (autoimmune regulator) promoter. J Biol Chem. 278: 19784-19790.

Pitkänen J and Peterson P. (2003) Autoimmune regulator: from loss of function to autoimmunity. Genes and Immunity 4: 12-21

Aapola U, Liiv I and Peterson P. (2002) Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. Nucleic Acids Research 30: 1-7

Liiv I, Teesalu K, Peterson P, Clemente MG, Perheentupa J, Uibo R. (2002) Epitope mapping of cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) by sera from patients with autoimmune polyglandular syndrome type 1. European J. Endocrinol.146: 113-119.

Nevala H, Karenko L, Stjernberg S, Raatikainen M, Suomalainen H, Rauta J, McDermott MF, Peterson P, Pettersson T and Ranki A. (2002) A novel TNF receptor 1 (TNFRSF1A) mutation (F112I) in a Finnish family with an autosomal dominant recurrent fever. Arthritis and Rheumatism 46: 1061-1066

Aapola U, Lyle R, Krohn K, Antonarakis SE, Peterson P. (2001) Isolation and Tissue Distribution of Mouse Dnmt3l gene. Cytogenetics and Cell Genetics, 92: 122-126

Cihakova D, Trebusak K, Heino M, Fadeyev V, Tiulpakov A, Battelino T, Tar A, Halász Z, Blümel P, Tawfik S, Krohn K, Lebl J and Peterson P. (2001) Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED. Human Mutation, 18: 225-232

Heino H, Peterson P, Kudoh J, Shimizu N, Antonarakis SE, Scott HS, and Krohn K (2001) APECED mutations in the Autoimmune Regulator (AIRE) gene. Human Mutation, 18: 205-211

Lebl J, Cihakova D, Trebusak K, Heino M, Battelino T, Halasz Z, Tar A, Blumel P, Fadejev V, Tyulpakov A, Krohn K, Peterson P. (2001) Autoimmune Polyglandular Syndrome-1 (APS-1; APECED) in Central and Eastern Europe: Novel Mutations of AIRE Gene and P450 Cytochrome Autoantibodies. Pediatric Research, 49; 122

Pitkänen J, Vähämurto P, Krohn K, Peterson P. (2001) Subcellular localization of the autoimmune regulator protein: characterization of nuclear targeting and transcriptional activation domain. J Biol Chem 276: 19597-19602

Tähtinen M, Strengell M, Collings A, Pitkänen J, Hakkarainen K, Ustav M, Wahren B, Peterson P, Kohleisen B, Ranki A, Krohn K. (2001) DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating bovine papilloma virus based pBN-vector. Vaccine. 19: 2039-2047

Aapola U, Shibuya K, Scott HS, Ollila O, Vihinen M, Heino M, Shintani A, Kawasaki K, Minoshima S, Krohn K, Antonarakis SE, Shimizu N, Kudoh J, Peterson P. (2000) Isolation and initial characterization of a novel zinc finger gene, DNMT3L on 21q22.3, related to cytosine-5-methyltransferase 3 gene family. Genomics 65: 293-298

Heino M, Peterson P, Sillanpää N, Guérin S, Wu L, Naquet P, Anderson G, Scott HS, Antonarakis SE, Jenkinson EJ, Krohn KJE. (2000) RNA and protein expression of the murine Autoimmune Regulator gene (Aire) in normal, RelB deficient and in NOD mouse. European J Immunol 30: 1884-1893.

Peterson P, Uibo R, Krohn K. (2000) Adrenal Autoimmunity: Results and Developments. Trends in Endocrinol Metabolism 11: 285-290.

Pitkänen J, Doucas V, Sternsdorf T, Nakajima T, Aratani S, Jensen K, Will H, Vähämurto P, Ollila J, Vihinen M, Scott HS, Antonarakis SE, Kudoh J, Shimizu N, Krohn K, Peterson P. (2000) The autoimmune regulator protein has transcriptional transactivating properties and interacts with common co-activator CBP. J Biol Chem 275: 16802-16809

Reimand K, Peterson P, Hyöty H, Uibo R, Cooke I, Weetman AP, Krohn K. (2000) 3b-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure. Journal of Clinical Endocrinology and Metabolism 85: 2324-2326

Collings A, Pitkänen J, Strengell M, Tähtinen M, Pitkänen J, Lagerstedt A, Hakkarainen K, Ovod V, Sutter G, Ustav M, Ustav E, Männik A, Ranki A, Peterson P, Krohn K. (1999) Humoral and cellular response to HIV-1 Nef in mice DNA-immunized with non-replicating and self-replicating expression vectors. Vaccine 18: 460-467

D. Beltran-Valero de Bernabe, Peterson P, Luopajärvi K, Krohn K, Rodriguez de Cordoba S, Ranki A. (1999) Mutational analysis of the HGO gene in Finnish alkaptonuria patients. J. Medical Genetics 36: 922-923

Heino M, Peterson P, Lagerstedt A, Ovod V, Ranki A, Kudoh J, Shimizu N, Scott HS, Antonarakis SE, Krohn K. (1999) Autoimmune regulator (AIRE) is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res Comm 257: 821-825

Heino M, Scott HS, Chen Q, Peterson P, Mäenpää U, Papasavvas MP, Mittaz L, Barras C, Rossier C, Stratakis A, Chrousos G, Nagamine K, Kudoh J, Shimizu N, Maclaren N, Antonarakis SE, Krohn K. (1999) Mutation analyses of Northern American APS-1 patients. Human Mutation, 13: 69-74

Mittaz L, Rossier C, Heino M, Peterson P, Krohn KJE, Gos A, Morris MA Kudoh J, Shimizu N, Antonarakis SE, Scott HS. (1999) Isolation and characterization of the mouse Aire gene. Biochem. Biophys. Res Comm. 255: 483-490

Seissler J, Schott M, Steinbrenner H, Peterson P, Scherbaum WA. (1999) Autoantibodies to adrenal cytochrome P450 antigens in isolated Addison’s disease and autoimune polyendocrine syndrome type II. Experimental and Clinical Endocrinology of Diabetes, 107: 208-213

Kemp EH, Ajjan RA, Husebye ES, Peterson P, Uibo R, Imrie H, Pearce S, Watson PF, Weetman AP. (1998) Analysis of a microsatellite polymorphism of the cytotoxic T lymphocyte antigen-4 (CTLA-4) gene in patients with autoimmune Addison’s disease. Clinical Endocrinology, 49: 609-613

Peterson P, Nagamine K, Scott HS, Heino M, Kudoh J, Shimizu N, Antonarakis SE, Krohn K. (1998) APECED: a monogenic autoimmune disease providing new clues to self tolerance. Immunology Today (Trends in Immunology), 19: 384-386

Rosatelli M, Meloni A, Meloni A, Devoto M, Cao A, Scott HS, Peterson P, Heino M, Krohn K, Nagamine K, Kudoh J, Shimizu N, Antonarakis SE. (1998) A common mutation in Sardinian autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy patients. Human Genetics 103: 428-434

Scott HS, Heino M, Peterson P, Lalioti MD, Mittaz L, Betterle C, Cohen A, Romeo G, Seri M, Lerone M, Collin P, Salo M, Metcalfe R, Weetman AP, Papasavvas MP, Rossier C, Nagamine K, Kudoh J, Shimizu N, Krohn KJE, Antonarakis SE. (1998) Common mutations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients of different origins. Molecular Endocrinology, 12: 1112-1119

Scott HS, Kyriakou D, Peterson P, Heino H, Tähtinen M, Krohn K, Chen H, Rossier C, Lalioti MD, Antonarakis SE.(1998) Cloning of C21ORF2 in the APECED critical region of human chromosome 21q22.3, and its exclusion as a candidate gene. Genomics 47: 64-70

Krohn K, Ovod V, Vilja P, Heino M, Scott H, Kyriakou DS, Antonarakis SE, Jacobs HT, Isola I, Peterson P. (1997) Immunochemical characterization of a novel mitochondrially located protein encoded by a nuclear gene within the DFNB8/10 critical region on 21q22.3. Biopchem. Biophys. Res Comm. 238: 806-810

Nagamine K, Peterson P, Scott HS, Kudoh J, Minoshima S, Heino M, Krohn KJE, Lalioti MD, Mullis PE, Antonarakis SE, Kawasaki K, Asakawa S, Ito F, and Shimizu N. (1997) Positional cloning of the APECED gene. Nature Genetics 17: 393-397

Peterson P, Salmi H, Hyöty H, Miettinen A, Ilonen J, Reijonen H, Åkerblom H, Krohn K and the Childhood Diabetes in Finland Study Group. (1997) Steroid 21-hydroxylase autoantibodies in insulin-dependent diabetes mellitus. Clinical Immunology and Immunopathology, 82: 37-42

Peterson, P, Uibo R, Peränen J, Krohn K. (1997) Immunoprecipitation of steroidogenic enzyme autoantigens with APS I sera. Further evidence for no crossreactivity between P450c17 and P450c21. Clinical and Experimental Immunology, 107: 335-340

Uibo R, Uibo O, Reimand K, Peterson P, Krohn K. (1997) Characterization by molecular cloning an antigen reactive with antireticulin antibodies. Ann N Y Acad Sci 815:509-511

Peterson P, Perheentupa J, Krohn K. (1996) Candidal antigens in autoimmune polyglandular syndrome I. Clinical and Diagnostic Laboratory Immunology, 3: 290-294

Peterson P, Partanen J, Aavik E, Salmi H, Krohn K. (1995) Steroid 21-hydroxylase gene polymorphism in Addison's disease patients. Tissue Antigens, 46: 63-67

Partanen J, Peterson P, Westman P, Aranko S, Krohn K. (1994) MHC class II and III in Addison's disease. MHC alleles do not predict autoantibody specificity and no independent role for 21-hydroxylase gene polymorphism in disease susceptibility. Human Immunology, 41: 135-140

Peterson, P and Krohn K (1994) Mapping of autoantigenic B-cell epitopes on steroid 17a-hydroxylase, in autoimmune Addison's disease, using recombinant proteins. Clinical and Experimental Immunology, 98: 104-109

Ranki A, Aavik E, Peterson P, Schauman K, Nurmilaakso P. (1994) Successful amplification of DNA specific for Finnish Borrelia Burgdorferi-isolates in erythema chronicum migrans but not in circumscribed scleroderma lesions. Journal of Investigative Dermatology, 102: 339-345

Uibo R, Aavik E, Peterson P, Perheentupa J, Aranko S, Pelkonen R, Krohn KJEK. (1994) Autoantibodies to cytochrome P450scc, P45017a and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease. Journal of Clinical Endocrinology and Metabolism, 78: 323-328

Krohn K, Uibo R, Aavik E, Peterson P, Savilahti K. (1992) Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17a-hydroxylase. Lancet, 339: 770-773

Ulla Aapola, PhD, 2004, superv. Pärt Peterson. Characterisation and Functional Studies of the DNA Cytosine-5-Methyltransferase 3-like Gene (DNMT3L-geenin karakterisointi ja toiminta). Tampere Ülikool

Maarit Heino, PhD, 2001, superv. Pärt Peterson, Kai Krohn. Identification of the Autoimmune Regulator Gene, its mutation pattern in APECED patients and Localisation of the Gene Expression (Autoimmune Regulator-geenin identifiointi, mutaatiot APECED potilailla ja geenin ilmentymisprofiili ). Tampere Ülikool

Pitkänen J, Rebane A, Rowell J, Murumägi A, Ströbel P, Möll K, Saare M, Heikkila J, Doucas V, Marx A, Peterson P. (2005) Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochem Biophys Res Commun. 2005 333:944-953

Tuomela M, Malm M, Wallen M, Stanescu I, Krohn K and Peterson P. (2005) Biodistribution and general safety of a naked DNA plasmid, GTU®-MULTIHIV, in a rat, using a quantitative PCR method. Vaccine 23: 890-896.

Webster KE, O'Bryan MK, Fletcher S, Crewther PE, Aapola U, Craig J, Harrison DK, Aung H, Phutikanit N, Lyle R, Meachem SJ, Antonarakis SE, de Kretser DM, Hedger MP, Peterson P, Carroll BJ, Scott HS (2005) Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci USA 102: 4068-4073

Aapola U, Mäenpää K, Kaipia A, Peterson P. (2004) Epigenetic modifications affect Dnmt3L expression. Biochem J. 380: 705-713

Akiyoshi H, Hatakeyama S, Pitkänen J, Mouri Y, Doucas V, Kudoh J, Tsurugaya K, Uchida D, Matsushima A, Oshikawa K, Nakayama KI, Shimizu N, Peterson P, Matsumoto M. (2004) Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. Journal of Biological Chemistry 279: 33984-33991

Krohn K and Peterson P. (2004) The central role of AIRE in thymic induction of tolerance to self antigens. Current Opinion in Endocrinology and Diabetes. 11: 26-30.

Peterson P, Pitkänen J, Sillanpää N, Krohn K. (2004) APECED: a model disease to study molecular aspects of endocrine autoimmunity. Clinical and Experimental Immunology 135: 348-357.

Sillanpää N, Magureanu CM, Murumägi A, Reinikainen A, Manninen A, Heino M, Ranki A, Saksela K, Krohn, Lahesmaa R and Peterson P. (2004) Autoimmune regulator induced changes in the gene expression profile of monocyte-dendritic cell –lineage. Molecular Immunology, 41: 1185-1198

Stjernberg-Salmela S, Pettersson T, Karenko L, Blazevic V, Nevala H, Pitkänen S, Peterson P, Ranki A. (2004) A novel tumour necrosis factor receptor mutation in a Finnish family with periodic fever syndrome. Scandinavian Journal of Rheumatology. 33: 140-144

Ströbel P, Baiersdorf N, Kerkau T, Murumägi A, Sillanpää N, Peterson P, Hummel V, Rieckmann P, Gold R, Schalke B, Nix W, Kiefer R, Powrie F, Müller-Hermelink HK and Marx A. (2004) Selective loss of CD4+ CD25+ regulatory T cells in thymomas. Annals of Neurology 56: 901-904

Chin RK, Lo JC, Kim O, Blink SE, Christiansen PA, Peterson P, Wang Y, Ware C, Fu YX. (2003) Lymphotoxin pathway directs thymic Aire expression. Nature Immunology 4: 1121-1127

Murumägi A, Vähämurto P, Peterson P. (2003) Characterization of regulatory elements and methylation pattern of AIRE (autoimmune regulator) promoter. J Biol Chem. 278: 19784-19790.

Pitkänen J and Peterson P. (2003) Autoimmune regulator: from loss of function to autoimmunity. Genes and Immunity 4: 12-21

Aapola U, Liiv I and Peterson P. (2002) Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. Nucleic Acids Research 30: 1-7

Liiv I, Teesalu K, Peterson P, Clemente MG, Perheentupa J, Uibo R. (2002) Epitope mapping of cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) by sera from patients with autoimmune polyglandular syndrome type 1. European J. Endocrinol.146: 113-119.

Nevala H, Karenko L, Stjernberg S, Raatikainen M, Suomalainen H, Rauta J, McDermott MF, Peterson P, Pettersson T and Ranki A. (2002) A novel TNF receptor 1 (TNFRSF1A) mutation (F112I) in a Finnish family with an autosomal dominant recurrent fever. Arthritis and Rheumatism 46: 1061-1066

Aapola U, Lyle R, Krohn K, Antonarakis SE, Peterson P. (2001) Isolation and Tissue Distribution of Mouse Dnmt3l gene. Cytogenetics and Cell Genetics, 92: 122-126

Cihakova D, Trebusak K, Heino M, Fadeyev V, Tiulpakov A, Battelino T, Tar A, Halász Z, Blümel P, Tawfik S, Krohn K, Lebl J and Peterson P. (2001) Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED. Human Mutation, 18: 225-232

Heino H, Peterson P, Kudoh J, Shimizu N, Antonarakis SE, Scott HS, and Krohn K (2001) APECED mutations in the Autoimmune Regulator (AIRE) gene. Human Mutation, 18: 205-211

Lebl J, Cihakova D, Trebusak K, Heino M, Battelino T, Halasz Z, Tar A, Blumel P, Fadejev V, Tyulpakov A, Krohn K, Peterson P. (2001) Autoimmune Polyglandular Syndrome-1 (APS-1; APECED) in Central and Eastern Europe: Novel Mutations of AIRE Gene and P450 Cytochrome Autoantibodies. Pediatric Research, 49; 122

Pitkänen J, Vähämurto P, Krohn K, Peterson P. (2001) Subcellular localization of the autoimmune regulator protein: characterization of nuclear targeting and transcriptional activation domain. J Biol Chem 276: 19597-19602

Tähtinen M, Strengell M, Collings A, Pitkänen J, Hakkarainen K, Ustav M, Wahren B, Peterson P, Kohleisen B, Ranki A, Krohn K. (2001) DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating bovine papilloma virus based pBN-vector. Vaccine. 19: 2039-2047

Aapola U, Shibuya K, Scott HS, Ollila O, Vihinen M, Heino M, Shintani A, Kawasaki K, Minoshima S, Krohn K, Antonarakis SE, Shimizu N, Kudoh J, Peterson P. (2000) Isolation and initial characterization of a novel zinc finger gene, DNMT3L on 21q22.3, related to cytosine-5-methyltransferase 3 gene family. Genomics 65: 293-298

Heino M, Peterson P, Sillanpää N, Guérin S, Wu L, Naquet P, Anderson G, Scott HS, Antonarakis SE, Jenkinson EJ, Krohn KJE. (2000) RNA and protein expression of the murine Autoimmune Regulator gene (Aire) in normal, RelB deficient and in NOD mouse. European J Immunol 30: 1884-1893.

Peterson P, Uibo R, Krohn K. (2000) Adrenal Autoimmunity: Results and Developments. Trends in Endocrinol Metabolism 11: 285-290.

Pitkänen J, Doucas V, Sternsdorf T, Nakajima T, Aratani S, Jensen K, Will H, Vähämurto P, Ollila J, Vihinen M, Scott HS, Antonarakis SE, Kudoh J, Shimizu N, Krohn K, Peterson P. (2000) The autoimmune regulator protein has transcriptional transactivating properties and interacts with common co-activator CBP. J Biol Chem 275: 16802-16809

Reimand K, Peterson P, Hyöty H, Uibo R, Cooke I, Weetman AP, Krohn K. (2000) 3b-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure. Journal of Clinical Endocrinology and Metabolism 85: 2324-2326

Collings A, Pitkänen J, Strengell M, Tähtinen M, Pitkänen J, Lagerstedt A, Hakkarainen K, Ovod V, Sutter G, Ustav M, Ustav E, Männik A, Ranki A, Peterson P, Krohn K. (1999) Humoral and cellular response to HIV-1 Nef in mice DNA-immunized with non-replicating and self-replicating expression vectors. Vaccine 18: 460-467

D. Beltran-Valero de Bernabe, Peterson P, Luopajärvi K, Krohn K, Rodriguez de Cordoba S, Ranki A. (1999) Mutational analysis of the HGO gene in Finnish alkaptonuria patients. J. Medical Genetics 36: 922-923

Heino M, Peterson P, Lagerstedt A, Ovod V, Ranki A, Kudoh J, Shimizu N, Scott HS, Antonarakis SE, Krohn K. (1999) Autoimmune regulator (AIRE) is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res Comm 257: 821-825

Heino M, Scott HS, Chen Q, Peterson P, Mäenpää U, Papasavvas MP, Mittaz L, Barras C, Rossier C, Stratakis A, Chrousos G, Nagamine K, Kudoh J, Shimizu N, Maclaren N, Antonarakis SE, Krohn K. (1999) Mutation analyses of Northern American APS-1 patients. Human Mutation, 13: 69-74

Mittaz L, Rossier C, Heino M, Peterson P, Krohn KJE, Gos A, Morris MA Kudoh J, Shimizu N, Antonarakis SE, Scott HS. (1999) Isolation and characterization of the mouse Aire gene. Biochem. Biophys. Res Comm. 255: 483-490

Seissler J, Schott M, Steinbrenner H, Peterson P, Scherbaum WA. (1999) Autoantibodies to adrenal cytochrome P450 antigens in isolated Addison’s disease and autoimune polyendocrine syndrome type II. Experimental and Clinical Endocrinology of Diabetes, 107: 208-213

Kemp EH, Ajjan RA, Husebye ES, Peterson P, Uibo R, Imrie H, Pearce S, Watson PF, Weetman AP. (1998) Analysis of a microsatellite polymorphism of the cytotoxic T lymphocyte antigen-4 (CTLA-4) gene in patients with autoimmune Addison’s disease. Clinical Endocrinology, 49: 609-613

Peterson P, Nagamine K, Scott HS, Heino M, Kudoh J, Shimizu N, Antonarakis SE, Krohn K. (1998) APECED: a monogenic autoimmune disease providing new clues to self tolerance. Immunology Today (Trends in Immunology), 19: 384-386

Rosatelli M, Meloni A, Meloni A, Devoto M, Cao A, Scott HS, Peterson P, Heino M, Krohn K, Nagamine K, Kudoh J, Shimizu N, Antonarakis SE. (1998) A common mutation in Sardinian autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy patients. Human Genetics 103: 428-434

Scott HS, Heino M, Peterson P, Lalioti MD, Mittaz L, Betterle C, Cohen A, Romeo G, Seri M, Lerone M, Collin P, Salo M, Metcalfe R, Weetman AP, Papasavvas MP, Rossier C, Nagamine K, Kudoh J, Shimizu N, Krohn KJE, Antonarakis SE. (1998) Common mutations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients of different origins. Molecular Endocrinology, 12: 1112-1119

Scott HS, Kyriakou D, Peterson P, Heino H, Tähtinen M, Krohn K, Chen H, Rossier C, Lalioti MD, Antonarakis SE.(1998) Cloning of C21ORF2 in the APECED critical region of human chromosome 21q22.3, and its exclusion as a candidate gene. Genomics 47: 64-70

Krohn K, Ovod V, Vilja P, Heino M, Scott H, Kyriakou DS, Antonarakis SE, Jacobs HT, Isola I, Peterson P. (1997) Immunochemical characterization of a novel mitochondrially located protein encoded by a nuclear gene within the DFNB8/10 critical region on 21q22.3. Biopchem. Biophys. Res Comm. 238: 806-810

Nagamine K, Peterson P, Scott HS, Kudoh J, Minoshima S, Heino M, Krohn KJE, Lalioti MD, Mullis PE, Antonarakis SE, Kawasaki K, Asakawa S, Ito F, and Shimizu N. (1997) Positional cloning of the APECED gene. Nature Genetics 17: 393-397

Peterson P, Salmi H, Hyöty H, Miettinen A, Ilonen J, Reijonen H, Åkerblom H, Krohn K and the Childhood Diabetes in Finland Study Group. (1997) Steroid 21-hydroxylase autoantibodies in insulin-dependent diabetes mellitus. Clinical Immunology and Immunopathology, 82: 37-42

Peterson, P, Uibo R, Peränen J, Krohn K. (1997) Immunoprecipitation of steroidogenic enzyme autoantigens with APS I sera. Further evidence for no crossreactivity between P450c17 and P450c21. Clinical and Experimental Immunology, 107: 335-340

Uibo R, Uibo O, Reimand K, Peterson P, Krohn K. (1997) Characterization by molecular cloning an antigen reactive with antireticulin antibodies. Ann N Y Acad Sci 815:509-511

Peterson P, Perheentupa J, Krohn K. (1996) Candidal antigens in autoimmune polyglandular syndrome I. Clinical and Diagnostic Laboratory Immunology, 3: 290-294

Peterson P, Partanen J, Aavik E, Salmi H, Krohn K. (1995) Steroid 21-hydroxylase gene polymorphism in Addison's disease patients. Tissue Antigens, 46: 63-67

Partanen J, Peterson P, Westman P, Aranko S, Krohn K. (1994) MHC class II and III in Addison's disease. MHC alleles do not predict autoantibody specificity and no independent role for 21-hydroxylase gene polymorphism in disease susceptibility. Human Immunology, 41: 135-140

Peterson, P and Krohn K (1994) Mapping of autoantigenic B-cell epitopes on steroid 17a-hydroxylase, in autoimmune Addison's disease, using recombinant proteins. Clinical and Experimental Immunology, 98: 104-109

Ranki A, Aavik E, Peterson P, Schauman K, Nurmilaakso P. (1994) Successful amplification of DNA specific for Finnish Borrelia Burgdorferi-isolates in erythema chronicum migrans but not in circumscribed scleroderma lesions. Journal of Investigative Dermatology, 102: 339-345

Uibo R, Aavik E, Peterson P, Perheentupa J, Aranko S, Pelkonen R, Krohn KJEK. (1994) Autoantibodies to cytochrome P450scc, P45017a and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease. Journal of Clinical Endocrinology and Metabolism, 78: 323-328

Krohn K, Uibo R, Aavik E, Peterson P, Savilahti K. (1992) Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17a-hydroxylase. Lancet, 339: 770-773