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Elulookirjeldus (CV)
1.Eesnimi Monika
2.Perekonnanimi Drews
3.Töökoht 1. Molekulaardiagnostika õppetool, Geenitehnoloogia Instituut, Tallinna Tehnikaülikool (TTÜ)
2. Vähiuuringute Tehnoloogia Arenduskeskus (VTAK)
4.Ametikoht 1. Vanemteadur (TTÜ)
2. Projektijuht (VTAK)
5.Sünniaeg 29.06.1967 (päev.kuu.aasta)
6.Haridus Cum laude M.Sc. bioloog-biokeemik, Tartu Ülikool, 1990;loodusteaduste doktor,1999, Tallinna Tehnikaülikool
7.Teenistuskäik 1989-1990, insener; 1991-1996, nooremteadur; 1996-2000, teadur; alates 2000 vanemteadur; alates 2002-2005, Welcome Trust, teadur; KBFI Molekulaargeneetika Labor;
alates 1.06.2005, erakorraline vanemteadur,Molekulaardiagnostika Õppetool, Geenitehnoloogia Instituut, Tallinna Tehnikaülikool;
alates 1.07.2005, projektijuht, Vähiuuringute Tehnoloogia Arenduskeskus
8.Teaduskraad Loodusteaduste doktor
9.Teaduskraadi välja
andnud asutus, aasta		 Tallinna Tehnikaülikool, 1999
10.Tunnustused Georg Sorose stipendium, 1993
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus		 Projektijuht, VTAK
12.Juhendamisel kaitstud
väitekirjad
13.Teadustöö põhisuunad Biotehnoloogia, kultiveeritavate imetaja-ja putukarakkude füsioloogia ja metabolism, vähiteraapias potentsiaali omavate rekombinantsete valkude ja monoklonaalsete antikehade ekspressiooni optimeerimine, kultiveerimismeetodite arendamine
14.Jooksvad grandid SF0222601As03; 2003 - 2007
ETF nr. 5129; 2002 - 2005
ETF nr. 5137; 2002 - 2005
15.Teaduspublikatsioonid

Paalme,T., Nisamedtinov,I., Abner, K., Laht, T.-M., Drews, M and Pehk, T. (2006)Application of 13C-[2]- and 13C-[1, 2] acetate in metabolic labeling studies of yeast and insect cells. Antonie van Leeuwenhoek. Electronically on-line published. DOI 10.1007/s10482-005-9053-7.

Kahru, A., Drews, M., Põllumaa, L., Kasemets, K., Veidebaum, T., Kogerman, P. (2005)Toxicity of nanoscale cationic polymers in vitro and in vivo - ALTEX, Vol. 22, Special Issue, p. 302[a1]

Päll, T., Gad, A., Kasak, L., Drews, M., Strömblad, S., Kogerman, P. (2004) Recombinant CD44-HABD is a novel and potent direct angiogenesis inhibitor enforcing endothelial cell-specific growth inhibition independently of hyoluronic acid binding. Oncogene, 23(47):7874-81.

Drews, M., Nisamedtinov, I. and Paalme T. (2003). Application of quasi-steady-state cultures. In: S. Sorvari (ed.), The 1st International Congress on Bioreactor Technology in Cell-, Tissue Culture and Biomedical Applications (ISBN 952-96302-0-8), Tampere, Finland 14 - 18 July 2003, BioBien Innovations (BBi), pp. 218-225.

Kasemets, K., Drews, M., Nisamedtinov, I., Adamberg, K. and Paalme, T. (2003) Modification of A-stat for the characterization of microorganisms. J. of Microbiological Methods, Vol. 55(1), 187-200.

Drews, M., Doverskog, M., Öhman, L., Chapman, B. E., Jacobsson, U., Kuchel, P. W. and Häggström, L. (2000) Pathways of glutamine metabolism in Spodopera frugiperda (Sf9) insect cells: evidence for the presence of the nitrogen assimilation system, and a metabolic switch by 1H/15N NMR. J. Biotechnol. 78: 23-37.

Siigur, E., Tõnismägi, K., Merits, A., Drews, M. and Siigur, J. (1999) Expression of fibrinolytic enzyme, lebetase, from Vipera lebetina snake venom by baculovirus system.Toxicon 37: 305.

Drews, M., Kasemets, K., Nizamedtinov, I. and Paalme, T. (1998) Continuous cultivation of insect and yeast cells at maximum specific growth rate. Proc. Estonian Acad. Sci. Chem. 47, (4), 175-188.

Siigur, E., Aaspõllu, A., Tõnismägi, K., Samel, M., Drews, M., Merits, A., Tu, A. and Siigur, J. (1998) Biochemical characterization, cDNA cloning and expression of the fibrinolytic enzyme. Lebetase from Vipera lebetina venom. Toxicon 36 (9): 1258.

Siigur, E., Tõnismägi, K., Merits, A., Drews, M. and Siigur, J. (1998) Expression of prolebetase from Vipera lebetina by baculovirus system. Plasminogen activating activity of SF-9 cell lysates. Fibrinolysis & Proteolysis, Vol. 12, suppl. I, p 66.

Drews, M. and Paalme, T. (1997) Elucidation of metabolic network of mammalian cell line K562 using 2-14C glucose label and stoichiometric modelling. Manuel J. T. Carrondo, Bryan Griffits and Jose L. P. Moreira (eds.), Animal Cell Technology: From Vaccines to Genetic Medicine, 697-702, 1997, Kluwer Academic Publishers.

Drews M., Paalme T. (1997) Baculovirus expression using chemostat culture of insect cells. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 213: 154-BIOT Part 1 APR 13 1997

Drews, M., Paalme, T. and Vilu, R. (1997) Chemostat culture of Spodoptera frugiperda Sf9 cells: nutrient requirement and baculovirus expression. Karl Maramorosch and Jun Mitsuhashi (eds) In: Invertebrate cell culture: Novel directions and biotechnology applications, pp. 115 - 122, Science Publisher, Inc., USA.

M. Drews, T. Paalme and R. Vilu. (1995) The growth and nutrient utilization of the insect cell line Spodoptera frugiperda Sf9 cells in batch and continuous culture. Journal of Biotechnology, 40 (3):187-198.

viimati muudetud: 12.08.2005

Curriculum Vitae (CV)
1.First Name Monika
2.Surname Drews
3.Institution 1. Chair of Molecular Diagnostics, Institute of Gene Technology, Tallinn University of Technology (TUT)
2. Competence Centre for Cancer Research (CCCR)
4.Position 1. Senior research scientist (TUT)
2. Project leader (CCCR)
5.Date of birth 29.06.1967 (day.month.year)
6.Education Cum laude, Tartu University, 1990; biologist-biochemist; Ph.D in Natural Sciences, Tallinn Technical University, 1999
7.Research and
professional experience		 Research associate, 1989-1990; junior research scientist, 1991-1996; research scientist 1996-2000; senior reseach scientist since 2000, Welcome Trust scientist, 2002-2005 National Institute of Chemical Physics and Biophysics;
since 1.06.2005, extraordinary senior research scientist, Department of Molecular Diagnostics, Institute of Gene Technology, Tallinn University of Technology;
since 1.07.2005, project leader, Competence Centre for Cancer Research
8.Academic degree Ph.D in Natural Sciences
9.Dates and sites of
earning the degrees		 Tallinn Technical University, 1999
10.Honours/awards Georg Soros stipend, 1993
11.Research-administrative
experience		 Project leader, CCCR
12.Supervised dissertations
13.Current research program Biotechnology, metabolism and physiology of industrially important cultured mammalian and insect cells, development and optimization of cultivation methods, the study of recombinant protein and monoclonal antibody production processes for development of cancer treatment strategies
14.Current grant funding SF0222601As03; 2003 - 2007
ESF Grant No. 5129; 2002 - 2005
ESF Grant No. 5137; 2002 - 2005
15.List of most important publications

Paalme,T., Nisamedtinov,I., Abner, K., Laht, T.-M., Drews, M and Pehk, T. (2006)Application of 13C-[2]- and 13C-[1, 2] acetate in metabolic labeling studies of yeast and insect cells. Antonie van Leeuwenhoek. Electronically on-line published. DOI 10.1007/s10482-005-9053-7.

Kahru, A., Drews, M., Põllumaa, L., Kasemets, K., Veidebaum, T., Kogerman, P. (2005)Toxicity of nanoscale cationic polymers in vitro and in vivo - ALTEX, Vol. 22, Special Issue, p. 302[a1]

Päll, T., Gad, A., Kasak, L., Drews, M., Strömblad, S., Kogerman, P. (2004) Recombinant CD44-HABD is a novel and potent direct angiogenesis inhibitor enforcing endothelial cell-specific growth inhibition independently of hyoluronic acid binding. Oncogene, 23(47):7874-81.

Drews, M., Nisamedtinov, I. and Paalme T. (2003). Application of quasi-steady-state cultures. In: S. Sorvari (ed.), The 1st International Congress on Bioreactor Technology in Cell-, Tissue Culture and Biomedical Applications (ISBN 952-96302-0-8), Tampere, Finland 14 - 18 July 2003, BioBien Innovations (BBi), pp. 218-225.

Kasemets, K., Drews, M., Nisamedtinov, I., Adamberg, K. and Paalme, T. (2003) Modification of A-stat for the characterization of microorganisms. J. of Microbiological Methods, Vol. 55(1), 187-200.

Drews, M., Doverskog, M., Öhman, L., Chapman, B. E., Jacobsson, U., Kuchel, P. W. and Häggström, L. (2000) Pathways of glutamine metabolism in Spodopera frugiperda (Sf9) insect cells: evidence for the presence of the nitrogen assimilation system, and a metabolic switch by 1H/15N NMR. J. Biotechnol. 78: 23-37.

Siigur, E., Tõnismägi, K., Merits, A., Drews, M. and Siigur, J. (1999) Expression of fibrinolytic enzyme, lebetase, from Vipera lebetina snake venom by baculovirus system.Toxicon 37: 305.

Drews, M., Kasemets, K., Nizamedtinov, I. and Paalme, T. (1998) Continuous cultivation of insect and yeast cells at maximum specific growth rate. Proc. Estonian Acad. Sci. Chem. 47, (4), 175-188.

Siigur, E., Aaspõllu, A., Tõnismägi, K., Samel, M., Drews, M., Merits, A., Tu, A. and Siigur, J. (1998) Biochemical characterization, cDNA cloning and expression of the fibrinolytic enzyme. Lebetase from Vipera lebetina venom. Toxicon 36 (9): 1258.

Siigur, E., Tõnismägi, K., Merits, A., Drews, M. and Siigur, J. (1998) Expression of prolebetase from Vipera lebetina by baculovirus system. Plasminogen activating activity of SF-9 cell lysates. Fibrinolysis & Proteolysis, Vol. 12, suppl. I, p 66.

Drews, M. and Paalme, T. (1997) Elucidation of metabolic network of mammalian cell line K562 using 2-14C glucose label and stoichiometric modelling. Manuel J. T. Carrondo, Bryan Griffits and Jose L. P. Moreira (eds.), Animal Cell Technology: From Vaccines to Genetic Medicine, 697-702, 1997, Kluwer Academic Publishers.

Drews M., Paalme T. (1997) Baculovirus expression using chemostat culture of insect cells. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 213: 154-BIOT Part 1 APR 13 1997

Drews, M., Paalme, T. and Vilu, R. (1997) Chemostat culture of Spodoptera frugiperda Sf9 cells: nutrient requirement and baculovirus expression. Karl Maramorosch and Jun Mitsuhashi (eds) In: Invertebrate cell culture: Novel directions and biotechnology applications, pp. 115 - 122, Science Publisher, Inc., USA.

M. Drews, T. Paalme and R. Vilu. (1995) The growth and nutrient utilization of the insect cell line Spodoptera frugiperda Sf9 cells in batch and continuous culture. Journal of Biotechnology, 40 (3):187-198.

last updated: 12.08.2005

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