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| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Ljudmilla |
| 2. | Perekonnanimi | Tšekulajeva |
| 3. | Töökoht | Tallinna Tehnikaülikool (TTÜ) |
| 4. | Ametikoht | Teadur |
| 5. | Sünniaeg | 01.10.1962 (päev.kuu.aasta) |
| 6. | Haridus | Kõrgem, Moskva Mendelejevi nimeline keemia-tehnoloogia Instituut - biotehnoloogiainsener 1989 Teaduste magister - TTÜ 2001 |
| 7. | Teenistuskäik | 1980-1985 laborant ja alates 1986 kuni 1989 vaneminsener Moskva Onkoloogia keskuses ETA Keemia Instituut, Tallinn - insener 1994-1999 TTÜ keemiainstituut - teadur 1999-käesoleva ajani |
| 8. | Teaduskraad | Teaduste magister |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tallinna Tehnikaülikool, 2001 |
| 10. | Tunnustused | |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
Eesti Keemia Seltsi liige |
| 12. | Juhendamisel kaitstud väitekirjad |
|
| 13. | Teadustöö põhisuunad | Tetrapürroolsete ühendite ja vähivastaste ravimite fotofüüsikaliste ja fotobioogilidte omaduste uurimine. Kasvajarakkude antioksüdantse süsteemi käitumise uurimine porfüriinide fotodünaamilisel toimel. |
| 14. | Jooksvad grandid | ETF grant nr. 5906, "Mõningate fotoaktiivsete tetrapürroolide ja dendrimeeride kompleksite süntees ja iseloomustamine" |
| 15. | Teaduspublikatsioonid |
Chekulayeva L.V., Shevchuk I.N., Chekulayev V.A., Ilmarinen K. Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells. - Journal of Environmental Pathology, Toxicology and Oncology, 2006, v.25(1-2), 51-77. Chekulayeva L., Shevchuk I., Chekulayev V. On the mechanism of the phototoxic action of haematoporphyrin derivative towards tumour cells. - Proc. Estonian Acad. Sci. Biology/Ecology, 2005, v.54(2), 83-119. Chekulayeva L.V., Shevchuk I.N., Chekulayev V.A. Influence of temperature on the efficiency of photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. - Experimental Oncology, 2004, v.26(2), 125-139. Chekulayeva L., Shevchuk I., Chekulayev V. Photodynamic therapy of tumours with chlorin-e6 is pH dependent. - Proc. Estonian Acad. Sci. Biology/Ecology, 2003, v.52(1), 40-54. Chekulayev V., Shevchuk I., Chekulayeva L. On the mechanism of cellular death under photoexcitation of haematoporphyrin derivative. - Proc. Estonian Acad. Sci. Biology/ Ecology, 2003, v.51(1), 55-72. Chekulayev V., Shevchuk I., Chekulayeva L., Jäälaid R. Kinetic studies on the mechanism of hematoporphyrin derivative photobleaching. - Proc. Estonian Acad. Sci. Chemistry, 2002, v.51(1), 49-70. Shevchuk I., Chekulayeva L., Chekulayev V. Influence of pH and glucose administration on the phototoxicity of chlorin-e6 towards Ehrlich carcinoma cells. - Experimental Oncology, 2002, v.24(2), 135-141. Shevchuk I., Chekulayev V., Chekulayeva L. The role of lipid peroxidation and protein degradation in the photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. - Experimental Oncology, 2002, v.24(3), 216-224. Chekulayev V., Shevchuk I., Chekulayeva L., Jäälaid R. Influence of extracellular magnesium on the antitumour efficiency of photodynamic therapy. - Proceedings of the Estonian Academy of Sciences - Chemistry, 2000, v.49(4), 216-233. Chekulayev V., Shevchuk I., Chekulayeva L., Kahru A. Study of the Photochemical and Phototoxic Properties of Lonidamine [1-(2,4-Dichlorobenzyl)-1h-Indazol-3-Carboxylic Acid]. - Journal of Photochemistry and Photobiology B: Biology, 1997, v.41(1-2), 11-21. Shevchuk I., Chekulayev V., Chekulayeva L. Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyanisole. - Journal of Photochemistry and Photobiology B: Biology, 1998, v.45(2-3), 136-143. |
viimati muudetud: 18.02.2006
| Curriculum Vitae (CV) | ||
| 1. | First Name | Ljudmilla |
| 2. | Surname | Tšekulajeva |
| 3. | Institution | Tallinn University of Technology |
| 4. | Position | Researcher |
| 5. | Date of birth | 01.10.1962 (day.month.year) |
| 6. | Education | Moscow Mendeleyev Chemical Technology Institute - Diploma in Biotechnology 1989 Tallinn Technical University - Diploma of Master of Science 2001 |
| 7. | Research and professional experience |
1980-1985 laboratory assistant, and beginning from 1986 to 1989 senior engineer of the Division of Clinical Immunology, All-Union Oncological Research Centre, Moscow Department of Bioorganic Chemistry, Institute of Chemistry of the Estonian Academy of Sciences, Tallinn - research engineer 1994-1999 Department of Chemistry of Tallinn University of Technology - researcher 1999-present |
| 8. | Academic degree | M.Sci degree in Natural Sciences |
| 9. | Dates and sites of earning the degrees |
Tallinn University of Technology, 2001 |
| 10. | Honours/awards | |
| 11. | Research-administrative experience |
Member of the Estonian Chemical Society |
| 12. | Supervised dissertations | |
| 13. | Current research program | Photophysical and photobiological properties of selected tetrapyrrolic compounds and antitumour drugs. Study of the role of antioxidant systems of neoplastic cells in their resistance to the phototoxic influence of selected porphyrins |
| 14. | Current grant funding | Estonian Science Foundation grant no. 5906, Synthesis and characterisation of dendrimer complexes of some photoactive tetrapyrrolic compounds |
| 15. | List of most important publications |
Chekulayeva L.V., Shevchuk I.N., Chekulayev V.A., Ilmarinen K. Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells. - Journal of Environmental Pathology, Toxicology and Oncology, 2006, v.25(1-2), 51-77. Chekulayeva L., Shevchuk I., Chekulayev V. On the mechanism of the phototoxic action of haematoporphyrin derivative towards tumour cells. - Proc. Estonian Acad. Sci. Biology/Ecology, 2005, v.54(2), 83-119. Chekulayeva L.V., Shevchuk I.N., Chekulayev V.A. Influence of temperature on the efficiency of photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. - Experimental Oncology, 2004, v.26(2), 125-139. Chekulayeva L., Shevchuk I., Chekulayev V. Photodynamic therapy of tumours with chlorin-e6 is pH dependent. - Proc. Estonian Acad. Sci. Biology/Ecology, 2003, v.52(1), 40-54. Chekulayev V., Shevchuk I., Chekulayeva L. On the mechanism of cellular death under photoexcitation of haematoporphyrin derivative. - Proc. Estonian Acad. Sci. Biology/ Ecology, 2003, v.51(1), 55-72. Chekulayev V., Shevchuk I., Chekulayeva L., Jäälaid R. Kinetic studies on the mechanism of hematoporphyrin derivative photobleaching. - Proc. Estonian Acad. Sci. Chemistry, 2002, v.51(1), 49-70. Shevchuk I., Chekulayeva L., Chekulayev V. Influence of pH and glucose administration on the phototoxicity of chlorin-e6 towards Ehrlich carcinoma cells. - Experimental Oncology, 2002, v.24(2), 135-141. Shevchuk I., Chekulayev V., Chekulayeva L. The role of lipid peroxidation and protein degradation in the photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. - Experimental Oncology, 2002, v.24(3), 216-224. Chekulayev V., Shevchuk I., Chekulayeva L., Jäälaid R. Influence of extracellular magnesium on the antitumour efficiency of photodynamic therapy. - Proceedings of the Estonian Academy of Sciences - Chemistry, 2000, v.49(4), 216-233. Chekulayev V., Shevchuk I., Chekulayeva L., Kahru A. Study of the Photochemical and Phototoxic Properties of Lonidamine [1-(2,4-Dichlorobenzyl)-1h-Indazol-3-Carboxylic Acid]. - Journal of Photochemistry and Photobiology B: Biology, 1997, v.41(1-2), 11-21. Shevchuk I., Chekulayev V., Chekulayeva L. Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyanisole. - Journal of Photochemistry and Photobiology B: Biology, 1998, v.45(2-3), 136-143. |
last updated: 18.02.2006
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