ERIS - Eesti teadus- ja arendustegevuse infosüsteem

Elulookirjeldus (CV)
1.	Eesnimi	Enn
2.	Perekonnanimi	Seppet
3.	Töökoht	TÜ arstiteaduskond, üld- ja molekulaarpatoloogia instituut, patoloogilise füsioloogia õppetool
4.	Ametikoht	korraline professor
5.	Sünniaeg	26.02.1950 (päev.kuu.aasta)
6.	Haridus	TÜ arstiteaduskond, arstidiplom 1974
7.	Teenistuskäik	1974-1981: noorem- ja vanemteadur, lihastalitluse laboratoorium, kehakultuuriteaduskond, Tartu Ülikool 1981-1992: hormonaalse regulatsiooni laboratooriumi juhataja, üld- ja molekulaarpatoloogia instituut, arstiteaduskond, Tartu Ülikool 1992 kuni käesoleva ajani: korraline professor, patoloogilise füsioloogia õppetool, üld- ja molekulaarpatoloogia instituut, arstiteaduskond, Tartu Ülikool
8.	Teaduskraad	Biol kand (1980) PhD (füsioloogia) 1991
9.	Teaduskraadi välja andnud asutus, aasta	Üleliiduline Kardioloogiakeskus, Moskva, 1980 Tartu Ülikool, 1991
10.	Tunnustused
11.	Teadusorganisatsiooniline ja –administratiivne tegevus	TÜ arstiteaduskonna teadusprodekaan 1994-2000 TÜ arstiteaduskonna aastakonverentsi orgkomitee aseesimees aastatel 1994-1997 Esimese Baltimaade katseloomateaduse alase kursuse “Laboratory Animals in Biomedical Research, May 1-11, 1994” Eesti-poolne koordinaator Põhjamaade ja Balti riikide raku bioenergeetikaalase suvekooli "Mitokondrid lihasrakkudes: metodoloogilised aspektid ja düsfunktsioon kardiovaskulaarsete haiguste puhul" Tartu, 15-21 juuni 2005 - koordinaator Rahvusvahelise konverentsi “XI ICLAS General Assembly and Joint Conference of ICLAS, Scand-LAS, and FinLAS - Frontiers in Laboratory Animal Science”, July 2-6, 1995, teadusprogrammi komitee liige Skandinaavia katseloomateaduse ühingu (ScandLASA) liige Euroopa Kardioloogia Ühingu ajakirja “Cardiovascular Research” (Elsevier Science B.V.) retsensent Ajakirja "Life Sciences" retsensent Eesti teadusfondi retsensent Ameerika Biograafia Instituudi Teadusliku Nõukogu liige Rahvusvahelise Südame Uurimise Ühingu liige Rahvusvahelise Südame-veresoonkonnateaduste Akadeemia liige Euroopa Biokeemiaühingute Föderatsiooni liige Soome Füsioloogia Seltsi liige Ameerika Füsioloogia Seltsi liige Eesti Füsioloogia Seltsi liige Eesti Biokeemia Seltsi liige Eesti Kardioloogide Seltsi liige Tartu Toome Rotary klubi liige
12.	Juhendamisel kaitstud väitekirjad	Evelin Seppet, PhD, 2004, juh. Enn Seppet. Interaction of mitochondria and ATPases in oxidative muscle cells in normal and pathological conditions. Tartu Ülikool. Tuuli Käämbre, PhD, 2004, juh. Enn Seppet, Valdur Saks. Intracellular energetic unit: structural and functional aspects. Tartu Ülikool. Lumme Kadaja, PhD, 2003, juh. Enn Seppet. Molecular approach to the regulation of mitochondrial function in oxidative muscle cells. Tartu Ülikool. Margus Eimre, MSc, 2002, juh. Enn Seppet. Mitokondrite ja ATPaaside integratsioonimehhanismid oksüdatiivsetes lihasrakkudes. Tartu Ülikool. Toomas Tiivel, PhD, 2002, juh. Valdur Saks, Enn Seppet. The role of the mitochondrial outer membrane in in vivo regulation of respiration in normal heart and skeletal muscle cells. Tallinna Tehnikaülikool. Tuuli Käämbre, MSc, 1999, juh. Enn Seppet, Valdur Saks. Oksüdatiivse fosforüülimise regulatsioon mitokondrites in vivo: interaktsioonid raku tsütoskeletiga. Tartu Ülikool. Allen Kaasik, PhD, 1998, juh. Enn Seppet. Thyroid hormone control over [beeta]-adrenergic signalling system in rat atria. Tartu Ülikool. Ave Minajeva, PhD, 1998, juh. Enn Seppet. Sarcoplasmic reticulum function: comparison of atrial and ventricular myocardium. Tartu Ülikool. Allen Kaasik, MSc, 1994, juh. Enn Seppet, Jorma Ohisalo. Türeoidhormooni mõju südame lihasraku signaalsüsteemidele: isoprenaliini ja adenosiini inotroopse toime moduleerimine. Tartu Ülikool. Lumme Kadaja, MSc, 1993, juh. Enn Seppet. Mitokondriaalse fosfokreatiini sünteesi türeoidne kontroll. Thyroid hormone control over mitochondrial phosphocreatine synthesis. Tartu Ülikool.
13.	Teadustöö põhisuunad	Kardiovaskulaarsüsteemi patofüsioloogia, lihasrakkude energeetiline metabolism
14.	Jooksvad grandid	Haridus- ja Teadusministeeriumi sihtfinantseeritav teadusteema (reg nr 0182549s03) Mitokondrite ja ATPaaside integratsiooni ja regulatsiooni mehhanismid normaalses ja haigestunud oksüdatiivses lihasrakus (teadusteema juht) ETF grant 5515 Mitokondrite ja ATPaaside funktsionaalsed kompleksid kui energeetilise metabolismi põhiüksused oksüdatiivsetes lihasrakkudes (grandihoidja) ETF grant 6142 Kompartmentaliseeritud energia transpordi võrgud kardiomüotsüütides ja eelkohastumise mehhanismid (põhitäitja)
15.	Teaduspublikatsioonid	Anmann T., Eimre M, Kuznetsov A.V., Andrienko T., Kaambre T., Sikk P., Seppet E., Tiivel T., Vendelin M., Seppet E. and Saks V.A. (2005). Calcium-induced contraction of sarcomeres changes regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal , 272, 3145-3161. Eimre M., Puhke R., Alev K., Seppet. E., Sikkut A., Peet N., Kadaja L, Lenzer A., Haviko T., Seene T., Saks V., Seppet E. Altered mitochondrial apparent affinity for ADP and impaired function of mitochondrial creatine kinase in gluteus medius of patients with hip osteoarthritis. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2005, Dec 15; [Epub ahead of print]. Saks V., Guerrero K., Vendelin M., Engelbrecht J., Seppet E. The creatine kinase isoenzymes in organized metabolic networks and regulation of cellular respiration: a new role for Maxwell’s demon. In: Creatine Kinase (Vial C., Ed.) in series: Molecular Anatomy and Physiology of Proteins (Uversky V.N., series Ed.), NovaScience Publishers, New York, 2005, in press. Seppet E., Eimre M., Peet N., Paju K., Orlova E., Ress M., Kovask S., Piirsoo A., Saks V.A., Gellerich F.N., Zierz S., Seppet E.K. (2005). Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Molecular and Cellular Biochemistry, 270(1-2), 49-61. Seppet E. K., Eimre M., Anmann T., Seppet E., Peet N., Käämbre T., Paju K., Piirsoo A., Kuznetsov A.V., Vendelin M., Gellerich F.N., Zierz S., Saks A.V. (2005). Intracellular energetic units in healthy and diseased hearts. Experimental and Clinical Cardiology, 10, 173-183. Kadaja L., Kisand KE., Peet N., Braun U., Metskula K., Teesalu K., Vibo R., Kisand KV., Uibo R., Jockusch H., Seppet EK. (2004). IgG from patients with liver diseases inhibit mitochondrial respiration in permeabilized oxidative muscle cells: impaired function of intracellular energetic units? Molecular and Cellular Biochemistry, 256/257(1-2), 291-303. Safiulina D., Kaasik A., Seppet E., Peet N., Zarkovski A., Seppet E. (2004). Method for in situ detection of the mitochondrial function in neurons. Journal of Neuroscience Methods, 137(1), 87-95 . Saks V.A., Kuznetsov A.V., Vendelin M., Guerrero K., Kay L., Seppet E.K. (2004). Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolism. Molecular and Cellular Biochemistry, 256/257(1-2), 185-199. Seppet E.K., Eimre M., Andrienko T., Kaambre T., Sikk P., Kuznetsov A.V., Saks V. (2004). Studies of mitochondrial respiration in muscle cells in situ: Use and misuse of experimental evidence in mathematical modelling. Molecular and Cellular Biochemistry, 256/257(1-2), 219-227. Vendelin M., Eimre M., Seppet E., Peet N., Andrienko T., Lemba M., Engelbrecht J., Seppet EK., Saks VA. (2004). Intracellular diffusion of adenosine phosphates is locally restricted in cardiac muscle. Molecular and Cellular Biochemistry, 256/257(1-2), 229-241. Puurand U., Kadaja L., Seppet E.K. (2003). Kindred DNA amplification from two distinct populations of cDNA fragments. BioTechniques, 34, 994-1000. Saks V.A., Kay L., Appaix F., Andrienko T. and Seppet E. Creatine kinase and brain energy metabolism: Function and disease. Eds. Téa Kekelidze and David Holtzman, NATO Science Series.Vol 342:3-25, 2003. IOS Press, The Netherlands. Saks V., Appaix F., Usson Y., Guerrero K., Olivares J., Seppet E, Aliev M., Margreiter R., Kuznetsov A. Localized control of oxidative phosphorylation within intracellular energetic units in heart cells: A possible solution of some old problems. In: Signal Transduction and Cardiac Hypertrophy. Dhalla NS et al (eds). Kluwer Academic Publishers, Boston, USA, 2003, pp. 265-284. Seppet E.K. (2003). Negative inotropy starts with the beta(3)-adrenoceptor. (2003). Cardiovascular Research, 59(2), 262-265 . Seppet E., Peet N., Paju K., Ress M., Saks V.A. Gellerich F.N. Chen Y., Trumbeckaite S., Prondzinsky R., Silber R.-E., Werdan K., Zierz S., Seppet E.K. Mitochondrial function in failing human myocardium in vivo: atrioventricular differences. In Cardiac Remodeling and Failure. Singal P.K. et al (Eds). Kluwer Academic Publishers, Boston, USA, 2003, pp. 459-470. Braun U., Paju K., Eimre M., Seppet E., Orlova E., Kadaja L., Trumbeckaite S., Gellerich F.N., Zierz S., Jockusch H., Seppet E.K. (2001). Lack of dystrophin is associated with altered integration of mitochondria and ATPases in slow-twitch muscle cells of MDX mice. Biochimica et Biophysica Acta-Bioenergetics, 1505, 258-270. Menin L., Panchichkina M., Keriel C., Olivares J., Braun U., Seppet E.K., Saks V.A. (2001). Macrocompartmentation of total creatine in cardiomyocytes revisited. Molecular and Cellular Biochemistry, 220, 149-159. Saks V.A., Kaambre T., Sikk P., Eimre M., Orlova E., Paju K., Piirsoo A., Appaix F., Kay L., Regitz-Zagrosek V., Fleck E., Seppet E. (2001). Intracellular energetic units in red muscle cells. Biochemical Journal, 356, 643-657. Seppet E.K., Kaambre T., Sikk P., Tiivel T., Vija H., Tonkonogi M., Sahlin K., Kay L., Appaix F., Braun U., Eimre M., Saks V.A. (2001). Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochimica et Biophysica Acta, 1504, 379-395. Gellerich F.N., Trumbeckaite S., Opalka J.R., Seppet E., Rasmussen H.N., Neuhoff C., Zierz S. (2000). Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases. Biochemical Society Transactions, 28(2), 164-169. Tiivel T., Kadaya L., Kuznetsov A., Käämbre T., Peet N., Sikk P., Braun U., Ventura-Clapier R., Saks V., Seppet E.K. (2000). Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Molecular and Cellular Biochemistry, 208, 119-128. Seppet E.K., Kaasik A., Paju K., Ohisalo J.J., Vetter R., Braun U. (1998). Mechanisms of thyroid hormone control over sensitivity and maximal contractile responsiveness to beta-adrenergic agonists in atria. In: Bioenergetics of the Cell: Quantitative Aspects. Molecular and Cellular Biochemistry, 184(1-2), 419-426. Kaasik A., Minajeva A., Paju K., Eimre M., Seppet E. (1997). Thyroid hormones differentially affect sarcoplasmic reticulum function in rat atria and ventricles. Molecular and Cellular Biochemistry, 176(1-2), 119-126. Kaasik A., Paju K., Vetter R., Seppet, E. (1997). Thyroid hormones increase the contractility but suppress the effects of beta-adrenergic agonist by decreasing phospholamban expression in rat atria. Cardiovascular Research, 35(1), 106-112. Minajeva A., Kaasik A., Paju K., Seppet E., Lompre A.-M., Veksler V., Ventura-Clapier R. (1997). Sarcoplasmic reticulum in determining atrio-ventricular contractile differences in rat heart. American Journal of Physiology-Heart and Circulatory Physiology, 273, H2498-H2507.

viimati muudetud: 05.10.2005

Curriculum Vitae (CV)
1.	First Name	Enn
2.	Surname	Seppet
3.	Institution	Chair of Pathophysiology, Institute of General and Molecular Pathology, Faculty of Medicine, University of Tartu, Estonia
4.	Position	Professor and Chairman
5.	Date of birth	26.02.1950 (day.month.year)
6.	Education	Medical Faculty, University of Tartu, MD,1974
7.	Research and professional experience	1974-1981: Junior and Senior Research Fellow, Laboratory of Muscle Research, University of Tartu, Estonia 1981-1992: Head, Laboratory of Hormonal Regulation, Faculty of Medicine, University of Tartu, Estonia 1992-present: Professor and Chairman, Chair of Pathophysiology, Institute of General and Molecular Pathology, Faculty of Medicine, University of Tartu, Estonia
8.	Academic degree	1980: Candidate of Sciences in Biochemistry 1991: Doctor of Philosophy (Physiology)
9.	Dates and sites of earning the degrees	1980: National Center for Cardiology, Moscow, USSR. 1991: University of Tartu, Estonia.
10.	Honours/awards
11.	Research-administrative experience	1994-2000,Vice-Dean for research and postgraduate degree education, Faculty of Medicine, University of Tartu Annual conference of Medical Faculty of Tartu University: Vice-President of organizatory committee in years 1994-1997 First course for laboratory animal science in Baltic states “Laboratory Animals in Biomedical Research, May 1-11, 1994” – Estonian Coordinator First Nordic-Baltic postgraduate summer-school in cellular bioenergetics "Mitochondria in Myocytes: Methodological Aspects and Dysfunction in Cardivascular Disease", in Tartu, June 15-21, 2005 - Coordinator Member of Scientific Program Committee of international conference “XI ICLAS General Assembly and Joint Conference of ICLAS, Scand-LAS, and FinLAS – Frontiers in Laboratory Animal Science”, July 2-6, 1995 Member Scandinavian Laboratory Animal Science (ScandLASA) Reviewer for the Journal of European Cardiologists Association “Cardiovascular Research” Elsevier Science B.V. Member of International Society for Heart Research Member of International Academy of Cardiovascular Sciences Reviewer for the Journal "Life Sciences" Reviewer for the Estonian Science Foundation Member of the Research Board of Advisors for the American Biographical Institute Member of Federation of European Biochemical Societies Member of the Research Board of Advisors for the American Biographical Institute Member of Finnish Physiological Society Member of American Physiological Society Member of Estonian Physiological Society Member of Estonian Biochemical Society Member of Estonian Cardiological Society Member of Tartu Toome Rotary Club
12.	Supervised dissertations	Evelin Seppet, PhD, 2004, superv. Enn Seppet. Interaction of mitochondria and ATPases in oxidative muscle cells in normal and pathological conditions. Tartu Ülikool. Tuuli Käämbre, PhD, 2004, superv. Enn Seppet, Valdur Saks. Intracellular energetic unit: structural and functional aspects. Tartu Ülikool. Lumme Kadaja, PhD, 2003, superv. Enn Seppet. Molecular approach to the regulation of mitochondrial function in oxidative muscle cells. Tartu Ülikool. Margus Eimre, MSc, 2002, superv. Enn Seppet. Mitokondrite ja ATPaaside integratsioonimehhanismid oksüdatiivsetes lihasrakkudes. Tartu Ülikool. Toomas Tiivel, PhD, 2002, superv. Valdur Saks, Enn Seppet. The role of the mitochondrial outer membrane in in vivo regulation of respiration in normal heart and skeletal muscle cells. Tallinna Tehnikaülikool. Tuuli Käämbre, MSc, 1999, superv. Enn Seppet, Valdur Saks. Oksüdatiivse fosforüülimise regulatsioon mitokondrites in vivo: interaktsioonid raku tsütoskeletiga. Tartu Ülikool. Allen Kaasik, PhD, 1998, superv. Enn Seppet. Thyroid hormone control over [beeta]-adrenergic signalling system in rat atria. Tartu Ülikool. Ave Minajeva, PhD, 1998, superv. Enn Seppet. Sarcoplasmic reticulum function: comparison of atrial and ventricular myocardium. Tartu Ülikool. Allen Kaasik, MSc, 1994, superv. Enn Seppet, Jorma Ohisalo. Türeoidhormooni mõju südame lihasraku signaalsüsteemidele: isoprenaliini ja adenosiini inotroopse toime moduleerimine. Tartu Ülikool. Lumme Kadaja, MSc, 1993, superv. Enn Seppet. Mitokondriaalse fosfokreatiini sünteesi türeoidne kontroll. Thyroid hormone control over mitochondrial phosphocreatine synthesis. Tartu Ülikool.
13.	Current research program	Pathophysiology of cardiovascular system, energetic metabolism of muscle cell
14.	Current grant funding	Ministry of Education of Estonia, Grant No 0182549s03 Mechanisms of integration and regulation of mitochondria and ATPases in normal and diseased oxidative muscle cell (Principal Investigator) Grant 5515 from the Estonian Science Foundation, Estonia. Functional complexes of mitochondria with ATPases as the principal units of energetical metabolism in oxidative muscle cells" (Principal Investigator). Grant 6142 from the Estonian Science Foundation, Estonia. Compartmentalized energy transfer in cardiomyocytes and mechanism of preconditioning (Senior Researcher).
15.	List of most important publications	Anmann T., Eimre M, Kuznetsov A.V., Andrienko T., Kaambre T., Sikk P., Seppet E., Tiivel T., Vendelin M., Seppet E. and Saks V.A. (2005). Calcium-induced contraction of sarcomeres changes regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal , 272, 3145-3161. Eimre M., Puhke R., Alev K., Seppet. E., Sikkut A., Peet N., Kadaja L, Lenzer A., Haviko T., Seene T., Saks V., Seppet E. Altered mitochondrial apparent affinity for ADP and impaired function of mitochondrial creatine kinase in gluteus medius of patients with hip osteoarthritis. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2005, Dec 15; [Epub ahead of print]. Saks V., Guerrero K., Vendelin M., Engelbrecht J., Seppet E. The creatine kinase isoenzymes in organized metabolic networks and regulation of cellular respiration: a new role for Maxwell’s demon. In: Creatine Kinase (Vial C., Ed.) in series: Molecular Anatomy and Physiology of Proteins (Uversky V.N., series Ed.), NovaScience Publishers, New York, 2005, in press. Seppet E., Eimre M., Peet N., Paju K., Orlova E., Ress M., Kovask S., Piirsoo A., Saks V.A., Gellerich F.N., Zierz S., Seppet E.K. (2005). Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Molecular and Cellular Biochemistry, 270(1-2), 49-61. Seppet E. K., Eimre M., Anmann T., Seppet E., Peet N., Käämbre T., Paju K., Piirsoo A., Kuznetsov A.V., Vendelin M., Gellerich F.N., Zierz S., Saks A.V. (2005). Intracellular energetic units in healthy and diseased hearts. Experimental and Clinical Cardiology, 10, 173-183. Kadaja L., Kisand KE., Peet N., Braun U., Metskula K., Teesalu K., Vibo R., Kisand KV., Uibo R., Jockusch H., Seppet EK. (2004). IgG from patients with liver diseases inhibit mitochondrial respiration in permeabilized oxidative muscle cells: impaired function of intracellular energetic units? Molecular and Cellular Biochemistry, 256/257(1-2), 291-303. Safiulina D., Kaasik A., Seppet E., Peet N., Zarkovski A., Seppet E. (2004). Method for in situ detection of the mitochondrial function in neurons. Journal of Neuroscience Methods, 137(1), 87-95 . Saks V.A., Kuznetsov A.V., Vendelin M., Guerrero K., Kay L., Seppet E.K. (2004). Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolism. Molecular and Cellular Biochemistry, 256/257(1-2), 185-199. Seppet E.K., Eimre M., Andrienko T., Kaambre T., Sikk P., Kuznetsov A.V., Saks V. (2004). Studies of mitochondrial respiration in muscle cells in situ: Use and misuse of experimental evidence in mathematical modelling. Molecular and Cellular Biochemistry, 256/257(1-2), 219-227. Vendelin M., Eimre M., Seppet E., Peet N., Andrienko T., Lemba M., Engelbrecht J., Seppet EK., Saks VA. (2004). Intracellular diffusion of adenosine phosphates is locally restricted in cardiac muscle. Molecular and Cellular Biochemistry, 256/257(1-2), 229-241. Puurand U., Kadaja L., Seppet E.K. (2003). Kindred DNA amplification from two distinct populations of cDNA fragments. BioTechniques, 34, 994-1000. Saks V.A., Kay L., Appaix F., Andrienko T. and Seppet E. Creatine kinase and brain energy metabolism: Function and disease. Eds. Téa Kekelidze and David Holtzman, NATO Science Series.Vol 342:3-25, 2003. IOS Press, The Netherlands. Saks V., Appaix F., Usson Y., Guerrero K., Olivares J., Seppet E, Aliev M., Margreiter R., Kuznetsov A. Localized control of oxidative phosphorylation within intracellular energetic units in heart cells: A possible solution of some old problems. In: Signal Transduction and Cardiac Hypertrophy. Dhalla NS et al (eds). Kluwer Academic Publishers, Boston, USA, 2003, pp. 265-284. Seppet E.K. (2003). Negative inotropy starts with the beta(3)-adrenoceptor. (2003). Cardiovascular Research, 59(2), 262-265 . Seppet E., Peet N., Paju K., Ress M., Saks V.A. Gellerich F.N. Chen Y., Trumbeckaite S., Prondzinsky R., Silber R.-E., Werdan K., Zierz S., Seppet E.K. Mitochondrial function in failing human myocardium in vivo: atrioventricular differences. In Cardiac Remodeling and Failure. Singal P.K. et al (Eds). Kluwer Academic Publishers, Boston, USA, 2003, pp. 459-470. Braun U., Paju K., Eimre M., Seppet E., Orlova E., Kadaja L., Trumbeckaite S., Gellerich F.N., Zierz S., Jockusch H., Seppet E.K. (2001). Lack of dystrophin is associated with altered integration of mitochondria and ATPases in slow-twitch muscle cells of MDX mice. Biochimica et Biophysica Acta-Bioenergetics, 1505, 258-270. Menin L., Panchichkina M., Keriel C., Olivares J., Braun U., Seppet E.K., Saks V.A. (2001). Macrocompartmentation of total creatine in cardiomyocytes revisited. Molecular and Cellular Biochemistry, 220, 149-159. Saks V.A., Kaambre T., Sikk P., Eimre M., Orlova E., Paju K., Piirsoo A., Appaix F., Kay L., Regitz-Zagrosek V., Fleck E., Seppet E. (2001). Intracellular energetic units in red muscle cells. Biochemical Journal, 356, 643-657. Seppet E.K., Kaambre T., Sikk P., Tiivel T., Vija H., Tonkonogi M., Sahlin K., Kay L., Appaix F., Braun U., Eimre M., Saks V.A. (2001). Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochimica et Biophysica Acta, 1504, 379-395. Gellerich F.N., Trumbeckaite S., Opalka J.R., Seppet E., Rasmussen H.N., Neuhoff C., Zierz S. (2000). Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases. Biochemical Society Transactions, 28(2), 164-169. Tiivel T., Kadaya L., Kuznetsov A., Käämbre T., Peet N., Sikk P., Braun U., Ventura-Clapier R., Saks V., Seppet E.K. (2000). Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Molecular and Cellular Biochemistry, 208, 119-128. Seppet E.K., Kaasik A., Paju K., Ohisalo J.J., Vetter R., Braun U. (1998). Mechanisms of thyroid hormone control over sensitivity and maximal contractile responsiveness to beta-adrenergic agonists in atria. In: Bioenergetics of the Cell: Quantitative Aspects. Molecular and Cellular Biochemistry, 184(1-2), 419-426. Kaasik A., Minajeva A., Paju K., Eimre M., Seppet E. (1997). Thyroid hormones differentially affect sarcoplasmic reticulum function in rat atria and ventricles. Molecular and Cellular Biochemistry, 176(1-2), 119-126. Kaasik A., Paju K., Vetter R., Seppet, E. (1997). Thyroid hormones increase the contractility but suppress the effects of beta-adrenergic agonist by decreasing phospholamban expression in rat atria. Cardiovascular Research, 35(1), 106-112. Minajeva A., Kaasik A., Paju K., Seppet E., Lompre A.-M., Veksler V., Ventura-Clapier R. (1997). Sarcoplasmic reticulum in determining atrio-ventricular contractile differences in rat heart. American Journal of Physiology-Heart and Circulatory Physiology, 273, H2498-H2507.

last updated: 05.10.2005