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| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Lumme |
| 2. | Perekonnanimi | Kadaja |
| 3. | Töökoht | Patofüsioloogia õppetool, üld-ja molekulaarpatoloogia instituut,arstiteaduskond,Tartu Ülikool |
| 4. | Ametikoht | Patoloogilise füsioloogia teadur |
| 5. | Sünniaeg | 17.08.1952 (päev.kuu.aasta) |
| 6. | Haridus | 1959–1967 Ingliste põhikool Rapla rajoonis Eestis 1967–1970 Rapla Keskkool Eestis 1971–1978 Tartu Ülikooli füüsika-keemiateaduskond, keemia osak. 1992–1993 Magistratuur (Biomeditsiin) TÜ arstiteaduskond 30.03.1993 Magistritöö "Mitokondriaalse fosfokreatiini sünteesi türeoidne kontroll" kaitsmine, magistrikraad biomeditsiini alal 2003–2004 Doktoriõppes (eksternina) TÜ arstiteaduskonnas 07.01.2004 doktoritöö "Mitokondrite funktsiooni regulatsiooni molekulaarsed aspektid oksüdatiivsetes lihasrakkudes" kaitsmine ning meditsiinidoktori kraad (doctor medicinae) |
| 7. | Teenistuskäik | Kutsealane teenistuskäik: 1981–1983 Tartu Ülikool, arstiteaduskond, ÜMPI hormonaalse regulatsiooni labor, vanemlaborant 1984–1988 Tartu Ülikool, ÜMPI hormonaalse regulatsiooni labor, insener 1989–1991 Tartu Ülikool, arstiteaduskond, ÜMPI, teadur 1993–2005 Tartu Ülikool, arstiteaduskond, ÜMPI,patofüsioloogia teadur Pedagoogiline tegevus: |
| 8. | Teaduskraad | Magister (Biomeditsiini alal) Doktorikraad, doctor medicinae |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Ülikool,1993 Tartu Ülikool,2004 |
| 10. | Tunnustused | Riiklikke tunnustusi ei ole |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
Rahvusvahelise Südameuuringute Assotsiatsiooni liige (ISHR) Skandinaavia Katseloomateaduse Assotsiatsiooni liige (Scand-LAS) |
| 12. | Juhendamisel kaitstud väitekirjad |
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| 13. | Teadustöö põhisuunad | Lihasraku energeetiline metabolism, mitokondrite regulatsiooni ja integratsioonimehhanismid teiste rakustruktuuridega normaalses ja haigestunud lihasrakus |
| 14. | Jooksvad grandid | ETF6142 Kompartmentaliseeritud energia transpordi võrgud kardiomüotsüütides ja eelkohastumise mehhanismid Olen veel ETF grandi (reg nr 5515) ning sihtfinantseeritava teema (reg nr 0182549s03) põhitäitja: Teadus- ja Haridusministeeriumi poolt sihtfinantseeritav teadusteema TARMP 0419 (reg nr. 0182549As03) Mitokondrite ja ATPaaside integratsiooni ja regulatsiooni mehhanismid normaalses ja haigestunud oksüdatiivses lihasrakus. ETF grant 5515 Mitokondrite ja ATPaaside funktsionaalsed kompleksid kui energeetilise metabolismi põhiüksused oksüdatiivsetes lihasrakkudes. |
| 15. | Teaduspublikatsioonid |
Kadaja, L., Kisand, K.E., Peet, N., Braun, U., Metsküla, K., Teesalu, K., Vibo, R., Kisand, K.V., Uibo, R., Jockusch, H., Seppet, E.K. IgG from patients with liver diseases inhibit mitochondrial respiration in permeabilized oxidative muscle cells: Impaired function of intracellular energetic units? Molecular and Cellular Biochemistry 2004, 256-257(1-2): 291-303 Puurand, Ü., Kadaja, L., Seppet, E. K. Kindred DNA amplification from two distinct populations of cDNA fragments. BioTechniques, 34: 994-1000, 2003. Braun, U., Paju, K., Eimre, M., Seppet, E., Orlova, E., Kadaja, L., Trumbeckaite, S., Gellerich, F. N., Zierz, S., Jockusch, H., Seppet E. K. Lack of dystrophin is associated with altered integration of the mitochondria and ATPases in slow-twitch muscle cells of MDX mice. Biochimica et Biophysica Acta 1505: 258–270, 2001. Tiivel, T., Kadaja, L., Kuznetsov, A., Käämbre, T., Peet, N., Sikk, P., Braun, U., Ventura-Clapier, R., Saks, V., Seppet, E. K. Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Molecular and Cellular Biochemistry 208: 119–128, 2000. Kuznetsov, V., Tiivel, T., Sikk, P., Käämbre, T., Kay, L., Daneshrad, Z., Rossi, A., Kadaja, L., Peet, N., Seppet, E., Saks, V. Striking difference between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. European. Journal of Biochemistry 241: 909–915, 1996. Seppet, E. K., Kadaya, L. Y., Hata, T., Kallikorm, A. P., Saks, V. A., Vetter, R., Dhalla, N. S. Thyroid control over membrane processes in rat heart. American Journal of Physiology 1991; 26: 66-71. Seppet, E. K., Kairane, C. B., Khuchua, Z. A., Kadaya, L. Y., Kallikorm, A. P., Saks, V. A. Hormone regulation of cardiac energy metabolism. III. Effect of thyroid state on distribution of creatine kinase isoenzymes and creatine-controlled respiration in cardiac muscle. Journal of Applied Cardiology 1991; 6: 301-311. Seppet, E. K., Kadaya, L. Y., Kallikorm, A. P., Saks, V. A. Hormone regulation of cardiac energy metabolism. II. The effect of thyroid state on the coupling between the reactions of oxidative phosphorylation and phosphocreatine synthesis in rat heart mitochondria. Journal of Applied Cardiology 1990; 5:367-381. |
viimati muudetud: 30.09.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Lumme |
| 2. | Surname | Kadaja |
| 3. | Institution | Department of Pathophysiology, Institute of General and Molecular Pathology, University of Tartu |
| 4. | Position | Research Fellow (pathophysiology) |
| 5. | Date of birth | 17.08.1952 (day.month.year) |
| 6. | Education | 1959–1967 Primary School in Ingliste, Rapla district,Estonia 1967–1970 Rapla Secondary School, Estonia 1971–1978 Faculty of Physics and Chemistry, University of Tartu 1992–1993 Master’s studies (Biomedicine), Faculty of Medicine, University of Tartu 30.03.1993 Master's thesis "Thyroid hormone control over mitochondrial phosphocreatine synthesis" and Master's degree (Biomed) 2003–2004 Doctoral studies (external student), Faculty of Medicine, Univesity of Tartu Jan.,7,2004 Doctoral Thesis "Molecular approach to the regulation of mitochondrial function in oxidative muscle cells" and the degree of doctor medicinae (D.M.) |
| 7. | Research and professional experience |
Professional Employment 1981–1983 Senior laboratory assistant, Institute of General and Molecular Pathology, Faculty of Medicine, University of Tartu 1984–1988 Engineer, Institute of General and Molecular Pathology, Faculty of Medicine, University of Tartu 1989–1991 Research Fellow, Institute of General and Molecular Pathology,Faculty of Medicine, University of Tartu 1993–2005 Research Fellow, Department of Pathophysiology, Institute of General and Molecular Pathology, University of Tartu |
| 8. | Academic degree | M.Sc. (Biomedicine) Doctoral Degree, D.M. |
| 9. | Dates and sites of earning the degrees |
Univesity of Tartu,1993 Univesity of Tartu,2004 |
| 10. | Honours/awards | No awards |
| 11. | Research-administrative experience |
The membership of International Society of Heart Researchers (ISHR) The membership of Scandinavian Society of Laboratory Animal Science (ScandLAS) |
| 12. | Supervised dissertations | |
| 13. | Current research program | Cellular energy metabolism, the mechanisms of mitochondrial regulation and integration with other cellular structures in healthy and diseased myocytes |
| 14. | Current grant funding | ETF6142 Compartmentalized energy transport networks in cardiomyocytes and mechanisms of preconditioning The grant (0182549As03) of Estonian Ministry of Education, TARMP 0419 The mechanisms of interaction and regulation of mitochondria with ATPases The grant of the Estonian Science Foundation (5515)Functional complexes of mitochondria with ATPases as basic units of energy metabolism in oxidative muscle cell |
| 15. | List of most important publications |
Kadaja, L., Kisand, K.E., Peet, N., Braun, U., Metsküla, K., Teesalu, K., Vibo, R., Kisand, K.V., Uibo, R., Jockusch, H., Seppet, E.K. IgG from patients with liver diseases inhibit mitochondrial respiration in permeabilized oxidative muscle cells: Impaired function of intracellular energetic units? Molecular and Cellular Biochemistry 2004, 256-257(1-2): 291-303 Puurand, Ü., Kadaja, L., Seppet, E. K. Kindred DNA amplification from two distinct populations of cDNA fragments. BioTechniques, 34: 994-1000, 2003. Braun, U., Paju, K., Eimre, M., Seppet, E., Orlova, E., Kadaja, L., Trumbeckaite, S., Gellerich, F. N., Zierz, S., Jockusch, H., Seppet E. K. Lack of dystrophin is associated with altered integration of the mitochondria and ATPases in slow-twitch muscle cells of MDX mice. Biochimica et Biophysica Acta 1505: 258–270, 2001. Tiivel, T., Kadaja, L., Kuznetsov, A., Käämbre, T., Peet, N., Sikk, P., Braun, U., Ventura-Clapier, R., Saks, V., Seppet, E. K. Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Molecular and Cellular Biochemistry 208: 119–128, 2000. Kuznetsov, V., Tiivel, T., Sikk, P., Käämbre, T., Kay, L., Daneshrad, Z., Rossi, A., Kadaja, L., Peet, N., Seppet, E., Saks, V. Striking difference between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. European. Journal of Biochemistry 241: 909–915, 1996. Seppet, E. K., Kadaya, L. Y., Hata, T., Kallikorm, A. P., Saks, V. A., Vetter, R., Dhalla, N. S. Thyroid control over membrane processes in rat heart. American Journal of Physiology 1991; 26: 66-71. Seppet, E. K., Kairane, C. B., Khuchua, Z. A., Kadaya, L. Y., Kallikorm, A. P., Saks, V. A. Hormone regulation of cardiac energy metabolism. III. Effect of thyroid state on distribution of creatine kinase isoenzymes and creatine-controlled respiration in cardiac muscle. Journal of Applied Cardiology 1991; 6: 301-311. Seppet, E. K., Kadaya, L. Y., Kallikorm, A. P., Saks, V. A. Hormone regulation of cardiac energy metabolism. II. The effect of thyroid state on the coupling between the reactions of oxidative phosphorylation and phosphocreatine synthesis in rat heart mitochondria. Journal of Applied Cardiology 1990; 5:367-381. |
last updated: 30.09.2005
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