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Elulookirjeldus (CV)
1.Eesnimi Lauri
2.Perekonnanimi Vares
3.Töökoht Tartu Ülikooli Tehnoloogiainstituut
4.Ametikoht Vanemteadur
5.Sünniaeg 27.03.1973 (päev.kuu.aasta)
6.Haridus Tallinna Tehnikaülikool, 1991-1996, lõpetanud keemiainsenerina.
7.Teenistuskäik • Alates juuli 2004 TÜ Tehnoloogiainstituut. Vanemteadur (kuni jaan. 2005 teadur);
• jaan. 2002 kuni dets. 2004 AstraZeneca R&D, keemia osakond, Södertälje, Rootsi. Vanemteadur;
• nov. 2000 kuni nov. 2001 Notre Dame Ülikool, USA. Järeldoktor;
• alates sept. 1999 Keemilise ja Bioloogilise Füüsika Instituut, Tallinn. Vanemteadur (kuni okt. 2000 teadur);
• jaan. 1999 kuni sept. 1999 TA Keemia Instituut, Tallinn. Teadur.
8.Teaduskraad Ph.D.
9.Teaduskraadi välja
andnud asutus, aasta		 Tartu Ülikool, 2000.
10.Tunnustused Minu Tallinna Tehnikaülikoolis sooritatud diplomitöö võitis esimese preemia üliõpilaste teadustööde kunkursil Eestis 1996-ndal aastal.
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus
12.Juhendamisel kaitstud
väitekirjad
13.Teadustöö põhisuunad • Atsetogeniinide analoogide süntees ning nende bioloogiliste ja füüsikaliste omaduste uurimine
• Ravimikandidaatide väljatöötamine polüskleroosi raviks.
• Tetrahüdrofuraanide ja tetrahüdropuraaride stereoselektiivne süntees kasutades asümmeetrilist Horner-Wadsworth-Emmons ja tsükliseerimise reakstioone. Nende meetodite rakendamine bioaktiivsete atsetogeniinide sünteesis.
• Konformatsiooniliselt piiratud ja mittepiiratud fosfolipiidide süntees ja nende omaduste uurimine.
14.Jooksvad grandid ETF (6520)
Tartu Ülikooli baasfinantseerimine (05906)
15.Teaduspublikatsioonid

Vares, L.; Koulov, A. V.; Smith, B. D. ”Synthesis and Supramolecular Properties of Conformationally Restricted Phospholipids” J. Org. Chem. 2003, 68, 10073.

Koulov, A. V.; Vares, L.; Jain, M.; Smith B. D. ”Cationic triple-chain amphiphiles facilitate vesicle fusion compared to double-chain or single-chain analogues” Biochim. Biophys. Acta 2002, 1564, 459.

Koulov A. V.; Vares L.; Smith B. D.; "Cationic triple-chain amphiphiles facilitate vesicle fusion compared to double-chain or single-chain analogues" BIOPHYSICAL JOURNAL 82 (1): 541A-541A 2646 Part 2, JAN 2002.

Vares, L.; Kann, N.; Rein, T. “A Versatile Stereocontrolled Approach to Chiral Tetrahydrofuran and Tetrahydropyran Derivatives by Use of Sequential Asymmetric Horner-Wadsworth-Emmons and Ring Closure Reactions” J. Org. Chem. 2002, 67, 7226.

Vares, L.; Koulov, A. V.; Smith, B. D. ”Highly impermeable vesicles composed of conformationally restricted phosphatidylethanolamine” Chem. Comm. 2002, 1482.

Rein T.; Vares L.; Kawasaki I.; Luhdorf A.; Nielsen K. "Stereocontrolled synthesis of chiral oxa- and azacycles via asymmetric horner-wadsworth-emmons reactions" ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 219: U95-U96 13-ORGN Part 2, MAR 26 2000.

Vares, L.; Rein, T. "A versatile stereocontrolled approach to chiral tetrahydrofuran and tetrahydropyran derivatives via sequential asymmetric Horner-Wadsworth-Emmons and palladium-catalyzed ring closure reactions" Org. Lett. 2000, 2, 2611.

Vares, L.; Rein, T. “A Versatile Stereocontrolled Approach to Chiral Tetrahydrofuran and Tetrahydropyran Derivatives by Use of Sequential Asymmetric Horner-Wadsworth-Emmons and Palladium-Catalyzed Ring Closure Reactions” Org. Lett. 2000, 2, 2611.(6) Rein, T.; Vares, L.; Kawasaki, I.; Pedersen, T. M.; Norrby, P. O.; Brandt, P.; Tanner, D. "Asymmetric Horner Wadsworth Emmons Reactions with Meso Dialdehydes: Scope, Mechanism, and Synthetic Applications" Phosphorus, Sulfur and Silicon 1999, 144 146, 169.

Parve, O.; Aidnik, M.; Lille, Ü.; Martin, I.; Vallikivi, I.; Vares, L.; Pehk, T. “The Tetrahydropyranyl-protected mandelic acid: a novel versatile chiral derivatazing agent" Tetrahedron:Asymmetry 1998, 9, 885.

Tullis, J. S.; Vares, L.; Kann, N.; Norrby, P.-O.; Rein, T. “Reagent Control of Geometric Selectivity and Enantiotopic Group Preference in Asymmetric Horner-Wadsworth-Emmons Reactions with meso-Dialdehydes” J. Org. Chem. 1998, 63, 8284.

Martin, I.; Anvelt, J.; Vares, L.; Kühn, I. and Claesson, A. "An Alternative Synthesis of the NMDA Antagonist CGS 19755 via Free Radical Carbamoylation of Ethyl Isonicotinate" Acta. Chem. Sand. 1995, 49, 230.

viimati muudetud: 24.01.2006

Curriculum Vitae (CV)
1.First Name Lauri
2.Surname Vares
3.Institution Tartu University Institute of Technology
4.Position Senior Researcher
5.Date of birth 27.03.1973 (day.month.year)
6.Education Tallinn Technical University, 1991-1996, graduated as chemistry engineer.
7.Research and
professional experience		 • Since Jul. 2004 University of Tartu Institute of Technology, Senior Researcher (up to Jan. 2005 Researcher);
• Jan. 2002 until dec. 2004 AstraZeneca, R&D Södertälje, Sweden. Senior Research Scientist;
• Nov. 2000 until Nov. 2001 University of Notre Dame, USA. Postdoctoral research associate, supervisor Prof. Bradley D. Smith;
• Since Sept. 1999 Institute of Chemical Physics and Biophysics, Tallinn, Estonia. Senior Researcher (until oct. 2000 researcher);
• Jan. 1999 until Sept. 1999 Institute of Chemistry at Tallinn Technical University, Tallinn, Estonia. Researcher.
8.Academic degree Ph.D.
9.Dates and sites of
earning the degrees		 Tartu University, 2000.
10.Honours/awards My Diploma work “The Application of Tetrahydropyranyloxy group in Stereoselective Alkylation Reactions” won the first prize in Competition of Students Scientific work in Estonia in 1996.
11.Research-administrative
experience
12.Supervised dissertations
13.Current research program • Acetogenin analogs: synthesis and its biological and physical properties
• Discovery of potential drugs against multiple sclerosis.
• Stereoselective synthesis of tetrahydropyran and tetrahydrofuran derivatives by use of sequential Horner-Wadsworth-Emmons and ring closure reactions. To apply the methods developed to the synthesis of bioactive acetogenins.
• Synthesis and supramolecular properties of conformationally restricted and corresponding flexible phospholipids.
14.Current grant funding The Estonian Science Foundation (6520)
Grant from the University of Tartu (05906)
15.List of most important publications

Vares, L.; Koulov, A. V.; Smith, B. D. ”Synthesis and Supramolecular Properties of Conformationally Restricted Phospholipids” J. Org. Chem. 2003, 68, 10073.

Koulov, A. V.; Vares, L.; Jain, M.; Smith B. D. ”Cationic triple-chain amphiphiles facilitate vesicle fusion compared to double-chain or single-chain analogues” Biochim. Biophys. Acta 2002, 1564, 459.

Koulov A. V.; Vares L.; Smith B. D.; "Cationic triple-chain amphiphiles facilitate vesicle fusion compared to double-chain or single-chain analogues" BIOPHYSICAL JOURNAL 82 (1): 541A-541A 2646 Part 2, JAN 2002.

Vares, L.; Kann, N.; Rein, T. “A Versatile Stereocontrolled Approach to Chiral Tetrahydrofuran and Tetrahydropyran Derivatives by Use of Sequential Asymmetric Horner-Wadsworth-Emmons and Ring Closure Reactions” J. Org. Chem. 2002, 67, 7226.

Vares, L.; Koulov, A. V.; Smith, B. D. ”Highly impermeable vesicles composed of conformationally restricted phosphatidylethanolamine” Chem. Comm. 2002, 1482.

Rein T.; Vares L.; Kawasaki I.; Luhdorf A.; Nielsen K. "Stereocontrolled synthesis of chiral oxa- and azacycles via asymmetric horner-wadsworth-emmons reactions" ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 219: U95-U96 13-ORGN Part 2, MAR 26 2000.

Vares, L.; Rein, T. "A versatile stereocontrolled approach to chiral tetrahydrofuran and tetrahydropyran derivatives via sequential asymmetric Horner-Wadsworth-Emmons and palladium-catalyzed ring closure reactions" Org. Lett. 2000, 2, 2611.

Vares, L.; Rein, T. “A Versatile Stereocontrolled Approach to Chiral Tetrahydrofuran and Tetrahydropyran Derivatives by Use of Sequential Asymmetric Horner-Wadsworth-Emmons and Palladium-Catalyzed Ring Closure Reactions” Org. Lett. 2000, 2, 2611.(6) Rein, T.; Vares, L.; Kawasaki, I.; Pedersen, T. M.; Norrby, P. O.; Brandt, P.; Tanner, D. "Asymmetric Horner Wadsworth Emmons Reactions with Meso Dialdehydes: Scope, Mechanism, and Synthetic Applications" Phosphorus, Sulfur and Silicon 1999, 144 146, 169.

Parve, O.; Aidnik, M.; Lille, Ü.; Martin, I.; Vallikivi, I.; Vares, L.; Pehk, T. “The Tetrahydropyranyl-protected mandelic acid: a novel versatile chiral derivatazing agent" Tetrahedron:Asymmetry 1998, 9, 885.

Tullis, J. S.; Vares, L.; Kann, N.; Norrby, P.-O.; Rein, T. “Reagent Control of Geometric Selectivity and Enantiotopic Group Preference in Asymmetric Horner-Wadsworth-Emmons Reactions with meso-Dialdehydes” J. Org. Chem. 1998, 63, 8284.

Martin, I.; Anvelt, J.; Vares, L.; Kühn, I. and Claesson, A. "An Alternative Synthesis of the NMDA Antagonist CGS 19755 via Free Radical Carbamoylation of Ethyl Isonicotinate" Acta. Chem. Sand. 1995, 49, 230.

last updated: 24.01.2006

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