[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Aleksander |
| 2. | Perekonnanimi | Žarkovski |
| 3. | Töökoht | Tartu Ülikool, farmakoloogia instituut |
| 4. | Ametikoht | Farmakoloogia ja toksikologia professor, instituudi juhataja |
| 5. | Sünniaeg | 31.01.1950 (päev.kuu.aasta) |
| 6. | Haridus | Tartu Ülikool, arstitedauskond, 1974 |
| 7. | Teenistuskäik | TÜ teadur, 1978-1979; õpetaja, 1979-1980; vanemõpetaja, 1981-1983; dotsent, 1983-1985; vanemteadur, 1985-1991; professor, alates 1991. |
| 8. | Teaduskraad | Med Kand. Meditsiini Teaduste doktor |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu ülikool, 1978 Eksperimentaalse Meditsiini Instituut ST.Peterburg, 1988 |
| 10. | Tunnustused | Eesti Vabariigi teaduspreemia meditsiini alal aastal 2000 |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
Eesti Farmakoloogia Selts, 1976 ajakirja Naunyn-Schmiedeberg's Archives of Pharmacology kolleegiumi liige 1993 Eur. Society on Biomedical Research of Alcoholism (liige) 1993 British Psychopharmacological Society (liige) 1996 Eur. Behavioural Pharmacology Society (liige) 1988 Euroopa Liit; grantide (biomeditsiin, biotehnoloogia) hindamise ekspert, 1996 Euroopa liit, INTAS grantide hindamise expert ETF komisjooni liige (Meditsiin) TÜ arstiteaduskonna nõukogu liige Eeesti Bioloogilise Psühhiaatria Seltsi president |
| 12. | Juhendamisel kaitstud väitekirjad |
Minika Jurgenson, MSc, 2005, juh. Aleksander Zarkovski. Plii toime käitumisele ja aju neurogeneesile. Ekspeimentaaluuring. Tartu Ülikool Anti Kalda, PhD, 1998, juh. Aleksander Zarkovski. Oxygen-glucose deprivation-induced neuronal death and its pharmacological prevention in cerebellar granule cells. Tartu Ülikool Elo Eriste, MSc, 1998, juh. Aleksander Zarkovski. Neuroprotective effects of the isomers of ketamine. Tartu Ülikool Paavo Pokk, PhD, 1997, juh. Aleksander Zarkovski. Stress due to sleep deprivation: Focus on GABA receptor chloride ionophore complex. Tartu Ülikool Toomas Kivastik, PhD, 1996, juh. Aleksander Zarkovski. Mechanisms of drug addiction: focus on positive reinforcing properties of morphine. Tartu Ülikool Kästutis Cereska, PhD, 1990, juh. Aleksander Zarkovski. The role of dopamine D1 and D2 receptors in the mechisms of the action of neuroleptics. Tartu Ülikool |
| 13. | Teadustöö põhisuunad | Neurodegeneratsiooni mehhanismid. Neuroprotektantide farmakoloogia. Aju plastilisuse ja neurogeneesi mehhanismid. Aju plastilisuse ja neurogeneesi stimuleerivate ainete toimemehhanismi uuringud |
| 14. | Jooksvad grandid | EV Hariduse Ministeeriumi Sihtfinantseerimise teema TARFR 2135 " Affektiivsete häirete ja neurodegeneratiivsete haiguste farmakoteraapia alused" (2001-2006) EAS Grant EU21465 " Ravimite koosmõjude eeluuring" 2005 EL VI Raamprogramm,grant nr. 512012 " Rakkude äratundmisest mälu formeerumiseni. Uued strateegiad düsfunktsionaalse plastilisuse, õppimise ja mälu ravis. ETF grant GARFR 6504 "Neuronaalse raku adhesiooni molekuli (NCAM) roll aju plastilisuses ja regeneratsioonis (2005-2008) |
| 15. | Teaduspublikatsioonid |
Arbatova J, D'Amato T, Vaarmann A, Zharkovsky A, Reeben M. Reduced serotonin and 3-hydroxyanthranilic acid levels in serum of cystatin B-deficient mice, a model system for progressive myoclonus epilepsy.EPILEPSIA 46: 49-51 Suppl. 5, 2005 Heidmets LT, Zharkovsky T, Jurgenson M, Jaako-Movits K, Zharkovsky A. Early post-natal, low-level lead exposure increases the number of PSA-NCAM expressing cells in the dentate gyrus of adult rat hippocampus.Neurotoxicology. 2005 Sep 14; [Epub ahead of print] PMID: 16169083 [PubMed - as supplied by publisher] Jaako-Movits K, Zharkovsky T, Kaasik A, Zharkovsky A. Chronic ethanol administration and hippocampal neurogenesis. EUROPEAN NEUROPSYCHOPHARMACOLOGY 15: S271-S271 Suppl. 2, APR 2005 Jaako-Movits K, Zharkovsky T, Romantchik O, Jurgenson M, Merisalu E, Heidmets LT, Zharkovsky A. Developmental lead exposure impairs contextual fear conditioning and reduces adult hippocampal neurogenesis in the rat brain.Int J Dev Neurosci. 2005 Sep 5; [Epub ahead of print] PMID: 16150564 [PubMed - as supplied by publisher] Kaasik A, Rikk T, Piirsoo A, Zharkovsky T, Zharkovsky A Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. EUROPEAN JOURNAL OF NEUROSCIENCE 22 (5): 1023-1031 SEP 2005 Safiulina D, Veksler V, Kaur A, Zharkovsky A, Kaasik A. Loss of mitochondrial membrane potential is associated with increase in mitochondrial volume. Physiological role in neurons. BIOPHYSICAL JOURNAL 88 (1): 506A-506A Part 2 Suppl. S, JAN 2005 Safiulina D, Veksler V, Zharkovsky A, Kaasik A. Loss of mitochondrial membrane potential is associated with increase in mitochondrial volume: Physiological role in neurones.J Cell Physiol. 2005 Aug 18; [Epub ahead of print] PMID: 16110491 [PubMed - as supplied by publisher] Poder P, Zilmer M, Starkopf J, Kals J, Talonpoika A, Pulges A, Langel U, Kullisaar T, Viirlaid S, Mahlapuu R, Zarkovski A, Arend A, Soomets U. An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. NEUROSCIENCE LETTERS 370 (1): 45-50 NOV 3 2004 Safiulina D, Kaasik A, Seppet E, Peet N, Zharkovsky A, Seppet E. Method for in situ detection of the mitochondrial function in neurons. Source: JOURNAL OF NEUROSCIENCE METHODS 137 (1): 87-95 AUG 15 2004 Safiulina D, Peet N, Zharkovsky A, Seppet E, Kaasik A. Neurotoxicty of dehydroepiandrosterone is associated with inhibition of NADH : ubiquinone oxidoreductase.BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1658: 140-140 Suppl. S, 2004 Jaako K, Zharkovsky T, Kaasik A, Zharkovsky A. Ethanol intoxication reduces, whereas ethanol withdrawal transiently enhances, production of the neural progenitor cells in the adult mouse dentate gyrus. NEUROSCIENCE RESEARCH COMMUNICATIONS 33 (3): 158-167 NOV-DEC 2003 Kaasik A, Safiulina D, Kalda A, Zharkovsky A. Dehydroepiandrosterone with other neurosteroids preserve neuronal mitochondria from calcium overload. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 87 (1): 97-103 OCT 2003 Zharkovsky A, Jaako K, Zharkovsky T, Beljaev S. Addictive drugs and hippocampal neurogenesis. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 19: S6-S6 Suppl. 1, JUN 2003 Zharkovsky T, Kaasik A, Jaako K, Zharkovsky A. Neurodegeneration and production of the new cells in the dentate gyrus of juvenile rat hippocampus after a single administration of ethanol. BRAIN RESEARCH 978 (1-2): 115-123 JUL 18 2003 Kaasik A, Kalda A, Jaako K, Zharkovsky A. Dehydroepiandrosterone sulphate prevents oxygen-glucose deprivation-induced injury in cerebellar granule cell culture. NEUROSCIENCE 102 (2): 427-432 2001 Kalda A, Kaasik A, Vassiljev V, Pokk P, Zharkovsky A. Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal death. BRAIN RESEARCH 853 (2): 370-373 JAN 24 2000 |
viimati muudetud: 12.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Aleksander |
| 2. | Surname | Žarkovski |
| 3. | Institution | University of Tartu, Department of Pharmacology |
| 4. | Position | Professor of pharmacology and toxicology, Head of the Department |
| 5. | Date of birth | 31.01.1950 (day.month.year) |
| 6. | Education | University of Tartu, Medical Faculty, 1974 |
| 7. | Research and professional experience |
University of tartu: researcher, 1978-1979; lecturer, 1979-1980; senior lecturer, 1981-1983; docent, 1983-1985; senior research fellow, 1985-1991; professor since 1991- |
| 8. | Academic degree | PhD Doctor of Medical Sciences |
| 9. | Dates and sites of earning the degrees |
University of Tartu, 1978 Institute of Experimental Medicine, St Petersburg, 1988 |
| 10. | Honours/awards | Estonian State Prize in Biomedical Research, 2000 |
| 11. | Research-administrative experience |
Estonian Pharmacologica society, liige 1976 Member of Editorial Board of Naunyn Schmiedebrerg's Archives of Pharmacology since 1993 Expert on Grant assessment in IV FWP European Community, (Biotech, Biomed) 1996 Eur. Society on Biomedical Research of Alcoholism (ember) 1993 British Psychopharmacological Society (member) 1996 EC INTAS grant programme reviewer ESF Komisjoni liige (Medical Sciences) Eur. Behavioural Pharmacology Society (member) 1988 Reviewer for applications for docentur/associating professorship/ full professorship in pharmacology and drug toxicology In Estonia and Finland Reviewer for articles in scientific journals such as Pharmacol Biochem. Behav., J Neurosci, Neurosci. Tartu University Medical faculty council (member) |
| 12. | Supervised dissertations |
Minika Jurgenson, MSc, 2005, superv. Aleksander Zarkovski. Plii toime käitumisele ja aju neurogeneesile. Ekspeimentaaluuring. Tartu Ülikool Anti Kalda, PhD, 1998, superv. Aleksander Zarkovski. Oxygen-glucose deprivation-induced neuronal death and its pharmacological prevention in cerebellar granule cells. Tartu Ülikool Elo Eriste, MSc, 1998, superv. Aleksander Zarkovski. Neuroprotective effects of the isomers of ketamine. Tartu Ülikool Paavo Pokk, PhD, 1997, superv. Aleksander Zarkovski. Stress due to sleep deprivation: Focus on GABA receptor chloride ionophore complex. Tartu Ülikool Toomas Kivastik, PhD, 1996, superv. Aleksander Zarkovski. Mechanisms of drug addiction: focus on positive reinforcing properties of morphine. Tartu Ülikool Kästutis Cereska, PhD, 1990, superv. Aleksander Zarkovski. The role of dopamine D1 and D2 receptors in the mechisms of the action of neuroleptics. Tartu Ülikool |
| 13. | Current research program | Mechanisms of the neurodegeneration. Pharmacology of new neuroprotectants. Mechanisms of brain plasticity and neurogenesis. Search for new drugs enhancing brain plasticity and neurogenesis. |
| 14. | Current grant funding | Ministry of higher Education Grant no TARFR 2135 " Pharmacotherapy of affective disorders and neurodegenerative diseases" (2001-2006) EAS Grant EU21465 "Drug Interaction. Preliminary analysis" (2005) EU 6FWP Grant no. 512012 " From cell - cell recognition to memory formation. New strategies for the treatment of dysfunctional plasticity, learning and memory" (2005-2008) ETF Grant GARFR 6504 " The role of neuronal adhesion molecules (NCAMs) in the brain plasticity and repair". (2005-2008) |
| 15. | List of most important publications |
Arbatova J, D'Amato T, Vaarmann A, Zharkovsky A, Reeben M. Reduced serotonin and 3-hydroxyanthranilic acid levels in serum of cystatin B-deficient mice, a model system for progressive myoclonus epilepsy.EPILEPSIA 46: 49-51 Suppl. 5, 2005 Heidmets LT, Zharkovsky T, Jurgenson M, Jaako-Movits K, Zharkovsky A. Early post-natal, low-level lead exposure increases the number of PSA-NCAM expressing cells in the dentate gyrus of adult rat hippocampus.Neurotoxicology. 2005 Sep 14; [Epub ahead of print] PMID: 16169083 [PubMed - as supplied by publisher] Jaako-Movits K, Zharkovsky T, Kaasik A, Zharkovsky A. Chronic ethanol administration and hippocampal neurogenesis. EUROPEAN NEUROPSYCHOPHARMACOLOGY 15: S271-S271 Suppl. 2, APR 2005 Jaako-Movits K, Zharkovsky T, Romantchik O, Jurgenson M, Merisalu E, Heidmets LT, Zharkovsky A. Developmental lead exposure impairs contextual fear conditioning and reduces adult hippocampal neurogenesis in the rat brain.Int J Dev Neurosci. 2005 Sep 5; [Epub ahead of print] PMID: 16150564 [PubMed - as supplied by publisher] Kaasik A, Rikk T, Piirsoo A, Zharkovsky T, Zharkovsky A Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. EUROPEAN JOURNAL OF NEUROSCIENCE 22 (5): 1023-1031 SEP 2005 Safiulina D, Veksler V, Kaur A, Zharkovsky A, Kaasik A. Loss of mitochondrial membrane potential is associated with increase in mitochondrial volume. Physiological role in neurons. BIOPHYSICAL JOURNAL 88 (1): 506A-506A Part 2 Suppl. S, JAN 2005 Safiulina D, Veksler V, Zharkovsky A, Kaasik A. Loss of mitochondrial membrane potential is associated with increase in mitochondrial volume: Physiological role in neurones.J Cell Physiol. 2005 Aug 18; [Epub ahead of print] PMID: 16110491 [PubMed - as supplied by publisher] Poder P, Zilmer M, Starkopf J, Kals J, Talonpoika A, Pulges A, Langel U, Kullisaar T, Viirlaid S, Mahlapuu R, Zarkovski A, Arend A, Soomets U. An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. NEUROSCIENCE LETTERS 370 (1): 45-50 NOV 3 2004 Safiulina D, Kaasik A, Seppet E, Peet N, Zharkovsky A, Seppet E. Method for in situ detection of the mitochondrial function in neurons. Source: JOURNAL OF NEUROSCIENCE METHODS 137 (1): 87-95 AUG 15 2004 Safiulina D, Peet N, Zharkovsky A, Seppet E, Kaasik A. Neurotoxicty of dehydroepiandrosterone is associated with inhibition of NADH : ubiquinone oxidoreductase.BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1658: 140-140 Suppl. S, 2004 Jaako K, Zharkovsky T, Kaasik A, Zharkovsky A. Ethanol intoxication reduces, whereas ethanol withdrawal transiently enhances, production of the neural progenitor cells in the adult mouse dentate gyrus. NEUROSCIENCE RESEARCH COMMUNICATIONS 33 (3): 158-167 NOV-DEC 2003 Kaasik A, Safiulina D, Kalda A, Zharkovsky A. Dehydroepiandrosterone with other neurosteroids preserve neuronal mitochondria from calcium overload. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 87 (1): 97-103 OCT 2003 Zharkovsky A, Jaako K, Zharkovsky T, Beljaev S. Addictive drugs and hippocampal neurogenesis. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 19: S6-S6 Suppl. 1, JUN 2003 Zharkovsky T, Kaasik A, Jaako K, Zharkovsky A. Neurodegeneration and production of the new cells in the dentate gyrus of juvenile rat hippocampus after a single administration of ethanol. BRAIN RESEARCH 978 (1-2): 115-123 JUL 18 2003 Kaasik A, Kalda A, Jaako K, Zharkovsky A. Dehydroepiandrosterone sulphate prevents oxygen-glucose deprivation-induced injury in cerebellar granule cell culture. NEUROSCIENCE 102 (2): 427-432 2001 Kalda A, Kaasik A, Vassiljev V, Pokk P, Zharkovsky A. Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal death. BRAIN RESEARCH 853 (2): 370-373 JAN 24 2000 |
last updated: 12.10.2005
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