[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Lagle |
| 2. | Perekonnanimi | Kasak |
| 3. | Töökoht | Keemilise ja Bioloogilise Füüsika Instituut AS Vähiuuringute Tehnoloogia Arenduskeskus |
| 4. | Ametikoht | teadur |
| 5. | Sünniaeg | 16.04.1953 (päev.kuu.aasta) |
| 6. | Haridus | Tartu Ülikool (TÜ), 1976 |
| 7. | Teenistuskäik | alates 1.sept.2005 KBFI, teadur 0,5 koormusega AS Vähiuuringute Tehnoloogia Arenduskeskus, teadur 0,5 koormusega 1. sept . 2001 - 1. sept. 2005 KBFI, teadur 1988-2000 TÜ Molekulaar-ja Rakubioloogia Instituut, teadur 1976-1988 TÜ Geneetika ja tsütoloogia kateeder, v. laborant |
| 8. | Teaduskraad | Teadusmagister (M.Sc) |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Ülikool, 1998 |
| 10. | Tunnustused | |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
|
| 12. | Juhendamisel kaitstud väitekirjad |
|
| 13. | Teadustöö põhisuunad | retseptorvalgu CD44 roll angiogeneesi inhibiitorina ja selle funktsiooni rakendatavus vähkkasvaja arengu kontrollimiseks retseptorvalgule CD44 uute interaktsioonipartnerite leidmine ja nende interaktsioonide bioloogilise rolli välja selgitamine |
| 14. | Jooksvad grandid | |
| 15. | Teaduspublikatsioonid |
Trummal K., Tõnismägi K., Siigur E., Aaspõllu A., Lopp A., Sillat T., Saat R., Kasak L., Tammiste I., Kogerman P., Kalkkinen N., Siigur J. (2005).A novel metalloprotease from Vipera lebetina induces human endothelial cell apoptosis. Toxicon, 46, 41-61 Päll, T., Gad, A., Kasak, L., Drews, M., Stromblad, S., & Kogerman, P. (2004). Recombinant CD44-HABD is a novel and potent direct angiogenesis inhibitor enforcing endothelial cell-specific growth inhibition independently of hyaluronic acid binding. Oncogene, 23(47), 7874-7881 Saumaa, S., Tover, A., Kasak, L., & Kivisaar, M. (2002). Different Spectra of Stationary-Phase Mutations in Early- Arising Versus Late-Arising Mutants of Pseudomonas Putida: Involvement of the Dna Repair Enzyme Muty and the Stationary- Phase Sigma Factor Rpos. Journal of Bacteriology, 184(24), 6957-6965 Kasak, L., Hõrak, R., & Kivisaar, M. (1997). Promoter-Creating Mutations in Pseudomonas Putida: a Model System for the Study of Mutation in Starving Bacteria. Proceedings of the National Academy of Sciences of the United States of America, 94(7), 3134-3139 |
viimati muudetud: 17.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Lagle |
| 2. | Surname | Kasak |
| 3. | Institution | National Institute of Chemical Physics and Biophysics (NICPB) Competence Centre for Cancer Research (CCCP) |
| 4. | Position | researcher |
| 5. | Date of birth | 16.04.1953 (day.month.year) |
| 6. | Education | Tartu University (TU), 1976 |
| 7. | Research and professional experience |
from 1. Sept. 2005 NICPB, researcher 0,5 CCCR, researcher 0,5 1. Sept. 2001 - 1. Sept. 2005 NICPB, researcher 1988-2000 Institute of Molecular and Cell Biology, TU, researcher 1976-1988 TU, Dep. of Genetics, Sen. lab. assistant |
| 8. | Academic degree | M.Sc. |
| 9. | Dates and sites of earning the degrees |
Tartu University, 1998 |
| 10. | Honours/awards | |
| 11. | Research-administrative experience |
|
| 12. | Supervised dissertations | |
| 13. | Current research program | CD44 as a novel and potential therapeutic angiogenesis inhibitor Screening of CD44 binding proteins and specification biological significance these interactions |
| 14. | Current grant funding | |
| 15. | List of most important publications |
Trummal K., Tõnismägi K., Siigur E., Aaspõllu A., Lopp A., Sillat T., Saat R., Kasak L., Tammiste I., Kogerman P., Kalkkinen N., Siigur J. (2005).A novel metalloprotease from Vipera lebetina induces human endothelial cell apoptosis. Toxicon, 46, 41-61 Päll, T., Gad, A., Kasak, L., Drews, M., Stromblad, S., & Kogerman, P. (2004). Recombinant CD44-HABD is a novel and potent direct angiogenesis inhibitor enforcing endothelial cell-specific growth inhibition independently of hyaluronic acid binding. Oncogene, 23(47), 7874-7881 Saumaa, S., Tover, A., Kasak, L., & Kivisaar, M. (2002). Different Spectra of Stationary-Phase Mutations in Early- Arising Versus Late-Arising Mutants of Pseudomonas Putida: Involvement of the Dna Repair Enzyme Muty and the Stationary- Phase Sigma Factor Rpos. Journal of Bacteriology, 184(24), 6957-6965 Kasak, L., Hõrak, R., & Kivisaar, M. (1997). Promoter-Creating Mutations in Pseudomonas Putida: a Model System for the Study of Mutation in Starving Bacteria. Proceedings of the National Academy of Sciences of the United States of America, 94(7), 3134-3139 |
last updated: 17.10.2005
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