[ sulge aken ]

Elulookirjeldus (CV)
1.Eesnimi Tõnis
2.Perekonnanimi Timmusk
3.Töökoht Geenitehnoloogia Instituut, Matemaatika- loodusteaduskond, Tallinna Tehnikaülikool
4.Ametikoht Professor, molekulaarbiolooogia õppetooli juhataja
5.Sünniaeg 07.01.1959 (päev.kuu.aasta)
6.Haridus 1977, Tallinna 7. Keskkool
1982, Tartu Ülikool, Bioloogia-geograafiateduskond, geneetik-tsütoloogi erialal
1994, Ph.D. molekulaarse neurobioloogia erialal, Karolinska Instituut, Stockholm, Rootsi.
2000, Neurobioloogia dotsent, Helsingi Ülikool, Soome
7.Teenistuskäik 1985.05 - 1991.07; nooremteadur, molekulaargeneetika labor, Keemilise ja Bioloogilise Füüsika Instituut, Tallinn, Eesti.
1991.07 - 1991.11; külalisteadur, Biotehnoloogia Instituut, Helsingi Ülikool, Helsingi, Soome.
1991.11 - 1994.06; doktorant, molekulaarse neurobioloogia labor, Karolinska Instituut, Stockholm, Rootsi.
1994.06 - 1995.04; teadur, molekulaarse neurobioloogia labor, Karolinska Instituut, Stockholm, Rootsi.
1995.04 - 1996.11; Rootsi Meditsiiniuuringute Fondi abiprofessor, Karolinska Instituut, Stockholm, Rootsi.
1996.11 - 1999.07; Rootsi Meditsiiniuuringute Fondi abiprofessor, Neurobioloogia Instituut, Biomeditsiini Keskus (BMC), Uppsala Ülikool, Uppsala, Rootsi.
1999.07 - 2001.07 ; vanemteadur, Biotehnoloogia Instituut, Helsingi Ülikool, Helsingi, Soome.
2001.08 - 2003.07 ; Soome Akadeemia vanemteadur, Biotehnoloogia Instituut, Helsingi Ülikool, Helsingi, Soome.
2002.09 - ; professor, Geenitehnoloogia Instituut, Tallinna Tehnikaülikool. molekulaarbioloogia oppetooli juhataja.
2003.02 - 2005.05; Wellcome Trusti vanemteadur, Keemilise ja Bioloogilise Füüsika Instituut, Tallinn.
2005.05 - Wellcome Trusti vanemteadur, Geenitehnoloogia Instituut, Tallinna Tehnikaülikool
8.Teaduskraad Ph.D.
9.Teaduskraadi välja
andnud asutus, aasta		 Karolinska Instituut, Stockholm, Rootsi, 1994
10.Tunnustused
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus		 1. Olen hinnanud anonüümse eksperdina rahvusvahelistesse teadusajakirjadesse Journal of Neuroscience, Neuroscience, Journal of Neurochemistry, Molecular Brain Research, Neuroscience Letters, Cell and Tissue Researsch, BBA, FEBS Letters, Experimental Cell Research, Cytokine, Journal of Molecular Biology, Journal of Biological Chemistry saadetud käsikirju.
2. Olen Eesti Tedusfondi keemia ja molekulaarbioloogia ekspertkomisjoni liige ja Haridus- ja Teadusministeeriumi Teaduskompetentsi Noukogu molekulaarbioloogia ekspertgrupi liige.
3. Rahvusvahelise Aju Uurimise Organisatsiooni (IBRO) neurobioloogia alase loengukursuse kaasorganiseerija 2005.06. Tallinna Tehnikaülikoolis
12.Juhendamisel kaitstud
väitekirjad

Anna Kazantseva, MSc, 2005, juh. Tõnis Timmusk. Genomic structure, promoter analysis and expression of the human BDNF and antiBDNF genes. Tallinna Tehnikaülikool

Karin Tamm, MSc, 2005, juh. Marko Piirsoo, Tõnis Timmusk, Jüri Kärner. BDNF-i geeni regulatsioon Schwanni rakkude arengus. Tartu Ülikool

Priit Pruunsild, MSc, 2005, juh. Tõnis Timmusk. Structure, alternative splicing and expression of human and mouse KCNIP gene family. Tallinna Tehnikaülikool

Tamara Aid, MSc, 2005, juh. Tõnis Timmusk, Kaia Palm. Mouse and rat BDNF gene structure revisited: BAC transgenic constructs for studying regulation of BDNF gene expression in vivo. Tallinna Tehnikaülikool
13.Teadustöö põhisuunad 1. Neurotrofiinide geenide ekspressiooni regulatsioon närvisüsteemis
2. Neuraalsete geenide ekspressiooni regulatsioon
3. Neurotroofsete faktorite ja nende retseptorite rakusisese signaali ülekande mehhanismid
4. Närvirakkude determinatsioon ja diferentseerumine
14.Jooksvad grandid 1. Wellcome Trusti Rahvusvahelise Vanemteaduri uurimisgrant 067952 " Neurotrofiinide geeniregulatsioon närvisüsteemis" , 2003 - 2008.
2. Eeti Teadusfondi grant 5555 "Drosophila neuralized geeni homoloogid imetajates", 2003 - 2005.
3. Eesti Haridus- ja Teadusministeeriumi sihtfnantseerimise grant 0222602s03 "Geeniekspressiooni regulatsioon närvisüsteemis" 2003 - 2007.
15.Teaduspublikatsioonid

Pruunsild P, Timmusk T. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. Genomics, 2005, 86, 581-593.

Uvarov, P., Pruunsild, P., Timmusk, T., Airaksinen M.S., KCC2 transgenes lacking neuron restrictive silencer element recapitulate CNS neuron-specific expression and developmental upregulation of endogenous KCC2 gene. J. Neurochem., 2005, Aug 25; [Epub ahead of print].

Laurén, J., Airaksinen M. S., Saarma, M., Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics, 2003, 81, 411-421.

Laurén, J., Airaksinen, M. S., Saarma, M., Timmusk, T. Two Novel Mammalian Nogo Receptor Homologs Differentially Expressed in the Central and Peripheral Nervous System. Mol. Cell. Neurosci., 2003, 24, 581-594.

Zuccato, C., Tartari, M., Crotti, A., Goffredo, D., Valenza, M., Conti, L., Cataudella, T., Leavitt, L., Hayden, M. R., Timmusk, T., Rigamonti D., Cattaneo, E. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature Genetics, 2003, 35, 76-83.

Airaksinen, M. S., Poteriaev, D., Lindahl, M., Timmusk, T., Rossi, J. and Saarma, M. Compounds related to or derived from GFR_4 and their use. US Patent application. Docket No. 108306-00014. August 21, 2002.

Palm, K., Timmusk, T. Mammalian neuralized family transcriptional regulators and uses therefore. US Patent Application 20020132293. September 19, 2002.

Saarma, M., Laurén, J., Lindholm, P. and Timmusk, T. Novel neurotrophic factors and uses thereof. US patent application. Filed 30.08.2002.

Timmusk, T., Palm, K., Belluardo, N., Mudo, G., Neuman, T. Dendritic localization of mammalian neuralized mRNA encoding a protein with transcription repression activities. Mol. Cell. Neurosci., 2002, 20, 649-668.

Lindahl, M. S., Poteryaev, D., Yu, L.-Y., Arumäe, U., Timmusk, T., Bongarzone, I., Aiello, A., Pierotti, M. A., Airaksinen, M. S., Saarma, M. Human GFRa4 is the receptor for persephin, and is selectively expressed in normal and malignant thyroid meddullary cells. J. Biol. Chem., 2001, 276, 9344-9351.

Sun, Y.-F., Yu, L.-Y., Saarma, M., Timmusk, T., Arumäe, U. Neuron-specific BH3-only splice variant of Bak is anti-apoptotic in neurons but pro-apoptotic in nonneuronal cells. J. Biol. Chem., 2001, 276, 16240-16247.

Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., Conti, L., MacDonald, M. E., Friedlander, R. M., Silani, V., Hayden, M. R., Timmusk, T., Sipione, S., Cattaneo, E. Loss of Huntingtin-Mediated BDNF gene transcription in Huntington's disease. Science, 2001, 293, 493-498.

Lindahl, M., Timmusk, T., Rossi, J., Saarma, M., Airaksinen, M. Expression and alternative splicing of mouse Gfra4 suggests roles in endocrine cell development. Mol. Cell. Neurosci., 2000, 15, 522-533.

Palm K., Metsis M., Timmusk T. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Mol. Brain Res., 1999, 72, 30-39.

Timmusk T., Palm K., Lendahl U., Metsis M. Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. J. Biol. Chem., 274, 1999, 1078-1084.

Condorelli D. F., Dell'Albani P., Timmusk T., Mudo G., Belluardo N. Differential regulation of BDNF and NT-3 mRNA levels in primary cultures of rat cerebellar neurons. Neurochem. Int., 1998, 32, 87-91.

Funakoshi H., Risling M., Carlstedt T., Lendahl U., Timmusk T., Metsis M., Yamamoto Y., Ibánez C.F. Targeted expression of a chimeric neurotrophin in the lesioned sciatic nerve accelerates regeneration of sensory and motor axons. Proc. Natl. Acad. Sci., 95, 1998, 5269-5274.

Palm K., Belluardo N., Metsis M., Timmusk T. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J. Neurosci., 1998, 18, 1280-1296.

Shieh P. B., Hu S.C., Bobb K., Timmusk T., Ghosh A. Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron, 1998, 20, 727-740.

Salin T., Timmusk T., Lendahl U., Metsis M. Structural and functional characterization of the rat neurotrophin-4 gene. Mol. Cell. Neurosci., 1997, 9, 264-275 .

Mudo G., Jiang X. H., Timmusk T., Bindoni M., Belluardo N. Change in neurotrophins and their receptor mRNAs in the rat forebrain following status epilepticus induced by pilocarpine. Epilepsia, 1996, 37, 198-207.

Belluardo N., Salin T., Dell´Albani P., Mudo G., Corsaro M., Jiang X. H., Timmusk T., Condorelli D. F. Neurotoxic injury in rat hippocampus differentially affects multiple trkB and trkC transcripts. Neuroscience Letters, 1995, 196, 1-4.

Condorelli D. F., Salin T., Dell'Albani P., Mudo G., Corsaro M., Timmusk T., Metsis M., Belluardo N. Neurotrophins and their trk receptors in cultured cells of the glial lineage and in white matter of the central nervous system. J. Mol. Neurosci., 1995, 6, 237-248.

Mudo G., Salin T., Condorelli D. F., Jiang X. H., Dell´Albani P., Timmusk T., Metsis M., Funakoshi H., Belluardo N. Seizures increase trkC expression in the dentate gyrus of rat hippocampus: role of glutamate receptor activation. J. Mol. Neurosci., 1995, 6, 11-22.

Salin T., Mudo G., Jiang, X.H., Timmusk T., Metsis M., Belluardo N. Up-regulation of trkB mRNA expression in the rat striatum after seizures. Neuroscience Letters, 1995, 194, 181-184.

Timmusk T., Lendahl U., Funakoshi H., Arenas E., Persson H., Metsis M. Identification of BDNF promoter regions mediating tissue-specific, axotomy- and neuronal activity-induced expression in transgenic mice. J. Cell Biol., 1995, 128, 185-199.

Timmusk T., Mudo G., Metsis M., Belluardo N. Expression of mRNAs for neurotrophins and their receptors in the rat choroid plexus and dura mater. Neuroreport, 1995, 6, 1997-2000.

Trupp M., Rydén M., Jörnvall H., Funakoshi H., Timmusk T., Arenas E., Ibanez C.F. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell Biol., 1995, 130, 137-148.

Condorelli D. F., Dell´Albani P., Mudo G., Timmusk T., Belluardo N. Expression of neurutrophins and their receptors in primary astroglial cultures: induction by cyclic AMP-elevating agents. J. Neurochem., 1994, 63, 509-516.

Kokaia Z., Metsis M., Kokaia M., Bengzon J., Elmér E., Smith M.-L., Timmusk T., Siesjö B. K., Persson H., Lindvall O. Brain insults induce increased expression of the BDNF gene through differfential usage of multiple promoters. Eur. J. Neurosci., 1994, 6, 587-596.

Laurenzi M. A., Barbany G., Timmusk T., Lindgren J. Å., Persson H. Expression of mRNA encoding neurotrophins and neurotrophin receptors in rat thymus, spleen tissue and immunocompetent cells: regulation of neurotrophin-4 mRNA expression by mitogens and leukotriene B4. Eur. J. Biochem., 1994, 223, 733-741.

Timmusk T., Belluardo N., Persson H., Metsis M. Developmental regulation of brain-derived neurotrophic factor messenger RNAs transcribed from different promoters in the rat brain. Neuroscience, 1994, 60, 287-291.

Timmusk T., Metsis M. Regulation of BDNF promoters in the rat hippocampus. Neurochem. Int., 1994, 25, 11-15.

Timmusk T., Persson H., Metsis M. Analysis of transcriptional initiation and translatability of brain-derived neurotrophic factor mRNAs in the rat brain. Neuroscience Letters, 1994, 177, 27-31.

Falkenberg T., Metsis M., Timmusk T., Lindefors N. Entorhinal cortex regulation of multiple brain-derived neurotrophic factor promoters in the rat hippocampus. Neuroscience, 57, 1993, 891-896.

Funakoshi H., Frisen J., Barbany G., Timmusk T., Zachrisson O., Verge V. M. K., Persson H. (1993). Differential expression of mRNAs for neurotrophins and their receptors following axotomy of the sciatic nerve. J.Cell Biol., 1993, 123, 455-465.

Ibánez C. F., Ernfors P., Timmusk T., Ip N. Y., Arenas E., Yancopoulos G., Persson H. Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion. Development, 1993, 117, 1345-1353.

Metsis M., Timmusk T., Arenas E., Persson H. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proc. Natl. Acad. Sci. USA, 1993, 90, 8802-8806.

Mudò G., Persson H., Timmusk T., Funakoshi H., Bindoni M., Belluardo N. Increased expression of trkB and trkC messenger RNAs in the rat forebrain after focal mechanical injury. Neuroscience, 1993, 57, 901-912.

Timmusk T., Belluardo N., Metsis M., Persson H. Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissues. Eur. J. Neurosci., 1993, 5, 605-613.

Timmusk T., Palm K., Metsis M., Reintam T., Paalme V., Saarma M., Persson H. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron, 1993, 10, 475-489.

Metsis M., Timmusk T., Allikmets R., Saarma M., Persson H. Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter. Gene, 1992, 121, 247-254.

Neuman T., Stephens R.W., Salonen E.-M., Timmusk T., Vaheri A. Induction of morphological differentiation of human neuroblastoma cells is accompanied by induction of tissue-type plasminogen activator. J. Neurosci. Res., 1989, 23, 274-281.

viimati muudetud: 15.10.2005

Curriculum Vitae (CV)
1.First Name Tõnis
2.Surname Timmusk
3.Institution Department of Gene Technology, Faculty of Science, Tallinn University of Technology
4.Position Professsor, Head of the Chair of Molecular Biology
5.Date of birth 07.01.1959 (day.month.year)
6.Education 1977, Tallinn Secondary School No 7
1982, Tartu University, Faculty of Biology, Tartu, Estonia, specialization in genetics and cytology.
1994, Ph.D. in molecular neurobiology, Karolinska Institute, Stockholm, Sweden.
2000, Docent of neurobiology, University of Helsinki, Finland.
7.Research and
professional experience		 1985.05 - 1991.07; jun. research fellow, Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
1991.07 - 1991.11; visiting scientist at the Laboratory of Neurobiology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
1991.11 - 1994.06; Ph. D. student, Dept. Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
1994.06 - 1995.04; Postdoctoral fellow, Karolinska Institute, Sweden.
1995.04 - 1996.11; Assistant Professor of Swedish Medical Research Council, Dept. Medical Chemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
1996.11 - 1999.07; Assistant Professor of Swedish Medical Research Council, Dept. Neuroscience, Biomedical Center (BMC), Uppsala University, Uppsala, Sweden.
1999.07 - 2001.07; Senior Research Scientist, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
2001.08 - 2003.07; Senior Research Scientist of the Academy of Finland, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
2002.09 - ; professor, Institute of Gene Technology, Tallinn University of Technology.
2003.02 - 2005.05; Wellcome Trust International Senior Research Fellow, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
2005.05 - ; Wellcome Trust International Senior Research Fellow, Institute of Gene Technology, Tallinn University of Technology
8.Academic degree Ph.D.
9.Dates and sites of
earning the degrees		 Karolinska Institute, Stockholm, Sweden, 1994
10.Honours/awards
11.Research-administrative
experience		 1. I have been the referee for manuscripts submitted to the following international scientific journals: Journal of Neuroscience, Neuroscience, Journal of Neurochemistry, Molecular Brain Research, Neuroscience Letters, Cell and Tissue Researsch, BBA, FEBS Letters, Experimental Cell Research, Cytokine, Journal of Molecular Biology, Journal of Biological Chemistry.
2. I am a member of the scientific expert panel of the Estonian Science Foundation and of the Council of Scientific Competence at the Estonian Ministry of Education and Research.
3. Co+organizer of the International Brain Organisation (IBRO) lecture course in neurobiology at Tallinn University of Technology in June 2005.
12.Supervised dissertations

Anna Kazantseva, MSc, 2005, superv. Tõnis Timmusk. Genomic structure, promoter analysis and expression of the human BDNF and antiBDNF genes. Tallinna Tehnikaülikool

Karin Tamm, MSc, 2005, superv. Marko Piirsoo, Tõnis Timmusk, Jüri Kärner. BDNF-i geeni regulatsioon Schwanni rakkude arengus. Tartu Ülikool

Priit Pruunsild, MSc, 2005, superv. Tõnis Timmusk. Structure, alternative splicing and expression of human and mouse KCNIP gene family. Tallinna Tehnikaülikool

Tamara Aid, MSc, 2005, superv. Tõnis Timmusk, Kaia Palm. Mouse and rat BDNF gene structure revisited: BAC transgenic constructs for studying regulation of BDNF gene expression in vivo. Tallinna Tehnikaülikool
13.Current research program 1. Regulation of neurotrophin gene expression
2. Regulation of neural gene expression
3. Neurotrophic factor signaling
4. Determination and differentiation of neural cells
14.Current grant funding 1. Wellcome Trust International Senior Fellowship 067952, " Regulation of neurotrophin gene expression in the nervous system" 2003 - 2008.
2. Estonian Science Foundation, grant 5555, "Mammalian homologues of the Drosophila gene neuralized", 2003 - 2007.
3. Estonian Ministry of Education and Research, Grant 0222602s03 " Regulation of gene expression in the nervous system" 2003 - 2007.
15.List of most important publications

Pruunsild P, Timmusk T. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. Genomics, 2005, 86, 581-593.

Uvarov, P., Pruunsild, P., Timmusk, T., Airaksinen M.S., KCC2 transgenes lacking neuron restrictive silencer element recapitulate CNS neuron-specific expression and developmental upregulation of endogenous KCC2 gene. J. Neurochem., 2005, Aug 25; [Epub ahead of print].

Laurén, J., Airaksinen M. S., Saarma, M., Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics, 2003, 81, 411-421.

Laurén, J., Airaksinen, M. S., Saarma, M., Timmusk, T. Two Novel Mammalian Nogo Receptor Homologs Differentially Expressed in the Central and Peripheral Nervous System. Mol. Cell. Neurosci., 2003, 24, 581-594.

Zuccato, C., Tartari, M., Crotti, A., Goffredo, D., Valenza, M., Conti, L., Cataudella, T., Leavitt, L., Hayden, M. R., Timmusk, T., Rigamonti D., Cattaneo, E. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature Genetics, 2003, 35, 76-83.

Airaksinen, M. S., Poteriaev, D., Lindahl, M., Timmusk, T., Rossi, J. and Saarma, M. Compounds related to or derived from GFR_4 and their use. US Patent application. Docket No. 108306-00014. August 21, 2002.

Palm, K., Timmusk, T. Mammalian neuralized family transcriptional regulators and uses therefore. US Patent Application 20020132293. September 19, 2002.

Saarma, M., Laurén, J., Lindholm, P. and Timmusk, T. Novel neurotrophic factors and uses thereof. US patent application. Filed 30.08.2002.

Timmusk, T., Palm, K., Belluardo, N., Mudo, G., Neuman, T. Dendritic localization of mammalian neuralized mRNA encoding a protein with transcription repression activities. Mol. Cell. Neurosci., 2002, 20, 649-668.

Lindahl, M. S., Poteryaev, D., Yu, L.-Y., Arumäe, U., Timmusk, T., Bongarzone, I., Aiello, A., Pierotti, M. A., Airaksinen, M. S., Saarma, M. Human GFRa4 is the receptor for persephin, and is selectively expressed in normal and malignant thyroid meddullary cells. J. Biol. Chem., 2001, 276, 9344-9351.

Sun, Y.-F., Yu, L.-Y., Saarma, M., Timmusk, T., Arumäe, U. Neuron-specific BH3-only splice variant of Bak is anti-apoptotic in neurons but pro-apoptotic in nonneuronal cells. J. Biol. Chem., 2001, 276, 16240-16247.

Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., Conti, L., MacDonald, M. E., Friedlander, R. M., Silani, V., Hayden, M. R., Timmusk, T., Sipione, S., Cattaneo, E. Loss of Huntingtin-Mediated BDNF gene transcription in Huntington's disease. Science, 2001, 293, 493-498.

Lindahl, M., Timmusk, T., Rossi, J., Saarma, M., Airaksinen, M. Expression and alternative splicing of mouse Gfra4 suggests roles in endocrine cell development. Mol. Cell. Neurosci., 2000, 15, 522-533.

Palm K., Metsis M., Timmusk T. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Mol. Brain Res., 1999, 72, 30-39.

Timmusk T., Palm K., Lendahl U., Metsis M. Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. J. Biol. Chem., 274, 1999, 1078-1084.

Condorelli D. F., Dell'Albani P., Timmusk T., Mudo G., Belluardo N. Differential regulation of BDNF and NT-3 mRNA levels in primary cultures of rat cerebellar neurons. Neurochem. Int., 1998, 32, 87-91.

Funakoshi H., Risling M., Carlstedt T., Lendahl U., Timmusk T., Metsis M., Yamamoto Y., Ibánez C.F. Targeted expression of a chimeric neurotrophin in the lesioned sciatic nerve accelerates regeneration of sensory and motor axons. Proc. Natl. Acad. Sci., 95, 1998, 5269-5274.

Palm K., Belluardo N., Metsis M., Timmusk T. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J. Neurosci., 1998, 18, 1280-1296.

Shieh P. B., Hu S.C., Bobb K., Timmusk T., Ghosh A. Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron, 1998, 20, 727-740.

Salin T., Timmusk T., Lendahl U., Metsis M. Structural and functional characterization of the rat neurotrophin-4 gene. Mol. Cell. Neurosci., 1997, 9, 264-275 .

Mudo G., Jiang X. H., Timmusk T., Bindoni M., Belluardo N. Change in neurotrophins and their receptor mRNAs in the rat forebrain following status epilepticus induced by pilocarpine. Epilepsia, 1996, 37, 198-207.

Belluardo N., Salin T., Dell´Albani P., Mudo G., Corsaro M., Jiang X. H., Timmusk T., Condorelli D. F. Neurotoxic injury in rat hippocampus differentially affects multiple trkB and trkC transcripts. Neuroscience Letters, 1995, 196, 1-4.

Condorelli D. F., Salin T., Dell'Albani P., Mudo G., Corsaro M., Timmusk T., Metsis M., Belluardo N. Neurotrophins and their trk receptors in cultured cells of the glial lineage and in white matter of the central nervous system. J. Mol. Neurosci., 1995, 6, 237-248.

Mudo G., Salin T., Condorelli D. F., Jiang X. H., Dell´Albani P., Timmusk T., Metsis M., Funakoshi H., Belluardo N. Seizures increase trkC expression in the dentate gyrus of rat hippocampus: role of glutamate receptor activation. J. Mol. Neurosci., 1995, 6, 11-22.

Salin T., Mudo G., Jiang, X.H., Timmusk T., Metsis M., Belluardo N. Up-regulation of trkB mRNA expression in the rat striatum after seizures. Neuroscience Letters, 1995, 194, 181-184.

Timmusk T., Lendahl U., Funakoshi H., Arenas E., Persson H., Metsis M. Identification of BDNF promoter regions mediating tissue-specific, axotomy- and neuronal activity-induced expression in transgenic mice. J. Cell Biol., 1995, 128, 185-199.

Timmusk T., Mudo G., Metsis M., Belluardo N. Expression of mRNAs for neurotrophins and their receptors in the rat choroid plexus and dura mater. Neuroreport, 1995, 6, 1997-2000.

Trupp M., Rydén M., Jörnvall H., Funakoshi H., Timmusk T., Arenas E., Ibanez C.F. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell Biol., 1995, 130, 137-148.

Condorelli D. F., Dell´Albani P., Mudo G., Timmusk T., Belluardo N. Expression of neurutrophins and their receptors in primary astroglial cultures: induction by cyclic AMP-elevating agents. J. Neurochem., 1994, 63, 509-516.

Kokaia Z., Metsis M., Kokaia M., Bengzon J., Elmér E., Smith M.-L., Timmusk T., Siesjö B. K., Persson H., Lindvall O. Brain insults induce increased expression of the BDNF gene through differfential usage of multiple promoters. Eur. J. Neurosci., 1994, 6, 587-596.

Laurenzi M. A., Barbany G., Timmusk T., Lindgren J. Å., Persson H. Expression of mRNA encoding neurotrophins and neurotrophin receptors in rat thymus, spleen tissue and immunocompetent cells: regulation of neurotrophin-4 mRNA expression by mitogens and leukotriene B4. Eur. J. Biochem., 1994, 223, 733-741.

Timmusk T., Belluardo N., Persson H., Metsis M. Developmental regulation of brain-derived neurotrophic factor messenger RNAs transcribed from different promoters in the rat brain. Neuroscience, 1994, 60, 287-291.

Timmusk T., Metsis M. Regulation of BDNF promoters in the rat hippocampus. Neurochem. Int., 1994, 25, 11-15.

Timmusk T., Persson H., Metsis M. Analysis of transcriptional initiation and translatability of brain-derived neurotrophic factor mRNAs in the rat brain. Neuroscience Letters, 1994, 177, 27-31.

Falkenberg T., Metsis M., Timmusk T., Lindefors N. Entorhinal cortex regulation of multiple brain-derived neurotrophic factor promoters in the rat hippocampus. Neuroscience, 57, 1993, 891-896.

Funakoshi H., Frisen J., Barbany G., Timmusk T., Zachrisson O., Verge V. M. K., Persson H. (1993). Differential expression of mRNAs for neurotrophins and their receptors following axotomy of the sciatic nerve. J.Cell Biol., 1993, 123, 455-465.

Ibánez C. F., Ernfors P., Timmusk T., Ip N. Y., Arenas E., Yancopoulos G., Persson H. Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion. Development, 1993, 117, 1345-1353.

Metsis M., Timmusk T., Arenas E., Persson H. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proc. Natl. Acad. Sci. USA, 1993, 90, 8802-8806.

Mudò G., Persson H., Timmusk T., Funakoshi H., Bindoni M., Belluardo N. Increased expression of trkB and trkC messenger RNAs in the rat forebrain after focal mechanical injury. Neuroscience, 1993, 57, 901-912.

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last updated: 15.10.2005

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