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Elulookirjeldus (CV)
1.Eesnimi Jaanus
2.Perekonnanimi Remme
3.Töökoht Tartu Ülikool
4.Ametikoht professor
5.Sünniaeg 18.12.1953 (päev.kuu.aasta)
6.Haridus 1972. Tallinna spordi-internaatkool
1980. Tartu Ülikool Bioloogia-Geograafia teadusk., bioloog-geneetik
7.Teenistuskäik 1980-1995 KBFI insensr, grupijuht, teadur, vanemteadur
1993-1997 Tartu Ülikool van. teadur, dotsent
1997 Tartu Ülikool, professor
8.Teaduskraad filosoofiadoktor
9.Teaduskraadi välja
andnud asutus, aasta		 Tartu Ülikool, 1993
10.Tunnustused Valgetähe orden 3. klass
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus		 2003, umbes 1 kuu TÜMRI juhataja
RNA ühingu ja ASBMB liige
12.Juhendamisel kaitstud
väitekirjad

Rya Ero, MSc, 2006, juh. Jaanus Remme. The effect of tRNA modification enzymes TrmA and TruB on aminoacylation of in vitro transcribed tRNA.. Tartu Ülikool

Arto Pulk, MSc, 2005, juh. Jaanus Remme. Escherichia coli 16S rRNA positsioonid, mis mängivad olulist rolli 70S ribosoomi assotsiatsioonis. Tartu Ülikool

Kai Virumäe, MSc, 2005, juh. Jaanus Remme. tRNA 3’-CCA rolluist translatsioonil ja aminohappe rollist aminoatsüül-tRNA selektsioonil. Tartu Ülikool

Triinu Siibak, MSc, 2005, juh. Jaanus Remme. Antibiootikumide kloramfennikool ja erütromütsiin mõju ribosoomide assambleerumisele eubakteris Escherichia. Tartu Ülikool

Diana Karitkina, MSc, 2004, juh. A. Liiv, J. Remme. Esherichia coli 23S rRNA heeliks 69 roll ribosoomis. Tartu Ülikool

Ülo Maiväli, PhD, 2004, juh. J. Remme. Studies on the strucuture-function relationship of the bacterial ribosome. Tartu Ülikool

Ülar Allas, MSc, 2002, juh. J. Remme. RNaas III roll Escherichia coli ribosomaalse RNA küpsemisel. Tartu Ülikool

Lauri Peil, MSc, 2001, juh. J. Remme. Pseudouridiini süntaasi RluD osalus Escherichia coli ribosoomide moodustumisel. Tartu Ülikool

Tiina Tamm, PhD, 2000, juh. E. Truve, J. Remme. Cocksfoot mottle virus: the genome organization and translational strategies. Tartu Ülikool

Aivar Liiv, PhD, 1998, juh. J. Remme. Ribosomal large subunit assembly in vivo. Tartu Ülikool

Tanel Tenson, PhD, 1997, juh. A. Mankin, J. Remme. Ribosomes, peptides and antibiotic resistance. Tartu Ülikool

Urmas Saarma, PhD, 1997, juh. J. Remme. Tuning ribosomal elongation cycle by mutagenesis of 23S rRNA. Tartu Ülikool

Ülo Maiväli, MSc, 1997, juh. J. Remme. Escherichia coli 23S ribosomaalse RNA mutatsioonide mõju valgusünteesile. Tartu Ülikool

Aivar Liiv, MSc, 1994, juh. J. Remme. Escherichia coli ribosoomide 50S subühiku assambleerumiseks vajalikud rRNA järjestused. Tartu Ülikool

Tanel Tenson, MSc, 1994, juh. J. Remme. Mõnda Escherichia coli ribosoomide biosünteesist. Tartu Ülikool
13.Teadustöö põhisuunad valgu biosünteesi aparaadi struktuur ja funktsioonid, RNA bioloogia
14.Jooksvad grandid Ribosoomi RNA struktuuri teke 2001-2005 (HHMI, USA)
Modifitseeritud nukleosiidide roll ribosoomides 2004-2007, ETF
15.Teaduspublikatsioonid

Liiv, A., Karitkina, D., Maiväli, Ü., Remme, J. (2005) Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis. BMC Molecular Biology 2005, 6, 18

Xu, J., Golshani, A., Aoki, H., Remme, J., Chosay, J., Shinabarger, D. L., and M. Ganoza, C. (2005) Protected nucleotide G2608 in 23S rRNA confers resistance to oxazolidinones in E. coli. Biochemical and Biophysical Research Communications 328, 471-476

Liiv, A., Remme, J. (2004) Importance of transient structures during post-transcriptional refolding of the pre-23 S rRNA and ribosomal large subunit assembly. J. Mol. Biol. 342, 725-741.

Maiväli, Ü. Remme, J. (2004) Definition of bases in 23S rRNA essential for ribosomal subunit association. RNA 10, 600-604

Ougland, R., Zhang, C-M., Liiv, A., Johanson, R. F., Seeberg, E., Hou, Y-M., Remme, J. Falnes, P. Ø. (2004) AlkB Restores the Biological Function of mRNA and tRNA Inactivated by Chemical Methylation. Mol. Cell 16, 107-116.

Allas, Ü., Liiv, A., Remme, J. Functional interaction between RNase III and the Escherichia coli ribosome. (2003) BMC Molecular Biology , 4, 8

Maiväli, Ü., Pulk, A., Loogväli, E., Remme, J. (2002) Accessibility of phosphates in domain I of 23 S rRNA in the ribosomal 50 S subunit as detected by Rp phosphorothioates. BBA - Gene Structure and Expression 1579, 1-7

Virumäe, K., Saarma, U., Horowitz, J., Remme, J. (2002) Functional Importance of the 3'-terminal Adenosine of tRNA in Ribosomal Translation. J. Biol. Chem. 277, 24128-24134

Maiväli, Ü., Saarma, U., and Remme, J. (2001) Mutations in the E. coli 23S ribosomal RNA increase peptidyl-tRNA dissociation rates from the ribosome. Molek. Biol. (Moscow) 35, (4), 666-671

Ofengand, J., Malhotra, A., Remme, J., Gutgsell, N.S., Del Campo, M., Jean-Charles, S., Peil, L., Kaya, Y. (2001) Pseudouridines and pseudouridine synthases of the ribosome. Cold Spring Harbor Symp. Quant. Biol. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, Vol. 66, pp. 147-159

Liiv, A. and Remme, J. (1998) Base-pairing of 23 S rRNA ends is essential for ribosomal large subunit assembly. J. Mol. Biol. 276, 537-545

Liiv, A., Tenson, T., Margus, T., and Remme, J. (1998) Multiple functions of the transcribed spacers in ribosomal RNA operons. Biol. Chem. 379, 783-793

Saarma, U., Spahn, C.M.T., Nierhaus, K.H., and Remme, J. (1998) Mutational analysis of the donor substrate binding site of the ribosomal peptidyltransferase centre. RNA 4, 189-194

Saarma, U., Remme, J., Ehrenberg, M., and Bilgin, N. (1997) An A to U transversion at position 1067 of 23 S rRNA from Escherichia coli impairs EF-Tu and EF-G function. J. Mol. Biol. 272, 327-335

Liiv, A., Tenson, T., and Remme, J. (1996) Analysis of the ribosomal large subunit assembly and 23S rRNA stability in vivo. J. Mol. Biol. 263, 396-410

Spahn, C. M. T., Remme, J., Schäfer, M. A., and Nierhaus, K. H. (1996) Mutational analysis of two highly conserved UGG sequences of 23S rRNA from Escherichia coli. J. Biol. Chem. 271, 32849-32856

Lewicki, B. T. U., Margus, T., Remme, J., and Niehaus, K. H. (1993) Coupling of rRNA transcription and ribosome assembly in vivo. Formation of active ribosomal subunits in Escherichia coli requires transcription of rRNA genes by host RNA polymerase which cannot be replaced by bacteriophage T7 RNA polymerase. J. Mol. Biol. 231, 581-593

Saarma, U., Lewicki, B. T. U., Margus, T., Nigul, S., Remme, J. (1993) Analysis of mutations in the 23S rRNA. In: The Translational Apparatus K.H. Nierhaus, F. Franceschi, A.R. Subramanian, B. Wittmann-Liebold (eds) Plenum Press New-York and London pp 163-172

Saarma, U. and Remme, J. (1992) Novel mutant of 23S RNA: characterization of functional properties. Nucl. Acids Res. 20, 3147-3152

Rheinberger, H-J., Geigenmüller, U., Gnirke, A., Hausner, T-P., Remme, J., Saruyama, H., Nierhaus, K.H. (1990) Allosteric three-site model for the ribosomal elongation cycle. In: The Ribosomes, Structure, Function and Genetics W.E. Hill, A. Dahlberg, R.A Garrett. P.B. Moore, D. Schlessinger, J.R. Warner (eds) Ameican Society for Microbiology Washington, D.C. pp 318-330

Remme, J., Margus, T., Villems, R., Nierhaus, K. H. (1989) The third ribosomal tRNA﷓binding site, the E site, is occupied in native polysomes. Eur. J. Biochem. 183, 281﷓284.

Jussupova, G., Remme, J., Belitsyna, N., Spirin, A. (1986) Ribosomal synthesis of polylysine from the individual Lys﷓tRNA in the absence of messenger RNA. Dokl.Acad. Nauk, 289, (3), 725﷓728.

Maimets, T., Remme, J., Villems, R. (1985) Stimulation of peptidyltransferase activity of ribosomal 50S subunits with alcohol Molecular Biology (Moscow) 19, (3), 617﷓622.

Remme, J., Metspalu, E., Maimets, T., Villems, R. (1985) The properties of the complex between ribosomal protein L2 and tRNA. FEBS Lett. 190, (2), 275﷓278.

Remme, J., Villems, R. (1985) On the physico﷓chemical rationale of the genetic code. FEBS Lett. 189, (2), 159﷓162.

Maimets, T., Remme, J., Villems, R. (1984) Ribosomal protein L16 binds to the 3' end of transfer RNA. FEBS Lett. 153, (2), 53﷓56.

Maimets, T., Ustav, M., Remme,J., Villems, R. (1984) Protein L16 from ribosomes of E. coli: possible role in the protein biosynthesis. Molecular Biology (Moscow). 18, (6), 1597﷓1604.

Remme, J., Maimets, T., Ustav, M., Villems, R. (1983) The interaction of ribosomal protein L16 and its fragments with tRNA. FEBS Lett. 153, (2), 267﷓269.

Ustav, M., Remme, J., Lind, A., Villems, R. (1979) A new efficient route to immobilization of ribonucleic acids and nucleotides on agarose. Bio-organic Chem. (Moscow) 5, (3), 365﷓369.

viimati muudetud: 25.10.2004

Curriculum Vitae (CV)
1.First Name Jaanus
2.Surname Remme
3.Institution Tartu University
4.Position professor
5.Date of birth 18.12.1953 (day.month.year)
6.Education 1972. Tallinn sports boarding school
1980. Tartu University, faculty of Biology and Geography,
biology, genetics
7.Research and
professional experience		 1980-1995 ICPB technician, research fellow, senior research fellow
1993-1997 Tartu University, senior research fellow, assistent professor
1997 Tartu University, professor
8.Academic degree doctor of philosophy
9.Dates and sites of
earning the degrees		 Tartu University, 1993
10.Honours/awards White-cross order, 3. class
11.Research-administrative
experience		 2003, about 1 month, director of IMCB
Member of RNA society and ASBMB
12.Supervised dissertations

Rya Ero, MSc, 2006, superv. Jaanus Remme. The effect of tRNA modification enzymes TrmA and TruB on aminoacylation of in vitro transcribed tRNA.. Tartu Ülikool

Arto Pulk, MSc, 2005, superv. Jaanus Remme. Escherichia coli 16S rRNA positsioonid, mis mängivad olulist rolli 70S ribosoomi assotsiatsioonis. Tartu Ülikool

Kai Virumäe, MSc, 2005, superv. Jaanus Remme. tRNA 3’-CCA rolluist translatsioonil ja aminohappe rollist aminoatsüül-tRNA selektsioonil. Tartu Ülikool

Triinu Siibak, MSc, 2005, superv. Jaanus Remme. Antibiootikumide kloramfennikool ja erütromütsiin mõju ribosoomide assambleerumisele eubakteris Escherichia. Tartu Ülikool

Diana Karitkina, MSc, 2004, superv. A. Liiv, J. Remme. Esherichia coli 23S rRNA heeliks 69 roll ribosoomis. Tartu Ülikool

Ülo Maiväli, PhD, 2004, superv. J. Remme. Studies on the strucuture-function relationship of the bacterial ribosome. Tartu Ülikool

Ülar Allas, MSc, 2002, superv. J. Remme. RNaas III roll Escherichia coli ribosomaalse RNA küpsemisel. Tartu Ülikool

Lauri Peil, MSc, 2001, superv. J. Remme. Pseudouridiini süntaasi RluD osalus Escherichia coli ribosoomide moodustumisel. Tartu Ülikool

Tiina Tamm, PhD, 2000, superv. E. Truve, J. Remme. Cocksfoot mottle virus: the genome organization and translational strategies. Tartu Ülikool

Aivar Liiv, PhD, 1998, superv. J. Remme. Ribosomal large subunit assembly in vivo. Tartu Ülikool

Tanel Tenson, PhD, 1997, superv. A. Mankin, J. Remme. Ribosomes, peptides and antibiotic resistance. Tartu Ülikool

Urmas Saarma, PhD, 1997, superv. J. Remme. Tuning ribosomal elongation cycle by mutagenesis of 23S rRNA. Tartu Ülikool

Ülo Maiväli, MSc, 1997, superv. J. Remme. Escherichia coli 23S ribosomaalse RNA mutatsioonide mõju valgusünteesile. Tartu Ülikool

Aivar Liiv, MSc, 1994, superv. J. Remme. Escherichia coli ribosoomide 50S subühiku assambleerumiseks vajalikud rRNA järjestused. Tartu Ülikool

Tanel Tenson, MSc, 1994, superv. J. Remme. Mõnda Escherichia coli ribosoomide biosünteesist. Tartu Ülikool
13.Current research program structure-function of protein biosyntheis apparatus, RNA biology
14.Current grant funding Formation of rRNA structure during ribosome assembly 2001-2005 (HHMI, USA)
The role of rRNA modifications in the ribosome 2004-2007, ESF
15.List of most important publications

Liiv, A., Karitkina, D., Maiväli, Ü., Remme, J. (2005) Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis. BMC Molecular Biology 2005, 6, 18

Xu, J., Golshani, A., Aoki, H., Remme, J., Chosay, J., Shinabarger, D. L., and M. Ganoza, C. (2005) Protected nucleotide G2608 in 23S rRNA confers resistance to oxazolidinones in E. coli. Biochemical and Biophysical Research Communications 328, 471-476

Liiv, A., Remme, J. (2004) Importance of transient structures during post-transcriptional refolding of the pre-23 S rRNA and ribosomal large subunit assembly. J. Mol. Biol. 342, 725-741.

Maiväli, Ü. Remme, J. (2004) Definition of bases in 23S rRNA essential for ribosomal subunit association. RNA 10, 600-604

Ougland, R., Zhang, C-M., Liiv, A., Johanson, R. F., Seeberg, E., Hou, Y-M., Remme, J. Falnes, P. Ø. (2004) AlkB Restores the Biological Function of mRNA and tRNA Inactivated by Chemical Methylation. Mol. Cell 16, 107-116.

Allas, Ü., Liiv, A., Remme, J. Functional interaction between RNase III and the Escherichia coli ribosome. (2003) BMC Molecular Biology , 4, 8

Maiväli, Ü., Pulk, A., Loogväli, E., Remme, J. (2002) Accessibility of phosphates in domain I of 23 S rRNA in the ribosomal 50 S subunit as detected by Rp phosphorothioates. BBA - Gene Structure and Expression 1579, 1-7

Virumäe, K., Saarma, U., Horowitz, J., Remme, J. (2002) Functional Importance of the 3'-terminal Adenosine of tRNA in Ribosomal Translation. J. Biol. Chem. 277, 24128-24134

Maiväli, Ü., Saarma, U., and Remme, J. (2001) Mutations in the E. coli 23S ribosomal RNA increase peptidyl-tRNA dissociation rates from the ribosome. Molek. Biol. (Moscow) 35, (4), 666-671

Ofengand, J., Malhotra, A., Remme, J., Gutgsell, N.S., Del Campo, M., Jean-Charles, S., Peil, L., Kaya, Y. (2001) Pseudouridines and pseudouridine synthases of the ribosome. Cold Spring Harbor Symp. Quant. Biol. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, Vol. 66, pp. 147-159

Liiv, A. and Remme, J. (1998) Base-pairing of 23 S rRNA ends is essential for ribosomal large subunit assembly. J. Mol. Biol. 276, 537-545

Liiv, A., Tenson, T., Margus, T., and Remme, J. (1998) Multiple functions of the transcribed spacers in ribosomal RNA operons. Biol. Chem. 379, 783-793

Saarma, U., Spahn, C.M.T., Nierhaus, K.H., and Remme, J. (1998) Mutational analysis of the donor substrate binding site of the ribosomal peptidyltransferase centre. RNA 4, 189-194

Saarma, U., Remme, J., Ehrenberg, M., and Bilgin, N. (1997) An A to U transversion at position 1067 of 23 S rRNA from Escherichia coli impairs EF-Tu and EF-G function. J. Mol. Biol. 272, 327-335

Liiv, A., Tenson, T., and Remme, J. (1996) Analysis of the ribosomal large subunit assembly and 23S rRNA stability in vivo. J. Mol. Biol. 263, 396-410

Spahn, C. M. T., Remme, J., Schäfer, M. A., and Nierhaus, K. H. (1996) Mutational analysis of two highly conserved UGG sequences of 23S rRNA from Escherichia coli. J. Biol. Chem. 271, 32849-32856

Lewicki, B. T. U., Margus, T., Remme, J., and Niehaus, K. H. (1993) Coupling of rRNA transcription and ribosome assembly in vivo. Formation of active ribosomal subunits in Escherichia coli requires transcription of rRNA genes by host RNA polymerase which cannot be replaced by bacteriophage T7 RNA polymerase. J. Mol. Biol. 231, 581-593

Saarma, U., Lewicki, B. T. U., Margus, T., Nigul, S., Remme, J. (1993) Analysis of mutations in the 23S rRNA. In: The Translational Apparatus K.H. Nierhaus, F. Franceschi, A.R. Subramanian, B. Wittmann-Liebold (eds) Plenum Press New-York and London pp 163-172

Saarma, U. and Remme, J. (1992) Novel mutant of 23S RNA: characterization of functional properties. Nucl. Acids Res. 20, 3147-3152

Rheinberger, H-J., Geigenmüller, U., Gnirke, A., Hausner, T-P., Remme, J., Saruyama, H., Nierhaus, K.H. (1990) Allosteric three-site model for the ribosomal elongation cycle. In: The Ribosomes, Structure, Function and Genetics W.E. Hill, A. Dahlberg, R.A Garrett. P.B. Moore, D. Schlessinger, J.R. Warner (eds) Ameican Society for Microbiology Washington, D.C. pp 318-330

Remme, J., Margus, T., Villems, R., Nierhaus, K. H. (1989) The third ribosomal tRNA﷓binding site, the E site, is occupied in native polysomes. Eur. J. Biochem. 183, 281﷓284.

Jussupova, G., Remme, J., Belitsyna, N., Spirin, A. (1986) Ribosomal synthesis of polylysine from the individual Lys﷓tRNA in the absence of messenger RNA. Dokl.Acad. Nauk, 289, (3), 725﷓728.

Maimets, T., Remme, J., Villems, R. (1985) Stimulation of peptidyltransferase activity of ribosomal 50S subunits with alcohol Molecular Biology (Moscow) 19, (3), 617﷓622.

Remme, J., Metspalu, E., Maimets, T., Villems, R. (1985) The properties of the complex between ribosomal protein L2 and tRNA. FEBS Lett. 190, (2), 275﷓278.

Remme, J., Villems, R. (1985) On the physico﷓chemical rationale of the genetic code. FEBS Lett. 189, (2), 159﷓162.

Maimets, T., Remme, J., Villems, R. (1984) Ribosomal protein L16 binds to the 3' end of transfer RNA. FEBS Lett. 153, (2), 53﷓56.

Maimets, T., Ustav, M., Remme,J., Villems, R. (1984) Protein L16 from ribosomes of E. coli: possible role in the protein biosynthesis. Molecular Biology (Moscow). 18, (6), 1597﷓1604.

Remme, J., Maimets, T., Ustav, M., Villems, R. (1983) The interaction of ribosomal protein L16 and its fragments with tRNA. FEBS Lett. 153, (2), 267﷓269.

Ustav, M., Remme, J., Lind, A., Villems, R. (1979) A new efficient route to immobilization of ribonucleic acids and nucleotides on agarose. Bio-organic Chem. (Moscow) 5, (3), 365﷓369.

last updated: 25.10.2004

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