[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Jaanus |
| 2. | Perekonnanimi | Harro |
| 3. | Töökoht | Tartu Ülikooli psühholoogiaosakond |
| 4. | Ametikoht | psühhofüsioloogia professor |
| 5. | Sünniaeg | 07.11.1962 (päev.kuu.aasta) |
| 6. | Haridus | Võru Kreutzwaldi Gümnaasium lõpetatud 1981 Tartu Ülikooli Arstiteaduskonna raviosakond lõpetatud 1987 |
| 7. | Teenistuskäik | August 1987 - juuli 1989 - TÜ farmakoloogia instituudi stazhöör-uurija August 1989 - juuni 1993 - TÜ ÜMPI eksperimentaalse ja kliinilise psühhofarmakoloogia laboratooriumi nooremteadur ja (1991. aasta septembrist) vanemteadur August 1989 - detsember 1990 - TÜ farmakoloogia instituudi assistent Juuli - detsember 1993 - TÜ füsioloogia instituudi neurobioloogia vanemteadur Jaanuar 1994 - märts 1996 - TÜ farmakoloogia instituudi neuropsühhofarmakoloogia erakorraline professor (ETF baasfinantseerimisel) September 1994 - jaanuar 1998 - TÜ Arstiteaduskonna prekliinilise meditsiini prodekaan Aprill 1996 - jaanuar 1998 - TÜ tervishoiu instituudi terviseedenduse erakorraline professor, õppetooli juhataja (Eesti Tervishoiu Projekti finantseerimisel) Veebruarist 1998 - praegusel ametikohal Veebruar 2000 – august 2001 – TÜ psühholoogiaosakonna juhataja Augustist 2001 – TÜ Sotsiaalteaduskonna dekaan Alates 2001 - Eesti Käitumis- ja Terviseteaduste Keskuse juhataja |
| 8. | Teaduskraad | meditsiinikandidaat meditsiinidoktor |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Ülikool 1990 Uppsala Ülikool 1993 |
| 10. | Tunnustused | Tartu Ülikooli ja Arstiteaduskonna ÜTÜ medalid 1987. aastal European College of Neuropsychopharmacology Fellowship Award 1993 Israel Hwasser'i auhind Uppsala Arstide Seltsilt 1994 (aasta parima arstiteadusliku doktoritöö eest) Academia Europeae auhind Baltimaade noortele teadlastele, 1996 Collegium Internationale Neuro-Psychopharmacologicum Ole Rafaelsen Fellowship Award 1998 Tartu linna medal 2002 Vabariigi teaduspreemia arstiteaduse valdkonnas 2005 |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
Eesti arstiteaduse hindamise ekspertgrupi liige 1994. aastal Septembrist 1994 jaanuarini 1998 - TÜ Arstiteaduskonna prekliinilise meditsiini prodekaan, Arstiteaduskonna nõukogu liige, Arstiteaduskonna õppekavade arenduskomisjoni liige, Biomeedikumi nõukogu liige, Arstiteaduskonna ja Karolinska Institutet'i ühistegevuse koordinaator. 1994-1999 Arstiteaduskonna kraadinõukogu liige Alates 2001 TÜ neuroteaduste doktorikooli nõukogu liige ETF programmide nõukogu liige (1997) 1996-2000 Sotsiaalministeeriumi Rahvatervise Arendusnõukogu liige 1999-2003 - Sotsiaalministeeriumi moodustatud rahvatervise sihtprogrammi koostamise nõukogu liige ja sihtprogrammi nõukogu liige Alates 2001 Eesti Teaduste Akadeemia rahvastiku ja rahvatervise nõukogu liige 1999. aastast Tartu Ülikooli Nõukogu valitud liige, eelarvekomisjoni liige Veebruarist 2000 augustini 2001 psühholoogiaosakonna juhataja Augustist 2001 Sotsiaalteaduskonna dekaan ja TÜ valitsuse liige 2001 - Eesti Käitumis- ja Terviseteaduste Keskuse loomine, asutamisest peale EKTTK juhataja Alates 2004 - Collegium Internationale Neuro-Psychopharmacologicum'i hariduskomitee liige ning CCEE regionaalkomitee teaduslik sekretär Veebruarist 2005 Eesti esindaja NATO Teadus- ja Tehnoloogiaorganisatsiooni HFM-paneelis 2005 - Käitumis- ja Terviseteaduste Doktorikooli rajamine, septembrist 2005 selle juhataja |
| 12. | Juhendamisel kaitstud väitekirjad |
Evelyn Kiive, PhD, 2005, juh. Jaanus Harro. Studies on peripheral markers of central serotonergic activity and behaviour. University of Tartu Aet Alttoa, MSc, 2004, juh. Jaanus Harro. Neurochemical regulation of rat exploratory behaviour: focus on dopaminergic and noradrenergic neurotransmission. University of Tartu Maiken Jaanisk, MSc, 2004, juh. Jaanus Harro, Jüri Allik. The stability of Eating Disorders Inventory (EDI-2) scales and associations with the activity of platelet monoamine oxidase (MAO). [in Estonian]. University of Tartu Riina Häidkind, PhD, 2004, juh. Jaanus Harro. Monoaminergic mechanisms in mood-associated behaviours and neurochemistry in rats.. University of Tartu Tanel Mällo, MSc, 2004, juh. Jaanus Harro. The role of corticotropin-releasing factor and locus coeruleus in the regulation of exploratory behaviour in rats. University of Tartu Marika Paaver, MSc, 2003, juh. Jaanus Harro. Impulsivity and platelet MAO activity: association with health-compromising behaviours like problem drinking, smoking and driving while impaired. University of Tartu Anneli Zirkel, MSc, 2002, juh. Jaanus Harro. Drug and alternative medicine usage among Estonian population. [in Estonian]. University of Tartu Inga Dorofejeva, MSc, 2002, juh. Peeter Torop, Jaanus Harro. Discourse of health promotion in Estonia: an analysis of health promotion projects of 1995-1998. University of Tartu Liis Merenäkk, MSc, 2002, juh. Maarike Harro, Jaanus Harro. Association of alcohol and drug use with personality characteristics and platelet MAO activity in schoolchildren. [in Estonian]. University of Tartu Margus Tõnissaar, MSc, 2002, juh. Jaanus Harro. Serotonergic regulation of social behaviour of rats in the social interaction test. University of Tartu Evelyn Kiive, MSc, 2001, juh. Jaanus Harro. Platelet monoamine oxidase activity in association with childhood aggressive and hyperactive behaviour, smoking, alcohol and illicit drug use. University of Tartu Annemari Arro, MSc, 2000, juh. Ago Rinken, Jaanus Harro. Binding of [3H] 8-OH-DPAT to rat brain membranes, and the effects of modulating factors. [in Estonian]. University of Tartu Diva Eensoo, MSc, 2000, juh. Jaanus Harro. Association of physical activity with mental health and personality. [in Estonian]. University of Tartu Ants Kask, PhD, 1999, juh. Jaanus Harro, Lembit Rägo. Behavioural effects of neuropeptide Y.. University of Tartu Riina Häidkind, MSc, 1999, juh. Jaanus Harro. Chronic mild stress model of depression: forced swimming behavior and monoamine neurochemistry. University of Tartu Charlotta Löfberg, PhD, 1996, juh. Lars Oreland, Jaanus Harro. Studies of cholecystokinin peptides and receptors in the central nervous system.. University of Uppsala Tiina Ööpik, MSc, 1993, juh. Jaanus Harro. The effect of selective CCK receptor antagonists on the morphine-conditioned place preference. [in Estonian]. Tartu Ülikool |
| 13. | Teadustöö põhisuunad | Ärevust ja hirmu tekitavate ja leevendavate farmakonide käitumis- ja biokeemilised efektid. Uudistava ja sotsiaalse käitumise käitumis-, neurokeemiline ja psühhofarmakoloogiline analüüs. Neuropeptiidide, eriti CCK, NPY ja CRF psühhofarmakoloogia aju määratletud närviringides. Depressiooni ja ärevuse eksperimentaalne ja teoreetiline modelleerimine. Monoamiinisüsteemide neurokeemiline regulatsioon. Isiksuse ja tervistmõjustava käitumise psühhobioloogia. |
| 14. | Jooksvad grandid | 1. EC 6. raamprogrammi integreeritud projekti NEWMOOD (LSHM-CT-2004-503474): “New molecules in mood disorders: a genomic, neurobiological and systems approach in animal models and human disorder” partnerlus (2004-2009) € 494 764 ehk 7 743 000 kr. 2. Haridusministeeriumi sihtfinantseeritav teema 2643 (2004-2008) “Afektiivsete häirete tekkepõhjused psühhobioloogiliste kohanemismehhanismide neurobioloogia, tüpoloogia ja dimensioonilisuse alusel” 2004 – 460 000 kr, 2005 – 690 000 kr. 3. ETF uuringutoetus 5450 (suund 5.6.) “Vereliistakute monoamiinide oksüdaasi aktiivsus ja teised monoamiinisüsteemide talitluse markerid impulsiivsuse ja riskiva käitumise ennustamisel” (2003-2006): 2003 – 125 000 kr, 2004 – 190 000 kr, 2005 – 144 706 + 25 536 kr. |
| 15. | Teaduspublikatsioonid |
A. Alttoa, K. Kõiv, M. Eller, A. Uustare, A. Rinken, J. Harro Effects of low dose N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine administration on exploratory and amphetamine-induced behavior and dopamine D2 receptor function in rats with high or low exploratory activity. Neuroscience (2005) 132: 979-990 D. Eensoo, M. Paaver, M. Harro, J. Harro Predicting drunk driving: contribution of alcohol use and related problems, traffic behaviour, personality and platelet monoamine oxidase (MAO) activity. Alcohol & Alcoholism (2005) 40: 140-146 E. Kiive, L. Merenäkk, M. Harro, J. Harro Changes in platelet monoamine oxidase activity, cholesterol levels and hyperactive behaviour in adolescents over a period of three years. Neuroscience Letters (2005) 384: 310-315 S.O. Fetissov, J. Harro, M. Jaanisk, A. Järv, I. Podar, J. Allik, I. Nilsson, P. Sakthivel, A.K. Lefvert, T. Hökfelt Autoantibodies against neuropeptides are associated with psychological traits in eating disorders. Proceedings of the National Academy of Sciences of the U.S.A. (2005) 102: 14865-14870 A. Alttoa, J. Harro Effect of CCK1 and CCK2 receptor blockade on amphetamine-stimulated exploratory behaviour and sensitization to amphetamine. European Neuropsychopharmacology (2004) 14: 324-331 D. Eensoo, M. Paaver, A. Pulver, M. Harro, J. Harro Low platelet MAO activity associated with high dysfunctional impulsivity and antisocial behaviour: evidence from drunk drivers. Psychopharmacology (2004) 172: 356-358 E. Kiive, J. Maaroos, J. Shlik, I. Tõru, J. Harro Growth hormone, cortisol and prolactin responses to physical exercise: higher prolactin response in depressed patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2004) 28: 1007-1013 J. Harro Animal models for better antidepressants: can pathogenetic approaches make a difference? Preclinica (2004) 2: 402-407 J. Harro Appendix A: Pharmacodynamics and pharmacokinetics. In: J. Panksepp (ed) Textbook of Biological Psychiatry, John Wiley & Sons 2004, pp 661-681 J. Harro, K. Fischer, S. Vansteelandt, M. Harro Both low and high activity of platelet monoamine oxidase increase the probability of becoming a smoker. European Neuropsychopharmacology (2004) 14: 65-69 J. Harro On Holy Ground: Modern neuropsychopharmacology in the old laboratories of Buchheim, Schmiedeberg and Kraepelin in Tartu/Dorpat. In: T.A. Ban, D. Healy, E. Shorter (eds) Reflections on Twentieth-Century Psychopharmacology. Animula, Budapest 2004, pp 355-360 J. Panksepp, J. Harro Future of neuropeptides in biological psychiatry and emotional psychopharmacology: Goals and strategies. In: J. Panksepp (ed) Textbook of Biological Psychiatry, John Wiley & Sons, 2004, pp 627-659 M. Tõnissaar, M.-A. Philips, M. Eller, J. Harro Sociability trait and serotonin metabolism in the rat social interaction test. Neuroscience Letters (2004) 367: 309-312 R. Häidkind, M. Eller, A. Kask, M. Harro, A. Rinken, L. Oreland, J. Harro Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatment. Neurochemistry International (2004) 45: 721-732 T. Mällo, C. Berggård, M. Eller, M. Damberg, L. Oreland, J. Harro Effect of long-term blockade of CRF1 receptors on exploratory behavior, monoamines and transcription factor AP-2. Pharmacology Biochemistry & Behavior (2004) 77: 855-865 J. Harro, A. Terasmaa, M. Eller, A. Rinken Effect of denervation of the locus coeruleus projections by DSP-4 treatment on [3H]-raclopride binding to dopamine D2 receptors and D2 receptor - G-protein interaction in the rat striatum. Brain Research (2003) 976: 209-216 L. Merenäkk, M. Harro, E. Kiive, K. Laidra, D. Eensoo, J. Allik, L. Oreland, J. Harro Association between substance use, personality traits and platelet MAO activity in preadolescents and adolescents. Addictive Behaviors (2003) 28: 1507-1514 R. Häidkind, M. Eller, M. Harro, A. Kask, A. Rinken, L. Oreland, J. Harro Effects of partial locus coeruleus denervation and chronic mild stress on behaviour and monoamine neurochemistry in the rat. European Neuropsychopharmacology (2003) 13: 19-28 A. Kask, J. Harro, S. von Hörsten, P. Redrobe, Y. Dumont, R. Quirion The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neuroscience & Biobehavioral Reviews (2002) 26: 259-283 E. Kiive, D. Eensoo, M. Harro, J. Harro Platelet monoamine oxidase activity in association with childhood aggressive and hyperactive behaviour: the effect of smoking? Personality & Individual Differences (2002) 33: 355-363 J. Harro Long-term partial 5-HT depletion: interference of anxiety and impulsivity? Psychopharmacology (2002) 164: 433-434 L. Oreland, M. Damberg, H. Garpenstrand, J. Harro, J. Hallman Platelet monoamine oxidase, transcription factor AP-2 and personality – a functional triangle? In: T. Nagatsu, T. Nabeshima, R. McCarty, D.S. Goldstein (eds) Catecholamine Research: From Molecular Insights to Clinical Medicine. Kluwer Academic/Plenum Publishers 2002, pp 439-442 M. Eller, J. Harro Partial denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 potentiates the long-term effect of parachloroamphetamine on 5-HT metabolism in the rat. Neuroscience Letters (2002) 322: 53-56 R. Häidkind, T. Kivastik, M. Eller, I. Kolts, L. Oreland, J. Harro Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 reduces dopamine release potential in the nucleus accumbens shell in conscious rats. Neuroscience Letters (2002) 332: 79-82 J. Harro, A.-M. Viru Endurance training by forced swimming reduces emotionality in rats. Biology of Sport (2001) 18: 119-125 J. Harro, L. Oreland Depression as a spreading adjustment disorder of monoaminergic neurons: a case for primary implication of the locus coeruleus. Brain Research Reviews (2001) 38: 79-128 J. Harro, M. Tõnissaar, M. Eller, A. Kask, L. Oreland Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry. Brain Research (2001) 899: 227-239 J. Harro, M. Tõnissaar, M. Eller The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat. Neuropeptides (2001) 35: 100-109 M. Damberg, M. Eller, M. Tõnissaar, L. Oreland, J. Harro Levels of transcription factors AP-2a and AP-2ß in the brainstem are correlated to monoamine turnover in the rat forebrain. Neuroscience Letters (2001) 313: 102-104 M. Harro, D. Eensoo, E. Kiive, L. Merenäkk, J. Alep, L. Oreland, J. Harro Platelet monoamine oxidase in healthy 9- and 15-years old children: the effect of gender, smoking and puberty. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2001) 25: 1497-1511 A. Kask, H. Schiöth, J. Harro, J. Wikberg, L. Rägo Orexigenic effect of the MC4 antagonist HS014 is only partially inhibited by neuropeptide Y Y1 receptor antagonists. Canadian Journal of Physiology and Pharmacology (2000) 78: 143-149 A. Kask, J. Harro Inhibition of amphetamine and apomorphine-induced behavioural effects by neuropeptide Y Y1 receptor antagonist BIBO 3304. Neuropharmacology (2000) 39: 1292-1302 A. Kask, M. Eller, L. Oreland, J. Harro Neuropeptide Y attenuates the effect of locus coeruleus denervation by DSP-4 treatment on social behaviour in the rat. Neuropeptides (2000) 34: 58-61 D. Eensoo, J. Harro, M. Harro, H. Rimm, A.-M. Viru Depressiveness, anxiety, perceived stress and self-efficacy in middle-aged men with different engagement in physical activity. Medicina dello Sport (2000) 53: 69-74 J.A. Prince, J. Harro, K. Blennow, C.G. Gottfries, L. Oreland Putamen mitochondrial energy metabolism is highly correlated to emotional and intellectual impairment in schizophrenics. Neuropsychopharmacology (2000) 22: 284-292 J. Harro, A. Meriküla, M. Lepiku, A.-R. Modiri, A. Rinken, L. Oreland Lesioning of the locus coeruleus projections by DSP-4 treatment: the effect on amphetamine-induced hyperlocomotion and dopamine D2 receptor binding in the rat. Pharmacology & Toxicology (2000) 86: 197-202 A. Kask, T. Kivastik, L. Rägo, J. Harro Neuropeptide Y Y1 receptor antagonist BIBP3226 produces conditioned place aversion in rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry (1999) 23: 705-711 H. Rimm, M. Harro, K. Karelson, M. Grauberg, A.-M. Viru, J. Harro State of mood and self-efficacy in relation to physical activity and fitness in young healthy men. Acta Psychiatrica Belgica (1999) 99: 16-26 J. Harro, H. Rimm, M. Harro, M. Grauberg, K. Karelson, A.-M. Viru Association of depressiveness with blunted growth hormone response to maximal physical exercise in young healthy men. Psychoneuroendocrinology (1999) 24: 505-517 J. Harro, R. Häidkind, M. Harro, A.-R. Modiri, P.-G. Gillberg, R. Pähkla, V. Matto, L. Oreland Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment. European Neuropsychopharmacology (1999) 10: 5-16 J. Harro, R. Pähkla, A.-R. Modiri, M. Harro, A. Kask, L. Oreland Dose-dependent effects of noradrenergic denervation by DSP-4 treatment on forced swimming and ß-adrenoceptor binding in the rat. Journal of Neural Transmission (1999) 106: 619-629 A. Kask, L. Rägo, J. Harro Anxiogenic-like effect of the NPY Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats. Regulatory Peptides (1998) 75/76: 255-262 A. Kask, L. Rägo, J. Harro Anxiolytic-like effects of NPY and NPY13-36 microinjected into vicinity of locus coeruleus in rats. Brain Research (1998) 788: 345-348 A. Kask, L. Rägo, J. Harro Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. British Journal of Pharmacology (1998) 124: 1507-1515 A. Kask, L. Rägo, J. Harro NPY Y1 receptors in the dorsal periaqueductal gray matter regulate anxiety in the social interaction test. Neuroreport (1998) 9: 2713-2716 A. Kask, L. Rägo, J. Harro Opposite effects of [Leu31,Pro34]NPY and NPY13-36 on hypnotic response to a2-adrenoceptor agonist dexmedetomidine microinjected into rat locus coeruleus. Neuroscience Research Communications (1998) 23: 41-44 A. Rinken, J. Harro, L. Engström, L. Oreland Role of fluidity of membranes on the guanyl nucleotide-dependent binding of cholecystokinin-8s to rat brain cortical membranes. Biochemical Pharmacology (1998) 55: 423-431 C. Löfberg, H. Ågren, J. Harro, L. Oreland Cholecystokinin in the CSF from depressed patients: possible relations to severity of depression and suicidal behaviour. European Neuropsychopharmacology (1998) 8: 153-157 C. Löfberg, J. Harro, V. Matto, L. Oreland Cholecystokinin peptides and receptor binding in rat brain after DSP-4 treatment. Neuropeptides (1998) 32: 103-108 A. Kask, J. Harro, P. Tuomainen, L. Rägo, P.T. Männistö Overflow of noradrenaline and dopamine in frontal cortex in [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treated rats: in vivo microdialysis study. Naunyn-Schmiedeberg’s Archives of Pharmacology (1997) 355: 267-272 A. Kask, L. Rägo, J. Harro a-Helical CRF9-41 prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in rats. Neuroreport (1997) 8: 3645-3647 J. Harro, C. Löfberg, R. Pähkla, V. Matto, L. Rägo, L. Oreland, L. Allikmets Different molecular forms of cholecystokinin and CCKB receptor binding in the rat brain after chronic antidepressant treatment. Naunyn-Schmiedeberg’s Archives of Pharmacology (1997) 355: 57-63 J. Harro, H. Rimm, M. Sallo, N. Jaanimägi, A. Päevloo, I. Villa Does the personality of parents influence the physical activity of their children? In: N. Armstrong, B.J. Kirby, J.R. Welsman (eds) Children and Exercise XIX: Promoting Children's Health and Well-being. E & FN Spon (Chapman & Hall) London 1997, pp 157-162 M.-H. Otter, V. Matto, R. Sõukand, T. Skrebuhhova, L. Allikmets, J. Harro Characterization of rat exploratory behaviour using the exploration box test. Methods and Findings in Experimental and Clinical Pharmacology (1997) 19: 683-691 M. Sallo, J. Harro, A. Viru Moderate to vigorous physical activities in preadolescent children. In: N. Armstrong, B.J. Kirby, J.R. Welsman (eds) Children and Exercise XIX: Promoting Children's Health and Well-being. E & FN Spon (Chapman & Hall) London 1997, pp 151-156 V. Matto, J. Harro, L. Allikmets The effect of drugs acting on CCK receptors and rat free exploration in the exploration box. Journal of Physiology and Pharmacology (1997) 48:239-251 V. Matto, J. Harro, L. Allikmets The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in rat. Neuropharmacology (1997) 36: 389-396 A. Kask, L. Rägo, J. Harro Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. European Journal of Pharmacology (1996) 317: R3-R4 C. Löfberg, J. Harro, C.-G. Gottfries, L. Oreland Cholecystokinin peptides and receptor binding in Alzheimer's disease. Journal of Neural Transmission [Parkinson's Disease and Dementia Section] (1996) 103: 851-860 J. Harro, C. Löfberg, J. Rehfeld, L. Oreland Cholecystokinin peptides and receptors in the rat brain during stress. Naunyn-Schmiedeberg's Archives of Pharmacology (1996) 354: 59-66 J. Harro, L. Oreland Depression as a spreading neuronal adjustment disorder. European Neuropsychopharmacology (1996) 6: 207-223 R. Pähkla, J. Harro, L. Rägo Behavioural effects of pinoline in the rat forced swimming, open field and elevated plus-maze tests. Pharmacological Research (1996) 34: 73-78 V. Matto, J. Harro, L. Allikmets The effects of cholecystokinin A and B receptor antagonists, devazepide and L 365,260, on citalopram-induced decrease of exploratory behaviour in rat. Journal of Physiology and Pharmacology (1996) 47: 661-669 A. Lang, J. Harro, A. Soosaar, S. Kõks, V.Volke, L. Oreland, M. Bourin, E. Vasar, J. Bradwejn, P.T. Männistö Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats. Naunyn-Schmiedeberg's Archives of Pharmacology (1995) 351: 363-370 J. Harro, E. Vasar, D. Koszycki, J. Bradwejn The CCK hypothesis of anxiety and panic. In: J. Panksepp (ed) Advances in Biological Psychiatry, Vol 1, JAI Press 1995, pp 235-262 J. Harro, E. Vasar, L. Oreland, P.T. Männistö Animal studies on CCK and anxiety. In: J. Bradwejn, E. Vasar (eds) CCK and Anxiety: from Neuron to Behaviour. R.G. Landes Company (1995) 57-72 J. Harro, L.Oreland, E. Vasar, J. Bradwejn Impaired exploratory behaviour after DSP-4 treatment in rats: implications for the increased anxiety after noradrenergic denervation. European Neuropsychopharmacology (1995) 5: 447-455 E. Peuranen, A. Lang, J. Harro, E. Vasar, P.T. Männistö Effect of caerulein and cholecystokinin antagonists on hypophyseal hormone secretion in single-housed and group-housed male rats. In: S. Seredenin, V.G. Longo (eds) Biological Basis of Individual Sensitivity to Psychotropic Drugs Harwood Academic Publishers Amsterdam 1994, pp 63-72 E. Vasar, A. Lang, J. Harro, M. Bourin, J. Bradwejn Evidence for potentiation by CCK antagonists of the effect of cholecystokinin octapeptide in the elevated plus-maze. Neuropharmacology (1994) 33: 729-735 E. Vasar, A. Lang, J. Harro, S. Kõks, V. Volke, S. Sihver, M. Bourin, J. Bradwejn, P.T. Männistö Subdiaphragmatic vagotomy does not prevent the anti-exploratory effect of caerulein in the elevated plus-maze. Neuropeptides (1994) 26: 39-45 F. Sherif, J. Harro, A. El-Hwuegi, L. Oreland Anxiolytic-like effect of the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA) on rat exploratory activity. Pharmacology Biochemistry & Behavior (1994) 49: 801-805 J. Harro, G. Wahlström, L. Oreland Cholecystokinin receptor binding after long-term ethanol treatment in rats. Alcohol & Alcoholism (1994) 29: 575-581 M. Welin, J. Harro, R. Yukhananov, F. Nyberg, L. Oreland Cholecystokinin receptor binding in morphine analgesia, tolerance, withdrawal and abstinence. Neuropeptides (1994) 26: 379-383 P.T. Männistö, A. Lang, J. Harro, E. Peuranen, J. Bradwejn, E. Vasar Opposite effects mediated by CCKA and CCKB receptors in behavioural and hormonal studies in rats. Naunyn-Schmiedeberg's Archives of Pharmacology (1994) 349: 478-484 E.Vasar, E.Peuranen, T.Ööpik, J.Harro, P.T.Männistö Ondansetron, an antagonist of 5-HT3 receptors, antagonizes the anti-exploratory effect of caerulein, an agonist of CCK receptors, in the elevated plus-maze. Psychopharmacology (1993) 110: 213-218 E.Vasar, J.Harro, A.Lang, A.Soosaar, T.Ööpik, S. Kõks, S.Sihver, V.Volke Anti-exploratory effect of N-methyl-D-aspartate in elevated plus-maze. Involvement of NMDA and CCK receptors. European Neuropsychopharmacology (1993) 3: 63-73 E.Vasar, P.T.Männistö, L.Oreland, J.Harro, E.Peuranen, A.Lang Social isolation modulates the sensitivity of cholecystokinin receptors in the rat brain. Naunyn-Schmiedeberg’s Archives of Pharmacology (1993) 248: 96-101 J.Harro, E.Vasar, J.Bradwejn Cholecystokinin in animal and human research on anxiety. Trends in Pharmacological Sciences (1993) 14: 244-249 J.Harro, L.Oreland Cholecystokinin receptors and memory: A radial maze study. Pharmacology Biochemistry & Behavior (1993) 44: 509-517 J.Harro Measurement of Exploratory Behaviour in Rodents. In: P.M.Conn (Ed.) Methods in Neurosciences, Vol. 14, Academic Press, San Diego (1993) pp. 359-377 J.Harro, P.Westerling, L.Oreland CCKB receptor activation reduces glutamate-induced depolarization in slices of rat cerebral cortex. Journal of Neural Transmission [General Section] (1993) 93: 61-66 A.Lang, E.Vasar, A.Soosaar, J.Harro The involvement of sigma and phencyclidine receptors in the action of antipsychotic drugs. Pharmacology & Toxicology (1992) 71: 132-138 E.Vasar, A.Soosaar, J.Harro, A.Lang Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol. European Neuropsychopharmacology (1992) 2: 447-454 E.Vasar, J.Harro, A.Põld, A.Lang CCK receptors and anxiety in rats. In: C.T.Dourish, S.J.Cooper, S.D.Iversen, L.L.Iversen (eds) Multiple Cholecystokinin Receptors in the CNS (1992) Oxford University Press, pp. 143-148 J.Harro, J.Marcusson, L.Oreland Alterations in brain cholecystokinin receptors in suicide victims. European Neuropsychopharmacology (1992) 2: 57-63 J.Harro, L.Oreland Age-related differences of cholecystokinin receptor binding in the rat brain. Progress in Neuro-Psychopharmacology & Biological Psychiatry (1992) 16: 369-375 J.Harro, S.S.Jossan, L.Oreland Changes in cholecystokinin receptor binding in rat brain after selective damage of locus coeruleus projections by DSP-4 treatment. Naunyn-Schmiedeberg´s Archives of Pharmacology (1992) 346: 425-431 P.T.Männistö, E.Peuranen, J.Harro, E.Vasar Possible role of cholecystokinin-A receptors in regulation of thyrotropin (TSH) secretion in male rats. Neuropeptides (1992) 23: 251-258 E.Vasar, J.Harro, A.Lang, A.Põld, A.Soosaar Differential involvement of CCK-A and CCK-B receptors in the regulation of locomotor activity in the mouse. Psychopharmacology (1991) 105: 393-399 J.Harro, E.Vasar Cholecystokinin-induced anxiety: How is it reflected in studies on exploratory behaviour? Neuroscience & Biobehavioral Reviews (1991) 15: 473-477 J.Harro, E.Vasar Evidence that CCKB receptors mediate the regulation of exploratory behaviour in the rat. European Journal of Pharmacology (1991) 193: 379-381 L.Rägo, A.Adojaan, J.Harro, R.-A.Kiivet Correlation between exploratory activity in an elevated plus-maze and number of central and peripheral benzodiazepine binding sites. Naunyn-Schmiedeberg´s Archives of Pharmacology (1991) 343: 301-306 J.Harro, A.Lang, E.Vasar Long-term diazepam treatment produces changes in cholecystokinin receptor binding in rat brain. European Journal of Pharmacology (1990) 180: 77-83 J.Harro, M.Põld, E.Vasar Anxiogenic-like action of caerulein, a CCK-8 receptor agonist, in the mouse: influence of acute and subchronic diazepam treatment. Naunyn-Schmiedeberg`s Archives of Pharmacology (1990) 341: 62-67 J.Harro, R.-A.Kiivet, A.Lang, E.Vasar Rats with anxious or non-anxious type of exploratory behaviour differ in their brain CCK-8 and benzodiazepine receptor characteristics. Behavioural Brain Research (1990) 39: 63-71 L.Rägo, R.-A.Kiivet, A.Adojaan, J.Harro, L.Allikmets Stress-protective action of beta-phenyl(GABA): involvement of central and peripheral type benzodiazepine binding sites. Pharmacology & Toxicology (1990) 66: 41-44 V.Klusa, R.-A.Kiivet, R.Muceniece, I.Liepa, J.Harro, S.Svirskis, A.Andermanis, L.Rägo Thymopentin antagonizes stress-induced changes of GABA/benzodiazepine receptor complex. Regulatory Peptides (1990) 27: 355-365 E.Vasar, A.Lang, J.Harro, L.Allikmets Adaptational changes on sigma and phencyclidine receptors during long-term treatment with haloperidol and raclopride in rats. Bulletin of Experimental Biology and Medicine (1989) 108: 306-309 J.Harro, M.Põld, E.Vasar, L.Allikmets Participation of CCK-8-ergic mechanisms in the regulation of emotional behaviour in rodents. Zhurnal Vysshey Nervnoy Deyatelnosty (1989) 39: 877-883 J.Harro, M.Põld, E.Vasar, L.Allikmets The role of brain cholecystokinin receptors in generation of anxiety states in mice and rats. In: K.V.Sudakov (Ed.) Systems Research in Physiology, Vol. 5. Gordon & Breach, London (1989) pp. 180-196 L.Rägo, R.-A.Kiivet, J.Harro, M.Põld Central- and peripheral-type benzodiazepine receptors: similar regulation by stress and GABA receptor agonists. Pharmacology Biochemistry & Behavior (1989) 32: 879-883 L.Rägo, R.-A.Kiivet, J.Harro, M.Põld Behavioral differences in an elevated plus-maze: correlation between anxiety and decreased number of GABA and benzodiazepine receptors in mouse cerebral cortex. Naunyn-Schmiedeberg´s Archives of Pharmacology (1988) 337: 675-678 L.K.Rägo, R.A.K.Kiivet, J.E.Harro, L.H.Allikmets Benzodiazepine binding sites in mice forebrain and kidneys: evidence for similar regulation by GABA agonists. Pharmacology Biochemistry & Behavior (1986) 24: 1-3 L.Rägo, R.-A.Kiivet, J.Harro Variation in behavioral response to baclofen: correlation with benzodiazepine binding sites in mouse forebrain. Naunyn-Schmiedeberg´s Archives of Pharmacology (1986) 333: 303-306 |
viimati muudetud: 10.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Jaanus |
| 2. | Surname | Harro |
| 3. | Institution | Department of Psychology, University of Tartu |
| 4. | Position | Professor of Psychophysiology |
| 5. | Date of birth | 07.11.1962 (day.month.year) |
| 6. | Education | Võru Kreutzwald Gymnasium, graduated in 1981 Faculty of Medicine, University of Tartu, graduated as MD 1987 |
| 7. | Research and professional experience |
August 1987 - July 1989 - Research Associate at the Department of Pharmacology, University of Tartu, Estonia August 1989 - June 1993 - Staff Scientist at the Laboratory of Psychopharmacology, Institute of General and Molecular Pathology, University of Tartu August 1989 - December 1990 - Assistant Professor in Basic Pharmacology, University of Tartu July - December 1993 - Senior Researcher in Neurobiology, Head, Psychopharmacology Unit, Department of Physiology, University of Tartu January 1994 -March 1996 - Professor of Neuropsychopharmacology (personal appointment), Department of Pharmacology, University of Tartu September 1994 - January 1998 - Vice Dean, Preclinical Medicine, Faculty of Medicine, University of Tartu April 1996 - January 1998 - Professor of Health Promotion (personal appointment), Estonian Health Project, affiliated to the Department of Public Health, University of Tartu Since February 1, 1998 - Full Professor of Psychophysiology, Department of Psychology, University of Tartu February 1, 2000 – August 31, 2001 – Head, Department of Psychology, University of Tartu Since August 1, 2001 – Dean, Faculty of Social Sciences, University of Tartu, and Member of the University Government Since 2001 - Director of the Estonian Centre of Excellence in Behavioural and Health Sciences |
| 8. | Academic degree | Candidate in Medical Sciences Doctor in Medical Sciences (PhD) |
| 9. | Dates and sites of earning the degrees |
University of Tartu 1990 University of Uppsala 1993 |
| 10. | Honours/awards | Autumn 1993 - European College of Neuropsychopharmacology Fellowship Award Autumn 1994 - Israel Hwasser's Prize (from the Uppsala Physicians' Society for the best academic dissertation thesis of the year) January 1996 - Academia Europeae Baltic Prize to young scholars February 27, 1998 - Docent of Pharmacology at the University of Uppsala, Sweden 1998 - CINP Ole Rafaelsen Travel Fellowship Award May 2002 - Medal of the Tartu City June 2003 – Invitatation to assume permanent professorship in pharmacology at the University of Umeå, Sweden; declined for personal reasons February 2005 – National Annual Prize in Medical Sciences |
| 11. | Research-administrative experience |
1994 - Member of the Estonian Medical Science Evaluation Panel September 1994 - January 1998 - Vice Dean, Preclinical Medicine, Faculty of Medicine, University of Tartu 1994 – 1999 - Member of the Permanent Scientific Degree Committee of the Faculty of Medicine of the University of Tartu September 1996 – December 2000 - Member of the Public Health Advisory Board at the Ministry of Social Affairs, Estonia Since September 1999 - Elected Member of the Tartu University Council 1999 - 2003 – Member of the Committee of the National Program of R&D in Public Health at the Ministry of Social Affairs, Estonia February 1, 2000 – August 31, 2001 – Head, Department of Psychology, University of Tartu Since August 1, 2001 – Dean, Faculty of Social Sciences, University of Tartu, and Member of the University Government Since 2001 – Member of the Estonian Academy of Sciences Committee of Population and Public Health Since 2001 – Member of the Board of the Neuroscience Graduate School, University of Tartu 2001 – Founding Director, and since then Chairman of the Board of the Estonian Centre of Excellence in Behavioural and Health Sciences (ECBHS) Since 2004 - Member of the Education Committee and Scientific Secretary of the CCEE Regional Committee of the Collegium Internationale Neuro-Psychopharmacologicum Since February 2005 – Representative of Estonia in the NATO Research and Technological Organization Panel “Human Factor and Medicine” Since September 2005 - Director of the Doctoral School in Behavioural and Health Sciences |
| 12. | Supervised dissertations |
Evelyn Kiive, PhD, 2005, superv. Jaanus Harro. Studies on peripheral markers of central serotonergic activity and behaviour. University of Tartu Aet Alttoa, MSc, 2004, superv. Jaanus Harro. Neurochemical regulation of rat exploratory behaviour: focus on dopaminergic and noradrenergic neurotransmission. University of Tartu Maiken Jaanisk, MSc, 2004, superv. Jaanus Harro, Jüri Allik. The stability of Eating Disorders Inventory (EDI-2) scales and associations with the activity of platelet monoamine oxidase (MAO). [in Estonian]. University of Tartu Riina Häidkind, PhD, 2004, superv. Jaanus Harro. Monoaminergic mechanisms in mood-associated behaviours and neurochemistry in rats.. University of Tartu Tanel Mällo, MSc, 2004, superv. Jaanus Harro. The role of corticotropin-releasing factor and locus coeruleus in the regulation of exploratory behaviour in rats. University of Tartu Marika Paaver, MSc, 2003, superv. Jaanus Harro. Impulsivity and platelet MAO activity: association with health-compromising behaviours like problem drinking, smoking and driving while impaired. University of Tartu Anneli Zirkel, MSc, 2002, superv. Jaanus Harro. Drug and alternative medicine usage among Estonian population. [in Estonian]. University of Tartu Inga Dorofejeva, MSc, 2002, superv. Peeter Torop, Jaanus Harro. Discourse of health promotion in Estonia: an analysis of health promotion projects of 1995-1998. University of Tartu Liis Merenäkk, MSc, 2002, superv. Maarike Harro, Jaanus Harro. Association of alcohol and drug use with personality characteristics and platelet MAO activity in schoolchildren. [in Estonian]. University of Tartu Margus Tõnissaar, MSc, 2002, superv. Jaanus Harro. Serotonergic regulation of social behaviour of rats in the social interaction test. University of Tartu Evelyn Kiive, MSc, 2001, superv. Jaanus Harro. Platelet monoamine oxidase activity in association with childhood aggressive and hyperactive behaviour, smoking, alcohol and illicit drug use. University of Tartu Annemari Arro, MSc, 2000, superv. Ago Rinken, Jaanus Harro. Binding of [3H] 8-OH-DPAT to rat brain membranes, and the effects of modulating factors. [in Estonian]. University of Tartu Diva Eensoo, MSc, 2000, superv. Jaanus Harro. Association of physical activity with mental health and personality. [in Estonian]. University of Tartu Ants Kask, PhD, 1999, superv. Jaanus Harro, Lembit Rägo. Behavioural effects of neuropeptide Y.. University of Tartu Riina Häidkind, MSc, 1999, superv. Jaanus Harro. Chronic mild stress model of depression: forced swimming behavior and monoamine neurochemistry. University of Tartu Charlotta Löfberg, PhD, 1996, superv. Lars Oreland, Jaanus Harro. Studies of cholecystokinin peptides and receptors in the central nervous system.. University of Uppsala Tiina Ööpik, MSc, 1993, superv. Jaanus Harro. The effect of selective CCK receptor antagonists on the morphine-conditioned place preference. [in Estonian]. Tartu Ülikool |
| 13. | Current research program | Behavioural and biochemical psychopharmacology of anxiogenic and anxiolytic drugs Behavioural, neurochemical and psychopharmacological analysis of novelty-related and social behaviours Psychopharmacology of neuropeptides (CCK, NPY, CRF) Experimental and theoretical modelling of depression and anxiety Neurochemistry of monoamine systems Psychobiology of personality and health-related behaviour |
| 14. | Current grant funding | 1. Institutional grant TSOPH2643 from the Estonian Ministry of Education (2004-2008) to J. Harro, “Etiopathogenesis of affective disorders: focus on neurobiology, typology and dimensionality of psychobiological mechanisms of adaptation.” Budget 2005: 690 000 EEK 2. EC 6th Framework Integrated Project NEWMOOD (“New molecules in mood disorders: a genomic, neurobiological and systems approach in animal models and human disorder” Partnership (2004-2009). Budget of the first 18 months: 155 075 € (2 426 900 EEK) 3. Estonian Science Foundation, grant ESF5450 “Platelet monoamine oxidase activity and other markers of monoaminergic systems in predicting impulsivity and risk-taking behaviour” (2003-2006). Budget 2004: 190 000 EEK, 2005 – 144 706 + 25 536 kr. |
| 15. | List of most important publications |
A. Alttoa, K. Kõiv, M. Eller, A. Uustare, A. Rinken, J. Harro Effects of low dose N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine administration on exploratory and amphetamine-induced behavior and dopamine D2 receptor function in rats with high or low exploratory activity. Neuroscience (2005) 132: 979-990 D. Eensoo, M. Paaver, M. Harro, J. Harro Predicting drunk driving: contribution of alcohol use and related problems, traffic behaviour, personality and platelet monoamine oxidase (MAO) activity. Alcohol & Alcoholism (2005) 40: 140-146 E. Kiive, L. Merenäkk, M. Harro, J. Harro Changes in platelet monoamine oxidase activity, cholesterol levels and hyperactive behaviour in adolescents over a period of three years. Neuroscience Letters (2005) 384: 310-315 S.O. Fetissov, J. Harro, M. Jaanisk, A. Järv, I. Podar, J. Allik, I. Nilsson, P. Sakthivel, A.K. Lefvert, T. Hökfelt Autoantibodies against neuropeptides are associated with psychological traits in eating disorders. Proceedings of the National Academy of Sciences of the U.S.A. (2005) 102: 14865-14870 A. Alttoa, J. Harro Effect of CCK1 and CCK2 receptor blockade on amphetamine-stimulated exploratory behaviour and sensitization to amphetamine. European Neuropsychopharmacology (2004) 14: 324-331 D. Eensoo, M. Paaver, A. Pulver, M. Harro, J. Harro Low platelet MAO activity associated with high dysfunctional impulsivity and antisocial behaviour: evidence from drunk drivers. Psychopharmacology (2004) 172: 356-358 E. Kiive, J. Maaroos, J. Shlik, I. Tõru, J. Harro Growth hormone, cortisol and prolactin responses to physical exercise: higher prolactin response in depressed patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2004) 28: 1007-1013 J. Harro Animal models for better antidepressants: can pathogenetic approaches make a difference? Preclinica (2004) 2: 402-407 J. Harro Appendix A: Pharmacodynamics and pharmacokinetics. In: J. Panksepp (ed) Textbook of Biological Psychiatry, John Wiley & Sons 2004, pp 661-681 J. Harro, K. Fischer, S. Vansteelandt, M. Harro Both low and high activity of platelet monoamine oxidase increase the probability of becoming a smoker. European Neuropsychopharmacology (2004) 14: 65-69 J. Harro On Holy Ground: Modern neuropsychopharmacology in the old laboratories of Buchheim, Schmiedeberg and Kraepelin in Tartu/Dorpat. In: T.A. Ban, D. Healy, E. Shorter (eds) Reflections on Twentieth-Century Psychopharmacology. Animula, Budapest 2004, pp 355-360 J. Panksepp, J. Harro Future of neuropeptides in biological psychiatry and emotional psychopharmacology: Goals and strategies. In: J. Panksepp (ed) Textbook of Biological Psychiatry, John Wiley & Sons, 2004, pp 627-659 M. Tõnissaar, M.-A. Philips, M. Eller, J. Harro Sociability trait and serotonin metabolism in the rat social interaction test. Neuroscience Letters (2004) 367: 309-312 R. Häidkind, M. Eller, A. Kask, M. Harro, A. Rinken, L. Oreland, J. Harro Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatment. Neurochemistry International (2004) 45: 721-732 T. Mällo, C. Berggård, M. Eller, M. Damberg, L. Oreland, J. Harro Effect of long-term blockade of CRF1 receptors on exploratory behavior, monoamines and transcription factor AP-2. Pharmacology Biochemistry & Behavior (2004) 77: 855-865 J. Harro, A. Terasmaa, M. Eller, A. Rinken Effect of denervation of the locus coeruleus projections by DSP-4 treatment on [3H]-raclopride binding to dopamine D2 receptors and D2 receptor - G-protein interaction in the rat striatum. Brain Research (2003) 976: 209-216 L. Merenäkk, M. Harro, E. Kiive, K. Laidra, D. Eensoo, J. Allik, L. Oreland, J. Harro Association between substance use, personality traits and platelet MAO activity in preadolescents and adolescents. Addictive Behaviors (2003) 28: 1507-1514 R. Häidkind, M. Eller, M. Harro, A. Kask, A. Rinken, L. Oreland, J. Harro Effects of partial locus coeruleus denervation and chronic mild stress on behaviour and monoamine neurochemistry in the rat. European Neuropsychopharmacology (2003) 13: 19-28 A. Kask, J. Harro, S. von Hörsten, P. Redrobe, Y. Dumont, R. Quirion The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neuroscience & Biobehavioral Reviews (2002) 26: 259-283 E. Kiive, D. Eensoo, M. Harro, J. Harro Platelet monoamine oxidase activity in association with childhood aggressive and hyperactive behaviour: the effect of smoking? Personality & Individual Differences (2002) 33: 355-363 J. Harro Long-term partial 5-HT depletion: interference of anxiety and impulsivity? Psychopharmacology (2002) 164: 433-434 L. Oreland, M. Damberg, H. Garpenstrand, J. Harro, J. Hallman Platelet monoamine oxidase, transcription factor AP-2 and personality – a functional triangle? In: T. Nagatsu, T. Nabeshima, R. McCarty, D.S. Goldstein (eds) Catecholamine Research: From Molecular Insights to Clinical Medicine. Kluwer Academic/Plenum Publishers 2002, pp 439-442 M. Eller, J. Harro Partial denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 potentiates the long-term effect of parachloroamphetamine on 5-HT metabolism in the rat. Neuroscience Letters (2002) 322: 53-56 R. Häidkind, T. Kivastik, M. Eller, I. Kolts, L. Oreland, J. Harro Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 reduces dopamine release potential in the nucleus accumbens shell in conscious rats. Neuroscience Letters (2002) 332: 79-82 J. Harro, A.-M. Viru Endurance training by forced swimming reduces emotionality in rats. Biology of Sport (2001) 18: 119-125 J. Harro, L. Oreland Depression as a spreading adjustment disorder of monoaminergic neurons: a case for primary implication of the locus coeruleus. Brain Research Reviews (2001) 38: 79-128 J. Harro, M. Tõnissaar, M. Eller, A. Kask, L. Oreland Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry. Brain Research (2001) 899: 227-239 J. Harro, M. Tõnissaar, M. Eller The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat. Neuropeptides (2001) 35: 100-109 M. Damberg, M. Eller, M. Tõnissaar, L. Oreland, J. Harro Levels of transcription factors AP-2a and AP-2ß in the brainstem are correlated to monoamine turnover in the rat forebrain. Neuroscience Letters (2001) 313: 102-104 M. Harro, D. Eensoo, E. Kiive, L. Merenäkk, J. Alep, L. Oreland, J. Harro Platelet monoamine oxidase in healthy 9- and 15-years old children: the effect of gender, smoking and puberty. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2001) 25: 1497-1511 A. Kask, H. Schiöth, J. Harro, J. Wikberg, L. Rägo Orexigenic effect of the MC4 antagonist HS014 is only partially inhibited by neuropeptide Y Y1 receptor antagonists. Canadian Journal of Physiology and Pharmacology (2000) 78: 143-149 A. Kask, J. Harro Inhibition of amphetamine and apomorphine-induced behavioural effects by neuropeptide Y Y1 receptor antagonist BIBO 3304. Neuropharmacology (2000) 39: 1292-1302 A. Kask, M. Eller, L. Oreland, J. Harro Neuropeptide Y attenuates the effect of locus coeruleus denervation by DSP-4 treatment on social behaviour in the rat. Neuropeptides (2000) 34: 58-61 D. Eensoo, J. Harro, M. Harro, H. Rimm, A.-M. Viru Depressiveness, anxiety, perceived stress and self-efficacy in middle-aged men with different engagement in physical activity. Medicina dello Sport (2000) 53: 69-74 J.A. Prince, J. Harro, K. Blennow, C.G. Gottfries, L. Oreland Putamen mitochondrial energy metabolism is highly correlated to emotional and intellectual impairment in schizophrenics. Neuropsychopharmacology (2000) 22: 284-292 J. Harro, A. Meriküla, M. Lepiku, A.-R. Modiri, A. Rinken, L. Oreland Lesioning of the locus coeruleus projections by DSP-4 treatment: the effect on amphetamine-induced hyperlocomotion and dopamine D2 receptor binding in the rat. Pharmacology & Toxicology (2000) 86: 197-202 A. Kask, T. Kivastik, L. Rägo, J. Harro Neuropeptide Y Y1 receptor antagonist BIBP3226 produces conditioned place aversion in rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry (1999) 23: 705-711 H. Rimm, M. Harro, K. Karelson, M. Grauberg, A.-M. Viru, J. Harro State of mood and self-efficacy in relation to physical activity and fitness in young healthy men. Acta Psychiatrica Belgica (1999) 99: 16-26 J. Harro, H. Rimm, M. Harro, M. Grauberg, K. Karelson, A.-M. Viru Association of depressiveness with blunted growth hormone response to maximal physical exercise in young healthy men. Psychoneuroendocrinology (1999) 24: 505-517 J. Harro, R. Häidkind, M. Harro, A.-R. Modiri, P.-G. Gillberg, R. Pähkla, V. Matto, L. Oreland Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment. European Neuropsychopharmacology (1999) 10: 5-16 J. Harro, R. Pähkla, A.-R. Modiri, M. Harro, A. Kask, L. Oreland Dose-dependent effects of noradrenergic denervation by DSP-4 treatment on forced swimming and ß-adrenoceptor binding in the rat. Journal of Neural Transmission (1999) 106: 619-629 A. Kask, L. Rägo, J. Harro Anxiogenic-like effect of the NPY Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats. Regulatory Peptides (1998) 75/76: 255-262 A. Kask, L. Rägo, J. Harro Anxiolytic-like effects of NPY and NPY13-36 microinjected into vicinity of locus coeruleus in rats. Brain Research (1998) 788: 345-348 A. Kask, L. Rägo, J. Harro Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. British Journal of Pharmacology (1998) 124: 1507-1515 A. Kask, L. Rägo, J. Harro NPY Y1 receptors in the dorsal periaqueductal gray matter regulate anxiety in the social interaction test. Neuroreport (1998) 9: 2713-2716 A. Kask, L. Rägo, J. Harro Opposite effects of [Leu31,Pro34]NPY and NPY13-36 on hypnotic response to a2-adrenoceptor agonist dexmedetomidine microinjected into rat locus coeruleus. Neuroscience Research Communications (1998) 23: 41-44 A. Rinken, J. Harro, L. Engström, L. Oreland Role of fluidity of membranes on the guanyl nucleotide-dependent binding of cholecystokinin-8s to rat brain cortical membranes. Biochemical Pharmacology (1998) 55: 423-431 C. Löfberg, H. Ågren, J. Harro, L. Oreland Cholecystokinin in the CSF from depressed patients: possible relations to severity of depression and suicidal behaviour. European Neuropsychopharmacology (1998) 8: 153-157 C. Löfberg, J. Harro, V. Matto, L. Oreland Cholecystokinin peptides and receptor binding in rat brain after DSP-4 treatment. Neuropeptides (1998) 32: 103-108 A. Kask, J. Harro, P. Tuomainen, L. Rägo, P.T. Männistö Overflow of noradrenaline and dopamine in frontal cortex in [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treated rats: in vivo microdialysis study. Naunyn-Schmiedeberg’s Archives of Pharmacology (1997) 355: 267-272 A. Kask, L. Rägo, J. Harro a-Helical CRF9-41 prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in rats. Neuroreport (1997) 8: 3645-3647 J. Harro, C. Löfberg, R. Pähkla, V. Matto, L. Rägo, L. Oreland, L. Allikmets Different molecular forms of cholecystokinin and CCKB receptor binding in the rat brain after chronic antidepressant treatment. Naunyn-Schmiedeberg’s Archives of Pharmacology (1997) 355: 57-63 J. Harro, H. Rimm, M. Sallo, N. Jaanimägi, A. Päevloo, I. Villa Does the personality of parents influence the physical activity of their children? In: N. Armstrong, B.J. Kirby, J.R. Welsman (eds) Children and Exercise XIX: Promoting Children's Health and Well-being. E & FN Spon (Chapman & Hall) London 1997, pp 157-162 M.-H. Otter, V. Matto, R. Sõukand, T. Skrebuhhova, L. Allikmets, J. Harro Characterization of rat exploratory behaviour using the exploration box test. Methods and Findings in Experimental and Clinical Pharmacology (1997) 19: 683-691 M. Sallo, J. Harro, A. Viru Moderate to vigorous physical activities in preadolescent children. In: N. Armstrong, B.J. Kirby, J.R. Welsman (eds) Children and Exercise XIX: Promoting Children's Health and Well-being. E & FN Spon (Chapman & Hall) London 1997, pp 151-156 V. Matto, J. Harro, L. Allikmets The effect of drugs acting on CCK receptors and rat free exploration in the exploration box. Journal of Physiology and Pharmacology (1997) 48:239-251 V. Matto, J. Harro, L. Allikmets The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in rat. Neuropharmacology (1997) 36: 389-396 A. Kask, L. Rägo, J. Harro Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. European Journal of Pharmacology (1996) 317: R3-R4 C. Löfberg, J. Harro, C.-G. Gottfries, L. Oreland Cholecystokinin peptides and receptor binding in Alzheimer's disease. Journal of Neural Transmission [Parkinson's Disease and Dementia Section] (1996) 103: 851-860 J. Harro, C. Löfberg, J. Rehfeld, L. Oreland Cholecystokinin peptides and receptors in the rat brain during stress. Naunyn-Schmiedeberg's Archives of Pharmacology (1996) 354: 59-66 J. Harro, L. Oreland Depression as a spreading neuronal adjustment disorder. European Neuropsychopharmacology (1996) 6: 207-223 R. Pähkla, J. Harro, L. Rägo Behavioural effects of pinoline in the rat forced swimming, open field and elevated plus-maze tests. Pharmacological Research (1996) 34: 73-78 V. Matto, J. Harro, L. Allikmets The effects of cholecystokinin A and B receptor antagonists, devazepide and L 365,260, on citalopram-induced decrease of exploratory behaviour in rat. Journal of Physiology and Pharmacology (1996) 47: 661-669 A. Lang, J. Harro, A. Soosaar, S. Kõks, V.Volke, L. Oreland, M. Bourin, E. Vasar, J. Bradwejn, P.T. Männistö Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats. Naunyn-Schmiedeberg's Archives of Pharmacology (1995) 351: 363-370 J. Harro, E. Vasar, D. Koszycki, J. Bradwejn The CCK hypothesis of anxiety and panic. In: J. Panksepp (ed) Advances in Biological Psychiatry, Vol 1, JAI Press 1995, pp 235-262 J. Harro, E. Vasar, L. Oreland, P.T. Männistö Animal studies on CCK and anxiety. In: J. Bradwejn, E. Vasar (eds) CCK and Anxiety: from Neuron to Behaviour. R.G. Landes Company (1995) 57-72 J. Harro, L.Oreland, E. Vasar, J. Bradwejn Impaired exploratory behaviour after DSP-4 treatment in rats: implications for the increased anxiety after noradrenergic denervation. European Neuropsychopharmacology (1995) 5: 447-455 E. Peuranen, A. Lang, J. Harro, E. Vasar, P.T. Männistö Effect of caerulein and cholecystokinin antagonists on hypophyseal hormone secretion in single-housed and group-housed male rats. In: S. Seredenin, V.G. Longo (eds) Biological Basis of Individual Sensitivity to Psychotropic Drugs Harwood Academic Publishers Amsterdam 1994, pp 63-72 E. Vasar, A. Lang, J. Harro, M. Bourin, J. Bradwejn Evidence for potentiation by CCK antagonists of the effect of cholecystokinin octapeptide in the elevated plus-maze. Neuropharmacology (1994) 33: 729-735 E. Vasar, A. Lang, J. Harro, S. Kõks, V. Volke, S. Sihver, M. Bourin, J. Bradwejn, P.T. Männistö Subdiaphragmatic vagotomy does not prevent the anti-exploratory effect of caerulein in the elevated plus-maze. Neuropeptides (1994) 26: 39-45 F. Sherif, J. Harro, A. El-Hwuegi, L. Oreland Anxiolytic-like effect of the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA) on rat exploratory activity. Pharmacology Biochemistry & Behavior (1994) 49: 801-805 J. Harro, G. Wahlström, L. Oreland Cholecystokinin receptor binding after long-term ethanol treatment in rats. Alcohol & Alcoholism (1994) 29: 575-581 M. Welin, J. Harro, R. Yukhananov, F. Nyberg, L. Oreland Cholecystokinin receptor binding in morphine analgesia, tolerance, withdrawal and abstinence. Neuropeptides (1994) 26: 379-383 P.T. Männistö, A. Lang, J. Harro, E. Peuranen, J. Bradwejn, E. Vasar Opposite effects mediated by CCKA and CCKB receptors in behavioural and hormonal studies in rats. Naunyn-Schmiedeberg's Archives of Pharmacology (1994) 349: 478-484 E.Vasar, E.Peuranen, T.Ööpik, J.Harro, P.T.Männistö Ondansetron, an antagonist of 5-HT3 receptors, antagonizes the anti-exploratory effect of caerulein, an agonist of CCK receptors, in the elevated plus-maze. Psychopharmacology (1993) 110: 213-218 E.Vasar, J.Harro, A.Lang, A.Soosaar, T.Ööpik, S. Kõks, S.Sihver, V.Volke Anti-exploratory effect of N-methyl-D-aspartate in elevated plus-maze. Involvement of NMDA and CCK receptors. European Neuropsychopharmacology (1993) 3: 63-73 E.Vasar, P.T.Männistö, L.Oreland, J.Harro, E.Peuranen, A.Lang Social isolation modulates the sensitivity of cholecystokinin receptors in the rat brain. Naunyn-Schmiedeberg’s Archives of Pharmacology (1993) 248: 96-101 J.Harro, E.Vasar, J.Bradwejn Cholecystokinin in animal and human research on anxiety. Trends in Pharmacological Sciences (1993) 14: 244-249 J.Harro, L.Oreland Cholecystokinin receptors and memory: A radial maze study. Pharmacology Biochemistry & Behavior (1993) 44: 509-517 J.Harro Measurement of Exploratory Behaviour in Rodents. In: P.M.Conn (Ed.) Methods in Neurosciences, Vol. 14, Academic Press, San Diego (1993) pp. 359-377 J.Harro, P.Westerling, L.Oreland CCKB receptor activation reduces glutamate-induced depolarization in slices of rat cerebral cortex. Journal of Neural Transmission [General Section] (1993) 93: 61-66 A.Lang, E.Vasar, A.Soosaar, J.Harro The involvement of sigma and phencyclidine receptors in the action of antipsychotic drugs. Pharmacology & Toxicology (1992) 71: 132-138 E.Vasar, A.Soosaar, J.Harro, A.Lang Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol. European Neuropsychopharmacology (1992) 2: 447-454 E.Vasar, J.Harro, A.Põld, A.Lang CCK receptors and anxiety in rats. In: C.T.Dourish, S.J.Cooper, S.D.Iversen, L.L.Iversen (eds) Multiple Cholecystokinin Receptors in the CNS (1992) Oxford University Press, pp. 143-148 J.Harro, J.Marcusson, L.Oreland Alterations in brain cholecystokinin receptors in suicide victims. European Neuropsychopharmacology (1992) 2: 57-63 J.Harro, L.Oreland Age-related differences of cholecystokinin receptor binding in the rat brain. Progress in Neuro-Psychopharmacology & Biological Psychiatry (1992) 16: 369-375 J.Harro, S.S.Jossan, L.Oreland Changes in cholecystokinin receptor binding in rat brain after selective damage of locus coeruleus projections by DSP-4 treatment. Naunyn-Schmiedeberg´s Archives of Pharmacology (1992) 346: 425-431 P.T.Männistö, E.Peuranen, J.Harro, E.Vasar Possible role of cholecystokinin-A receptors in regulation of thyrotropin (TSH) secretion in male rats. Neuropeptides (1992) 23: 251-258 E.Vasar, J.Harro, A.Lang, A.Põld, A.Soosaar Differential involvement of CCK-A and CCK-B receptors in the regulation of locomotor activity in the mouse. Psychopharmacology (1991) 105: 393-399 J.Harro, E.Vasar Cholecystokinin-induced anxiety: How is it reflected in studies on exploratory behaviour? Neuroscience & Biobehavioral Reviews (1991) 15: 473-477 J.Harro, E.Vasar Evidence that CCKB receptors mediate the regulation of exploratory behaviour in the rat. European Journal of Pharmacology (1991) 193: 379-381 L.Rägo, A.Adojaan, J.Harro, R.-A.Kiivet Correlation between exploratory activity in an elevated plus-maze and number of central and peripheral benzodiazepine binding sites. Naunyn-Schmiedeberg´s Archives of Pharmacology (1991) 343: 301-306 J.Harro, A.Lang, E.Vasar Long-term diazepam treatment produces changes in cholecystokinin receptor binding in rat brain. European Journal of Pharmacology (1990) 180: 77-83 J.Harro, M.Põld, E.Vasar Anxiogenic-like action of caerulein, a CCK-8 receptor agonist, in the mouse: influence of acute and subchronic diazepam treatment. Naunyn-Schmiedeberg`s Archives of Pharmacology (1990) 341: 62-67 J.Harro, R.-A.Kiivet, A.Lang, E.Vasar Rats with anxious or non-anxious type of exploratory behaviour differ in their brain CCK-8 and benzodiazepine receptor characteristics. Behavioural Brain Research (1990) 39: 63-71 L.Rägo, R.-A.Kiivet, A.Adojaan, J.Harro, L.Allikmets Stress-protective action of beta-phenyl(GABA): involvement of central and peripheral type benzodiazepine binding sites. Pharmacology & Toxicology (1990) 66: 41-44 V.Klusa, R.-A.Kiivet, R.Muceniece, I.Liepa, J.Harro, S.Svirskis, A.Andermanis, L.Rägo Thymopentin antagonizes stress-induced changes of GABA/benzodiazepine receptor complex. Regulatory Peptides (1990) 27: 355-365 E.Vasar, A.Lang, J.Harro, L.Allikmets Adaptational changes on sigma and phencyclidine receptors during long-term treatment with haloperidol and raclopride in rats. Bulletin of Experimental Biology and Medicine (1989) 108: 306-309 J.Harro, M.Põld, E.Vasar, L.Allikmets Participation of CCK-8-ergic mechanisms in the regulation of emotional behaviour in rodents. Zhurnal Vysshey Nervnoy Deyatelnosty (1989) 39: 877-883 J.Harro, M.Põld, E.Vasar, L.Allikmets The role of brain cholecystokinin receptors in generation of anxiety states in mice and rats. In: K.V.Sudakov (Ed.) Systems Research in Physiology, Vol. 5. Gordon & Breach, London (1989) pp. 180-196 L.Rägo, R.-A.Kiivet, J.Harro, M.Põld Central- and peripheral-type benzodiazepine receptors: similar regulation by stress and GABA receptor agonists. Pharmacology Biochemistry & Behavior (1989) 32: 879-883 L.Rägo, R.-A.Kiivet, J.Harro, M.Põld Behavioral differences in an elevated plus-maze: correlation between anxiety and decreased number of GABA and benzodiazepine receptors in mouse cerebral cortex. Naunyn-Schmiedeberg´s Archives of Pharmacology (1988) 337: 675-678 L.K.Rägo, R.A.K.Kiivet, J.E.Harro, L.H.Allikmets Benzodiazepine binding sites in mice forebrain and kidneys: evidence for similar regulation by GABA agonists. Pharmacology Biochemistry & Behavior (1986) 24: 1-3 L.Rägo, R.-A.Kiivet, J.Harro Variation in behavioral response to baclofen: correlation with benzodiazepine binding sites in mouse forebrain. Naunyn-Schmiedeberg´s Archives of Pharmacology (1986) 333: 303-306 |
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