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| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Vootele |
| 2. | Perekonnanimi | Võikar |
| 3. | Töökoht | Närviteaduste uurimiskeskus, Helsingi ülikool |
| 4. | Ametikoht | teadur |
| 5. | Sünniaeg | 26.04.1969 (päev.kuu.aasta) |
| 6. | Haridus | kõrgharidus |
| 7. | Teenistuskäik | 1987-1994 – üliõpilane, arstiteaduskond, Tartu ülikool 1994-1998 – assistent, Füsioloogia instituut, Tartu ülikool 1998 – külalisteadur, Biotehnoloogia instituut, Helsingi ülikool 1999-2002 – doktorant, Soome närviteaduste kraadiõppekool (juhendajad prof. Heikki Rauvala ja prof. Eero Vasar) 2003-... – teadur, Närviteaduste uurimiskeskus, Helsingi ülikool |
| 8. | Teaduskraad | MD |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu ülikool, 1994 |
| 10. | Tunnustused | 2004 - Eesti Vabariigi teaduspreemia, meditsiiniteadus (teadusgrupi juht prof. Eero Vasar) |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
International Behavioural and Neural Genetics Society, lihtliige Eelretsenseerija ajakirjadele Genes, Brain and Behavior; Physiology & Behavior; Brain Research; Behavioural Brain Research; Brain, Behavior and Immunity 1997 - treeningkursus 'Laboratory animals in biomedical research' (Tartu, Eesti): organisaator ja õpetaja 1999 - rahvusvaheline sümpoosium 'Brain plasticity and behaviour' (Helsinki, Soome): organiseerimiskomitee liige 2000 - doktorantide kursus 'Behavioral analysis of transgenic mice' (Helsinki, Soome): organisaator ja lektor 2004 - Skandinaavia Laboriloomateaduse Ühingu 34. sümpoosium (Tallinn, Eesti): teaduskomitee liige |
| 12. | Juhendamisel kaitstud väitekirjad |
Anne Polus, MSc, 2005, juh. Vootele Võikar, Heikki Rauvala. Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences (in Finnish). Helsinki, Finland Cecilia Andergård, MSc, 2001, juh. Vootele Võikar, Heikki Rauvala. Behavioral analysis of three inbred strains of mice commonly used in transgenic research. Helsinki, Finland Nina Perälä, MSc, 2001, juh. Matti Airaksinen, Vootele Võikar. The behaviour and seizure susceptibility of potassium chloride co-transporter 3 hypomorphic mice. Oulu, Finland Susanna Söderlund, MSc, 1999, juh. Vootele Võikar, Heikki Rauvala. Studies on the behaviour of mice: effects of N-syndecan deficiency. Helsinki, Finland |
| 13. | Teadustöö põhisuunad | Hiirte käitumisanalüüs – geenimutatsioonidega hiired, geneetilise tausta mõju, uuringuteks vajaliku metoodika väljatöötamine ning hindamine Hirmu ja ärevuse mehhanismid Õppimise ja mälu neurobioloogia |
| 14. | Jooksvad grandid | |
| 15. | Teaduspublikatsioonid |
Koponen E, Rantamäki T, Voikar V, Saarelainen T, MacDonald E, Castrén E. Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. Cell Mol Neurobiol (2005) in press Tornberg J, Voikar V, Savilahti H, Rauvala H, Airaksinen MS. Behavioural phenotypes of hypomorphic KCC2-deficient mice. Eur J Neurosci (2005) 21:1327-1337. Voikar V, Polus A, Vasar E, Rauvala H. Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences. Genes Brain Behav (2005) 4:240-252. Koponen E, Voikar V, Riekki R, Saarelainen T, Rauramaa T, Rauvala H, Taira T, Castren E. Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of trkB/PLC-gamma pathway, reduced anxiety and facilitated learning. Mol Cell Neurosci (2004) 26:166-181. Voikar V, Rossi J, Rauvala H, Airaksinen MS. Impaired behavioural flexibility and memory in mice lacking GDNF family receptor α2. Eur J Neurosci (2004) 20:308-312. Voikar V, Vasar E, Rauvala H. Behavioral alterations induced by repeated testing in C57BL/6J and 129S2/Sv mice: implications for phenotyping screens. Genes Brain Behav (2004) 3:27-38. Rossi J, Herzig KH, Voikar V, Hiltunen PH, Segerstråle M, Airaksinen MS. Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor GFRα2. J Clin Invest (2003) 112:707-716. Kaksonen M, Pavlov I, Voikar V, Lauri SE, Hienola A, Riekki R, Lakso M, Taira T, Rauvala H. Syndecan-3 deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory. Mol Cell Neurosci (2002) 21:158-172. Pavlov I, Voikar V, Kaksonen M, Lauri SE, Hienola A, Taira T, Rauvala H. Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice. Mol Cell Neurosci (2002) 20:330-342. Voikar V, Rauvala H, Ikonen E. Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease. Behav Brain Res (2002) 132: 1-10. Voikar V, Kõks S, Vasar E, Rauvala H. Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies. Physiol Behav (2001) 72: 271-281. Kõks S, Bourin M, Voikar V, Soosaar A, Vasar E. Role of CCK in anti-exploratory action of paroxetine, 5-HT reuptake inhibitor. Int J Neuropsychopharmacol (1999) 2, 9-16. Kõks S, Soosaar A, Voikar V, Bourin M, Vasar E. BOC-CCK-4, CCK-B receptor agonist, antagonizes anxiolytic-like action of morphine in elevated plus-maze. Neuropeptides (1999) 33: 63-69. Voikar V, Soosaar A, Volke V, Kõks S, Bourin M, Männistö PT, Vasar E. Apomorphine-induced behavioral sensitization in rats: individual differences, role of dopamine and NMDA receptors. Eur Neuropsychopharmacol (1999) 9:507-514. Kõks S, Soosaar A, Voikar V, Volke V, Ustav M, Männistö PT, Bourin M, Vasar E. Opioid antagonist naloxone potentiates anxiogenic-like action of CCK agonists in elevated plus-maze. Neuropeptides (1998) 32: 235-240. Kõks S, Vasar E, Soosaar A, Lang A, Volke V, Võikar V, Bourin M, Männistö PT. Relation of exploratory behavior of rats in elevated plus-maze to brain receptor binding properties and serum growth hormone levels. Eur Neuropsychopharmacol (1997) 7: 289-294. |
viimati muudetud: 06.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Vootele |
| 2. | Surname | Võikar |
| 3. | Institution | Neuroscience Center, University of Helsinki |
| 4. | Position | researcher |
| 5. | Date of birth | 26.04.1969 (day.month.year) |
| 6. | Education | higher education |
| 7. | Research and professional experience |
1987-1994 - undergraduate student, Medical Faculty, University of Tartu 1994-1998 - assistant, Department of Physiology, University of Tartu 1998 – visiting researcher, Institute of Biotechnology, University of Helsinki 1999-2002 – PhD student, Finnish Graduate School of Neuroscience (supervisors Prof. Heikki Rauvala and Prof. Eero Vasar) 2003-... – researcher, Neuroscience Center, University of Helsinki |
| 8. | Academic degree | MD |
| 9. | Dates and sites of earning the degrees |
University of Tartu, 1994 |
| 10. | Honours/awards | 2004 - Estonian Science Award, medical sciences (group leader prof. Eero Vasar) |
| 11. | Research-administrative experience |
International Behavioural and Neural Genetics Society, member Referee for the journals Genes, Brain and Behavior; Physiology & Behavior; Brain Research; Behavioural Brain Research; Brain, Behavior and Immunity 1997, October, Training course ’Laboratory Animals in Biomedical Research’ (Tartu, Estonia): organizer and teacher 1999, June 29 - July 1, Symposium 'Brain Plasticity and Behaviour' (Helsinki, Finland): member of organizing committee 2000, May, Graduate course ‘Behavioral analysis of transgenic mice’ (Helsinki, Finland): organizer and lecturer 2004, May 13-16, 34th annual symposium of the Scandinavian Society for Laboratory Animal Science (Tallinn, Estonia): member of scientific committee |
| 12. | Supervised dissertations |
Anne Polus, MSc, 2005, superv. Vootele Võikar, Heikki Rauvala. Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences (in Finnish). Helsinki, Finland Cecilia Andergård, MSc, 2001, superv. Vootele Võikar, Heikki Rauvala. Behavioral analysis of three inbred strains of mice commonly used in transgenic research. Helsinki, Finland Nina Perälä, MSc, 2001, superv. Matti Airaksinen, Vootele Võikar. The behaviour and seizure susceptibility of potassium chloride co-transporter 3 hypomorphic mice. Oulu, Finland Susanna Söderlund, MSc, 1999, superv. Vootele Võikar, Heikki Rauvala. Studies on the behaviour of mice: effects of N-syndecan deficiency. Helsinki, Finland |
| 13. | Current research program | Application of genetically modified mice in behavioural neuroscience; studies on environmental factors and genetic background affecting behavioural phenotype; development and validation of test batteries Neurobiology of fear and anxiety Neurobiology of learning and memory |
| 14. | Current grant funding | |
| 15. | List of most important publications |
Koponen E, Rantamäki T, Voikar V, Saarelainen T, MacDonald E, Castrén E. Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. Cell Mol Neurobiol (2005) in press Tornberg J, Voikar V, Savilahti H, Rauvala H, Airaksinen MS. Behavioural phenotypes of hypomorphic KCC2-deficient mice. Eur J Neurosci (2005) 21:1327-1337. Voikar V, Polus A, Vasar E, Rauvala H. Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences. Genes Brain Behav (2005) 4:240-252. Koponen E, Voikar V, Riekki R, Saarelainen T, Rauramaa T, Rauvala H, Taira T, Castren E. Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of trkB/PLC-gamma pathway, reduced anxiety and facilitated learning. Mol Cell Neurosci (2004) 26:166-181. Voikar V, Rossi J, Rauvala H, Airaksinen MS. Impaired behavioural flexibility and memory in mice lacking GDNF family receptor α2. Eur J Neurosci (2004) 20:308-312. Voikar V, Vasar E, Rauvala H. Behavioral alterations induced by repeated testing in C57BL/6J and 129S2/Sv mice: implications for phenotyping screens. Genes Brain Behav (2004) 3:27-38. Rossi J, Herzig KH, Voikar V, Hiltunen PH, Segerstråle M, Airaksinen MS. Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor GFRα2. J Clin Invest (2003) 112:707-716. Kaksonen M, Pavlov I, Voikar V, Lauri SE, Hienola A, Riekki R, Lakso M, Taira T, Rauvala H. Syndecan-3 deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory. Mol Cell Neurosci (2002) 21:158-172. Pavlov I, Voikar V, Kaksonen M, Lauri SE, Hienola A, Taira T, Rauvala H. Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice. Mol Cell Neurosci (2002) 20:330-342. Voikar V, Rauvala H, Ikonen E. Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease. Behav Brain Res (2002) 132: 1-10. Voikar V, Kõks S, Vasar E, Rauvala H. Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies. Physiol Behav (2001) 72: 271-281. Kõks S, Bourin M, Voikar V, Soosaar A, Vasar E. Role of CCK in anti-exploratory action of paroxetine, 5-HT reuptake inhibitor. Int J Neuropsychopharmacol (1999) 2, 9-16. Kõks S, Soosaar A, Voikar V, Bourin M, Vasar E. BOC-CCK-4, CCK-B receptor agonist, antagonizes anxiolytic-like action of morphine in elevated plus-maze. Neuropeptides (1999) 33: 63-69. Voikar V, Soosaar A, Volke V, Kõks S, Bourin M, Männistö PT, Vasar E. Apomorphine-induced behavioral sensitization in rats: individual differences, role of dopamine and NMDA receptors. Eur Neuropsychopharmacol (1999) 9:507-514. Kõks S, Soosaar A, Voikar V, Volke V, Ustav M, Männistö PT, Bourin M, Vasar E. Opioid antagonist naloxone potentiates anxiogenic-like action of CCK agonists in elevated plus-maze. Neuropeptides (1998) 32: 235-240. Kõks S, Vasar E, Soosaar A, Lang A, Volke V, Võikar V, Bourin M, Männistö PT. Relation of exploratory behavior of rats in elevated plus-maze to brain receptor binding properties and serum growth hormone levels. Eur Neuropsychopharmacol (1997) 7: 289-294. |
last updated: 06.10.2005
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