[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Vallo |
| 2. | Perekonnanimi | Matto |
| 3. | Töökoht | Tartu Ülikool, Farmaatsia Instituut |
| 4. | Ametikoht | vanemteadur (biofarmaatsia) |
| 5. | Sünniaeg | 04.02.1969 (päev.kuu.aasta) |
| 6. | Haridus | (1) 1976-1987 Tallinna 42. Keskkool, õpilane (2) September 1987 - Juuni 1991 Tartu Ülikooli Arstiteaduskonna üliõpilane (3) August 1991- Jaanuar 1992 Helsingi Ülikooli Arstiteaduskonna üliõpilane (4) Jaanuar 1992 - Juuni 1993 Tartu Ülikooli Arstiteaduskonna üliõpilane (5) Juuni 1993 - Tartu Ülikooli Arstiteaduskonna lõpetaja, arsti aste (6) September 1993 - Jaanuar 1998 Tartu Ülikooli Farmakoloogia Instituudi doktorant (7) 3. juuni 1998, Tartu Ülikool, meditsiinidoktor |
| 7. | Teenistuskäik | (1)1989-1991 ja 1992-1993 TÜ Psühhiaatriakliiniku lasteosakonna hooldaja ja med.-vend (2) 1993-1997 TÜ Farmakoloogia Instituudi vanemlaborant ja assistent (osalise koormusega) (3) 1997-1998 TÜ Farmakoloogia Instituudi assistent (4) 1999 TÜ Farmakoloogia Instituudi vanemassistent (5) 1999–2001 TÜ Farmakoloogia Instituudi erakorraline vanemteadur (6) 2002–2004 TÜ Farmakoloogia Instituudi vanemassistent (7) 2003 Helsingi Ülikooli (HÜ) neurofüsioloogia teadur (8) 2004-2005 HÜ neurofüsioloogia vanemteadur (9) Käesolevalt: TÜ Farmaatsia Instituut, vanemteadur (biofarmaatsia) |
| 8. | Teaduskraad | meditsiinidoktor |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Ülikool, 3. Juuni 1998 |
| 10. | Tunnustused | 1) “Ants and Maria Silvere and Sigfried Pant Memorial Scholarship at Tartu University Foundation” stipendium, 1997 (2) The European Neuropeptide Club Award, 1997 (3) Eesti Vabariigi Haridusministeeriumi üliõpilaste teadustööde konkursi 3. koht, 1997 (4) Lundbeck Eesti AS 1998 auhind bioloogilises psühhiaatrias (koos mag. Tatjana Skrebuhhova-Malmros’iga) (5) European College of Neuropsychopharmacology (ECNP) Fellowship Award, 2000 (6) 1st Baltic Regional Meeting in Biological Psychiatry, WFSBP postrerite 1. preemia, Vilnius, Leedu, 2000 (7) WFSBP Young Investigator Travel Award 2001 (8) ESRS Poster Prize, Praha Tshehhi Vabariik, 5–9 oktoober 2004, European Sleep Research Society 17th Congress |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
(1) Rudolf Buchheim Conference in Neuropharmacology (Mai, 1995) organiseerimiskomitee liige (2) 2nd Baltic Regional Meeting of Biological Psychiatry (Mai-Juuni, 2001) organiseerimiskomitee sekretär (3) Eesti Farmakoloogia, Psühhiaatrite ja Katseloomateaduse seltside liige |
| 12. | Juhendamisel kaitstud väitekirjad |
|
| 13. | Teadustöö põhisuunad | a) Characterization of binding sites and interaction to neuropeptides of serotonin reuptake inhibitors citalopram, fluoxetine and other antidepressants, projektijuht prof. L. Allikmets. Projekti põhieesmärgiks oli iseloomustada selektiivsete serotoniini tagasihaarde inhibiitorite (SSRI) sidumiskohtade neurokeemilisi omadusi ning SSRIde võimalikke interaktsioone neuropeptiididega. Katsete tulemusel selgus, et SSRIdel ei ole olulist neurokeemilist interaktsiooni koletsüstokiniinergilise närviülekandega, kuid selline seos võib ilmneda käitumuslikul tasandil kaudsete mehhanismide vahendusel suurenenud ärevusnivoo tingimustes. b) The mechanism of affective disorders and the kinetics and mechanism of action of the novel antidepressants, projektijuht prof. L. Allikmets. Projekti raames uuriti põhjalikult erinevate serotoniini retseptorite osa anitidepressantide toimemehhanismis, samuti teiste psühhotroopsete ainete kaudset mõju ning füsioloogilisi faktoreid, mis mõjustavad antidepressantide toimete avaldumist. Katsete tulemused näitasid, et serotoniini 5-HT2A/2C retseptorid võivad olla haaratud antidepressantide ja ka antipsühhootikumide toimetes. c) Elucidation of the mechanism of anxiogenic/anxiolytic action of antidepressants, projektijuht prof. L. Allikmets. Projekt on tihedalt seotud eelneva projektiga, eelnevale lisaks uuriti põhjalikult 5-HT1A jt serotoniiniretseptorite osa neurokeemilistes ja käitumiskatsetes rõhuasetusega emotsionaalsel käitumisele. Tulemuste alusel võib väita, et serotoniinergilise närviülekande osa on antidepressantide poolt vahendatud emotsionaalse käitumise efektides kompleksne ning ei ole võimalik välja tuua selgelt hirmu tekitavat/vähendavat serotoniini retseptoralatüüpi. d) Mechanism of action of second generation antipsychotics: interaction with glutamatergic and serotoninergic systems, projektijuht prof. L. Allikmets. Projekt on suunatud uute, atüüpiliste antipsühhootikumide toimemehhanismide täpsustamisele. Selgitati põhiliselt dopamiinergilise närviülekande ergastumisest kui kaootilise käitumise mudelist tulenevate fenomenide neurobioloogiat ja nende mõjutamist uute, atüüpiliste antipsühhootikumidega. e) Role of accumbal dopamine in molecular mechanisms of ethanol dependence, projektijuhid prof. Liisa Ahtee ja prof. T. Petteri Piepponen, HÜ Farmaatsia teaduskonna Farmakoloogia ja Toksikoloogia osakond. Töö pôhitulemuseks oli, et dopamiini vabanemine N. Accumbensis on osaliselt sôltuv etanooli manustamise viisist. f) Sleep in aging women (EU project QLK6-CT-2000-00499), projekti koordinaator dotsent, Soome Akadeemia vanemteadur Tarja Porkka-Heiskanen (HÜ Biomeditsiini Instituut, Füsioloogia osakond), alaprojekt Non-REM sleep and basal forebrain GABA levels in young and aged female rats. |
| 14. | Jooksvad grandid | |
| 15. | Teaduspublikatsioonid |
Tani P, Lindberg N, Matto V, Appelberg B, Nieminen-von Wendt T, von Wendt L, Porkka-Heiskanen T. Higher plasma ACTH levels in adults with Asperger syndrome. J Psychosom Res. 2005 Jun;58(6):533-6. Wigren HM, Matto V, Schepens M, Kalinchuk A, Stenberg D, Porkka-Heiskanen T. Excitation of cells in the basal forebrain results in subsequent increase in sleep which resembles recovery sleep induced by sleep deprivation SLEEP 28: A22-A22 65 Suppl. S 2005 Allikmets L, Pruus K, Rudissaar R, Matto V. Serotonin- and dopaminergic mechanisms of action of the atypical antipsychotics EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 19: S22-S22 Suppl. 1 JUN 2003 Allikmets L, Vaarmann A, Matto V Anxiety in depression and antidepressants EUROPEAN NEUROPSYCHOPHARMACOLOGY 13: S271-S271 Suppl. 4 SEP 2003 Rudissaar R, Pruus K, Matto V, Allikmets L. The effects of atypical antipsychotics on the apomorphine-induced aggressiveness and quipazine-induced wet dog shakes in rats EUROPEAN NEUROPSYCHOPHARMACOLOGY 13: S352-S352 Suppl. 4 SEP 2003 Allikmets L, Pruus K, Matto V Do the serotonin receptors mediate anxiogenic-like effect of antidepressants in rats? EUROPEAN NEUROPSYCHOPHARMACOLOGY 12: S190-S191 Suppl. 3 OCT 2002 Pruus K, Rudisaar R, Vaarmann A, Matto V, Allikmets. 1-(1-naphthyl)-Piperazine, a mixed 5-HT1A and 5-HT2A/2C receptor ligand, elicits an anxiolytic-Like effect in the open-field test without changes in 5-HT metabolism METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 24 (3): 151-157 APR 2002 Pruus K, Rudissaar R, Matto V, Allikmets L. Changes in the effects of antidepressants under the influence of agonists and antagonists of 5-HT1A receptors in rats EUROPEAN NEUROPSYCHOPHARMACOLOGY 12: S191-S191 Suppl. 3 OCT 2002 Pruus K, Vaarmann A, Rudissaar R, Allikmets L, Matto V. Role of 5-HT1A receptors in the mediation of acute citalopram effects - A 8-OH-DPAT challenge study PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 26 (2): 227-232 FEB 2002 Allikmets L, Skrebuhhova-Malmros T, Pruus K, Matto V. Effect of serotonin and GABAergic compounds on apomorphine-induced aggressive behavior in male rats AGGRESSIVE BEHAVIOR 27 (3): 203-203 2001 K. Pruus, A. Vaarmann, L. Allikmets, V. Matto. “Five- minutes forced swimming decreases noradrenaline content in rat frontal cortex” Baltic Journal of Laboratory Animal Science, 2001, 11, 5–10 L. Allikmets, V. Matto. Changes in brain monoaminergic systems in apomorphine-sensitized aggressive male Wistar rats. In: Prevention and control of aggression and the impact on victims (ed.: M. Martinez), Kluver Academic/Plenum Publishers, N.Y., 2001. Matto V, Vaarmann A, Allikmets L Apomorphine-induced aggressive behaviour in para-chlorophenylalanine-treated male rats: Implications to brain [H-3]Ketanserin binding and monoamine content PHARMACOLOGY & TOXICOLOGY 88 (3): 147-151 MAR 2001 Rudissaar R, Pruus K, Vaarmann A, Pannel P, Skrebuhhova-Malmros T, Allikmets L, Matto V. Acute trazodone and quipazine treatment attenuates apomorphine-induced aggressive behaviour in male rats without major impact on emotional behaviour or monoamine content post mortem PHARMACOLOGICAL RESEARCH 43 (4): 349-358 APR 2001 Skrebuhhova-Malmros T, Allikmets L, Matto V Additive effect of clonidine and fluoxetine on apomorphine-induced aggressive behavior in adult male Wistar rats ARCHIVES OF MEDICAL RESEARCH 32 (3): 193-196 MAY-JUN 2001 Matto V, Vaarmann A, Rudissaar R, Pruus K, Skrebuhhova-Malmros T, Allikmets L. Apomorphine-induced aggressive behaviour and post-mortem monoamine content in male Wistar rats NEUROSCIENCE LETTERS 289 (2): 131-134 AUG 4 2000 Pruus K, Rudissaar R, Skrebuhhova T, Allikmets L, Matto V. Changes in [3H]citalopram binding in cerebral cortex after antidepressant treatment in monoamine-impaired rats. Boll Chim Farm. 2000 Jan-Feb;139(1):41-5. Pruus K, Skrebuhhova-Malmros T, Rudissaar R, Matto V, Allikmets L. 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 51 (4): 833-846 Part 2 DEC 2000 Rudissaar R, Pruus K, Skrebuhhova-Malmros T, Allikmets L, Matto V. Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 22 (8): 637-640 OCT 2000 Skrebuhhova-Malmros T, Pruus K, Rudissaar R, Allikmets L, Matto V. The serotonin 5-HT2A receptor subtype does not mediate apomorphine-induced aggressive behaviour in male Wister rats PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 67 (2): 339-343 OCT 2000 V. Matto, A. Vaarmann, K. Pruus, R. Rudissaar, T. Skrebuhhova-Malmros, L. Allikmets.” Moderately increased dopamine metabolism in apomorphine-aggressive adult male Wistar rats post mortem”. Pharmaceutical and Pharmacological Letters, 2000, 10(2), 59–62 V. Matto, L. Allikmets: Apomorphine-induced aggressive behaviour in adult male Wistar rats: a reliable model of psychotic behaviour. Baltic Journal of Laboratory Animal Science, 2000, 10, 175–180 Harro J, Haidkind R, Harro M, Modiri AR, Gillberg PG, Pahkla R, Matto V, Oreland L. Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment EUROPEAN NEUROPSYCHOPHARMACOLOGY 10 (1): 5-16 DEC 1999 Matto V, Allikmets L Acute and chronic citalopram treatment differently modulates rat exploratory behavior in the exploration box test: No evidence for increased anxiety or changes in the [H-3]raclopride binding PHARMACOLOGY 58 (2): 59-69 FEB 1999 Matto V, Skrebuhhova T, Allikmets L Apomorphine-induced upregulation of serotonin 5-HT2A receptors in male rats is independent from development of aggressive behaviour JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 50 (2): 335-344 JUN 1999 Rudissaar R, Pruus K, Skrebuhhova T, Allikmets L, Matto V . Modulatory role of 5-HT3 receptors in mediation of apomorphine-induced aggressive behaviour in male rats BEHAVIOURAL BRAIN RESEARCH 106 (1-2): 91-96 DEC 1999 Skrebuhhova-Malmros T, Allikmets L, Rudissaar R, Pruus K, Matto V. Ondansetron fails to reverse antidepressant-elicited antiexploratory effects in the elevated plus-maze and open field tests MEDICAL SCIENCE RESEARCH 27 (12): 835-837 DEC 1999 Skrebuhhova T, Allikmets L, Matto V 5-HT2A receptors mediate the effect of antidepressants in the elevated plus-maze test but have a partial role in the forced swimming test MEDICAL SCIENCE RESEARCH 27 (4): 277-280 APR 1999 Skrebuhhova T, Allikmets L, Matto V Effects of anxiogenic drugs in rat forced swimming test METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 21 (3): 173-178 APR 1999 Skrebuhhova T, Allikmets L, Matto V [H-3]-ketanserin binding and elevated plus-maze behavior after chronic antidepressant treatment in DSP-4 and P-CPA pretreated rats: Evidence for partial involvement of 5-HT2A receptors METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 21 (7): 483-490 SEP 1999 T. Skrebuhhova-Malmros, K. Pruus, R. Rudissaar, L. Allikmets, V. Matto “Modulation of forced swimming, open-field, and apomorphine-induced aggressive behaviour by 5-HT2A and 5-HT3 receptor ligands in male Wistar rats” Pharmaceutical and Pharmacological Letters, 1999, vol. 9, pp. 70-73 Allikmets L, Matto V, Skrebuhhova T Anxiogenics have similarities with antidepressants in forced swimming (Porsolt') test NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 358 (4): 3 Suppl. 3 1998 Lofberg C, Harro J, Matto V, Oreland L. Cholecystokinin peptides and receptor binding in rat brain after DSP-4 treatment NEUROPEPTIDES 32 (2): 103-108 APR 1998 Matto V, Allikmets L Apomorphine-induced aggressive and nonaggressive rats differ in [H-3]raclopride-sensitive D-2 receptor binding characteristics MEDICAL SCIENCE RESEARCH 26 (7): 499-501 JUL 1998 Matto V, Allikmets L, Skrebuhhova T Apomorphine-induced aggressiveness and [H-3]citalopram binding after antidepressant treatment in rats PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 59 (3): 747-752 MAR 1998 Matto V, Skrebuhhova T, Allikmets L The effect of antidepressants on rat aggressive behavior in the electric footshock and apomorphine-induced aggressiveness paradigms METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 20 (4): 329-337 MAY 1998 T. Skrebuhhova, L. Allikmets, V. Matto “Functional integrity of [3H]raclopride-sensitive dopamine D2 and serotonin 5-HT2A receptors in rat brain after acute monoamine depletion” Pharmaceutical and Pharmacological Letters, 1998, vol. 8, pp. 170-173 V. Matto, L. Allikmets “Comparison of rat exploratory behaviour after noradrenergic denervation in elevated zero-maze and open field tests.” Baltic Journal of Laboratory Animal Science, 1998, vol. 8, pp. 16-19. V. Matto, L. Allikmets “Rapid changes in the affinity of the 5-hydroxytryptamine transporter binding sites in rat frontal cortex after single citalopram injection.” Pharmaceutical and Pharmacological Letters, 1998, vol. 8, pp. 90-92. V. Matto, L. Allikmets “Rat exploratory behaviour after acute or repeated antidepressant treatment in open-field and exploration-box tests.” Baltic Journal of Laboratory Animal Science, 1998, vol. 8, pp. 145-157. Allikmets L, Matto V Do the antidepressants have antiaggressive effect? NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 356 (4): 86-86 Suppl. 1 1997 Harro J, Lofberg C, Pahkla R, Matto V, Rago L, Oreland L, Allikmets L. Different molecular forms of cholecystokinin and CCKB receptor binding in the rat brain after chronic antidepressant treatment NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 355 (1): 57-63 JAN 1997 Matto V, Harro J, Allikmets L The effect of drugs acting on CCK receptors and rat free exploration in the exploration box JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 48 (2): 239-251 JUN 1997 Matto V, Harro J, Allikmets L The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in rat NEUROPHARMACOLOGY 36 (3): 389-396 MAR 1997 M. Otter, T. Skrebuhhova, V. Matto, J. Harro. “Measurement of exploratory behaviour in rat.” In: Welfare and Science. Proceedings of the Sixth Symposium of the Federation of European Laboratory Animal Science Associations. Royal Society of Medicine Press, London, 1997, pp.21-23. Otter MH, Matto V, Soukand R, Skrebuhhova T, Allikmets L, Harro J. Characterization of rat exploratory behavior using the exploration box test METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 19 (10): 683-691 DEC 1997 Allikmets L, Matto V, Harro J Anxiogenic component in the mechanism of action of antidepressants is essential for clinical effect NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 354 (4): 143-143 Suppl. 1 1996 Allikmets L, Matto V, Harro J Do the antidepressants have anxiogenic action? BIOLOGICAL PSYCHIATRY 39 (7): 433-433 APR 1 1996 Matto V, Allikmets L, Harro J The effect of CCKA and CCKB receptor antagonists on rat exploratory behaviour in the elevated zero-maze NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 354 (4): 146-146 Suppl. 1 1996 Matto V, Harro J, Allikmets L The effects of cholecystokinin A and B receptor antagonists, devazepide and L 365260, on citalopram-induced decrease of exploratory behaviour in rat JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 47 (4): 661-669 DEC 1996 |
viimati muudetud: 28.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Vallo |
| 2. | Surname | Matto |
| 3. | Institution | University of Tartu, Department of Pharmacy |
| 4. | Position | senior researcher (biopharmacy) |
| 5. | Date of birth | 04.02.1969 (day.month.year) |
| 6. | Education | (1) 1976-1987 Tallinn 42th Secondary School, pupil (2) September 1987 - June 1991 University of Tartu, Faculty of Medicine, student (3) August 1991- January 1992 University of Helsinki, Faculty of Medicine, student (4) January 1992 - June 1993 University of Tartu, Faculty of Medicine, student (5) June 1993 - University of Tartu graduate, M.D. (6) September 1993 - January 1998 University of Tartu, Department of Pharmacology, Ph.D. student (7) June 3rd, 1998, University of Tartu, Dr. med. |
| 7. | Research and professional experience |
(1)1989-1991 and 1992-1993 Tartu University Clinics, Division of Child Psychiaty, hospital attendant (2) 1993-1997 University of Tartu, Department of Pharmacology, senior laboratory assistant and teaching assistant (part-time) (3) 1997-1998 University of Tartu, Department of Pharmacology, teaching assistant (4) 1999 University of Tartu, Department of Pharmacology, senior teaching assistant (5) 1999–2001 University of Tartu, Department of Pharmacology, extraordinary senior researcher (post-doc fellow) (6) 2002 –2004 University of Tartu, Department of Pharmacology, senior teaching assistant (7) 2003 University of Helsinki, researcher (neurophysiology) (8) 2004-2005 University of Helsinki, senior researcher (neurophysiology) (9) Present: University of Tartu, Department of Pharmacy, senior researcher (biopharmacy) |
| 8. | Academic degree | Doctor of Medical Sciences (Dr. Med.) |
| 9. | Dates and sites of earning the degrees |
University of Tartu, June 3rd, 1998 |
| 10. | Honours/awards | 1) “Ants and Maria Silvere and Sigfried Pant Memorial Scholarship at Tartu University Foundation” scholarship, 1997 (2) The European Neuropeptide Club Award, 1997 (3) 3rd Prize of the students competition organized by the Ministry of Education, Republic of Estonia, 1997 (4) Lundbeck Eesti AS 1998 award in biological psychiatry (with MSc. Tatjana Skrebuhhova-Malmros) (5) European College of Neuropsychopharmacology (ECNP) Fellowship Award, 2000 (6) 1st Baltic Regional Meeting in Biological Psychiatry, WFSBP 1st Poster Prize, Vilnius, Leedu, 2000 (7) WFSBP Young Investigator Travel Award 2001 (8) ESRS Poster Prize, Prague, October 2004, European Sleep Research Society 17th Congress |
| 11. | Research-administrative experience |
(1) Rudolf Buchheim Conference in Neuropharmacology (May, 1995) Member of the Orginizing Committee (2) 2nd Baltic Regional Meeting of Biological Psychiatry (May-June, 2001) Secretary of the Orginizing Committee (3) Member of Society/Association of Pharmacology, Psychiatry, Laboratory Animal Science |
| 12. | Supervised dissertations | |
| 13. | Current research program | a) Characterization of binding sites and interaction to neuropeptides of serotonin reuptake inhibitors citalopram, fluoxetine and other antidepressants, PI Prof. L. Allikmets. The aim of the project was to characterize the binding neurochemical characteristics and interaction with neuropeptides of the selective serotonin reuptake inhibitors (SSRI). The results revealed that the SSRIs do not have a robust interaction with the cholecystokinetic neurotransmission, while such an association is possible on the behavioral level under circumstances of increased anxiety. b) The mechanism of affective disorders and the kinetics and mechanism of action of the novel antidepressants, PI Prof. L. Allikmets. The project dealt with the elucidation of the role of serotonin receptors in the mechanism of action of antidepressants, as well as psychopharmacological and physiological factors influencing the effects of antidepressants. We found that the serotonin 5-HT2A/2C receptors may be implicated in the mechanism of action of antidepressants and othe psychotropics. c) Elucidation of the mechanism of anxiogenic/anxiolytic action of antidepressants, PI Prof. L. Allikmets. The project was closely associated with the previous one, in addition the role of serotonin 5-HT1A et al. receptors on the emotional and motivational behaviour was studied. It was found that the serotonin-receptor-mediated emotional impairment is a complex phenomenon without a clear "anxiogenic" 5-HT receptor subtype. d) Mechanism of action of second generation antipsychotics: interaction with glutamatergic and serotoninergic systems, PI Prof. L. Allikmets. The project was focused on the investigation of the mechanism of action of the novel, second generation antipsychotics. The role of the dopaminergic neurotransmission in the context of novel antipsychotics in the mediation of frantic behaviour was studied. e) Role of accumbal dopamine in molecular mechanisms of ethanol dependence, PI Prof. Liisa Ahtee and Prof. T. Petteri Piepponen, University of Helsinki, Department of Pharmacy, Division of Pharmacology and Toxicology. The main result of the study was that the release of dopamine in Nucleus Accumbens is partly dependent on the route of ethanol administration. f) Sleep in aging women (EU project QLK6-CT-2000-00499), PI Docent, senior researcher of the Academy of Finland Tarja Porkka-Heiskanen (University of Helsinki, Institute of Biomedicine, Division of Physiology) subproject Non-REM sleep and basal forebrain GABA levels in young and aged female rats. |
| 14. | Current grant funding | |
| 15. | List of most important publications |
Tani P, Lindberg N, Matto V, Appelberg B, Nieminen-von Wendt T, von Wendt L, Porkka-Heiskanen T. Higher plasma ACTH levels in adults with Asperger syndrome. J Psychosom Res. 2005 Jun;58(6):533-6. Wigren HM, Matto V, Schepens M, Kalinchuk A, Stenberg D, Porkka-Heiskanen T. Excitation of cells in the basal forebrain results in subsequent increase in sleep which resembles recovery sleep induced by sleep deprivation SLEEP 28: A22-A22 65 Suppl. S 2005 Allikmets L, Pruus K, Rudissaar R, Matto V. Serotonin- and dopaminergic mechanisms of action of the atypical antipsychotics EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 19: S22-S22 Suppl. 1 JUN 2003 Allikmets L, Vaarmann A, Matto V Anxiety in depression and antidepressants EUROPEAN NEUROPSYCHOPHARMACOLOGY 13: S271-S271 Suppl. 4 SEP 2003 Rudissaar R, Pruus K, Matto V, Allikmets L. The effects of atypical antipsychotics on the apomorphine-induced aggressiveness and quipazine-induced wet dog shakes in rats EUROPEAN NEUROPSYCHOPHARMACOLOGY 13: S352-S352 Suppl. 4 SEP 2003 Allikmets L, Pruus K, Matto V Do the serotonin receptors mediate anxiogenic-like effect of antidepressants in rats? EUROPEAN NEUROPSYCHOPHARMACOLOGY 12: S190-S191 Suppl. 3 OCT 2002 Pruus K, Rudisaar R, Vaarmann A, Matto V, Allikmets. 1-(1-naphthyl)-Piperazine, a mixed 5-HT1A and 5-HT2A/2C receptor ligand, elicits an anxiolytic-Like effect in the open-field test without changes in 5-HT metabolism METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 24 (3): 151-157 APR 2002 Pruus K, Rudissaar R, Matto V, Allikmets L. Changes in the effects of antidepressants under the influence of agonists and antagonists of 5-HT1A receptors in rats EUROPEAN NEUROPSYCHOPHARMACOLOGY 12: S191-S191 Suppl. 3 OCT 2002 Pruus K, Vaarmann A, Rudissaar R, Allikmets L, Matto V. Role of 5-HT1A receptors in the mediation of acute citalopram effects - A 8-OH-DPAT challenge study PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 26 (2): 227-232 FEB 2002 Allikmets L, Skrebuhhova-Malmros T, Pruus K, Matto V. Effect of serotonin and GABAergic compounds on apomorphine-induced aggressive behavior in male rats AGGRESSIVE BEHAVIOR 27 (3): 203-203 2001 K. Pruus, A. Vaarmann, L. Allikmets, V. Matto. “Five- minutes forced swimming decreases noradrenaline content in rat frontal cortex” Baltic Journal of Laboratory Animal Science, 2001, 11, 5–10 L. Allikmets, V. Matto. Changes in brain monoaminergic systems in apomorphine-sensitized aggressive male Wistar rats. In: Prevention and control of aggression and the impact on victims (ed.: M. Martinez), Kluver Academic/Plenum Publishers, N.Y., 2001. Matto V, Vaarmann A, Allikmets L Apomorphine-induced aggressive behaviour in para-chlorophenylalanine-treated male rats: Implications to brain [H-3]Ketanserin binding and monoamine content PHARMACOLOGY & TOXICOLOGY 88 (3): 147-151 MAR 2001 Rudissaar R, Pruus K, Vaarmann A, Pannel P, Skrebuhhova-Malmros T, Allikmets L, Matto V. Acute trazodone and quipazine treatment attenuates apomorphine-induced aggressive behaviour in male rats without major impact on emotional behaviour or monoamine content post mortem PHARMACOLOGICAL RESEARCH 43 (4): 349-358 APR 2001 Skrebuhhova-Malmros T, Allikmets L, Matto V Additive effect of clonidine and fluoxetine on apomorphine-induced aggressive behavior in adult male Wistar rats ARCHIVES OF MEDICAL RESEARCH 32 (3): 193-196 MAY-JUN 2001 Matto V, Vaarmann A, Rudissaar R, Pruus K, Skrebuhhova-Malmros T, Allikmets L. Apomorphine-induced aggressive behaviour and post-mortem monoamine content in male Wistar rats NEUROSCIENCE LETTERS 289 (2): 131-134 AUG 4 2000 Pruus K, Rudissaar R, Skrebuhhova T, Allikmets L, Matto V. Changes in [3H]citalopram binding in cerebral cortex after antidepressant treatment in monoamine-impaired rats. Boll Chim Farm. 2000 Jan-Feb;139(1):41-5. Pruus K, Skrebuhhova-Malmros T, Rudissaar R, Matto V, Allikmets L. 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 51 (4): 833-846 Part 2 DEC 2000 Rudissaar R, Pruus K, Skrebuhhova-Malmros T, Allikmets L, Matto V. Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 22 (8): 637-640 OCT 2000 Skrebuhhova-Malmros T, Pruus K, Rudissaar R, Allikmets L, Matto V. The serotonin 5-HT2A receptor subtype does not mediate apomorphine-induced aggressive behaviour in male Wister rats PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 67 (2): 339-343 OCT 2000 V. Matto, A. Vaarmann, K. Pruus, R. Rudissaar, T. Skrebuhhova-Malmros, L. Allikmets.” Moderately increased dopamine metabolism in apomorphine-aggressive adult male Wistar rats post mortem”. Pharmaceutical and Pharmacological Letters, 2000, 10(2), 59–62 V. Matto, L. Allikmets: Apomorphine-induced aggressive behaviour in adult male Wistar rats: a reliable model of psychotic behaviour. Baltic Journal of Laboratory Animal Science, 2000, 10, 175–180 Harro J, Haidkind R, Harro M, Modiri AR, Gillberg PG, Pahkla R, Matto V, Oreland L. Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment EUROPEAN NEUROPSYCHOPHARMACOLOGY 10 (1): 5-16 DEC 1999 Matto V, Allikmets L Acute and chronic citalopram treatment differently modulates rat exploratory behavior in the exploration box test: No evidence for increased anxiety or changes in the [H-3]raclopride binding PHARMACOLOGY 58 (2): 59-69 FEB 1999 Matto V, Skrebuhhova T, Allikmets L Apomorphine-induced upregulation of serotonin 5-HT2A receptors in male rats is independent from development of aggressive behaviour JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 50 (2): 335-344 JUN 1999 Rudissaar R, Pruus K, Skrebuhhova T, Allikmets L, Matto V . Modulatory role of 5-HT3 receptors in mediation of apomorphine-induced aggressive behaviour in male rats BEHAVIOURAL BRAIN RESEARCH 106 (1-2): 91-96 DEC 1999 Skrebuhhova-Malmros T, Allikmets L, Rudissaar R, Pruus K, Matto V. Ondansetron fails to reverse antidepressant-elicited antiexploratory effects in the elevated plus-maze and open field tests MEDICAL SCIENCE RESEARCH 27 (12): 835-837 DEC 1999 Skrebuhhova T, Allikmets L, Matto V 5-HT2A receptors mediate the effect of antidepressants in the elevated plus-maze test but have a partial role in the forced swimming test MEDICAL SCIENCE RESEARCH 27 (4): 277-280 APR 1999 Skrebuhhova T, Allikmets L, Matto V Effects of anxiogenic drugs in rat forced swimming test METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 21 (3): 173-178 APR 1999 Skrebuhhova T, Allikmets L, Matto V [H-3]-ketanserin binding and elevated plus-maze behavior after chronic antidepressant treatment in DSP-4 and P-CPA pretreated rats: Evidence for partial involvement of 5-HT2A receptors METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 21 (7): 483-490 SEP 1999 T. Skrebuhhova-Malmros, K. Pruus, R. Rudissaar, L. Allikmets, V. Matto “Modulation of forced swimming, open-field, and apomorphine-induced aggressive behaviour by 5-HT2A and 5-HT3 receptor ligands in male Wistar rats” Pharmaceutical and Pharmacological Letters, 1999, vol. 9, pp. 70-73 Allikmets L, Matto V, Skrebuhhova T Anxiogenics have similarities with antidepressants in forced swimming (Porsolt') test NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 358 (4): 3 Suppl. 3 1998 Lofberg C, Harro J, Matto V, Oreland L. Cholecystokinin peptides and receptor binding in rat brain after DSP-4 treatment NEUROPEPTIDES 32 (2): 103-108 APR 1998 Matto V, Allikmets L Apomorphine-induced aggressive and nonaggressive rats differ in [H-3]raclopride-sensitive D-2 receptor binding characteristics MEDICAL SCIENCE RESEARCH 26 (7): 499-501 JUL 1998 Matto V, Allikmets L, Skrebuhhova T Apomorphine-induced aggressiveness and [H-3]citalopram binding after antidepressant treatment in rats PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 59 (3): 747-752 MAR 1998 Matto V, Skrebuhhova T, Allikmets L The effect of antidepressants on rat aggressive behavior in the electric footshock and apomorphine-induced aggressiveness paradigms METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 20 (4): 329-337 MAY 1998 T. Skrebuhhova, L. Allikmets, V. Matto “Functional integrity of [3H]raclopride-sensitive dopamine D2 and serotonin 5-HT2A receptors in rat brain after acute monoamine depletion” Pharmaceutical and Pharmacological Letters, 1998, vol. 8, pp. 170-173 V. Matto, L. Allikmets “Comparison of rat exploratory behaviour after noradrenergic denervation in elevated zero-maze and open field tests.” Baltic Journal of Laboratory Animal Science, 1998, vol. 8, pp. 16-19. V. Matto, L. Allikmets “Rapid changes in the affinity of the 5-hydroxytryptamine transporter binding sites in rat frontal cortex after single citalopram injection.” Pharmaceutical and Pharmacological Letters, 1998, vol. 8, pp. 90-92. V. Matto, L. Allikmets “Rat exploratory behaviour after acute or repeated antidepressant treatment in open-field and exploration-box tests.” Baltic Journal of Laboratory Animal Science, 1998, vol. 8, pp. 145-157. Allikmets L, Matto V Do the antidepressants have antiaggressive effect? NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 356 (4): 86-86 Suppl. 1 1997 Harro J, Lofberg C, Pahkla R, Matto V, Rago L, Oreland L, Allikmets L. Different molecular forms of cholecystokinin and CCKB receptor binding in the rat brain after chronic antidepressant treatment NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 355 (1): 57-63 JAN 1997 Matto V, Harro J, Allikmets L The effect of drugs acting on CCK receptors and rat free exploration in the exploration box JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 48 (2): 239-251 JUN 1997 Matto V, Harro J, Allikmets L The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in rat NEUROPHARMACOLOGY 36 (3): 389-396 MAR 1997 M. Otter, T. Skrebuhhova, V. Matto, J. Harro. “Measurement of exploratory behaviour in rat.” In: Welfare and Science. Proceedings of the Sixth Symposium of the Federation of European Laboratory Animal Science Associations. Royal Society of Medicine Press, London, 1997, pp.21-23. Otter MH, Matto V, Soukand R, Skrebuhhova T, Allikmets L, Harro J. Characterization of rat exploratory behavior using the exploration box test METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 19 (10): 683-691 DEC 1997 Allikmets L, Matto V, Harro J Anxiogenic component in the mechanism of action of antidepressants is essential for clinical effect NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 354 (4): 143-143 Suppl. 1 1996 Allikmets L, Matto V, Harro J Do the antidepressants have anxiogenic action? BIOLOGICAL PSYCHIATRY 39 (7): 433-433 APR 1 1996 Matto V, Allikmets L, Harro J The effect of CCKA and CCKB receptor antagonists on rat exploratory behaviour in the elevated zero-maze NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 354 (4): 146-146 Suppl. 1 1996 Matto V, Harro J, Allikmets L The effects of cholecystokinin A and B receptor antagonists, devazepide and L 365260, on citalopram-induced decrease of exploratory behaviour in rat JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 47 (4): 661-669 DEC 1996 |
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