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| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Tambet |
| 2. | Perekonnanimi | Teesalu |
| 3. | Töökoht | Tartu Ülikool |
| 4. | Ametikoht | vanemteadur |
| 5. | Sünniaeg | 24.01.1969 (päev.kuu.aasta) |
| 6. | Haridus | Tartu 10. Keskkool, 1986 Tartu Ülikool, Bioloogia-geograafia teaduskond, 1986-1991 Helsingi Ülikool, Loodusteaduskond, geneetika osakond, geneetika magister, 1993 Helsingi Ülikool, Arstiteaduskond, Haartmanni Instituut, PhD aren´gubioloogias, 1999. |
| 7. | Teenistuskäik | Teadur, Helsingi Ülikool, Biotehnoloogia Instituut, 1991-1992 Teadur, San Raffaele Biomedical Science Park (Milano, Itaalia), Molekulaargeneetika üksus, 1993-1998 Teadur, Helsingi Ülikool, Haartmani Instituut, 1998-1999 Järeldoktor, Helsingi Ülikool, Haartmani Instituut, 1999-2001 Vanemteadur, Tartu Ülikool, Närvikliinik, alates 2002 2005 külalisteadur, The Burnham Institute, La Jolla, California (USA) |
| 8. | Teaduskraad | geneetikamagister PhD arengubioloogia |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Helsingi Ülikool, 1993 Helsingi Ülikool, 1999 |
| 10. | Tunnustused | 1992 Põhjamaade Ministrite nõukogu, Copenhagen, Denmark 1993 Commission of the European Communities, Brussels, Belgium 1993-1995 Fondazione Centro S. Romanello sul Monte Tabor, Milan, Italy 1996 Kordelinin Säätiö, Helsinki, Finland 1996-1997 Comitato Promotore Telethon, Rome, Italy 1997 Comitato Camillo Golgi, Milan, Italy 1998 Nordic Council of Ministers, Copenhagen, Denmark 1999 HYKS-Säätiö, Helsinki, Finland 1999-2001 Finnish Academy, Helsinki, Finland - Full tuition scholarship for academic merit and competition |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
2000-2001, vastutav koepanga projekti eest Tartu Ülikoolis |
| 12. | Juhendamisel kaitstud väitekirjad |
|
| 13. | Teadustöö põhisuunad | Regulation of gene expression in baker’s yeast Cell migration in embryonic deveopment and tissue morphogenesis in mouse Mechanisms of invasion of mouse trophoblasts Expression mapping of NF-KB transcription factors during mouse development Extracellular proteolytic mechanisms during inflammatory demyelination in the mouse CNS Expression mapping of plasminogen activators and functionally related molecules in the normal human CNS and in glioma invasion |
| 14. | Jooksvad grandid | ETF5446 - Rakuvälise maatriksi valkude ja proteolüütiliste ensüümide regulatsiooni mehhanismide analüüs glioomide invasioonis ning glioomide eksperimentaalne teraapia. SF0182123s02 - Närvisüsteemi orgaanilised haigused Eestis: levik ja patsientide elukvaliteeti mõjustavad tegurid ETF6465 - Mitteväikserakulise kopsuvähi diferentsiaalselt ekspresseeruvate geenide avastamine, kasvajate molekulaarne fenotüpiseerimine varajase diagnostika ja ravistrateegiate optimiseerimiseks |
| 15. | Teaduspublikatsioonid |
Gronholm M, Teesalu T, Tyynela J, Piltti K, Bohling T, Wartiovaara K, Vaheri A, Carpen O. Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system. Mol Cell Neurosci. 2005 Apr;28(4):683-93. Orr S, Alexandre E, Clark BJ, Gray N, Helin H, Ravid R, Read M, Richert L, Roosipuu R, Jonsson-Rylander AC, Syring C, Teesalu T, Thasler WE, Trafford J, Van Der Valk J, Weiss TS, Womack C, Ylikomi T. Fourth meeting of the European Network of Research Tissue Banks - future strategy to increase collaborations in the supply of human tissue for biomedical research. Cell Tissue Bank. 2005;6(2):131-8. Teesalu T, Kulla A, Simisker A, Siren V, Lawrence DA, Asser T, Vaheri A. Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. Thromb Haemost. 2004 Aug;92(2):358-68. Chen RW, Aalto Y, Teesalu T, Durst M, Knuutila S, Aaltonen LM, Vaheri A. Establishment and characterisation of human papillomavirus type 16 DNA immortalised human tonsillar epithelial cell lines. Eur J Cancer. 2003 Mar;39(5):698-707. Gronholm M, Vossebein L, Carlson CR, Kuja-Panula J, Teesalu T, Alfthan K, Vaheri A, Rauvala H, Herberg FW, Tasken K, Carpen O. Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. J Biol Chem. 2003 Oct 17;278(42):41167-72. Kulla A, Burkhardt K, Meyer-Puttlitz B, Teesalu T, Asser T, Wiestler OD, Becker AJ. Analysis of the TP53 gene in laser-microdissected glioblastoma vasculature. Acta Neuropathol (Berl). 2003 Apr;105(4):328-32. Teesalu T, Kulla A, Asser T, Simisker A, and Vaheri A, “Plasminogen Activators in CNS Physiology and Disease”; in: Plasminogen: Structure, Activation, and Regulation, ed. David M. Waisman, Kluwer Academic. 2003. Orr S, Alexandre E, Clark B, Combes R, Fels LM, Gray N, Jonsson-Rylander AC, Helin H, Koistinen J, Oinonen T, Richert L, Ravid R, Salonen J, Teesalu T, Thasler W, Trafford J, Van Der Valk J, Von Versen R, Weiss T, Womack C, Ylikomi T. The establishment of a network of European human research tissue banks. Cell Tissue Bank. 2002;3(2):133-7. Teesalu T, Kulla A, Asser T, Koskiniemi M, Vaheri A. Tissue plasminogen activator as a key effector in neurobiology and neuropathology. Biochem Soc Trans. 2002 Apr;30(2):183-9. Teesalu T, Hinkkanen AE, Vaheri A. Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice. Am J Pathol. 2001 Dec;159(6):2227-37. Muggia A, Teesalu T, Neri A, Blasi F, Talarico D. Trophoblast giant cells express NF-kappa B2 during early mouse development. Dev Genet. 1999;25(1):23-30. Teesalu T, Masson R, Basset P, Blasi F, Talarico D. Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation. Dev Dyn. 1999 Mar;214(3):248-58. Guttinger M, Sutti F, Panigada M, Porcellini S, Merati B, Mariani M, Teesalu T, Consalez GG, Grassi F. Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis. J Cell Biol. 1998 May 18;141(4):1061-71. Teesalu T, Blasi F, Talarico D. Expression and function of the urokinase type plasminogen activator during mouse hemochorial placental development. Dev Dyn. 1998 Sep;213(1):27-38. Teesalu T, Grassi F, Guttinger M. Expression pattern of the epithelial v-like antigen (Eva) transcript suggests a possible role in placental morphogenesis. Dev Genet. 1998;23(4):317-23. Teesalu T, Blasi F, Talarico D. Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes. Mech Dev. 1996 May;56(1-2):103-16. Russo P, Simonen M, Uimari A, Teesalu T, Makarow M. Dual regulation by heat and nutrient stress of the yeast HSP150 gene encoding a secretory glycoprotein. Mol Gen Genet. 1993 May;239(1-2):273-80. |
viimati muudetud: 20.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Tambet |
| 2. | Surname | Teesalu |
| 3. | Institution | University of Tartu |
| 4. | Position | senior research fellow |
| 5. | Date of birth | 24.01.1969 (day.month.year) |
| 6. | Education | Tartu Secondary School No. 10, graduation certificate, 1986 University of Tartu, Faculty of Biology and Geography, 1986-1991 University of Helsinki, Faculty of Natural Sciences, Department of Genetics: M.Sc. in genetics -1993 Dissertation entitled “Regulation of yeast hsp150 gene by heat and nitrogen starvation”. Thesis supervisor: Ass. Professor Marja Makarow. University of Helsinki, Faculty of Medicine, Haartman Institute, Ph.D. in developmental biology -1999. Dissertation entitled: “Molecular mechanisms of mouse trophoblast invasion”. Thesis supervisor: Professor Antti Vaheri. |
| 7. | Research and professional experience |
Research fellow, University of Helsinki, Institute of Biotechnology, Yeast laboratory, 1991-1992 Research fellow, San Raffaele Biomedical Science Park (Milan, Italy), Molecular Genetics Unit, 1993-1998 Research fellow, University of Helsinki, Haartman Institute, 1998-1999 Post-doc, University of Helsinki, Haartman Institute, 1999-2001 Senior researcher, University of Tartu, Department of Neurology and Neurosurgery, since 2002 2005 Visiting Scientist, The Burnham Institute, La Jolla, California (USA) |
| 8. | Academic degree | M.Sc. in genetics Ph.D. in developmental biology |
| 9. | Dates and sites of earning the degrees |
University of Helsinki, 1993 University of Helsinki, 1999 |
| 10. | Honours/awards | Honors 1992 Nordic Council of Ministers, Copenhagen, Denmark 1993 Commission of the European Communities, Brussels, Belgium 1993-1995 Fondazione Centro S. Romanello sul Monte Tabor, Milan, Italy 1996 Kordelinin Säätiö, Helsinki, Finland 1996-1997 Comitato Promotore Telethon, Rome, Italy 1997 Comitato Camillo Golgi, Milan, Italy 1998 Nordic Council of Ministers, Copenhagen, Denmark 1999 HYKS-Säätiö, Helsinki, Finland 1999-2001 Finnish Academy, Helsinki, Finland - Full tuition scholarship for academic merit and competition |
| 11. | Research-administrative experience |
2000-2001, Responsible for the Project of Research Tissue bank of the University of Tartu, Department of Research and Institutional Development |
| 12. | Supervised dissertations | |
| 13. | Current research program | Regulation of gene expression in baker’s yeast Cell migration in embryonic deveopment and tissue morphogenesis in mouse Mechanisms of invasion of mouse trophoblasts Expression mapping of NF-KB transcription factors during mouse development Extracellular proteolytic mechanisms during inflammatory demyelination in the mouse CNS Expression mapping of plasminogen activators and functionally related molecules in the normal human CNS and in glioma invasion |
| 14. | Current grant funding | ETF5446 - Regulation of extracellular matrix proteins and proteases during progression of maligant gliomas: from understanding of basic mechanisms to experimental theraphy. SF0182123s02 - Different pathogenetic aspects of diseases of nervous system, prevalence and factors influencing quality of life of patients ETF6465 - Mitteväikserakulise kopsuvähi diferentsiaalselt ekspresseeruvate geenide avastamine, kasvajate molekulaarne fenotüpiseerimine varajase diagnostika ja ravistrateegiate optimiseerimiseks |
| 15. | List of most important publications |
Gronholm M, Teesalu T, Tyynela J, Piltti K, Bohling T, Wartiovaara K, Vaheri A, Carpen O. Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system. Mol Cell Neurosci. 2005 Apr;28(4):683-93. Orr S, Alexandre E, Clark BJ, Gray N, Helin H, Ravid R, Read M, Richert L, Roosipuu R, Jonsson-Rylander AC, Syring C, Teesalu T, Thasler WE, Trafford J, Van Der Valk J, Weiss TS, Womack C, Ylikomi T. Fourth meeting of the European Network of Research Tissue Banks - future strategy to increase collaborations in the supply of human tissue for biomedical research. Cell Tissue Bank. 2005;6(2):131-8. Teesalu T, Kulla A, Simisker A, Siren V, Lawrence DA, Asser T, Vaheri A. Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. Thromb Haemost. 2004 Aug;92(2):358-68. Chen RW, Aalto Y, Teesalu T, Durst M, Knuutila S, Aaltonen LM, Vaheri A. Establishment and characterisation of human papillomavirus type 16 DNA immortalised human tonsillar epithelial cell lines. Eur J Cancer. 2003 Mar;39(5):698-707. Gronholm M, Vossebein L, Carlson CR, Kuja-Panula J, Teesalu T, Alfthan K, Vaheri A, Rauvala H, Herberg FW, Tasken K, Carpen O. Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. J Biol Chem. 2003 Oct 17;278(42):41167-72. Kulla A, Burkhardt K, Meyer-Puttlitz B, Teesalu T, Asser T, Wiestler OD, Becker AJ. Analysis of the TP53 gene in laser-microdissected glioblastoma vasculature. Acta Neuropathol (Berl). 2003 Apr;105(4):328-32. Teesalu T, Kulla A, Asser T, Simisker A, and Vaheri A, “Plasminogen Activators in CNS Physiology and Disease”; in: Plasminogen: Structure, Activation, and Regulation, ed. David M. Waisman, Kluwer Academic. 2003. Orr S, Alexandre E, Clark B, Combes R, Fels LM, Gray N, Jonsson-Rylander AC, Helin H, Koistinen J, Oinonen T, Richert L, Ravid R, Salonen J, Teesalu T, Thasler W, Trafford J, Van Der Valk J, Von Versen R, Weiss T, Womack C, Ylikomi T. The establishment of a network of European human research tissue banks. Cell Tissue Bank. 2002;3(2):133-7. Teesalu T, Kulla A, Asser T, Koskiniemi M, Vaheri A. Tissue plasminogen activator as a key effector in neurobiology and neuropathology. Biochem Soc Trans. 2002 Apr;30(2):183-9. Teesalu T, Hinkkanen AE, Vaheri A. Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice. Am J Pathol. 2001 Dec;159(6):2227-37. Muggia A, Teesalu T, Neri A, Blasi F, Talarico D. Trophoblast giant cells express NF-kappa B2 during early mouse development. Dev Genet. 1999;25(1):23-30. Teesalu T, Masson R, Basset P, Blasi F, Talarico D. Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation. Dev Dyn. 1999 Mar;214(3):248-58. Guttinger M, Sutti F, Panigada M, Porcellini S, Merati B, Mariani M, Teesalu T, Consalez GG, Grassi F. Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis. J Cell Biol. 1998 May 18;141(4):1061-71. Teesalu T, Blasi F, Talarico D. Expression and function of the urokinase type plasminogen activator during mouse hemochorial placental development. Dev Dyn. 1998 Sep;213(1):27-38. Teesalu T, Grassi F, Guttinger M. Expression pattern of the epithelial v-like antigen (Eva) transcript suggests a possible role in placental morphogenesis. Dev Genet. 1998;23(4):317-23. Teesalu T, Blasi F, Talarico D. Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes. Mech Dev. 1996 May;56(1-2):103-16. Russo P, Simonen M, Uimari A, Teesalu T, Makarow M. Dual regulation by heat and nutrient stress of the yeast HSP150 gene encoding a secretory glycoprotein. Mol Gen Genet. 1993 May;239(1-2):273-80. |
last updated: 20.10.2005
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