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Elulookirjeldus (CV)
1.Eesnimi Igor
2.Perekonnanimi Ševtšuk
3.Töökoht Tallinna Tehnikaülikool
4.Ametikoht vanemteadur
5.Sünniaeg 20.01.1953 (päev.kuu.aasta)
6.Haridus Tartu Ülikool, füüsika-keemiateaduskond, 1975. a.
7.Teenistuskäik TA Keemia Instituut: 1975-1976 van. insener; 1976-1984 nooremteadur; 1984-1995 vanemteadur;
1996 - Tallinna Tehnikaülikool vanemteadur
8.Teaduskraad keemiakandidaat
9.Teaduskraadi välja
andnud asutus, aasta		 Eesti TA Keemia Instituut, 1984
10.Tunnustused
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus		 Eesti Toksikoloogia seltsi juhatuse liige
12.Juhendamisel kaitstud
väitekirjad

Ljudmilla Tšekulajeva, MSc, 2001, juh. Igor Ševtšuk. Kasvajate ravis kasutatavate mõningate porfüriinide fotokeemilised transformatsioonid. Tallinna Tehnikaülikool
13.Teadustöö põhisuunad Tetrapürroolsed ühendid, fotokeemia, fotodünaamiline efekt
14.Jooksvad grandid Mõningate fotoaktiivsete tetrapürroolide ja dendrimeeride kompleksite süntees ja iseloomustamine - ETF grant nr. 5906 (2004-2007), juht
15.Teaduspublikatsioonid

Chekulayeva L.V., Shevchuk I.N., Chekulayev V.A., Ilmarinen K. Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells. Journal of Environmental Pathology, Toxicology and Oncology, 2006, v.25(1-2), 51-77.

Chekulayeva L., Shevchuk I., Chekulayev V. On the mechanism of the phototoxic action of haematoporphyrin derivative towards tumour cells. Proc. Estonian Acad. Sci. Biology Ecology. 2005, v.54(2), 83-119.

Smorodin E.P., Kurtenkov O.A., Shevchuk I.N., Tanner R.H. The Isolation and Characterization of Human Natural alpha-Gal-Specific IgG Antibodies Applicable to the Detection of alpha-Gal-Glycosphingolipids. J. Immunoassay and Immunochemistry. 2005, v.26(2), 145-156.

Chekulayeva L.V., Shevchuk I.N., Chekulayev V.A. Influence of temperature on the efficiency of photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. Experimental Oncology. 2004, v.26(2), 125-139.

Chekulayeva L., Shevchuk I., Chekulayev V. Photodynamic therapy of tumours with chlorin-e6 is pH dependent. Proc. Estonian Acad. Sci. Biology Ecology. 2003, v.52(1), 40-54.

Chekulayev V., Shevchuk I., Chekulayeva L. On the mechanism of cellular death under photoexcitation of haematoporphyrin derivative. Proc. Estonian Acad. Sci. Biology Ecology. 2003, v.51(1), 55-72.

Chekulayev V., Shevchuk I., Chekulayeva L., Jäälaid R. Kinetic studies on the mechanism of hematoporphyrin derivative photobleaching. Proc. Estonian Acad. Sci. Chemistry. 2002, v.51(1), 49-70.

Shevchuk, I., Chekulayeva, L., Chekulayev, V. Influence of pH and glucose administration on the phototoxicity of chlorin-e6 towards Ehrlich carcinoma cells. Experimental Oncology, 2002, v.24(2), 135-141.

Shevchuk I., Chekulayev V., Chekulayeva L. The role of lipid peroxidation in the photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. Experimental Oncology. 2002, v.24(3), 216-224.

L. Chekulayeva, I. Shevchuk, R. Jäälaid, and V. Chekulayev, L-Buthionine-[S,R]-sulfoximine may enhance the rate of haematoporphyrin derivative photosensitized inactivation of tumour cells without lowering of the intracellular content of glutathione, Proc. Estonian Acad. Sci. Chem., 2000, v.49, 109-120.

V. Chekulayev, I. Shevchuk, L. Chekulayeva, and R. Jäälaid, Influence of extracellular magnesium on the antitumour efficiency of photodynamic therapy, Proc. Estonian Acad. Sci. Chem., 2000, v.49, 216-233.

Shevchuk, I., Chekulayev, V., Chekulayeva, L. Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyanisole. J. Photochem. Photobiol. B-Biology. 1998, v.45(2-3), 136-143.

V. Chekulayev, I. Shevchuk, and L. Chekulayeva, Effects of light exposure on the uptake and destruction of hematoporphyrin derivative in Ehrlich carcinoma cell suspension, Proc. Estonian Acad. Sci. Chem.,1998, v.47, 73-91.

Chekulayev V., Shevchuk I., Chekulayeva L., Kahru, A. Study of the Photochemical and Phototoxic Properties of Lonidamine [1-(2,4-Dichlorobenzyl)-1h-Indazol-3-Carboxylic Acid]. J. Photochem. Photobiol. B-Biology. 1997, v.41(1-2), 11-21.

V. Chekulayev, I. Shevchuk, and L. Chekulayeva, Photooxidation of hematoporphyrin derivative - bovine serum albumin complex, Proc. Estonian Acad. Sci. Chem., 1997, v.46, 168-185.

Shevchuk I., Chekulayev V., Moan J., Berg K. Effects of the inhibitors of energy metabolism, lonidamine and levamisole, on 5-aminolevulinic-acid-induced photochemotherapy. International Journal of Cancer. 1996, v.67(6), 791-799.

V. Chekulayev, I. Shevchuk, L. Chekulayeva, and A. Kahru, Increasing the efficiency of photosensitized damage of Ehrlich ascites carcinoma cells using haematoporphyrin derivative and chlorin-e6 in combination with lonidamine, Proc. Estonian Acad. Sci. Biol., 1996, v.45, 102-127.

V.Chekulayev, I.Shevchuk, V.Mihkelsoo, and A.Kallikorm, A change in the sulfhydryl status of ehrlich carcinoma cells by exposure to light in the presence of chlorln-e6 trimethyl ester. The effect of L-buthionine-[S, R]-sulfoximine on the photosensitized damage of tumor cells, Proc. Estonian Acad. Sci. Chem. 1992, v.41, 52-61.

V.Chekulayev, I.Shevchuk, V.Mihkelsoo, and A.Kallikorm, Influence of metronidazole and some electron acceptors on the chlorin e6 hotosensitized killing of Ehrlich carcinoma cells, Proc. SPIE Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, Thomas J. Dougherty; Ed. 1992, v.1645, 131-140.

V.Chekulayev, I.Shevchuk, V.Mihkelsoo, and A.Kallikorm, The effect of metronidazole on the chlorin e6 photosensitized death of Ehrlich carcinoma cells, Proc. Estonian Acad. Sci. Chem. 1992, v.41, 18-25.

I.Shevchuk and M.Gubergrits, Reactivity of alternate polyarenes under photooxidation, Polynucl. Aromat. Hydrocarbons: Meas. , Means, Metab. , Int. Symp. , 11th. 1991, 831-838.

V.Chekulayev, I.Shevchuk, A.Kahru, V.Mihkelsoo, and A.Kallikorm, Investigation of the photodynamic properties of some chlorophyll a derivatives: the effect of doxorubicin on the chlorin e6 photosensitized death of Ehrlich carcinoma cells, Proc. SPIE Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, Thomas J. Dougherty; Ed. 1991, v.1426, 367-377.

B.L.Sergeev, S.P.Bogovskii, R.K.Tanner, T.I.Veidebaum, and I.N.Shevchuk, Photolysis of aflatoxin B1 in the presence of pyridine N-oxide, Experimental Oncology. 1989, v.11, 76-78.

A.Murel, S.Vilde, M.Pank, I.Shevchuk, and O.Kirret, Chromatophoresis: A new approach to the theory and practice of chromatofocusing : II. Experimental verification, Journal of Chromatography A. 1986, v.362, 101-112.

I.Shevchuk, Reactivity of polyarenes in photooxidative degradation, Proc. Estonian Acad. Sci. Chem. 1986, v.35, 128-133.

viimati muudetud: 28.02.2006

Curriculum Vitae (CV)
1.First Name Igor
2.Surname Ševtšuk
3.Institution Tallinn University of Technology
4.Position senior researcher
5.Date of birth 20.01.1953 (day.month.year)
6.Education Tartu University, 1975
7.Research and
professional experience		 1975-1976 engineer, 1976-1984 researcher, 1984-1995 senior researcher at Institute of Chemistry at Estonian Academy of Sciences;
1996 - Tallinn University of Technology, senior researcher
8.Academic degree A Candidate of Science degree
9.Dates and sites of
earning the degrees		 Institute of Chemistry at Estonian Academy of Sciences, 1984
10.Honours/awards
11.Research-administrative
experience		 Member of the board of Estonian Society of Toxicology
12.Supervised dissertations

Ljudmilla Tšekulajeva, MSc, 2001, superv. Igor Ševtšuk. Kasvajate ravis kasutatavate mõningate porfüriinide fotokeemilised transformatsioonid. Tallinna Tehnikaülikool
13.Current research program Chemistry of tetrapyrroles, photochemistry, photodynamic effect
14.Current grant funding Estonian Science Foundation grant no. 5906, PI - Synthesis and characterisation of dendrimer complexes of some photoactive tetrapyrrolic compounds
15.List of most important publications

Chekulayeva L.V., Shevchuk I.N., Chekulayev V.A., Ilmarinen K. Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells. Journal of Environmental Pathology, Toxicology and Oncology, 2006, v.25(1-2), 51-77.

Chekulayeva L., Shevchuk I., Chekulayev V. On the mechanism of the phototoxic action of haematoporphyrin derivative towards tumour cells. Proc. Estonian Acad. Sci. Biology Ecology. 2005, v.54(2), 83-119.

Smorodin E.P., Kurtenkov O.A., Shevchuk I.N., Tanner R.H. The Isolation and Characterization of Human Natural alpha-Gal-Specific IgG Antibodies Applicable to the Detection of alpha-Gal-Glycosphingolipids. J. Immunoassay and Immunochemistry. 2005, v.26(2), 145-156.

Chekulayeva L.V., Shevchuk I.N., Chekulayev V.A. Influence of temperature on the efficiency of photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. Experimental Oncology. 2004, v.26(2), 125-139.

Chekulayeva L., Shevchuk I., Chekulayev V. Photodynamic therapy of tumours with chlorin-e6 is pH dependent. Proc. Estonian Acad. Sci. Biology Ecology. 2003, v.52(1), 40-54.

Chekulayev V., Shevchuk I., Chekulayeva L. On the mechanism of cellular death under photoexcitation of haematoporphyrin derivative. Proc. Estonian Acad. Sci. Biology Ecology. 2003, v.51(1), 55-72.

Chekulayev V., Shevchuk I., Chekulayeva L., Jäälaid R. Kinetic studies on the mechanism of hematoporphyrin derivative photobleaching. Proc. Estonian Acad. Sci. Chemistry. 2002, v.51(1), 49-70.

Shevchuk, I., Chekulayeva, L., Chekulayev, V. Influence of pH and glucose administration on the phototoxicity of chlorin-e6 towards Ehrlich carcinoma cells. Experimental Oncology, 2002, v.24(2), 135-141.

Shevchuk I., Chekulayev V., Chekulayeva L. The role of lipid peroxidation in the photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. Experimental Oncology. 2002, v.24(3), 216-224.

L. Chekulayeva, I. Shevchuk, R. Jäälaid, and V. Chekulayev, L-Buthionine-[S,R]-sulfoximine may enhance the rate of haematoporphyrin derivative photosensitized inactivation of tumour cells without lowering of the intracellular content of glutathione, Proc. Estonian Acad. Sci. Chem., 2000, v.49, 109-120.

V. Chekulayev, I. Shevchuk, L. Chekulayeva, and R. Jäälaid, Influence of extracellular magnesium on the antitumour efficiency of photodynamic therapy, Proc. Estonian Acad. Sci. Chem., 2000, v.49, 216-233.

Shevchuk, I., Chekulayev, V., Chekulayeva, L. Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyanisole. J. Photochem. Photobiol. B-Biology. 1998, v.45(2-3), 136-143.

V. Chekulayev, I. Shevchuk, and L. Chekulayeva, Effects of light exposure on the uptake and destruction of hematoporphyrin derivative in Ehrlich carcinoma cell suspension, Proc. Estonian Acad. Sci. Chem.,1998, v.47, 73-91.

Chekulayev V., Shevchuk I., Chekulayeva L., Kahru, A. Study of the Photochemical and Phototoxic Properties of Lonidamine [1-(2,4-Dichlorobenzyl)-1h-Indazol-3-Carboxylic Acid]. J. Photochem. Photobiol. B-Biology. 1997, v.41(1-2), 11-21.

V. Chekulayev, I. Shevchuk, and L. Chekulayeva, Photooxidation of hematoporphyrin derivative - bovine serum albumin complex, Proc. Estonian Acad. Sci. Chem., 1997, v.46, 168-185.

Shevchuk I., Chekulayev V., Moan J., Berg K. Effects of the inhibitors of energy metabolism, lonidamine and levamisole, on 5-aminolevulinic-acid-induced photochemotherapy. International Journal of Cancer. 1996, v.67(6), 791-799.

V. Chekulayev, I. Shevchuk, L. Chekulayeva, and A. Kahru, Increasing the efficiency of photosensitized damage of Ehrlich ascites carcinoma cells using haematoporphyrin derivative and chlorin-e6 in combination with lonidamine, Proc. Estonian Acad. Sci. Biol., 1996, v.45, 102-127.

V.Chekulayev, I.Shevchuk, V.Mihkelsoo, and A.Kallikorm, A change in the sulfhydryl status of ehrlich carcinoma cells by exposure to light in the presence of chlorln-e6 trimethyl ester. The effect of L-buthionine-[S, R]-sulfoximine on the photosensitized damage of tumor cells, Proc. Estonian Acad. Sci. Chem. 1992, v.41, 52-61.

V.Chekulayev, I.Shevchuk, V.Mihkelsoo, and A.Kallikorm, Influence of metronidazole and some electron acceptors on the chlorin e6 hotosensitized killing of Ehrlich carcinoma cells, Proc. SPIE Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, Thomas J. Dougherty; Ed. 1992, v.1645, 131-140.

V.Chekulayev, I.Shevchuk, V.Mihkelsoo, and A.Kallikorm, The effect of metronidazole on the chlorin e6 photosensitized death of Ehrlich carcinoma cells, Proc. Estonian Acad. Sci. Chem. 1992, v.41, 18-25.

I.Shevchuk and M.Gubergrits, Reactivity of alternate polyarenes under photooxidation, Polynucl. Aromat. Hydrocarbons: Meas. , Means, Metab. , Int. Symp. , 11th. 1991, 831-838.

V.Chekulayev, I.Shevchuk, A.Kahru, V.Mihkelsoo, and A.Kallikorm, Investigation of the photodynamic properties of some chlorophyll a derivatives: the effect of doxorubicin on the chlorin e6 photosensitized death of Ehrlich carcinoma cells, Proc. SPIE Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, Thomas J. Dougherty; Ed. 1991, v.1426, 367-377.

B.L.Sergeev, S.P.Bogovskii, R.K.Tanner, T.I.Veidebaum, and I.N.Shevchuk, Photolysis of aflatoxin B1 in the presence of pyridine N-oxide, Experimental Oncology. 1989, v.11, 76-78.

A.Murel, S.Vilde, M.Pank, I.Shevchuk, and O.Kirret, Chromatophoresis: A new approach to the theory and practice of chromatofocusing : II. Experimental verification, Journal of Chromatography A. 1986, v.362, 101-112.

I.Shevchuk, Reactivity of polyarenes in photooxidative degradation, Proc. Estonian Acad. Sci. Chem. 1986, v.35, 128-133.

last updated: 28.02.2006

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