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Elulookirjeldus (CV)
1.Eesnimi Tõnis
2.Perekonnanimi Örd
3.Töökoht Eesti Biokeskus
4.Ametikoht Vanemteadur
5.Sünniaeg 17.10.1957 (päev.kuu.aasta)
6.Haridus Tartu Ülikool 1976-1981, bioloog-geneetik
7.Teenistuskäik 1981-1997 Eesti Teaduste Akadeemia Keemilise ja Bioloogilise Füüsika Instituut - nooremteadur, teadur ja vanemteadur;
1992-1994 California Ülikool Los Angeleses (California, USA) - teadlane-uurija;
1994-1996 La Jolla Vähiuurimise Instituut (The Burnham Institute) (California, USA) - teadlane-uurija;
1997-1998 Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut - vanemteadur;
1999-praeguseni Eesti Biokeskus - vanemteadur
8.Teaduskraad Bioloogiakandidaat
9.Teaduskraadi välja
andnud asutus, aasta		 Tartu Ülikool, 1990
10.Tunnustused
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus
12.Juhendamisel kaitstud
väitekirjad

Kati Meerits, MSc, 2005, juh. Tõnis Örd. Transkriptsioonifaktori ATF4 ja kinaasilaadse valgu NIPK mõju rakkude kasvule ja elulemusele. Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut

Maili Jakobson, MSc, 2001, juh. Tõnis Örd. Polüpürimidiinjärjestusega seonduva valgu neuraalne homoloog PTBH: uus rakutuuma valk, mis seondub prokaspaas-2-ga. Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut

Kersti Lilleväli, MSc, 2000, juh. Tõnis Örd. Polüpürimidiinjärjestusega seonduva valgu neuraalset homoloogi kodeeriva geeni ekspressiooni analüüs hiires. Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut
13.Teadustöö põhisuunad Apoptoosi ja stressivastuse mehhanismide uurimine
14.Jooksvad grandid "Stressivastuse ja apoptoosi mehhanismide iseloomustamine" (Eesti Teadusfondi grant nr. 6000)
15.Teaduspublikatsioonid

Örd, D., Örd, T. Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. Biochemical and Biophysical Research Communications 330 (2005), 210-218.

Örd, D., Örd, T. Mouse NIPK interacts with ATF4 and affects its transcriptional activity. Experimental Cell Research 286 (2003) 308-320.

Lilleväli, K., Kulla, A., Örd, T. Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain. Mechanisms of Development 101 (2001) 217-220.

Keane, R. W., Srinivasan, A., Foster, L. M., Testa, M. P., Örd, T., Nonner, D., Wang, H.-G., Reed, J. C., Bredesen, D. E., Kayalar, C. Activation of CPP32 During Apoptosis of Neurons and Astrocytes. Journal of Neuroscience Research 48 (1997) 168-180.

Örd, T., Adessi, C., Wang, L., Freeze, H. The Cysteine Proteinase Gene cprG in D. discoideum Has a Serine-Rich Domain That Contains GlcNAc-1-P. Archives of Biochemistry and Biophysics 339 (1997) 64-72.

Kayalar, C., Örd, T., Testa, M. P., Zhong, L., Bredesen, D. E. Cleavage of Actin by the Pro-apoptotic Cysteine Protease ICE to Reverse DNase I Inhibition. Proceedings of the National Academy of Sciences of the USA 93 (1996) 2234-2238.

Srinivasan, A., Foster, L. M., Testa, M. P., Örd, T., Keane, R. W., Bredesen, D. E., Kayalar, C. Bcl-2 Expression in Neural Cells Blocks Activation of ICE/ced-3 Family Proteases during Apoptosis. The Journal of Neuroscience 16 (1996) 5654-5660.

Kane, D. J., Örd, T., Anton, R., Bredesen, D. E. Expression of Bcl-2 Inhibits Necrotic Neural Cell Death. Journal of Neuroscience Research 40 (1995) 269-275.

Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., Gralla, E. D., Valentine, J. S., Örd, T., Bredesen, D. E. Bcl-2 Inhibition of Neural Death: Decreased Generation of Reactive Oxygen Species. Science 262 (1993) 1274-1277.

Kolmer, M., Örd, T., Alhonen, L., Hyttinen, J.-M., Saarma, M., Villems, R., Janne, J. Assignment of Human Prochymosin Pseudogene to Chromosome 1. Genomics 10 (1991) 496-498.

Kolmer, M., Örd, T., Ulmanen, I. Expression of Recombinant Calf Prochymosin in Mammalian Cell Culture. Journal of Biotechnology 20 (1991) 131-140.

Örd, T., Kolmer, M., Janne, J., Villems, R., Saarma, M. Molecular Cloning, Structure and Chromosomal Localization of Human Prochymosin Pseudogene. In: “Structure and Function of the Aspartic Proteinases: Genetics, Structures, and Mechanisms” (B. M. Dunn, ed.) in series: Advances in Experimental Medicine and Biology, vol. 306 (1991) 121-126.

Örd, T., Kolmer, M., Villems, R., Saarma, M. Structure of the Human Genomic Region Homologous to the Bovine Prochymosin-encoding Gene. Gene 91 (1990) 241-246.

Kolmer, M., Örd, T., Ulmanen, I. Cloning and Expression of Chymosin in Mammalian Cells. Doklady Akademii Nauk SSSR 308 (1989) 234-237.

Örd, T., Piiper, J. Structure of the 5’-terminal Region of the Prochymosin Gene in Human Genome. Doklady Akademii Nauk SSSR 301 (1989) 761-764.

Örd, T., Torp, A., Kolmer, M. Molecular Cloning of the Chymosin Gene and Analysis of Its Expression. Biotechnology (Mosk) 3 (1987) 351-354.

Saarma, M., Örd, T., Talpsepp, T., Toots, I. Isolation of 5S RNA-protein Complexes from Rat Liver Ribosomes. Molecular Biology (Mosk) 17 (1983) 112-117.

Õun, V., Ilves, H., Talpsepp, T., Örd, T., Habicht, J., Toots, I., Saarma, M. Cloning and Analysis of the Highly Repetitive Sequence in Rat Liver DNA. Doklady Akademii Nauk SSSR 266 (1982) 745-747.

Saarma, M., Metspalu, A., Villems, R., Örd, T., Toots, I. 5S RNA and 5.8S RNA Build up Eukaryotic Subribosomal Domains Active in tRNA Binding. FEBS Letters 136 (1981) 255-258.

viimati muudetud: 04.08.2005

Curriculum Vitae (CV)
1.First Name Tõnis
2.Surname Örd
3.Institution Estonian Biocentre
4.Position Senior Scientist
5.Date of birth 17.10.1957 (day.month.year)
6.Education Tartu University 1976-1981, biology-genetics
7.Research and
professional experience		 1981-1997 Estonian Academy of Sciences, Institute of Chemical Physics and Biophysics - Junior Scientist, Scientist and Senior Scientist;
1992-1994 University of California, Los Angeles (California, USA) - Research Fellow;
1994-1996 La Jolla Cancer Research Foundation (The Burnham Institute) (California, USA) - Research Fellow;
1997-1998 University of Tartu, Institute of Molecular and Cell Biology - Senior Scientist;
1999-present Estonian Biocentre - Senior Scientist
8.Academic degree Cand. Sci. (Biology)
9.Dates and sites of
earning the degrees		 Tartu University, 1990
10.Honours/awards
11.Research-administrative
experience
12.Supervised dissertations

Kati Meerits, MSc, 2005, superv. Tõnis Örd. Transkriptsioonifaktori ATF4 ja kinaasilaadse valgu NIPK mõju rakkude kasvule ja elulemusele. Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut

Maili Jakobson, MSc, 2001, superv. Tõnis Örd. Polüpürimidiinjärjestusega seonduva valgu neuraalne homoloog PTBH: uus rakutuuma valk, mis seondub prokaspaas-2-ga. Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut

Kersti Lilleväli, MSc, 2000, superv. Tõnis Örd. Polüpürimidiinjärjestusega seonduva valgu neuraalset homoloogi kodeeriva geeni ekspressiooni analüüs hiires. Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut
13.Current research program Characterization of mechanisms of apoptosis and stress response
14.Current grant funding "Characterization of mechanisms of stress response and apoptosis" (Estonian Science Foundation grant 6000)
15.List of most important publications

Örd, D., Örd, T. Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. Biochemical and Biophysical Research Communications 330 (2005), 210-218.

Örd, D., Örd, T. Mouse NIPK interacts with ATF4 and affects its transcriptional activity. Experimental Cell Research 286 (2003) 308-320.

Lilleväli, K., Kulla, A., Örd, T. Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain. Mechanisms of Development 101 (2001) 217-220.

Keane, R. W., Srinivasan, A., Foster, L. M., Testa, M. P., Örd, T., Nonner, D., Wang, H.-G., Reed, J. C., Bredesen, D. E., Kayalar, C. Activation of CPP32 During Apoptosis of Neurons and Astrocytes. Journal of Neuroscience Research 48 (1997) 168-180.

Örd, T., Adessi, C., Wang, L., Freeze, H. The Cysteine Proteinase Gene cprG in D. discoideum Has a Serine-Rich Domain That Contains GlcNAc-1-P. Archives of Biochemistry and Biophysics 339 (1997) 64-72.

Kayalar, C., Örd, T., Testa, M. P., Zhong, L., Bredesen, D. E. Cleavage of Actin by the Pro-apoptotic Cysteine Protease ICE to Reverse DNase I Inhibition. Proceedings of the National Academy of Sciences of the USA 93 (1996) 2234-2238.

Srinivasan, A., Foster, L. M., Testa, M. P., Örd, T., Keane, R. W., Bredesen, D. E., Kayalar, C. Bcl-2 Expression in Neural Cells Blocks Activation of ICE/ced-3 Family Proteases during Apoptosis. The Journal of Neuroscience 16 (1996) 5654-5660.

Kane, D. J., Örd, T., Anton, R., Bredesen, D. E. Expression of Bcl-2 Inhibits Necrotic Neural Cell Death. Journal of Neuroscience Research 40 (1995) 269-275.

Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., Gralla, E. D., Valentine, J. S., Örd, T., Bredesen, D. E. Bcl-2 Inhibition of Neural Death: Decreased Generation of Reactive Oxygen Species. Science 262 (1993) 1274-1277.

Kolmer, M., Örd, T., Alhonen, L., Hyttinen, J.-M., Saarma, M., Villems, R., Janne, J. Assignment of Human Prochymosin Pseudogene to Chromosome 1. Genomics 10 (1991) 496-498.

Kolmer, M., Örd, T., Ulmanen, I. Expression of Recombinant Calf Prochymosin in Mammalian Cell Culture. Journal of Biotechnology 20 (1991) 131-140.

Örd, T., Kolmer, M., Janne, J., Villems, R., Saarma, M. Molecular Cloning, Structure and Chromosomal Localization of Human Prochymosin Pseudogene. In: “Structure and Function of the Aspartic Proteinases: Genetics, Structures, and Mechanisms” (B. M. Dunn, ed.) in series: Advances in Experimental Medicine and Biology, vol. 306 (1991) 121-126.

Örd, T., Kolmer, M., Villems, R., Saarma, M. Structure of the Human Genomic Region Homologous to the Bovine Prochymosin-encoding Gene. Gene 91 (1990) 241-246.

Kolmer, M., Örd, T., Ulmanen, I. Cloning and Expression of Chymosin in Mammalian Cells. Doklady Akademii Nauk SSSR 308 (1989) 234-237.

Örd, T., Piiper, J. Structure of the 5’-terminal Region of the Prochymosin Gene in Human Genome. Doklady Akademii Nauk SSSR 301 (1989) 761-764.

Örd, T., Torp, A., Kolmer, M. Molecular Cloning of the Chymosin Gene and Analysis of Its Expression. Biotechnology (Mosk) 3 (1987) 351-354.

Saarma, M., Örd, T., Talpsepp, T., Toots, I. Isolation of 5S RNA-protein Complexes from Rat Liver Ribosomes. Molecular Biology (Mosk) 17 (1983) 112-117.

Õun, V., Ilves, H., Talpsepp, T., Örd, T., Habicht, J., Toots, I., Saarma, M. Cloning and Analysis of the Highly Repetitive Sequence in Rat Liver DNA. Doklady Akademii Nauk SSSR 266 (1982) 745-747.

Saarma, M., Metspalu, A., Villems, R., Örd, T., Toots, I. 5S RNA and 5.8S RNA Build up Eukaryotic Subribosomal Domains Active in tRNA Binding. FEBS Letters 136 (1981) 255-258.

last updated: 04.08.2005

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