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Elulookirjeldus (CV)
1.Eesnimi Kalle
2.Perekonnanimi Kilk
3.Töökoht Üld- ja Molekulaarbioloogia Instituut, Tartu Ülikool
4.Ametikoht Teadur (järeldoktor)
5.Sünniaeg 21.03.1978 (päev.kuu.aasta)
6.Haridus kõrgeim
7.Teenistuskäik 1996-2000 bakalaureuseõpe Tartu Ülikooli Füüsika-keemia teaduskonnas
2000-2001 külalistudeng The Scripps Research Instituudis Neurofarmakoloogia osakonnas, California.
2000-2002 Magistriõpingud Tartu Ülikooli Arstiteaduskonnas.
2001-2004 Doktoriõpingud Stockholmi Ülikooli Neurokeemia ja neurotoksikoloogia instituudis.
8.Teaduskraad PhD
9.Teaduskraadi välja
andnud asutus, aasta		 Stockholmi Ülikool 2005
10.Tunnustused
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus
12.Juhendamisel kaitstud
väitekirjad
13.Teadustöö põhisuunad Peptiidsed nukleiinhapped, transport, rakku-pugevad peptiidid neuropeptiid galaniin, oksüdatiivne stress
14.Jooksvad grandid
15.Teaduspublikatsioonid

Kilk K, El-Andaloussi S, Jarver P, Meikas A, Valkna A, Bartfai T, Kogerman P, Metsis M, Langel U. Evaluation of transportan 10 in PEI mediated plasmid delivery assay. J Control Release. 2005 Mar 21;103(2):511-23. Epub 2005 Jan 26.

Kilk K, Langel U. Cellular delivery of peptide nucleic acid by cell-penetrating peptides. Methods Mol Biol. 2005;298:131-41.

Hua XY, Hayes CS, Hofer A, Fitzsimmons B, Kilk K, Langel U, Bartfai T, Yaksh TL. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 2004 Feb;308(2):574-82. Epub 2003 Nov 10.

Kilk K, Elmquist A, Saar K, Pooga M, Land T, Bartfai T, Soomets U, Langel U.Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA.Neuropeptides. 2004 Oct;38(5):316-24.

Mazarati A, Lu X, Kilk K, Langel U, Wasterlain C, Bartfai T. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus. Eur J Neurosci. 2004 Jun;19(12):3235-44.

Howitt SG, Kilk K, Wang Y, Smith DM, Langel U, Poyner DR. The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions. Br J Pharmacol. 2003 Jan;138(2):325-32.

Conner AC, Hay DL, Howitt SG, Kilk K, Langel U, Wheatley M, Smith DM, Poyner DR. Interaction of calcitonin-gene-related peptide with its receptors. Biochem Soc Trans. 2002 Aug;30(4):451-5. Review.

Oras A, Kilk K, Kunapuli S, Barnard EA, Jarv J. Kinetic analysis of [35S]dATP alpha S interaction with P2y(1) nucleotide receptor. Neurochem Int. 2002 Apr;40(5):381-6.

Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hokfelt T, Wasterlain C, Bartfai T, Langel U. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7136-41.

Kilk K, Magzoub M, Pooga M, Eriksson LE, Langel U, Graslund A. Cellular internalization of a cargo complex with a novel peptide derived from the third helix of the islet-1 homeodomain. Comparison with the penetratin peptide. Bioconjug Chem. 2001 Nov-Dec;12(6):911-6.

Magzoub M, Kilk K, Eriksson LE, Langel U, Graslund A. Interaction and structure induction of cell-penetrating peptides in the presence of phospholipid vesicles. Biochim Biophys Acta. 2001 May 2;1512(1):77-89.

viimati muudetud: 03.08.2005

Curriculum Vitae (CV)
1.First Name Kalle
2.Surname Kilk
3.Institution Department of General and Molecular Pathology, Tartu Ülikool
4.Position postdoctoral research fellow
5.Date of birth 21.03.1978 (day.month.year)
6.Education highest
7.Research and
professional experience		 1996-2000 BSc studies at University of Tartu, Faculty of Physics and Chemistry
2000-2001 visiting student at The Scripps Research Institute, dept. Neuropharmacology, California
2000-2002 MS studies at University of Tartu, Faculty of Medicine
2001-2004 PhD studies at University of Stockholm, dept. Neurochemistry and Neurotoxicology
8.Academic degree PhD
9.Dates and sites of
earning the degrees		 University of Stockholm 2005
10.Honours/awards
11.Research-administrative
experience
12.Supervised dissertations
13.Current research program Peptide nucleic acids, drug delivery, cell-penetrating peptides, neuropeptide galanin, oxidative stress
14.Current grant funding
15.List of most important publications

Kilk K, El-Andaloussi S, Jarver P, Meikas A, Valkna A, Bartfai T, Kogerman P, Metsis M, Langel U. Evaluation of transportan 10 in PEI mediated plasmid delivery assay. J Control Release. 2005 Mar 21;103(2):511-23. Epub 2005 Jan 26.

Kilk K, Langel U. Cellular delivery of peptide nucleic acid by cell-penetrating peptides. Methods Mol Biol. 2005;298:131-41.

Hua XY, Hayes CS, Hofer A, Fitzsimmons B, Kilk K, Langel U, Bartfai T, Yaksh TL. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 2004 Feb;308(2):574-82. Epub 2003 Nov 10.

Kilk K, Elmquist A, Saar K, Pooga M, Land T, Bartfai T, Soomets U, Langel U.Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA.Neuropeptides. 2004 Oct;38(5):316-24.

Mazarati A, Lu X, Kilk K, Langel U, Wasterlain C, Bartfai T. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus. Eur J Neurosci. 2004 Jun;19(12):3235-44.

Howitt SG, Kilk K, Wang Y, Smith DM, Langel U, Poyner DR. The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions. Br J Pharmacol. 2003 Jan;138(2):325-32.

Conner AC, Hay DL, Howitt SG, Kilk K, Langel U, Wheatley M, Smith DM, Poyner DR. Interaction of calcitonin-gene-related peptide with its receptors. Biochem Soc Trans. 2002 Aug;30(4):451-5. Review.

Oras A, Kilk K, Kunapuli S, Barnard EA, Jarv J. Kinetic analysis of [35S]dATP alpha S interaction with P2y(1) nucleotide receptor. Neurochem Int. 2002 Apr;40(5):381-6.

Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hokfelt T, Wasterlain C, Bartfai T, Langel U. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7136-41.

Kilk K, Magzoub M, Pooga M, Eriksson LE, Langel U, Graslund A. Cellular internalization of a cargo complex with a novel peptide derived from the third helix of the islet-1 homeodomain. Comparison with the penetratin peptide. Bioconjug Chem. 2001 Nov-Dec;12(6):911-6.

Magzoub M, Kilk K, Eriksson LE, Langel U, Graslund A. Interaction and structure induction of cell-penetrating peptides in the presence of phospholipid vesicles. Biochim Biophys Acta. 2001 May 2;1512(1):77-89.

last updated: 03.08.2005

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