[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Toivo |
| 2. | Perekonnanimi | Maimets |
| 3. | Töökoht | Tartu Ülikool |
| 4. | Ametikoht | Rakubioloogia professor |
| 5. | Sünniaeg | 29.12.1957 (päev.kuu.aasta) |
| 6. | Haridus | Tartu Ülikool, 1991, Ph.D. (molekulaarbioloogia) Moskva Ülikool, 1984, bioloogiakandidaat (molekulaarbioloogia) Tartu Ülikool, 1980, diplom (bioloog, bioloogia ja keemia õpetaja) |
| 7. | Teenistuskäik | 2001- Geeni- ja keskkonnatehnoloogia tippkeskus, juhataja 1992- Tartu Ülikool, rakubioloogia professor 2003-2005 Eesti Vabariigi Haridus- ja teadusminister 1999- 2003 Tartu Ülikooli Molekulaar- ja rakubioloogia instituut, juhataja 1995-1998, Tartu Ülikool, teadus- ja arendusprorektor 1993-1995, Tartu Ülikool, bioloogia-geograafiateaduskonna dekaan 1986-1992, Eesti Biokeskus, teadussekretär 1978-1986, Tartu Ülikool, insener, teadur, vanemteadur |
| 8. | Teaduskraad | Ph.D. (molekulaarbioloogia) bioloogiakandidaat (molekulaarbioloogia) |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Ülikool, 1991 Moskva Ülikool, 1984 |
| 10. | Tunnustused | Valgetähe orden, IV järk (2001) Eesti Kaitseliidu teenetemedal (2002) Püha Gediminase orden (Leedu Vabariik), II järk (2004) |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
Academia Europea, liige Euroopa Vähiuuringute Assotsiatsioon (EACR), liige Ameerika Vähiuuringute Assotsiatsioon, liige Eesti Inimesegeneetika Ühing, liige UNESCO Rahvusvaheline Bioeetika Komitee, liige Tartu Ülikooli Eetikakeskus, abijuhataja Tartu Ülikooli nõukogu, teaduskonna nõukogu ning instituudi nõukogu liige. |
| 12. | Juhendamisel kaitstud väitekirjad |
Arvi Jõers, PhD, 2004, juh. Toivo Maimets. Regulation of p53-dependent transcription.. Tartu Ülikool Lilian Kadaja, PhD, 2004, juh. Toivo Maimets. Studies on modulation of the activity of tumor suppressor protein p53.. Tartu Ülikool Viljar Jaks, PhD, 2003, juh. Toivo Maimets. p53- a switch in cellular circuit.. Tartu Ülikool Arnold Kristjuhan, PhD, 1998, juh. Toivo Maimets. Studies on transcriptional activator properties of tumor suppressor protein p53. Tartu Ülikool |
| 13. | Teadustöö põhisuunad | Kasvajate supressorvalgu p53 roll rakutsükli, DNA transkriptsiooni ja replikatsiooni regulaatorina. Rakusisesed signaaliülekanderajad ning nende kasvajaseoselised häiritused. |
| 14. | Jooksvad grandid | *Eesti Teadusfond,grant "CD43- ja p53- vahendatud signaaliradade vahelise seose uurimine" *EV Haridus- ja teadusministeerium, sihtfinantseerimine "Kasvajaseoselised muutused rakusisestes signaaliülekande radades". *EV Haridus- ja teadusministeerium, Tippkeskuste programm "Geeni- ja keskkonnatehnoloogia Tippkeskus" |
| 15. | Teaduspublikatsioonid |
Pauklin S, Kristjuhan A, Maimets T, Jaks V. ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress. Biochem Biophys Res Commun. (2005) 334(2), 386-394. Joers A., Jaks V., Kase J., Maimets T. p53-dependent transcription can exhibit both on/off and graded response after genotoxic stress. Oncogene (2004) 23,6175-6185. Kadaja L, Laos S, Maimets T. Overexpression of leukocyte marker CD43 causes activation of the tumor suppressor proteins p53 and ARF. Oncogene (2004) 23, 2523-2530. Lepik D., Jaks V., Värv S., Kadaja L., Maimets T. Electroporation and carrier DNA cause p53 activation, cell cycle arrest and apoptosis. Analytical Biochemistry (2003), 318, 52-59. Jaks V., Jõers A., Kristjuhan A., Maimets T. p53 protein accumulation in addition to its transcriptional activation is required for p53-dependent cell cycle arrest after treatment of cells with camptothecin. Oncogene (2001) 20, 1212-1219. Krinka D., Raid R., Pata I., Kärner J., Maimets T. In Situ hybridization of chick embryos with p53-specific probe and their immunostaining with anti-p53 antibodies. Anat. Embryol. (2001) 204, 207 – 215. Maimets T. Valgu p53 kasutusvõimalused molekulaarse markerina erinevate kasvajate puhul. Eesti Arst (2000). Kadaja L., Jesnowski R., Maimets T., Liebe S., Lohr M. Construction of recombinant retroviruses expressing mutated k-ras or mutated p53 genes. Ann N Y Acad Sci (1999) 880, 371-373. Maimets T. Molekulaarne rakubioloogia. Ilmamaa 1999, 248 lk. Jõers A., Kristjuhan A., Kadaja L., Maimets T. Tumour associated mutants of p53 can inhibit transcriptional activity of p53 without heterooligomerization. Oncogene (1998) 17, 2351-2358. Kristjuhan A., Jaks V., Rimm I., Tooming T., Maimets T. Oligomerization of p53 is necessary to inhibit its transcriptional transactivation property at high protein concentration. Oncogene (1998) 16, 2413-2418. Lepik D., Ilves I., Kristjuhan A., Maimets T., Ustav M. p53 protein is a suppressor of papillomavirus DNA amplificational replication. J. Virol. (1998) 72, 6822-6831. Kristjuhan A., Maimets T. Protein P53 modulates transcription from a promoter containing its binding site in concentration-dependent manner. Eur. J. Biochem. (1995) 234, 827 - 831. Wagner P., Simanis V., Maimets T., Keenan E., Addison C., Brain R., Grimaldi M., Sturzbecher H.-W., Jenkins J. A human tumour-derived mutant p53 protein induces a p34cdc2 reversible growth arrest in fission yeast. Oncogene (1991) 6, 1539-1547. Stürzbecher H.-W., Maimets T., Chumakov P., Brain R., Addison C., Simanis V., Rudge K., Philp R., Grimaldi M., Court W., Jenkins J. p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis. Oncogene (1990) 5, 795-801. Jenkins J.R., Stürzbecher H.-W., Brain R., Grimaldi M., Maimets T., Rudge K., Court W., Addison C. Identification and analysis of human p53 mutants which are trans-dominant modulators of DNA replication in vivo. Cancer Cells (1989) 7, 127-135. Maimets T.O. Bacterial expression of human p53 oncogene as a fusion protein. Proc. USSR Acad. Sci. (1988) 302, 1501-1503. Sturzbecher H.-W., Brain R., Maimets T., Addison C., Rudge K., Jenkins J. Mouse p53 blocks SV40 DNA replication in vitro and downregulates T antigen DNA helicase activity. Oncogene (1988) 3, 101-109. Maimets T.O., Jenkins J.R. Modified oncoprotein p53 in HT1080 tumor cell line. Proc. USSR Acad. Sci. (1987) 296, 757-759. Saarma R.J., Maimets T.O., Anton R.G., Lind A.J. Studies on ras-family oncogenes in tumors of human brain. In: Actual problems of neurology and neurosurgery. Tartu University Press. (1986) 165-170. Maimets T.O., Remme J.L., Villems R.L.-E. Stimulation of peptidyltransferase activity of 50S subunits with alcohols. Molecular Biology (USSR) (1985) 3, 617-622. Remme J., Metspalu E., Maimets T., Villems R. The properties of the complex between ribosomal protein L2 and tRNA. FEBS Lett. (1985) 190, 275-278. Maimets T.O., Ustav M. B., Remme J.L.,Villems R.L.-E. E.coli ribosomal protein L16: its possible role in protein biosynthesis. Molecular Biology (USSR) (1984) 18, 1597-1605. Maimets T., Remme J., Villems R. Ribosomal protein L16 binds to the 3'-end of transfer RNA. FEBS Lett. (1984) 166, 53-56. Maimets T., Ustav M., Villems R. The role of protein L16 and its fragments in the peptidyltransferase activity of 50-S riboso¬mal subunits. Eur. J. Biochem. (1983) 135, 127-130. Remme J., Maimets T., Ustav M., Villems R. The interaction of ribosomal protein L16 and its fragments with tRNA. FEBS Lett. (1983) 153, 267-269. Metspalu E., Ustav M., Maimets T., Villems R. The composition and properties of the Escherichia coli 5S RNA-protein complex. Eur. J. Biochem. (1982) 121, 383-389. Maimets T.O., Ustav M.B., Villems R.L.-E., Saarma M.J., Lind. A.J. Binding of Escherichia coli 50 S ribosomal subunit proteins with two large 5S RNA fragments. Molecular Biology (USSR) (1981) 6, 569-574. Metspalu E., Maimets T., Ustav M., Villems R. A quarternary complex consisting of two molecules of tRNA and ribosomal pro¬teins L2 and Ll7. FEBS Lett. (1981) 132, 105-108. Sedman J., Maimets T., Ustav M., Villems R. The interaction of 5S RNA and its large fragments with ribosomal proteins. FEBS Lett. (1981) 136, 251-254. Villems R., Koger A., Lind A., Maimets T., Metspalu E., Saarma M., Sarapuu T., Ustav M. Affinity chromatography of Escherichia coli ribosomal protein on the immobilized ribonucleic acids. Properties of the complexes. Biological implications of protein- nucleic acid interactions. (J.Augustyniak ed.) Elsevier/North Holland Biomedical Press, Amsterdam, N.Y., Oxford, Poznan. (1980) 91-99. |
viimati muudetud: 22.09.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Toivo |
| 2. | Surname | Maimets |
| 3. | Institution | University of Tartu |
| 4. | Position | Professor of Cell Biology |
| 5. | Date of birth | 29.12.1957 (day.month.year) |
| 6. | Education | University of Tartu 1991, Ph.D. (molecular biology) Moscow University 1984, kandidat nauk (molecular biology) University of Tartu 1980, diploma (genetics and cytology) |
| 7. | Research and professional experience |
1992- Professor of Cell Biology, University of Tartu 2001- Director, National Centre of Excellence for Gene and Environmental Technologies 2003- 2005 Minister of Education and Research, Republic of Estonia 1999- 2003 Director, Institute of Molecular and Cell Biology, University of Tartu 1995-1998 Pro-rector for Research and Development, University of Tartu 1993-1995 Dean, Faculty of Biology and Geography, University of Tartu 1986-1992 Secretary for Science, Estonian Biocentre |
| 8. | Academic degree | Ph.D. (molecular biology) kandidat nauk (molecular biology) |
| 9. | Dates and sites of earning the degrees |
University of Tartu 1991 Moscow University 1984 |
| 10. | Honours/awards | 4th Class Order of the White Star, from the Republic of Estonia Estonian League of Defence, Medal of Merits 2nd Class Order of St. Gediminas, from the Republic of Lithuania |
| 11. | Research-administrative experience |
Academia Europea, Member European Association for Cancer Research, Member American Association for Cancer Research, Member Estonian Genetics Association, Member UNESCO International Bioethics Committee, member Tartu University Centre of Ethics, co-director |
| 12. | Supervised dissertations |
Arvi Jõers, PhD, 2004, superv. Toivo Maimets. Regulation of p53-dependent transcription.. Tartu Ülikool Lilian Kadaja, PhD, 2004, superv. Toivo Maimets. Studies on modulation of the activity of tumor suppressor protein p53.. Tartu Ülikool Viljar Jaks, PhD, 2003, superv. Toivo Maimets. p53- a switch in cellular circuit.. Tartu Ülikool Arnold Kristjuhan, PhD, 1998, superv. Toivo Maimets. Studies on transcriptional activator properties of tumor suppressor protein p53. Tartu Ülikool |
| 13. | Current research program | Role of tumor suppressor protein p53 as a regulator of cell cycle, DNA replication and transcription. Intracellular signal transduction pathways and their tumor-specific irregularities. |
| 14. | Current grant funding | *Estonian Science Foundation, grant "Studies on interactions of CD43- and p53-mediated signal transduction pathways". *Estonian Ministry of Education and Research, targeted financing "Tumor-associated changes of signal transduction pathways" *Estonian Ministry of Education and Research, Program of Centers of Excellence, "Center of Excellence for Gene and Environmental Technologies". |
| 15. | List of most important publications |
Pauklin S, Kristjuhan A, Maimets T, Jaks V. ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress. Biochem Biophys Res Commun. (2005) 334(2), 386-394. Joers A., Jaks V., Kase J., Maimets T. p53-dependent transcription can exhibit both on/off and graded response after genotoxic stress. Oncogene (2004) 23,6175-6185. Kadaja L, Laos S, Maimets T. Overexpression of leukocyte marker CD43 causes activation of the tumor suppressor proteins p53 and ARF. Oncogene (2004) 23, 2523-2530. Lepik D., Jaks V., Värv S., Kadaja L., Maimets T. Electroporation and carrier DNA cause p53 activation, cell cycle arrest and apoptosis. Analytical Biochemistry (2003), 318, 52-59. Jaks V., Jõers A., Kristjuhan A., Maimets T. p53 protein accumulation in addition to its transcriptional activation is required for p53-dependent cell cycle arrest after treatment of cells with camptothecin. Oncogene (2001) 20, 1212-1219. Krinka D., Raid R., Pata I., Kärner J., Maimets T. In Situ hybridization of chick embryos with p53-specific probe and their immunostaining with anti-p53 antibodies. Anat. Embryol. (2001) 204, 207 – 215. Maimets T. Valgu p53 kasutusvõimalused molekulaarse markerina erinevate kasvajate puhul. Eesti Arst (2000). Kadaja L., Jesnowski R., Maimets T., Liebe S., Lohr M. Construction of recombinant retroviruses expressing mutated k-ras or mutated p53 genes. Ann N Y Acad Sci (1999) 880, 371-373. Maimets T. Molekulaarne rakubioloogia. Ilmamaa 1999, 248 lk. Jõers A., Kristjuhan A., Kadaja L., Maimets T. Tumour associated mutants of p53 can inhibit transcriptional activity of p53 without heterooligomerization. Oncogene (1998) 17, 2351-2358. Kristjuhan A., Jaks V., Rimm I., Tooming T., Maimets T. Oligomerization of p53 is necessary to inhibit its transcriptional transactivation property at high protein concentration. Oncogene (1998) 16, 2413-2418. Lepik D., Ilves I., Kristjuhan A., Maimets T., Ustav M. p53 protein is a suppressor of papillomavirus DNA amplificational replication. J. Virol. (1998) 72, 6822-6831. Kristjuhan A., Maimets T. Protein P53 modulates transcription from a promoter containing its binding site in concentration-dependent manner. Eur. J. Biochem. (1995) 234, 827 - 831. Wagner P., Simanis V., Maimets T., Keenan E., Addison C., Brain R., Grimaldi M., Sturzbecher H.-W., Jenkins J. A human tumour-derived mutant p53 protein induces a p34cdc2 reversible growth arrest in fission yeast. Oncogene (1991) 6, 1539-1547. Stürzbecher H.-W., Maimets T., Chumakov P., Brain R., Addison C., Simanis V., Rudge K., Philp R., Grimaldi M., Court W., Jenkins J. p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis. Oncogene (1990) 5, 795-801. Jenkins J.R., Stürzbecher H.-W., Brain R., Grimaldi M., Maimets T., Rudge K., Court W., Addison C. Identification and analysis of human p53 mutants which are trans-dominant modulators of DNA replication in vivo. Cancer Cells (1989) 7, 127-135. Maimets T.O. Bacterial expression of human p53 oncogene as a fusion protein. Proc. USSR Acad. Sci. (1988) 302, 1501-1503. Sturzbecher H.-W., Brain R., Maimets T., Addison C., Rudge K., Jenkins J. Mouse p53 blocks SV40 DNA replication in vitro and downregulates T antigen DNA helicase activity. Oncogene (1988) 3, 101-109. Maimets T.O., Jenkins J.R. Modified oncoprotein p53 in HT1080 tumor cell line. Proc. USSR Acad. Sci. (1987) 296, 757-759. Saarma R.J., Maimets T.O., Anton R.G., Lind A.J. Studies on ras-family oncogenes in tumors of human brain. In: Actual problems of neurology and neurosurgery. Tartu University Press. (1986) 165-170. Maimets T.O., Remme J.L., Villems R.L.-E. Stimulation of peptidyltransferase activity of 50S subunits with alcohols. Molecular Biology (USSR) (1985) 3, 617-622. Remme J., Metspalu E., Maimets T., Villems R. The properties of the complex between ribosomal protein L2 and tRNA. FEBS Lett. (1985) 190, 275-278. Maimets T.O., Ustav M. B., Remme J.L.,Villems R.L.-E. E.coli ribosomal protein L16: its possible role in protein biosynthesis. Molecular Biology (USSR) (1984) 18, 1597-1605. Maimets T., Remme J., Villems R. Ribosomal protein L16 binds to the 3'-end of transfer RNA. FEBS Lett. (1984) 166, 53-56. Maimets T., Ustav M., Villems R. The role of protein L16 and its fragments in the peptidyltransferase activity of 50-S riboso¬mal subunits. Eur. J. Biochem. (1983) 135, 127-130. Remme J., Maimets T., Ustav M., Villems R. The interaction of ribosomal protein L16 and its fragments with tRNA. FEBS Lett. (1983) 153, 267-269. Metspalu E., Ustav M., Maimets T., Villems R. The composition and properties of the Escherichia coli 5S RNA-protein complex. Eur. J. Biochem. (1982) 121, 383-389. Maimets T.O., Ustav M.B., Villems R.L.-E., Saarma M.J., Lind. A.J. Binding of Escherichia coli 50 S ribosomal subunit proteins with two large 5S RNA fragments. Molecular Biology (USSR) (1981) 6, 569-574. Metspalu E., Maimets T., Ustav M., Villems R. A quarternary complex consisting of two molecules of tRNA and ribosomal pro¬teins L2 and Ll7. FEBS Lett. (1981) 132, 105-108. Sedman J., Maimets T., Ustav M., Villems R. The interaction of 5S RNA and its large fragments with ribosomal proteins. FEBS Lett. (1981) 136, 251-254. Villems R., Koger A., Lind A., Maimets T., Metspalu E., Saarma M., Sarapuu T., Ustav M. Affinity chromatography of Escherichia coli ribosomal protein on the immobilized ribonucleic acids. Properties of the complexes. Biological implications of protein- nucleic acid interactions. (J.Augustyniak ed.) Elsevier/North Holland Biomedical Press, Amsterdam, N.Y., Oxford, Poznan. (1980) 91-99. |
last updated: 22.09.2005
[ sulge aken ]