[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Tanel |
| 2. | Perekonnanimi | Tenson |
| 3. | Töökoht | Tartu Ülikooli Tehnoloogiainstituut |
| 4. | Ametikoht | vanemteadur |
| 5. | Sünniaeg | 05.08.1970 (päev.kuu.aasta) |
| 6. | Haridus | 1992. aastal lõpetanud Tartu Ülikooli bioloogia erialal |
| 7. | Teenistuskäik | 1994-1996, külalisteadur Illinoisi Ülikoolis Chicagos (USA) 1997-1998, vanemteadur Eesti Biokeskuses 1998-2000, vanemteadur Tartu Ülikoolis 2001, külalisteadur Uppsala Ülikoolis (Rootsi) 2002- käesoleva ajani, vanemteadur Tartu Ülikoolis |
| 8. | Teaduskraad | Magister PhD |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Ülikool, 1994 Tartu Ülikool, 1997 |
| 10. | Tunnustused | |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
Molekulaarse mikrobioloogia labori rajamine Tartu Ülikooli Tehnoloogiainstituudis |
| 12. | Juhendamisel kaitstud väitekirjad |
|
| 13. | Teadustöö põhisuunad | Valgusünteesi molekulaarsed mehhanismid, translatsiooni inhibeerivad antibiootikumid, antibiootikumiresistentsus, mikroobiökoloogia |
| 14. | Jooksvad grandid | ETF, "Antibiootikumid ja kasvava peptiidi väljumine ribosoomist", kestus 2001-2005, 2005 aasta eelarve 136470 krooni; The Wellcome Trust, "Ribosoomi suurt subühikut inhibeerivad antibiootikumid: toimemehhanismid ja antibiootikumiresistentsus", kestus 2003-2008, 2005 aasta eelarve 1500000 krooni; Sihtfinantseerimine, "Antibiootikumide toimemehhanismid", kestus 2003-2007, 2005 aasta eelarve 1103000 krooni; EAS, "Ribosoomis kasvava peptiidi poolt reguleeritavad geeniekspressioonisüsteemid", kestus 2005-2007, 2005 aasta eelarve 780000 krooni |
| 15. | Teaduspublikatsioonid |
Luidalepp, H., Hallier, M., Felden, B., and Tenson, T. (2005). tmRNA decreases the bactericidal activity of aminoglycosides and the susceptibility to inhibitors of cell wall synthesis. RNA Biology, Vol. 2, Issue: 2, 70 - 74. Sorensen, M.A., Elf, J., Bouakaz, E., Tenson, T., Sanyal, S., Björk, G., and Ehrenberg, M. Over expression of a tRNA Leu isoacceptor changes charging pattern of leucine tRNAs and reveals new codon reading. Journal of Molecular Biology, in the press Antoun, A., Pavlov, M.Y., Tenson, T., and Ehrenberg, M. (2004). Ribosome formation from subunits studied by stopped-flow and Rayleigh light scattering. Biological Procedures Online, 6(1): 35-54. Lovmar, M., Tenson, T., and Ehrenberg, M. (2004). Kinetics of macrolide action: The josamycin and erythromycin cases. Journal of Biological Chemistry, 279(51): 53506-53515. Vimberg, V., Xiong, L., Bailey, M., Tenson, T., and Mankin, A. (2004). Peptide mediated macrolide resistance reveals possible specific interactions in the nascent peptide exit tunnel. Molecular Microbiology, 54(2): 376-385. Antoun, A., Pavlov, M.Y., Andersson, K., Tenson, T., and Ehrenberg, M. (2003). The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis. EMBO Journal, 22(20): 5593-5601. Elf, J., Nilsson, D., Tenson, T., and Ehrenberg, M. (2003). Selective charging of tRNA isoacceptors explains patterns of codon usage. Science, 300(5626): 1718-1722. Tenson, T., Lovmar, M., and Ehrenberg, M. (2003). The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. Journal of Molecular Biolology, 330(5): 1005-1014. Ehrenberg, M., and Tenson, T. (2002). A new beginning of the end of translation. Nature Structural Biology, 9(2): 85-87. Tenson, T., and Ehrenberg, M. (2002). Regulatory nascent peptides in the ribosomal tunnel. Cell, 108: 591-594. Belova, L., Tenson, T., Xiong, L., McNicholas, P.M., and Mankin, A.S. (2001). A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit. Proc.Natl.Acad.Sci.USA., 98: 3726-3731. Tenson, T., and Mankin, A.S. (2001). Short peptides conferring resistance to macrolide antibiotics. Peptides, 22: 1661-1668. Khaitovich, P., Tenson, T., Kloss, P., and Mankin, A.S. (1999). Reconstitution of functionally active Thermus aquaticus large ribosomal subunits with in vitro transcribed rRNA. Biochemistry, 38: 1780-1788. Khaitovich, P., Tenson, T., Mankin, A.S., and Green, R. (1999). Peptidyl transferase activity catalyzed by protein-free 23S ribosomal RNA remains elusive. RNA, 5: 605-608. Tenson, T., Vega Herrera, J., Kloss, P.S., Guarneros, G., and Mankin, A.S. (1999). Inhibition of translation and cell growth by minigene expression. Journal of Bacteriology, 181: 1617-1622. Liiv, A., Tenson, T., Margus, T., and Remme, J. (1998). Multiple functions of the transcribed spacers in ribosomal RNA operons. Biological Chemistry, 379: 783-793. Tenson, T., Xiong, L., Kloss, P., and Mankin, A.S. (1997). Erythromycin resistance peptides selected from random peptide libraries. Journal of Biological Chemistry, 272: 17425-17430. Dam, M., Douthwaite, S., Tenson, T., and Mankin, A.S. (1996) Mutations in domain II of 23 S rRNA facilitate translation of a 23 S rRNA-encoded pentapeptide conferring erythromycin resistance. Journal Molecular Biolology, 259: 1-6. Liiv, A., Tenson, T., and Remme, J. (1996). Analysis of the ribosomal large subunit assembly and 23S rRNA stability in vivo. Journal Molecular Biolology, 263: 396-410. Tenson, T., DeBlasio, A. and Mankin, A. (1996) A functional peptide encoded in the Escherichia coli 23S rRNA. Proc.Natl.Acad.Sci.USA., 93: 5641-5646. Tenson, T. and Mankin, A. (1995) Comparison of functional peptide encoded in the Escherichia coli 23S rRNA with other peptides involved in cis-regulation of translation. Biochem.Cell Biol., 73: 1061-1070. |
viimati muudetud: 03.08.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Tanel |
| 2. | Surname | Tenson |
| 3. | Institution | Institute of Technology, University of Tartu |
| 4. | Position | senior scientist |
| 5. | Date of birth | 05.08.1970 (day.month.year) |
| 6. | Education | 1992, graduated from University of Tartu as biologist |
| 7. | Research and professional experience |
1994-1996, visiting scientist at the University of Illinois at Chicago (USA) 1997-1998, senior scientist at Estonian Biocenter 1998-2000, senior scientist at University of Tartu 2001, visiting scientist at Uppsala University (Sweden) 2002-present, senior scientist at University of Tartu |
| 8. | Academic degree | Master of Science PhD |
| 9. | Dates and sites of earning the degrees |
University of Tartu, 1994 University of Tartu, 1997 |
| 10. | Honours/awards | |
| 11. | Research-administrative experience |
Establishing the Molecular Microbiology laboratory at the Institute of Technology, University of Tartu |
| 12. | Supervised dissertations | |
| 13. | Current research program | Molecular mechanisms of protein biosynthesis, antibiotics inhibiting translation, antibiotic resistance, microbial ecology |
| 14. | Current grant funding | Estonian Science Foundation, "Antibiotics and Exit of the Nascent Peptide from the Ribosome", duration 2001-2005, budget for 2005: 136470 Estonian Crowns; The Wellcome Trust, "Antibiotics Targeting Large Ribosomal Subunit: Mechanisms of Action and Antibiotic Resistance", duration 2003-2008, budget for 2005: 1500000 Estonian Crowns; Targeted Financing from Estoninan Government, "The Mechanisms of Action of Antibiotics", duration 2003-2007, budget for 2005: 1103000 Estonian Crowns; Enterprise Estonia, "Gene Expression Systems Regulated by the Nascent Peptide in the Ribosome", duration: 2005-2007, budget for 2005: 780000 Estonian Crowns; |
| 15. | List of most important publications |
Luidalepp, H., Hallier, M., Felden, B., and Tenson, T. (2005). tmRNA decreases the bactericidal activity of aminoglycosides and the susceptibility to inhibitors of cell wall synthesis. RNA Biology, Vol. 2, Issue: 2, 70 - 74. Sorensen, M.A., Elf, J., Bouakaz, E., Tenson, T., Sanyal, S., Björk, G., and Ehrenberg, M. Over expression of a tRNA Leu isoacceptor changes charging pattern of leucine tRNAs and reveals new codon reading. Journal of Molecular Biology, in the press Antoun, A., Pavlov, M.Y., Tenson, T., and Ehrenberg, M. (2004). Ribosome formation from subunits studied by stopped-flow and Rayleigh light scattering. Biological Procedures Online, 6(1): 35-54. Lovmar, M., Tenson, T., and Ehrenberg, M. (2004). Kinetics of macrolide action: The josamycin and erythromycin cases. Journal of Biological Chemistry, 279(51): 53506-53515. Vimberg, V., Xiong, L., Bailey, M., Tenson, T., and Mankin, A. (2004). Peptide mediated macrolide resistance reveals possible specific interactions in the nascent peptide exit tunnel. Molecular Microbiology, 54(2): 376-385. Antoun, A., Pavlov, M.Y., Andersson, K., Tenson, T., and Ehrenberg, M. (2003). The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis. EMBO Journal, 22(20): 5593-5601. Elf, J., Nilsson, D., Tenson, T., and Ehrenberg, M. (2003). Selective charging of tRNA isoacceptors explains patterns of codon usage. Science, 300(5626): 1718-1722. Tenson, T., Lovmar, M., and Ehrenberg, M. (2003). The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. Journal of Molecular Biolology, 330(5): 1005-1014. Ehrenberg, M., and Tenson, T. (2002). A new beginning of the end of translation. Nature Structural Biology, 9(2): 85-87. Tenson, T., and Ehrenberg, M. (2002). Regulatory nascent peptides in the ribosomal tunnel. Cell, 108: 591-594. Belova, L., Tenson, T., Xiong, L., McNicholas, P.M., and Mankin, A.S. (2001). A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit. Proc.Natl.Acad.Sci.USA., 98: 3726-3731. Tenson, T., and Mankin, A.S. (2001). Short peptides conferring resistance to macrolide antibiotics. Peptides, 22: 1661-1668. Khaitovich, P., Tenson, T., Kloss, P., and Mankin, A.S. (1999). Reconstitution of functionally active Thermus aquaticus large ribosomal subunits with in vitro transcribed rRNA. Biochemistry, 38: 1780-1788. Khaitovich, P., Tenson, T., Mankin, A.S., and Green, R. (1999). Peptidyl transferase activity catalyzed by protein-free 23S ribosomal RNA remains elusive. RNA, 5: 605-608. Tenson, T., Vega Herrera, J., Kloss, P.S., Guarneros, G., and Mankin, A.S. (1999). Inhibition of translation and cell growth by minigene expression. Journal of Bacteriology, 181: 1617-1622. Liiv, A., Tenson, T., Margus, T., and Remme, J. (1998). Multiple functions of the transcribed spacers in ribosomal RNA operons. Biological Chemistry, 379: 783-793. Tenson, T., Xiong, L., Kloss, P., and Mankin, A.S. (1997). Erythromycin resistance peptides selected from random peptide libraries. Journal of Biological Chemistry, 272: 17425-17430. Dam, M., Douthwaite, S., Tenson, T., and Mankin, A.S. (1996) Mutations in domain II of 23 S rRNA facilitate translation of a 23 S rRNA-encoded pentapeptide conferring erythromycin resistance. Journal Molecular Biolology, 259: 1-6. Liiv, A., Tenson, T., and Remme, J. (1996). Analysis of the ribosomal large subunit assembly and 23S rRNA stability in vivo. Journal Molecular Biolology, 263: 396-410. Tenson, T., DeBlasio, A. and Mankin, A. (1996) A functional peptide encoded in the Escherichia coli 23S rRNA. Proc.Natl.Acad.Sci.USA., 93: 5641-5646. Tenson, T. and Mankin, A. (1995) Comparison of functional peptide encoded in the Escherichia coli 23S rRNA with other peptides involved in cis-regulation of translation. Biochem.Cell Biol., 73: 1061-1070. |
last updated: 03.08.2005
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