[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Madis |
| 2. | Perekonnanimi | Metsis |
| 3. | Töökoht | Tervise Arengu Instituut |
| 4. | Ametikoht | vanemteadur |
| 5. | Sünniaeg | 26.06.1958 (päev.kuu.aasta) |
| 6. | Haridus | 1976-1981 - Moskva Ülikool |
| 7. | Teenistuskäik | 1981-1985 - Tartu Riikliku Ülikooli Üld- ja molekulaarpatoloogia Instituudi nooremteadur 1986-1990 - KBFI vanemteadur 1990-30/06/2005 - Karolinska Instituut, uurija, grupijuht (0,1 koormus alates 2004) 1996-2001 - TTÜ molekulaarbioloogia professor 01/01/2001 30/08/2001 - The Scripps Reasearch Institute, La Jolla, California, Associate professor (alates 09/2001 adjungeeritud neurofarmakoloogia professor) 2004 -> TAI vanemteadur |
| 8. | Teaduskraad | bioloogiateaaduste kandidaat molekulaarse neurobioloogia dotsent |
| 9. | Teaduskraadi välja andnud asutus, aasta |
1985, TÜ 1995, Karolinska Instituut |
| 10. | Tunnustused | mitmed |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
Nõukogu liige KBFIs, TTÜ GTIs grupijuhtide nõukokogu liige KIs |
| 12. | Juhendamisel kaitstud väitekirjad |
Adrian Brunkhorst, PhD, 2005, juh. Madis Metsis. A study on the TFIID subunit TAF4. Karolinska Institute Kairi Tammoja, MSc, 2003, juh. Madis Metsis. Genome-wide characterization of TGF-beta taget genes. TTÜ Kaia Palm, PhD, 1998, juh. Madis Metsis. Regulation of neuronal gene expression. Karolinska Institute Tuija Salin, PhD, 1997, juh. Madis Metsis. Regulation of neurotrophins and their receptors: molecular aspects and functional implications. Karolinska Institute Tõnis Timmusk, PhD, 1994, juh. Madis Metsis. Structure and regulation of neurotrophin and their low-affinity receptor genes. Karolinska Instituut |
| 13. | Teadustöö põhisuunad | varasemad: geeniregulatsioon närvisüsteemis, neurotroofsete faktorite bioloogia praegused: transkriptsioonilised regulatoorsed võrgud närvisüsteemis (suunaga deprseiooniga seotud süsteemidele) ja kasvajates (suunaga närvisysteemi kasvajatele, kopsukasvajatele ja reproduktiivse süsteemi ning muude susguhormoonide s~ltuvatele kasvajatele) |
| 14. | Jooksvad grandid | |
| 15. | Teaduspublikatsioonid |
Brunkhorst A, Karlen M, Shi J, Mikolajczyk M, Nelson MA, Metsis M, Hermanson O. A specific role for the TFIID subunit TAF4 and RanBPM in neural progenitor differentiation. Mol Cell Neurosci. 2005 Jun;29(2):250-8. Kilk K, El-Andaloussi S, Jarver P, Meikas A, Valkna A, Bartfai T, Kogerman P, Metsis M, Langel U. Evaluation of transportan 10 in PEI mediated plasmid delivery assay. J Control Release. 2005 Mar 21;103(2):511-23. Epub 2005 Jan 26. Brunkhorst A, Neuman T, Hall A, Arenas E, Bartfai T, Hermanson O, Metsis M. Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity. Biochem Biophys Res Commun. 2004 Dec 10;325(2):574-9. Metsis M, Brunkhorst A, Neuman T. Cell-type-specific expression of the TFIID component TAF(II)135 in the nervous system. Exp Cell Res. 2001 Oct 1;269(2):214-21. Metsis M. Genes for neurotrophic factors and their receptors: structure and regulation. Cell Mol Life Sci. 2001 Jul;58(8):1014-20. Review. Schultz R, Metsis M, Hokfelt T, Parvinen M, Pelto-Huikko M. Expression of neurotrophin receptors in rat testis. Upregulation of TrkA mRNA with hCG treatment. Mol Cell Endocrinol. 2001 Aug 20;182(1):121-7. Pombo PM, Barettino D, Espliguero G, Metsis M, Iglesias T, Rodriguez-Pena A. Transcriptional repression of neurotrophin receptor trkB by thyroid hormone in the developing rat brain. J Biol Chem. 2000 Dec 1;275(48):37510-7. |
viimati muudetud: 01.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Madis |
| 2. | Surname | Metsis |
| 3. | Institution | National Institute of Health Development |
| 4. | Position | senior researcher |
| 5. | Date of birth | 26.06.1958 (day.month.year) |
| 6. | Education | 1976-1981 - Moscow University |
| 7. | Research and professional experience |
1981-1985 - junior researcher, TU IGMP 1986-1990 - senior researcher, NICPBP 1990-30/06/2005 - Karolinska Instituut, researcher, group leader (0,1 employment since 2004) 1996-2001 - TTU professor of molecular biology 01/01/2001 30/08/2001 - The Scripps Reasearch Institute, La Jolla, California, Associate professor (since 09/2001 aadjunct professor of neuropharmacology) 2004 -> NIHD senior researcher |
| 8. | Academic degree | PhD. docent in molecular biology ( Dr. Hab.) |
| 9. | Dates and sites of earning the degrees |
1985, Tartu University 1995, Karlinska Institute |
| 10. | Honours/awards | several |
| 11. | Research-administrative experience |
member of institue board at NICPBP, IBT at TTU member of groupleader board at KI |
| 12. | Supervised dissertations |
Adrian Brunkhorst, PhD, 2005, superv. Madis Metsis. A study on the TFIID subunit TAF4. Karolinska Institute Kairi Tammoja, MSc, 2003, superv. Madis Metsis. Genome-wide characterization of TGF-beta taget genes. TTÜ Kaia Palm, PhD, 1998, superv. Madis Metsis. Regulation of neuronal gene expression. Karolinska Institute Tuija Salin, PhD, 1997, superv. Madis Metsis. Regulation of neurotrophins and their receptors: molecular aspects and functional implications. Karolinska Institute Tõnis Timmusk, PhD, 1994, superv. Madis Metsis. Structure and regulation of neurotrophin and their low-affinity receptor genes. Karolinska Instituut |
| 13. | Current research program | earlier directions: gene regulation in nervous system, biology of neurotrophic factors current: transcriptional networks in nervous system (with emphasis on deprssion related systems) and transcriptional networks on tumors (with emphasis on nervous system tumors, lung tumors and repåroductive system and other sex hormone dependent tumors) |
| 14. | Current grant funding | |
| 15. | List of most important publications |
Brunkhorst A, Karlen M, Shi J, Mikolajczyk M, Nelson MA, Metsis M, Hermanson O. A specific role for the TFIID subunit TAF4 and RanBPM in neural progenitor differentiation. Mol Cell Neurosci. 2005 Jun;29(2):250-8. Kilk K, El-Andaloussi S, Jarver P, Meikas A, Valkna A, Bartfai T, Kogerman P, Metsis M, Langel U. Evaluation of transportan 10 in PEI mediated plasmid delivery assay. J Control Release. 2005 Mar 21;103(2):511-23. Epub 2005 Jan 26. Brunkhorst A, Neuman T, Hall A, Arenas E, Bartfai T, Hermanson O, Metsis M. Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity. Biochem Biophys Res Commun. 2004 Dec 10;325(2):574-9. Metsis M, Brunkhorst A, Neuman T. Cell-type-specific expression of the TFIID component TAF(II)135 in the nervous system. Exp Cell Res. 2001 Oct 1;269(2):214-21. Metsis M. Genes for neurotrophic factors and their receptors: structure and regulation. Cell Mol Life Sci. 2001 Jul;58(8):1014-20. Review. Schultz R, Metsis M, Hokfelt T, Parvinen M, Pelto-Huikko M. Expression of neurotrophin receptors in rat testis. Upregulation of TrkA mRNA with hCG treatment. Mol Cell Endocrinol. 2001 Aug 20;182(1):121-7. Pombo PM, Barettino D, Espliguero G, Metsis M, Iglesias T, Rodriguez-Pena A. Transcriptional repression of neurotrophin receptor trkB by thyroid hormone in the developing rat brain. J Biol Chem. 2000 Dec 1;275(48):37510-7. |
last updated: 01.10.2005
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