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Elulookirjeldus (CV)
1.Eesnimi Arnold
2.Perekonnanimi Kristjuhan
3.Töökoht Tartu Ülikooli Molekulaar- ja Rakubioloogi Instituut
4.Ametikoht vanemteadur
5.Sünniaeg 28.11.1969 (päev.kuu.aasta)
6.Haridus 1992 Lõpetanud Tartu Ülokooli bioloogia erialal
1994 MSc. molekulaarbioloogia erialal, Tartu Ülikool
1998 PhD. rakubioloogia erialal, Tartu Ülikool
7.Teenistuskäik 1998-2000 Teadur, Molekulaar- ja Rakubioloogia Instituut, Tartu Ülikool
2000-2004 Järeldoktor, London Research Institute, Cancer Research UK
2004- Vanemteadur, Molekulaar- ja Rakubioloogia Instituut, Tartu Ülikool
8.Teaduskraad PhD.
9.Teaduskraadi välja
andnud asutus, aasta		 Tartu Ülikool, 1998
10.Tunnustused
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus
12.Juhendamisel kaitstud
väitekirjad

Siim Pauklin, MSc, 2005, juh. Arnold Kristjuhan, Viljar Jaks, Toivo Maimets. Tuumorsupressor ARF ja ATM/ATR kinaaside komplementaarne roll apoptoosi indutseerumises vastusena onkogeensele stressile. Tartu Ülikool
13.Teadustöö põhisuunad
14.Jooksvad grandid MERG-CT-2004-011741, "Studies of transcription-coupled modifications of chromatin", rahastab Euroopa Komisjon.
15.Teaduspublikatsioonid

Pauklin, S., Kristjuhan, A., Maimets, T., Jaks, V. (2005). ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress. Biochem. Biophys. Res. Commun. 334:386-94.

Gilbert, C., Kristjuhan, A., Winkler, G. S., Svejstrup, J. Q. (2004). Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation. Mol. Cell 14:457-464.

Kristjuhan, A., Svejstrup, J. Q. (2004). Evidence for distinct mechanisms facilitating transcript elongation through chromatin in vivo. EMBO J. 23:4243-4252.

Kristjuhan, A., Wittschieben, B. Ø., Walker, J., Roberts, D., Cairns, B. R., Svejstrup, J. Q. (2003). Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation. Proc. Natl. Acad. Sci. USA 100:7551-7556.

Kristjuhan, A., Walker, J., Suka, N., Grunstein, M., Roberts, D., Cairns, B. R., Svejstrup, J. Q. (2002). Transcriptional inhibition of genes with severe histone H3 hypoacetylation in the coding region. Mol. Cell 10:925-933.

Winkler, G. S., Kristjuhan, A., Erdjument-Bromage, H., Tempst, P., Svejstrup, J. Q. (2002). Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc. Natl. Acad. Sci. USA 99:3517-3522.

Jaks, V., Jõers, A., Kristjuhan, A., Maimets, T. (2001). p53 protein accumulation in addition to the transactivation activity is required for p53-dependent cell cycle arrest after treatment of cells with camptothecin. Oncogene 20:1212-1219.

Kaldalu, N., Lepik, D., Kristjuhan, A., Ustav, M. (2000). Monitoring and purification of proteins using bovine papillomavirus E2 epitope tags. Biotechniques 28:456-460, 462.

Jõers, A., Kristjuhan, A., Kadaja, L., Maimets, T. (1998). Tumour associated mutants of p53 can inhibit transcriptional activity of p53 without heterooligomerization. Oncogene 17:2351-2358.

Kristjuhan, A., Jaks, V., Rimm, I., Tooming, T., Maimets, T. (1998). Oligomerization of p53 is necessary to inhibit its transcriptional transactivation property at high protein concentration. Oncogene 16:2413-2418.

Lepik, D., Ilves, I., Kristjuhan, A., Maimets, T., Ustav, M. (1998). p53 protein is a suppressor of papillomavirus DNA amplificational replication. J. Virol. 72:6822-6831.

Kristjuhan, A., Maimets, T. (1995). Protein p53 modulates transcription from a promoter containing its binding site in a concentration-dependent manner. Eur. J. Biochem. 234:827-831.

viimati muudetud: 02.08.2005

Curriculum Vitae (CV)
1.First Name Arnold
2.Surname Kristjuhan
3.Institution Institute of Molecular and Cell Bilogy, University of Tartu
4.Position senior research scientist
5.Date of birth 28.11.1969 (day.month.year)
6.Education
7.Research and
professional experience		 1998-2000 Research Scientist, Institute of Molecular and Cell Biology, University of Tartu
2000-2004 Research Fellow, London research institute, Cancer Research UK, United Kingdom
2004- Senior Research Scientist, Institute of Molecular and Cell Biology, University of Tartu
8.Academic degree PhD.
9.Dates and sites of
earning the degrees		 University of Tartu, 1998
10.Honours/awards
11.Research-administrative
experience
12.Supervised dissertations

Siim Pauklin, MSc, 2005, superv. Arnold Kristjuhan, Viljar Jaks, Toivo Maimets. Tuumorsupressor ARF ja ATM/ATR kinaaside komplementaarne roll apoptoosi indutseerumises vastusena onkogeensele stressile. Tartu Ülikool
13.Current research program
14.Current grant funding MERG-CT-2004-011741, "Studies of transcription-coupled modifications of chromatin", funded by European Commission.
15.List of most important publications

Pauklin, S., Kristjuhan, A., Maimets, T., Jaks, V. (2005). ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress. Biochem. Biophys. Res. Commun. 334:386-94.

Gilbert, C., Kristjuhan, A., Winkler, G. S., Svejstrup, J. Q. (2004). Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation. Mol. Cell 14:457-464.

Kristjuhan, A., Svejstrup, J. Q. (2004). Evidence for distinct mechanisms facilitating transcript elongation through chromatin in vivo. EMBO J. 23:4243-4252.

Kristjuhan, A., Wittschieben, B. Ø., Walker, J., Roberts, D., Cairns, B. R., Svejstrup, J. Q. (2003). Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation. Proc. Natl. Acad. Sci. USA 100:7551-7556.

Kristjuhan, A., Walker, J., Suka, N., Grunstein, M., Roberts, D., Cairns, B. R., Svejstrup, J. Q. (2002). Transcriptional inhibition of genes with severe histone H3 hypoacetylation in the coding region. Mol. Cell 10:925-933.

Winkler, G. S., Kristjuhan, A., Erdjument-Bromage, H., Tempst, P., Svejstrup, J. Q. (2002). Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc. Natl. Acad. Sci. USA 99:3517-3522.

Jaks, V., Jõers, A., Kristjuhan, A., Maimets, T. (2001). p53 protein accumulation in addition to the transactivation activity is required for p53-dependent cell cycle arrest after treatment of cells with camptothecin. Oncogene 20:1212-1219.

Kaldalu, N., Lepik, D., Kristjuhan, A., Ustav, M. (2000). Monitoring and purification of proteins using bovine papillomavirus E2 epitope tags. Biotechniques 28:456-460, 462.

Jõers, A., Kristjuhan, A., Kadaja, L., Maimets, T. (1998). Tumour associated mutants of p53 can inhibit transcriptional activity of p53 without heterooligomerization. Oncogene 17:2351-2358.

Kristjuhan, A., Jaks, V., Rimm, I., Tooming, T., Maimets, T. (1998). Oligomerization of p53 is necessary to inhibit its transcriptional transactivation property at high protein concentration. Oncogene 16:2413-2418.

Lepik, D., Ilves, I., Kristjuhan, A., Maimets, T., Ustav, M. (1998). p53 protein is a suppressor of papillomavirus DNA amplificational replication. J. Virol. 72:6822-6831.

Kristjuhan, A., Maimets, T. (1995). Protein p53 modulates transcription from a promoter containing its binding site in a concentration-dependent manner. Eur. J. Biochem. 234:827-831.

last updated: 02.08.2005

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