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| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Jüri |
| 2. | Perekonnanimi | Siigur |
| 3. | Töökoht | Keemilise ja bioloogilise Füüsika Instituut(KBFI) |
| 4. | Ametikoht | Bioorgaanilise keemia laboratooriumi juhataja, vanemteadur,teadussekretär |
| 5. | Sünniaeg | 11.04.1941 (päev.kuu.aasta) |
| 6. | Haridus | Tartu Ülikool, orgaaniline keemia, 1959-1964; aspirantuur 1967 -1970 , Tartu Ülikool, füüsikaline orgaaniline keemia |
| 7. | Teenistuskäik | Eesti TA Keemia Instituut, nooremteadur 1965, 1967; sõdur NSVL1965-1966; aspirant, Tartu Ülikool, orgaanilise keemia kateeder, 1967 - 1970;Tartu Ülikool, Keemilise Kineetika ja Katalüüsi laboratoorium, nooremteadur, 1970 - 1971;Eesti Põllumajanduse Akadeemia, vanemõpetaja, 1971 - 1974; Eesti TA Küberneetika Instituut, biokeemia labor, vanemteadur 1974 - 1980;Eesti TA Keemilise ja Bioloogilise Füüsika Instituut, teadussekretär 1980 - , bioorgaanilise keemia laboratooriumi juhataja 1991 - |
| 8. | Teaduskraad | Keemiakandidaat, Ph.D vanemteadur |
| 9. | Teaduskraadi välja andnud asutus, aasta |
Tartu Riiklik Ülikool, 1971 NSVL Teaduste Akadeemia,Moskva,1985 |
| 10. | Tunnustused | 1987 - Eesti NSV Teaduse ja Tehnika Preemia; 1989 - Ülemaailmse Toksinoloogia Ühingu liige (IST); 1991 - Eesti Teaduste Akadeemia Aukiri; 1993 - George Sorose (Rahvusvahelise Teadusfondi) Stipendium; 1993 - 1994, 1995-1997 Fogarty grant - auhind NIH (National Institute of Health, USA) |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
Instituudi teadussekretar, instituudi nõukogu liige, keemia ja molekulaarbioloogia ekspertkomisjoni liige (ETF); laboratooriumi juhatamine, grantide juhendamine, FEBS Letters, BBA, Thromb.Res., Comp.Biochem.Phys., Toxicon artiklite retsenseerimine |
| 12. | Juhendamisel kaitstud väitekirjad |
Mari Samel, cand, 1987, juh. Jüri Siigur. Rästiku (Vipera berus berus) mürgi komponentide eraldamine ja iseloomustamine.. ENSV TA Keemia Instituut, Tallinn |
| 13. | Teadustöö põhisuunad | 1.7. Orgaaniline ja biokeemia;1.8. molekulaarbioloogia; Proteoomika: Valkude ja ensüümide struktuur ja funktsioon; rekombinantsete ja mutantsete valkude saamine, vere hüübimissüsteemi mõjutavad valgud; MALDI TOF mass spektromeetria, maomürkide keemia ja biokeemia |
| 14. | Jooksvad grandid | ETF 5554,Hemostaasi, angiogeneesi ja apoptoosi mõjutavad valgud viperiidsete madude mürkidest. |
| 15. | Teaduspublikatsioonid |
Aaspõllu, A., Siigur, J. and Siigur, E. cDNA cloning of a novel P–I lebetase isoform Le-4. Toxicon 2005, 46(5), 591-594. Trummal, K. Tõnismägi, K., Siigur, E., Aaspõllu, A., Lopp, A., Sillat, T., Saat, R., Kasak, L., Tammiste, I., Kogerman, P. , Kalkkinen, N. and Siigur, J. A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Toxicon 2005, 46(1), 46-61. Siigur, E., Aaspollu, A., Trummal, K., Tonismagi, K., Tammiste, I., Kalkkinen, N., Siigur, J. Factor X activator from Vipera lebetina venom is synthesized from different genes. Biochim Biophys Acta. 2004,1702(1), 41-51 Siigur,J. & Siigur,E. (2004) Lebetase. In Handbook of Proteolytic Enzymes, 2 edn (Barrett,AJ, Rawlings,ND & Woessner,JF eds), p.707-709, Elsevier, London. Siigur, E., Aaspollu, A., Siigur, J. Anticoagulant serine fibrinogenases from Vipera lebetina venom. Structure-function relationships. Thromb. Haemost. 2003, 89(5), 835-840. Siigur, J., Trummal, K., Tõnismägi, K., Samel, M., Siigur,E., Vija, H., Tammiste, I., and Subbi, J. Use of MALDI-TOF mass spectrometry for specificity studies of biomedically important proteases. Spectroscopy. 2002, 16, 161-170. Siigur, E., Aaspõllu, A., Siigur, J. Sequence diversity of Vipera lebetina snake venom gland serine proteinase homologs – result of alternative splicing or genome alteration. Gene. 2001, 263( 1,2), 199-203. .Siigur, E., Tõnismägi, K., Trummal, K., Samel, M., Vija, H., Subbi, J., Siigur, J. Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity. Biochim. Biophys. Acta. 2001, 1568(1), 90-98. Siigur, J., Aaspõllu, A., Tõnismägi, K., Trummal, K. Samel, M., Vija, H., Subbi, J., Siigur. E. Proteases from Vipera lebetina venom affecting coagulation and fibrinolysis. Haemostasis, 2001; 31, 123-132. Siigur, E., Samel, M., Tonismagi, K., Siigur, J. Cross-reactivities of polyclonal antibodies against factor V activating enzyme,a serine proteinase from Vipera lebetina (snake) venom. Comp Biochem Physiol B Biochem Mol Biol. 2000, 126(3), 377-82. Siigur, J. and Siigur, E. Polypeptides and proteins active in the coagulation process. In: Methods and Tools in Biosciences and Medicine. Animal Toxins. Facts and Protocols., Eds. Herve Rochat and Marie-France Martin-Eauclaire, Birkhäuser Verlag, Basel Boston Berlin, 2000 pp. 320-346. Trummal, K., Vija, H., Subbi, J., Siigur, J. MALDI-TOF mass spectrometry analysis of substrate specificity of lebetase, a direct-acting fibrinolytic metalloproteinase from Vipera lebetina snake venom. Biochim Biophys Acta. 2000, 1476(2), 331-336. Saidi, N., Samel, M., Siigur, J., Jensen, P.E.H. Lebetase, an α(β)-fibrin(ogen)olytic metalloproteinase of Vipera lebetina snake venom, is inhibited by hyman α-macroglobulins. Biochim Biophys Acta, 1999, 1434(1), 94-102. Siigur, E., Aaspõllu, A., Siigur, J. Molecular cloning and sequence analysis of a cDNA for factor V activating enzyme, a coagulant protein from Vipera lebetina snake venom. Biochem. Biophys. Res.Commun., 1999, 262, 328-332. Siigur, E., Aaspõllu, A., Siigur, J. Molecular cloning and sequence analysis of a cDNA for factor V activating enzyme. Biochem. Biophys. Res. Commun.1999,262(2): 328-332. Siigur, E., Samel, M., Tõnismägi, K., Subbi, J., Reintamm, T., Siigur J. Isolation, properties and N-terminal amino acid sequence of a factor V activator from Vipera lebetina (Levantine viper) snake venom. Biochim Biophys Acta – Protein Structure & Molecular Enzymology, 1998, 1429(1), 239-248. Siigur, J., Samel, M., Tõnismägi, K., Subbi, J., Siigur, E., Tu, A.T. Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom. Thrombosis Research, 1998, 90(1), 39-49. Siigur, E., Aaspõllu, A., Tu, A.T., Siigur, J. cDNA cloning and deduced amino acid sequence of a fibrinolytic enzyme (lebetase) from Vipera lebetina snake venom. Biochem. Biophys. Res.Commun. 1996, 224, 229-236. Siigur, J., Tõnismägi, K., Tu, A.T., Siigur, E. Cross-reactivities of polyclonal antibodies against lebetase, fibrinolytic enzyme of Levantine viper (Vipera lebetina) venom. Toxicon 1996, 34, 5, 608-613. |
viimati muudetud: 05.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Jüri |
| 2. | Surname | Siigur |
| 3. | Institution | National Institute of Chemical Physics and Biophysics (NICPB) |
| 4. | Position | Head of laboratory of bioorganic chemistry, senior research scientist, scientific secretary |
| 5. | Date of birth | 11.04.1941 (day.month.year) |
| 6. | Education | (1959-1964) Tartu State University, Department of ChemistryDiploma: organic chemistry (1967 – 1970), post graduate student, Tartu State University, physical organic chemistry |
| 7. | Research and professional experience |
1965-1967 junior research scientist, Institute of Chemistry, Tallinn, 1971 junior research scientist, Tartu State University, 1971-1974 senior lecturer, Estonian Agricultural Academy, Tartu, 1974-1980 senior research scientist, Institute of Cybernetics, Tallinn, 1980-present scientific secretary, 1991-present head of laboratory of bioorganic chemistry, National Institute of Chemical Physics and Biophysics |
| 8. | Academic degree | candidate of chemistry,Ph.D senior research scientist |
| 9. | Dates and sites of earning the degrees |
Tartu State University, 1971 Academy of Sciences of the USSR,1985 |
| 10. | Honours/awards | 1987- Estonian State prize for science and technology, 1991- Honour Certificate of Estonian Academy of Sciences, 1993- Georg Soros stipend, 1993-1994, 1995-1997- Fogarty Grant Awards, NIH, USA |
| 11. | Research-administrative experience |
member of scientific council of institute, member of expert commission of chemistry and molecular biology of Estonian Science Foundation (ETF),referee of articles in: FEBS Letters, Biochim. Biophys. Acta, Thromb. Res., Comp. Biochem.Phys., Toxicon |
| 12. | Supervised dissertations |
Mari Samel, cand, 1987, superv. Jüri Siigur. Rästiku (Vipera berus berus) mürgi komponentide eraldamine ja iseloomustamine.. ENSV TA Keemia Instituut, Tallinn |
| 13. | Current research program | Structure and function of proteins, enzymes affecting haemostasis, proteomics, recombinant proteins, MALDI-TOF mass spectrometry, chromatography, chemistry and biochemistry of snake venoms |
| 14. | Current grant funding | ETF 5554, Proteins affecting haemostasis, angiogenesis and apoptosis from viper snake venoms. |
| 15. | List of most important publications |
Aaspõllu, A., Siigur, J. and Siigur, E. cDNA cloning of a novel P–I lebetase isoform Le-4. Toxicon 2005, 46(5), 591-594. Trummal, K. Tõnismägi, K., Siigur, E., Aaspõllu, A., Lopp, A., Sillat, T., Saat, R., Kasak, L., Tammiste, I., Kogerman, P. , Kalkkinen, N. and Siigur, J. A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Toxicon 2005, 46(1), 46-61. Siigur, E., Aaspollu, A., Trummal, K., Tonismagi, K., Tammiste, I., Kalkkinen, N., Siigur, J. Factor X activator from Vipera lebetina venom is synthesized from different genes. Biochim Biophys Acta. 2004,1702(1), 41-51 Siigur,J. & Siigur,E. (2004) Lebetase. In Handbook of Proteolytic Enzymes, 2 edn (Barrett,AJ, Rawlings,ND & Woessner,JF eds), p.707-709, Elsevier, London. Siigur, E., Aaspollu, A., Siigur, J. Anticoagulant serine fibrinogenases from Vipera lebetina venom. Structure-function relationships. Thromb. Haemost. 2003, 89(5), 835-840. Siigur, J., Trummal, K., Tõnismägi, K., Samel, M., Siigur,E., Vija, H., Tammiste, I., and Subbi, J. Use of MALDI-TOF mass spectrometry for specificity studies of biomedically important proteases. Spectroscopy. 2002, 16, 161-170. Siigur, E., Aaspõllu, A., Siigur, J. Sequence diversity of Vipera lebetina snake venom gland serine proteinase homologs – result of alternative splicing or genome alteration. Gene. 2001, 263( 1,2), 199-203. .Siigur, E., Tõnismägi, K., Trummal, K., Samel, M., Vija, H., Subbi, J., Siigur, J. Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity. Biochim. Biophys. Acta. 2001, 1568(1), 90-98. Siigur, J., Aaspõllu, A., Tõnismägi, K., Trummal, K. Samel, M., Vija, H., Subbi, J., Siigur. E. Proteases from Vipera lebetina venom affecting coagulation and fibrinolysis. Haemostasis, 2001; 31, 123-132. Siigur, E., Samel, M., Tonismagi, K., Siigur, J. Cross-reactivities of polyclonal antibodies against factor V activating enzyme,a serine proteinase from Vipera lebetina (snake) venom. Comp Biochem Physiol B Biochem Mol Biol. 2000, 126(3), 377-82. Siigur, J. and Siigur, E. Polypeptides and proteins active in the coagulation process. In: Methods and Tools in Biosciences and Medicine. Animal Toxins. Facts and Protocols., Eds. Herve Rochat and Marie-France Martin-Eauclaire, Birkhäuser Verlag, Basel Boston Berlin, 2000 pp. 320-346. Trummal, K., Vija, H., Subbi, J., Siigur, J. MALDI-TOF mass spectrometry analysis of substrate specificity of lebetase, a direct-acting fibrinolytic metalloproteinase from Vipera lebetina snake venom. Biochim Biophys Acta. 2000, 1476(2), 331-336. Saidi, N., Samel, M., Siigur, J., Jensen, P.E.H. Lebetase, an α(β)-fibrin(ogen)olytic metalloproteinase of Vipera lebetina snake venom, is inhibited by hyman α-macroglobulins. Biochim Biophys Acta, 1999, 1434(1), 94-102. Siigur, E., Aaspõllu, A., Siigur, J. Molecular cloning and sequence analysis of a cDNA for factor V activating enzyme, a coagulant protein from Vipera lebetina snake venom. Biochem. Biophys. Res.Commun., 1999, 262, 328-332. Siigur, E., Aaspõllu, A., Siigur, J. Molecular cloning and sequence analysis of a cDNA for factor V activating enzyme. Biochem. Biophys. Res. Commun.1999,262(2): 328-332. Siigur, E., Samel, M., Tõnismägi, K., Subbi, J., Reintamm, T., Siigur J. Isolation, properties and N-terminal amino acid sequence of a factor V activator from Vipera lebetina (Levantine viper) snake venom. Biochim Biophys Acta – Protein Structure & Molecular Enzymology, 1998, 1429(1), 239-248. Siigur, J., Samel, M., Tõnismägi, K., Subbi, J., Siigur, E., Tu, A.T. Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom. Thrombosis Research, 1998, 90(1), 39-49. Siigur, E., Aaspõllu, A., Tu, A.T., Siigur, J. cDNA cloning and deduced amino acid sequence of a fibrinolytic enzyme (lebetase) from Vipera lebetina snake venom. Biochem. Biophys. Res.Commun. 1996, 224, 229-236. Siigur, J., Tõnismägi, K., Tu, A.T., Siigur, E. Cross-reactivities of polyclonal antibodies against lebetase, fibrinolytic enzyme of Levantine viper (Vipera lebetina) venom. Toxicon 1996, 34, 5, 608-613. |
last updated: 05.10.2005
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