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Elulookirjeldus (CV)
1.Eesnimi Peeter
2.Perekonnanimi Sikk
3.Töökoht Keemilise ja Bioloogilise Füüsika Instituut
4.Ametikoht Vanemteadur
5.Sünniaeg 16.10.1943 (päev.kuu.aasta)
6.Haridus Tartu Ülikooli Keemiaosakond
7.Teenistuskäik 1969 - 1972 Tartu Ülikooli Orgaanilise keemia kateedri vanemlaborant
1972 - 1979 Eesti TA Küberneetika instituut, nooremteadur
1980 - ... Keemilise ja Bioloogilise Füüsika Instituut, vanemteadur
8.Teaduskraad Keemiakandidaat
9.Teaduskraadi välja
andnud asutus, aasta		 Eesti TA Keemia Instituut 1978
10.Tunnustused Eesti teaduspreemia 1978 (kaasautor)
11.Teadusorganisatsiooniline
ja –administratiivne
tegevus
12.Juhendamisel kaitstud
väitekirjad
13.Teadustöö põhisuunad rakufüsioloogia, raku bioenergeetika
14.Jooksvad grandid
15.Teaduspublikatsioonid

Anmann T., Eimre M, Kuznetsov A.V., Andrienko T., Kaambre T., Sikk P., Seppet E., Tiivel T., Vendelin M., Seppet E. and Saks V.A. (2005) Calcium-induced contraction of sarcomeres changes regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal 272, 3145-3161.

Kulp, M., Kaljurand, M., Kaambre, T., Sikk, P., Saks, V. (2004) In situ monitoring of kinetics of metabolic conversion of ATP to ADP catalyzed by MgATPases of muscle Gastrocnemius skinned fibers using micellar electrokinetic chromatography. Electrophoresis 17, 2996-3002

Seppet, E. K., Eimre, M., Andrienko, T., Kaambre, T., Sikk, P., Kuznetsov, A. V., Saks, V. (2004) Studies of mitochondrial respiration in muscle cells in situ: Use and misuse of experimental evidence in mathematical modeling Mol. Cell. Biochem. 256, 219–227.

Andrienko, T. Kuznetsov, A., V., Kaambre, T., Usson, Y., Orosco, A., Appaix, F., Tiivel, T., Sikk, P., Vendelin, M., Margreiter, R., Saks, V. A. (2003) Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells. J. Exp. Biol. 206, 2059-2072.

Appaix, F., Kuznetsov, A. V., Usson, Y., Kay, L., Andrienko, T., Olivares, J., Kaambre,T., Sikk, P., Margreiter, R., Saks, V. .(2003) Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria. Exp. Physiol. 88, 175-90.

Saks, V., Kuznetsov, A., Andrienko, T., Usson, Y., Appaix, F., Guerrero, K., Kaambre, T., Sikk, P., Lemba, M., Vendelin, M. (2003) Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells. Biophys J. 84, 3436-3456.

Appaix, F., Guerrero, K., Rampal, D., Izikki, M., Kaambre, T., Sikk, P., Brdiczka, D., Riva-Lavieille, C., Olivares, J., Longuet, M., Antonsson, B., Saks V.A. (2002) Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochim. Biophys. Acta 1556, 155-167.

Saks, V. A., Kaambre, T., Sikk, P., Eimre, M., Orlova, E., Paju, K., Piirsoo, A., Appaix, F., Kay, L., Regitz-Zagrosek, V., Fleck, E., Seppet, E. (2001) Intracellular energetic units in red muscle cells Biochem. J. 356: 643-657.

Seppet, E. K., Kaambre, T., Sikk, P., Tiivel, T., Vija, H., Tonkonogi, M., Sahlin, K., Kay, L., Appaix, F., Braun, U., Eimre, M., Saks, V. A. (2001) Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochim. Biophys. Acta 1504, 379-95.

Tiivel, T., Kadaya, L., Kuznetsov, A., Kaambre, T., Peet, N., Sikk, P., Braun, U., Ventura-Clapier, R., Saks, V., Seppet, E. K. (2000) Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Mol. Cell. Biochem. 208, 119-28.

Kaambre, T., Tougu, V., Kaambre, P., Vija, H., Sikk, P. (1999) Hydrolysis of emulsified mixtures of triacylglycerols by pancreatic lipase. Biochim. Biophys. Acta 1431, 97-106.

Seppet, E. K., Kadaya, L., Peet, N., Käämbre, T., Sikk, P., Saks, V. A. (1998) The 27.5 kD protein appears to control the oxidative phosphorylation in slow twitch muscle cells, Pathophysiology, 5: 121.

Kay, L., Li, Z., Mericskay, M., Olivares, J., Tranqui, L., Fontaine, E., Tiivel, T., Sikk, P., Kaambre, T., Samuel, J. L., Rappaport, L., Usson, Y., Leverve, X., Paulin, D., Saks, V. A. (1997) Study of regulation of mitochondrial respiration in vivo. An analysis of influence of ADP diffusion and possible role of cytoskeleton. Biochim. Biophys. Acta 1322, 41-59.

Parve, O., Vallikivi, I., Metsala, A., Lille, Ü., Tõugu, V., Sikk, P., Käämbre, T., Vija H., Pehk, T. (1997) Lipase-catalysed enantioselective hydrolysis: Interpretation of the kinetic results in terms of frontier orbital localisation, Tetrahedron 53, 4889-4900.

Kuznetsov, A. V., Tiivel, T., Sikk, P., Kaambre, T., Kay, L., Daneshrad, Z., Rossi, A., Kadaja, L., Peet, N., Seppet, E., Saks, V. A. (1996) Striking differences between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. Eur. J. Biochem. 241, 909-915.

Sikk P.F,, Oza A.V., Lyokene A.G., Aaviksaar A.A. (1986) The role of the N-terminal amino group in the activity of pancreatic lipase. Bioorg Khim. 12,985-987.

Sikk P, Osa A, Aaviksaar A (1985) Irreversible inhibition of pancreatic lipase by bis-p-nitrophenyl methylphosphonate.FEBS Lett.184,193-196.

viimati muudetud: 11.10.2005

Curriculum Vitae (CV)
1.First Name Peeter
2.Surname Sikk
3.Institution National Institute of Chemical Physics and Biophysics
4.Position Senior research scientist
5.Date of birth 16.10.1943 (day.month.year)
6.Education University of Tartu, Department of Chemistry
7.Research and
professional experience		 1969 - 1972 University of Tartu, Department of organic chemistry, senior technician
1972 - 1979 Institute of Cybernetics, junior research scientist
1980 - ... National Institute of Chemical Physics and Biophysics, senior research scientist
8.Academic degree Ph. D. in chemistry
9.Dates and sites of
earning the degrees		 Institute of Chemistry of the Estonian Acad. Sci. 1978
10.Honours/awards Estonian award of science 1978 (coauthor)
11.Research-administrative
experience
12.Supervised dissertations
13.Current research program cell physiology, cellular bioenergetics
14.Current grant funding
15.List of most important publications

Anmann T., Eimre M, Kuznetsov A.V., Andrienko T., Kaambre T., Sikk P., Seppet E., Tiivel T., Vendelin M., Seppet E. and Saks V.A. (2005) Calcium-induced contraction of sarcomeres changes regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal 272, 3145-3161.

Kulp, M., Kaljurand, M., Kaambre, T., Sikk, P., Saks, V. (2004) In situ monitoring of kinetics of metabolic conversion of ATP to ADP catalyzed by MgATPases of muscle Gastrocnemius skinned fibers using micellar electrokinetic chromatography. Electrophoresis 17, 2996-3002

Seppet, E. K., Eimre, M., Andrienko, T., Kaambre, T., Sikk, P., Kuznetsov, A. V., Saks, V. (2004) Studies of mitochondrial respiration in muscle cells in situ: Use and misuse of experimental evidence in mathematical modeling Mol. Cell. Biochem. 256, 219–227.

Andrienko, T. Kuznetsov, A., V., Kaambre, T., Usson, Y., Orosco, A., Appaix, F., Tiivel, T., Sikk, P., Vendelin, M., Margreiter, R., Saks, V. A. (2003) Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells. J. Exp. Biol. 206, 2059-2072.

Appaix, F., Kuznetsov, A. V., Usson, Y., Kay, L., Andrienko, T., Olivares, J., Kaambre,T., Sikk, P., Margreiter, R., Saks, V. .(2003) Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria. Exp. Physiol. 88, 175-90.

Saks, V., Kuznetsov, A., Andrienko, T., Usson, Y., Appaix, F., Guerrero, K., Kaambre, T., Sikk, P., Lemba, M., Vendelin, M. (2003) Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells. Biophys J. 84, 3436-3456.

Appaix, F., Guerrero, K., Rampal, D., Izikki, M., Kaambre, T., Sikk, P., Brdiczka, D., Riva-Lavieille, C., Olivares, J., Longuet, M., Antonsson, B., Saks V.A. (2002) Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochim. Biophys. Acta 1556, 155-167.

Saks, V. A., Kaambre, T., Sikk, P., Eimre, M., Orlova, E., Paju, K., Piirsoo, A., Appaix, F., Kay, L., Regitz-Zagrosek, V., Fleck, E., Seppet, E. (2001) Intracellular energetic units in red muscle cells Biochem. J. 356: 643-657.

Seppet, E. K., Kaambre, T., Sikk, P., Tiivel, T., Vija, H., Tonkonogi, M., Sahlin, K., Kay, L., Appaix, F., Braun, U., Eimre, M., Saks, V. A. (2001) Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochim. Biophys. Acta 1504, 379-95.

Tiivel, T., Kadaya, L., Kuznetsov, A., Kaambre, T., Peet, N., Sikk, P., Braun, U., Ventura-Clapier, R., Saks, V., Seppet, E. K. (2000) Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Mol. Cell. Biochem. 208, 119-28.

Kaambre, T., Tougu, V., Kaambre, P., Vija, H., Sikk, P. (1999) Hydrolysis of emulsified mixtures of triacylglycerols by pancreatic lipase. Biochim. Biophys. Acta 1431, 97-106.

Seppet, E. K., Kadaya, L., Peet, N., Käämbre, T., Sikk, P., Saks, V. A. (1998) The 27.5 kD protein appears to control the oxidative phosphorylation in slow twitch muscle cells, Pathophysiology, 5: 121.

Kay, L., Li, Z., Mericskay, M., Olivares, J., Tranqui, L., Fontaine, E., Tiivel, T., Sikk, P., Kaambre, T., Samuel, J. L., Rappaport, L., Usson, Y., Leverve, X., Paulin, D., Saks, V. A. (1997) Study of regulation of mitochondrial respiration in vivo. An analysis of influence of ADP diffusion and possible role of cytoskeleton. Biochim. Biophys. Acta 1322, 41-59.

Parve, O., Vallikivi, I., Metsala, A., Lille, Ü., Tõugu, V., Sikk, P., Käämbre, T., Vija H., Pehk, T. (1997) Lipase-catalysed enantioselective hydrolysis: Interpretation of the kinetic results in terms of frontier orbital localisation, Tetrahedron 53, 4889-4900.

Kuznetsov, A. V., Tiivel, T., Sikk, P., Kaambre, T., Kay, L., Daneshrad, Z., Rossi, A., Kadaja, L., Peet, N., Seppet, E., Saks, V. A. (1996) Striking differences between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. Eur. J. Biochem. 241, 909-915.

Sikk P.F,, Oza A.V., Lyokene A.G., Aaviksaar A.A. (1986) The role of the N-terminal amino group in the activity of pancreatic lipase. Bioorg Khim. 12,985-987.

Sikk P, Osa A, Aaviksaar A (1985) Irreversible inhibition of pancreatic lipase by bis-p-nitrophenyl methylphosphonate.FEBS Lett.184,193-196.

last updated: 11.10.2005

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