[ sulge aken ]
| Elulookirjeldus (CV) | ||
| 1. | Eesnimi | Allen |
| 2. | Perekonnanimi | Kaasik |
| 3. | Töökoht | TÜ Farmakoloogia Instituut |
| 4. | Ametikoht | vanemteadur |
| 5. | Sünniaeg | 23.08.1970 (päev.kuu.aasta) |
| 6. | Haridus | 1995-1998 Tallinna 5. Keskkool 1988-1992 TÜ Bioloogia-geograafia teaduskond -biokeemia 1992-1994 magistrantuur TÜ Patofüsioloogia instituudi juures 1994-1998 doktorantuur TÜ Patofüsioloogia instituudi ja Helsingi Ülikooli Biomeditsiini Instituudi juures |
| 7. | Teenistuskäik | 1994-1997 TÜ Patofüsioloogia instituudi lektor 1998-1999 TÜ Patofüsioloogia instituudi teadur 1999-2000 postdoktorantuur, INSERM U446, University of Paris-Sud (10 months) 2000- TÜ Farmakoloogia instituudi vanemteadur 2003- TÜ Molekulaarse ja Kliinilise Meditsiini Keskuse juhataja asetäitja |
| 8. | Teaduskraad | 1998 PhD (Patofüsioloogia) Tartu Ülikool |
| 9. | Teaduskraadi välja andnud asutus, aasta |
1994 MSc (Biomeditsiin) Tartu Ülikool |
| 10. | Tunnustused | 2000 Eesti Vabariigi Teaduspreemia meditsiini alal 2001 Eesti Vabariigi Presidendi noore teadlase preemia |
| 11. | Teadusorganisatsiooniline ja –administratiivne tegevus |
ETF, SA Arhimedese, EL FP5 ja INTAS'e retsensent/evaluaator |
| 12. | Juhendamisel kaitstud väitekirjad |
|
| 13. | Teadustöö põhisuunad | Bioenergeetika, neuroprotektantide farmakoloogia |
| 14. | Jooksvad grandid | Eesti Teadusfond Mitokondri mahu regulatsioon ning selle roll neuronites ja kardiomüotsüütides 2005-2008 |
| 15. | Teaduspublikatsioonid |
Kaasik A, Rikk T, Piirsoo A, Zharkovsky T, Zharkovsky A Upregulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. Eur J Neurosci. 2005 Sep;22(5):1023-31 Safiulina D, Veksler V, Zharkovsky A, Kaasik A. Loss of mitochondrial membrane potential is associated with increase in mitochondrial volume. J Cell Physiol. 2005 Aug 18; [Epub ahead of print] Available online Kaasik A, Joubert F, Ventura-Clapier R, Veksler V. A novel mechanism of regulation of cardiac contractility by mitochondrial functional state. FASEB J. 2004 Aug;18(11):1219-27. Safiulina D, Kaasik A, Seppet E, Peet N, Zharkovsky A, Seppet E. Method for in situ detection of the mitochondrial function in neurons. J Neurosci Methods. 2004 Aug 15;137(1):87-95. Ventura-Clapier R, Kaasik A, Veksler V. Structural and functional adaptations of striated muscles to CK deficiency. Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):29-41 Kaasik A, Safiulina D, Kalda A, Zharkovsky A. Dehydroepiandrosterone with other neurosteroids preserve neuronal mitochondria from calcium overload. J Steroid Biochem Mol Biol. 2003 Oct;87(1):97-103. Kaasik A, Veksler V, Boehm E, Novotova M, Ventura-Clapier R. From energy store to energy flux: a study in creatine kinase-deficient fast skeletal muscle. FASEB J. 2003 Apr;17(6):708-10. Zharkovskaja T, Kaasik A, Jaako K, Zharkovsky A. Neurodegeneration and production of the new cells in the dentate gyrus of juvenile rat hippocampus after single administration of ethanol. Brain Research. 2003 Jul 18;978(1-2):115-23. Kaasik A, Kalda A, Jaako K, Zharkovsky A. Dehydroepiandrosterone sulphate prevents oxygen-glucose deprivation-induced injury in cerebellar granule cell culture. Neurosci. 2001;102(2):427-32. Kaasik A, Paju K, Minajeva A, Ohisalo JJ. Decreased expression of phospholamban is not associated with lower b-adrenergic activation in rat atria. Mol Cell Biochem. 2001 Jul;223(1-2):109-15. Kaasik A, Veksler V, Boehm E, Novotova M, Minajeva A, Ventura-Clapier R. Energetic crosstalk between organelles: architectural integration of energy production and utilization. Circ Res. 2001 Jul 20;89(2):153-9. Kalda A, Kaasik A, Vassiljev V, Pokk P, Zharkovsky A. Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal death. Brain Res. 2000 Jan 24;853(2):370-3. De Sousa E, Veksler V, Minajeva A, Kaasik A, Mateo P, Mayoux E, Hoerter J, Bigard X, Serrurier B, Ventura-Clapier R. Subcellular creatine kinase alterations. Implications in heart failure. Circ Res. 1999 Jul 9;85(1):68-76. Kaasik A, Minajeva A, De Sousa E, Ventura-Clapier R, Veksler V. Nitric oxide inhibits cardiac energy production via inhibition of mitochondrial creatine kinase. FEBS Lett. 1999 Feb 5;444(1):75-7. Kaasik A, Vassiljev V, Poldoja E, Kalda A, Zharkovsky A. Do nuclear condensation or fragmentation and DNA fragmentation reflect the mode of neuronal death? Neuroreport. 1999 Jun 23;10(9):1937-42 Seppet EK, Kaasik A, Minajeva A, Paju K, Ohisalo JJ, Vetter R, Braun U. Mechanisms of thyroid hormone control over sensitivity and maximal contractile responsiveness to beta-adrenergic agonists in atria. Mol Cell Biochem. 1998 Jul;184(1-2):419-26. Kaasik A, Minajeva A, Paju K, Eimre M, Seppet EK. Thyroid hormones differentially affect sarcoplasmic reticulum function in rat atria and ventricles. Mol Cell Biochem. 1997 Nov;176(1-2):119-26. Kaasik A, Paju K, Vetter R, Seppet EK. Thyroid hormones increase the contractility but suppress the effects of beta-adrenergic agonist by decreasing phospholamban expression in rat atria. Cardiovasc Res. 1997 Jul;35(1):106-12. Minajeva A, Kaasik A, Paju K, Seppet E, Lompre AM, Veksler V, Ventura-Clapier R. Sarcoplasmic reticulum function in determining atrioventricular contractile differences in rat heart. Am J Physiol. 1997 Nov;273(5 Pt 2):H2498-507. Kaasik A, Ohisalo JJ. Membrane-bound phosphodiesterases in rat myocardium. J Pharm Pharmacol. 1996 Sep;48(9):962-4. Kaasik A, Elomaa VV, Seppet EK, Ohisalo JJ. Low particulate type IV phosphodiesterase activity in hypothyroid rat atria. J Mol Cell Cardiol. 1994 Dec;26(12):1587-92. Kaasik A, Seppet EK, Ohisalo JJ. Enhanced negative inotropic effect of an adenosine A1-receptor agonist in rat left atria in hypothyroidism. J Mol Cell Cardiol. 1994 Apr;26(4):509-17. |
viimati muudetud: 11.10.2005
| Curriculum Vitae (CV) | ||
| 1. | First Name | Allen |
| 2. | Surname | Kaasik |
| 3. | Institution | Department of Pharmacology, University of Tartu |
| 4. | Position | senior scientist |
| 5. | Date of birth | 23.08.1970 (day.month.year) |
| 6. | Education | 1995-1998 Tallinn Secondary School N 5 1988-1992 Faculty of Biology (Biochemistry) 1992-1994 M.Sci. studies at Dept. Pathophysiology, Univ. Tartu 1994-1998 Ph.D. studies at Dept. Pathophysiology, Univ. Tartu and at Institute of Biomedicine, Univ. Helsinki |
| 7. | Research and professional experience |
1994-1997 lecturer, Dept Pathophysiology, University of Tartu 1998-1999 researcher, Dept Pharmacology, University of Tartu 1999-2000 postdoctoral fellow/visiting researcher, INSERM U446 and Dept of Pharmacology Univ Tartu 2000- senior researcher, Dept Pharmacology, Univ Tartu 2003- vice director, Centre of Molecular and Clinical Medicine, University of Tartu |
| 8. | Academic degree | 1998 PhD (Pathophysiology)University of Tartu |
| 9. | Dates and sites of earning the degrees |
1994 MSc (Biomedicine) University of Tartu |
| 10. | Honours/awards | 2000 Estonian Republic National Award 2001 Estonian Presidents young investigator award |
| 11. | Research-administrative experience |
Expert at EC Research Directorate, INTAS, Archimedes and Estonian Science Foundation |
| 12. | Supervised dissertations | |
| 13. | Current research program | Bioenergetics, Pharmacology of the neuroprotectants |
| 14. | Current grant funding | Estonian Foundation of Science. Regulation of mitochondrial volume in neurons and cardiomyocytes 2005-2008. |
| 15. | List of most important publications |
Kaasik A, Rikk T, Piirsoo A, Zharkovsky T, Zharkovsky A Upregulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. Eur J Neurosci. 2005 Sep;22(5):1023-31 Safiulina D, Veksler V, Zharkovsky A, Kaasik A. Loss of mitochondrial membrane potential is associated with increase in mitochondrial volume. J Cell Physiol. 2005 Aug 18; [Epub ahead of print] Available online Kaasik A, Joubert F, Ventura-Clapier R, Veksler V. A novel mechanism of regulation of cardiac contractility by mitochondrial functional state. FASEB J. 2004 Aug;18(11):1219-27. Safiulina D, Kaasik A, Seppet E, Peet N, Zharkovsky A, Seppet E. Method for in situ detection of the mitochondrial function in neurons. J Neurosci Methods. 2004 Aug 15;137(1):87-95. Ventura-Clapier R, Kaasik A, Veksler V. Structural and functional adaptations of striated muscles to CK deficiency. Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):29-41 Kaasik A, Safiulina D, Kalda A, Zharkovsky A. Dehydroepiandrosterone with other neurosteroids preserve neuronal mitochondria from calcium overload. J Steroid Biochem Mol Biol. 2003 Oct;87(1):97-103. Kaasik A, Veksler V, Boehm E, Novotova M, Ventura-Clapier R. From energy store to energy flux: a study in creatine kinase-deficient fast skeletal muscle. FASEB J. 2003 Apr;17(6):708-10. Zharkovskaja T, Kaasik A, Jaako K, Zharkovsky A. Neurodegeneration and production of the new cells in the dentate gyrus of juvenile rat hippocampus after single administration of ethanol. Brain Research. 2003 Jul 18;978(1-2):115-23. Kaasik A, Kalda A, Jaako K, Zharkovsky A. Dehydroepiandrosterone sulphate prevents oxygen-glucose deprivation-induced injury in cerebellar granule cell culture. Neurosci. 2001;102(2):427-32. Kaasik A, Paju K, Minajeva A, Ohisalo JJ. Decreased expression of phospholamban is not associated with lower b-adrenergic activation in rat atria. Mol Cell Biochem. 2001 Jul;223(1-2):109-15. Kaasik A, Veksler V, Boehm E, Novotova M, Minajeva A, Ventura-Clapier R. Energetic crosstalk between organelles: architectural integration of energy production and utilization. Circ Res. 2001 Jul 20;89(2):153-9. Kalda A, Kaasik A, Vassiljev V, Pokk P, Zharkovsky A. Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal death. Brain Res. 2000 Jan 24;853(2):370-3. De Sousa E, Veksler V, Minajeva A, Kaasik A, Mateo P, Mayoux E, Hoerter J, Bigard X, Serrurier B, Ventura-Clapier R. Subcellular creatine kinase alterations. Implications in heart failure. Circ Res. 1999 Jul 9;85(1):68-76. Kaasik A, Minajeva A, De Sousa E, Ventura-Clapier R, Veksler V. Nitric oxide inhibits cardiac energy production via inhibition of mitochondrial creatine kinase. FEBS Lett. 1999 Feb 5;444(1):75-7. Kaasik A, Vassiljev V, Poldoja E, Kalda A, Zharkovsky A. Do nuclear condensation or fragmentation and DNA fragmentation reflect the mode of neuronal death? Neuroreport. 1999 Jun 23;10(9):1937-42 Seppet EK, Kaasik A, Minajeva A, Paju K, Ohisalo JJ, Vetter R, Braun U. Mechanisms of thyroid hormone control over sensitivity and maximal contractile responsiveness to beta-adrenergic agonists in atria. Mol Cell Biochem. 1998 Jul;184(1-2):419-26. Kaasik A, Minajeva A, Paju K, Eimre M, Seppet EK. Thyroid hormones differentially affect sarcoplasmic reticulum function in rat atria and ventricles. Mol Cell Biochem. 1997 Nov;176(1-2):119-26. Kaasik A, Paju K, Vetter R, Seppet EK. Thyroid hormones increase the contractility but suppress the effects of beta-adrenergic agonist by decreasing phospholamban expression in rat atria. Cardiovasc Res. 1997 Jul;35(1):106-12. Minajeva A, Kaasik A, Paju K, Seppet E, Lompre AM, Veksler V, Ventura-Clapier R. Sarcoplasmic reticulum function in determining atrioventricular contractile differences in rat heart. Am J Physiol. 1997 Nov;273(5 Pt 2):H2498-507. Kaasik A, Ohisalo JJ. Membrane-bound phosphodiesterases in rat myocardium. J Pharm Pharmacol. 1996 Sep;48(9):962-4. Kaasik A, Elomaa VV, Seppet EK, Ohisalo JJ. Low particulate type IV phosphodiesterase activity in hypothyroid rat atria. J Mol Cell Cardiol. 1994 Dec;26(12):1587-92. Kaasik A, Seppet EK, Ohisalo JJ. Enhanced negative inotropic effect of an adenosine A1-receptor agonist in rat left atria in hypothyroidism. J Mol Cell Cardiol. 1994 Apr;26(4):509-17. |
last updated: 11.10.2005
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