| title: |
Clinical and prognostic significance of ventricular repolarization temporal variability in patients with various forms of coronary artery disease |
| reg no: |
ETF5046 |
| project type: |
Estonian Science Foundation research grant |
| subject: |
3. Medical Sciences
|
| status: |
completed |
| institution: |
Estonian Institute of Cardiology |
| head of project: |
Jüri Kaik |
| duration: |
01.01.2002 - 31.12.2005 |
| description: |
The aim of the study is to establish the peculiarities of the registration of new, potentially very informative parameters reflecting temporal aspects of ventricular repolarization -QT interval variability (QTV) and QT interval rate-adaptation (QTA) in healthy subjects and in patients with various forms of coronary artery disease (CAD). Specific changes in these parameters preceeding the onset of life-threatening arrhythmias will be assesse. An advanced, clinically acceptable algorithm for QTV determination at Holter monitoring as well as techniques for QTA assessment at exercise test and transesophageal atrial stimulation will be evaluated. The results of the study together with the data of 2 studies undergoing in Tallinn Technical University Biomedical Engineering Centre (ESF grant No4272"Algorithms for discrimination of life-threatening cardiac arrhythmias" J.Lass, and the project No 0140238 "Interpretation of physiological signals" prof. H.Hinrikus) will serve as the basis for creation of novel soft- and hardware.Correlation between the above-mentioned parameters and the results of other myocardial electrical instability determination methods (invasive and non-invasive) as well as clinical and prognostic significance of these parameters alone and in combination with the data of other methods for identification of patients with life-threatening arrhythmias will be investigated. The utilization of the study results- non-invasive analysis of temporal ventricular repolarization heterogeneity - provides an important tool for sudden death risk stratification and assessment of antiarrhythmic drug treatment benefits/drawbacks and can considerably affect the arrhythmia-related high mortality characteristic to CAD patients. |