| title: | The prognostic value of ultrasonographic investigations in predicting multiorgan failure and organ damage in asphyxiated newborn infants |
|---|---|
| reg no: | ETF5054 |
| project type: | Estonian Science Foundation research grant |
| subject: |
3. Medical Sciences |
| status: | completed |
| institution: | Clinicum of Tartu University |
| head of project: | Pilvi Ilves |
| duration: | 01.01.2002 - 31.12.2004 |
| description: | Severe asphyxia is likely to cause disturbances in a number of organ systems other than the brain. In 50-60% of severely asphyxiated infants multiorgan failure develops. Unfortunately encepahalopathy as well as the clinical picture of the failure of other organs develops over the first days of life, being the most expressed after 1-2 days, at a time when it is too late to start organ saving treatment. Measurements of cerebral blood flow velocity have provided useful prognostic information in full term asphyxiated infants. So far few studies describe prognostic value of Doppler ultrasonography in predicting multiorgan failure in asphyxiated infants. The aims of the study are: - to identify the normal range of blood flow velocities in cerebral, mesenteric and renal arteries in healthy term newborns and infants -to identify the pattern of changes in cerebral, mesenteric and renal blood flow velocities in asphyxiated infants -to identify the prognostic value of changes in cerebral, mesenteric and renal blood flow velocities in the development of multiorgan failure and permanent organ damage in asphyxiated infants The goal of investigators is early identification of severely asphyxiated infants with serious threat of irreversible organ damage in order to commence adequate treatment and early habilitation before the permanent organ damage occurs. On the other hand the study may give us the possibility to identify the large majority of asphyxiated infants with low risk of organ failure to avoid unnecessary diagnostic and therapeutic interventions. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Pilvi Ilves | The Service of Radiology Tartu University Clinics | physician | |
| 2. | Mare Lintrop | Service of Radiology, Tartu University Clinics | the head of the unit | |
| 3. | Tuuli Metsvaht | Clinics of Anesthesiology and Intensive Care; Tartu University Clinics | the head of the unit | |