| title: | The role of nitric oxide in the pathogenesis of atopic dermatitis |
|---|---|
| reg no: | ETF5299 |
| project type: | Estonian Science Foundation research grant |
| subject: |
3. Medical Sciences |
| status: | completed |
| institution: | University of Tartu |
| head of project: | Helgi Silm |
| duration: | 01.01.2002 - 31.12.2005 |
| description: | Immunomodulating properties of nitric oxide (NO) are probably involved in the pathogenesis of atopic dermatitis. The aim of the current study is to characterize the role of NO in the pathogenesis of atopic dermatitis by measuring the rate of NO synthesis in the skin during distinct phases of the disease and establishing the contribution of various isoforms. To complete the aim we intend to: 1) measure the activity of NOS isoenzymes in atopic dermatitis skin biopsies; 2) detect the possible changes in amount of NOS protein (by Western blotting) and in the localization of enzyme (by immunohistochemistry) in atopic dermatitis skin; 3) measure the activity of NOS isoforms in lymphocytes derived from blood and skin biopsies in order to elucidate their part in NO production. Detailed characterization of the role of NO in atopic dermatitis may have important implications for clinical management of the disease. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Helgi Silm | University of Tartu Faculty of Medicine Dept. of Dermatology | professor and head | |
| 2. | Annika Volke | University of Tartu | Ph.D. student | |
| 3. | Vallo Volke | University of Tartu | researcher | |