| title: | Prevention of multiorgan failure in sepsis: infusion therapy, microcirculation, antibacterial treatment and plasma exchange. |
|---|---|
| reg no: | ETF5304 |
| project type: | Estonian Science Foundation research grant |
| subject: |
3. Medical Sciences |
| status: | completed |
| institution: | University of Tartu |
| head of project: | Joel Starkopf |
| duration: | 01.01.2002 - 31.12.2005 |
| description: | Specific aims of the study are: - to clarify the pharmacokinetics of antibiotic drugs in critically ill septic patients; - to investigate the effect of fresh frozen plasma transfusion on circulating blood volume, microcirculation and blood antioxidant capacity in septic patients; - to clarify if the concept of plasma exchange alters the morbidity or mortality of the critically ill septic patients. Clinical significance: Results from the present study will give us better understanding of kinetics of antibiotic drugs in septic patients, and possibly could lead to certain modifications of treatment algoritms and principles. In addition, information obtained from the study would be valuable for the debate whether the cristalloid or colloid solutions should be preferred for infusion therapy in critically ill patient. Up today, the use of fresh frozen plasma for blood volume substitution has been empirical and not widely used. The results of the present study would give the scientific basic for acceptance or rejection of treatment strategy, the use of which so far has been based only on experience and intuition of medical staff. The plasma exchange is the treatment option, which potentially could avoid, when performed in appropriate time in the course of illness, the development of multiorgan failure in sepsis The main objective of the study is to determine the treatment strategies to prevent the development of multiorgan failure in course of sepsis. Better knowledge and understanding of pathophysiology of sepsis and multiorgan failure, introduction of new methods of patient monitoring and treatment would be the absolute prerequisite for further development in such complicated field of intensive care. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Marek Eerme | Tartu University Clinics, Clinic of Anaesthesiology and Intensive Care | physician | |
| 2. | Juri Karjagin | Tartu University Clinics, Clinic of Anaesthesiology and Intensive Care | research fellow | |
| 3. | Nadezda O'Konnel | Tartu University Clinics, Clinic of Anaesthesiology and Intensive Care | physician | |
| 4. | Annika Reintam | Tartu University Clinics, Clinic of Anaesthesiology and Intensive Care | physician | |
| 5. | Joel Starkopf | University of Tartu, Faculty of Medicine | head of the clinic, Clinic of Anaesthesiology and Intensive Care, University of Tartu | |
| 6. | Peeter Tähepõld | Tartu University Clinics, Clinic of Cardiovascluar and Thoracic Surgery | physician | |