| title: | Action of physical exercise on endogeneous production of 19-norandrosterone in female athletes |
|---|---|
| reg no: | ETF5455 |
| project type: | Estonian Science Foundation research grant |
| subject: |
3. Medical Sciences |
| status: | accepted |
| institution: | TU Faculty of Exercise and Sport Science |
| head of project: | Kalle Karelson |
| duration: | 01.01.2003 - 31.12.2006 |
| description: | The aim: to clarify the factors and conditions, which evoke endogeneous production of 19-norandrosterone (a dopy substance) Hypothesis: Hard, physical exercises evoke endogeneous production of 19-norandrosterone in the biosynthesis of estradiol as a by-product. The amount of production of 19-norandrosterone is dependent on secretion of estradiol, testosterone and progesterone in phases of varian-menstrual cycle. In female endurance athletes the production of 19-norandrosterone will be assessed after treadmill test at the individual maximal performance. The 19-norandrosterone will be determined in blood and urine together with recording changes in estradiol, testosterone, progesterone, lutropin, cortisol, follitropin, prolactin, glucose and lactate levels in blood. The testing will take place on day 4 to 6, day 12 to 13 and 18-21 of the ovarian-mestrual cycle. Expected results: a) data confirming the hypotheses, b) elaboration of a new research direction in order to clarify the adaptive significance of endogeneous 19-norandrosterone in muscular activity, c) proposal to improve the detection of 19-norandrosterone in the antidoping control in order to differentiate the endogeneously preduled and exogeneous (administered) 19-norandrosterone in the body. ... |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Tamara Janson | Inst. of Exerc.Biol | docent | |
| 2. | Kalle Karelson | TU Faculty of Exercise and Sport Science | senior researcher | |
| 3. | Kadri Matt | Gynecological Clinics | docent | |
| 4. | Atko-Meeme Viru | University of Tartu, Faculty of Sports Sciences | professor emeritus | |