| title: | Alterations in wound healing process in patients with implanted polypropylene mesh: A clinical study using groin hernia model. |
|---|---|
| reg no: | ETF5491 |
| project type: | Estonian Science Foundation research grant |
| subject: |
3. Medical Sciences |
| status: | completed |
| institution: | Clinicum of Tartu University |
| head of project: | Matis Märtson |
| duration: | 01.01.2003 - 31.12.2003 |
| description: | The purpose of this study is to investigate the influence of the systemic effect of implanted biomaterial to reparative processes in groin hernia clinical model. We will be comparing the patients with implanted polypropylene mesh (Lichtenstein method) with control group (Bassini method). Aim of this comparison is: to find differences in wound cellular reactions. We count the amount and types of migrated cells. Especially the number and relative amount of macrophages and fibroblast, the presence and amount of microbes will be interesting. to find the presence and differences in the levels of cytokine mediators (IL-1alpha, IL-1betha, IL-6, TNF-alpha, TGF-betha among others) in wound fluid. to assess clinically the outcome of patients (postoperative pain, wound infections, neuralgia, recurrence rate and time for full recovery from surgery) Main hypotheses: (1) The implantation of polypropylene mesh initiate also the systemic inflammatory reaction, which can make alterations in normal wound healing. The clinical importance of these alterations must evaluate and possibly prevent. (2) Despite the alterations in wound healing, the tension-free hernia repair has certain adventages compared to conventional methods in short term follow-up. (3) Long term follow up of the study group may demonstrate the findings not previously described in literature. The correlations of those possible findings with early phase wound reactions may assess retrospectively. It will make possible to select patients for surgery where using of biomaterials is not advocated preoperatively. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Urmas Lepner | University Clinic of Surgery, Tartu | docent, chair of general surgery | |
| 2. | Matis Märtson | Clinicum of Tartu University | resident | |