title: Verification of sustained high-intensity exercise on the basis more selective biochemical parameters and endothelial function
reg no: ETF5496
project type: Estonian Science Foundation research grant
subject: 3. Medical Sciences
status: accepted
institution: TU Faculty of Medicine
head of project: Eve Pihl
duration: 01.01.2003 - 31.12.2006
description: The main goal of the given research is to assess the effect of sustained intensive physical load on the functional properties of the endothelium and establish connections of the respective changes with oxidative stress and selective biochemical indices.

Concrete research tasks:
to study the possible effect of sustained intensive physical load on the characteristics of the function/dysfunction of the endothelium;
to assess the functional characteristics of the endothelium in connection with several biochemical indices (including hormonal, oxidative stress and nutrition indices) following sustained intensive physical load and during the recovery period;
to establish possible relationships between the functional status of the endothelium, hormonal, oxidative stress and malnutrition characteristics in connection with overall functional performance of the organism and the phenomenon of overtraining.

Main outcome of the study is related with the verification of the sustained high-intensity physical load on the basis of more selective biochemical markers and endothelial function. Our study results are important in adequate evaluation of the functional status and possible overtraining syndrome of the athlete using new biochemical- immunological and endothelial function markers.

project group
no name institution position  
1.Ceslava KairaneDepartment of Biochemistryvanemassistent 
2.Jaak KalsDepartment of Biochemistrydoktorant 
3.Kati KruusaaukInstitute of Exercise Biologymagistrant 
4.Margit LimakSports Medicine Foundation 
5.Agnes MägiSports Medicine Foundationarst 
6.Eve PihlTU Faculty of Medicineresearcher