| title: | Chronic inflammation in surgical diseases: A. Mechanisms of pathogenesis of peptic ulcer and gastric cancer and new diagnostic markers B. Research in the pathogenesis of vascular damage of the kidney transplant |
|---|---|
| reg no: | SF0182558s03 |
| project type: | targeted financing |
| subject: |
3. Medical Sciences |
| status: | accepted |
| institution: | University of Tartu |
| head of project: | Ants Peetsalu |
| duration: | 01.01.2003 - 31.12.2007 |
| description: | A. The aim of the investigation is to establish the mechanisms of pathogenesis and risks of peptic ulcer, gastric atrophy as a precancerous state and gastric cancer. The clinical part of the investigation is aimed at finding out how exactly it is possible to diagnose the above conditions in their different stages on the basis of the test panel of blood serum (H. pylori antibodies, pepsinogen I and II and gastrin-17, cellular fibronectin and other markers). The reliability of the test panel will be studied in comparison with the methods of gastroscopy and gastric biopsy. The experimental part will deal with the relationships between changes in the energetic metabolism of gastric epithelial cells in humans and expression of transcription factors, suppression of apoptosis mechanisms, adaptation to different stressors and the effect of nonsteroid anti-inflammatory drugs. B. The mechanisms of chronic inflammation will be investigated in patients with kidney disease (glomerusclerosis, atherosclerosis). Our earlier results, obtained on the basis of an experimental model, have been sufficiently well grounded for planning further comparison of serological and morphological parameters, which will be obtained using kidney biopsy (transplant, chronic kidney disease). This would allow to clarify the nature of vascular damage in patients with the kidney transplant, to establish the correlation between biochemical (oxidative stress, lipid metabolism, etc.) and molecular markers in different stages of disease progression as well as their application in diagnostics. The proposed results of the investigation would allow to better understand the pathogenesis of the studied diseases and to introduce new, less invasive and more efficient diagnostic methods as well as to improve the existing treatment guidelines. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Marju Gruno | TÜ kirurgiakl | teadur | |
| 2. | Jaanus Kahu | University of Tartu | resident (uroltranspl) | |
| 3. | Ingrid Liiv | University of Tartu | teadur | |
| 4. | Kadri Lilienthal | University of Tartu | resident (nefrol.) | |
| 5. | Aleksander Lõhmus | University of Tartu | arst-õppejõud, uroloog | |
| 6. | Mai Ots | TÜ sisekliinik | dotsent | |
| 7. | Ülle Pechter | University of Tartu | teadur | |
| 8. | Ants Peetsalu | University of Tartu | ||
| 9. | Margot Peetsalu | University of Tartu | teadur | |
| 10. | Elviira Seppet | TÜK sisekliinik | arst-õppejõud, nefroloog | |
| 11. | Toomas Sillakivi | University of Tartu | teadur | |
| 12. | Jaan Soplepmann | University of Tartu | teadur | |
| 13. | Agu Tamm | University of Tartu | lad.med. õt, prof. | |
| 14. | Andres Tein | University of Tartu | teadur | |