| title: | Functional proteomics - structure-activity relationships and molecular recognition in natural protein systems |
|---|---|
| reg no: | SF0222603s03 |
| project type: | targeted financing |
| subject: |
1.6-1.9. Chemistry and Molecular Biology 2. Engineering |
| status: | accepted |
| institution: | Institute of Chemical Physics and Biophysics |
| head of project: | Jüri Siigur |
| duration: | 01.01.2003 - 31.12.2007 |
| description: | The research program continues a previous project "Molecular biology0220378s98". It is aimed at proteomics studies, with particular emphasis on structure-function relationships, recognition and complex formation, which are essential cellular processes. Multifunctional proteins will be studied, which affect haemostasis, protective mechanisms in cells, angiogenesis, apoptosis and intracellular calcium regulation. The results will improve understanding on how proteins recognize their targets: calmodulin-activated enzymes, DNA, blood factors, receptors and platelets or cancer cells. The resulting knowledge is fundamental as it concerns basic forces and mechanisms which are universally involved in folding, gene regulation, biomolecular recognition and catalysis ¿ all these being important for understanding the functional integrity of normal and pathological cellular processes. The basic knowledge is indispensable for medicine and drug design. The proteins in study are potential thrombolytic and anticancer agents. The project is interdisciplinary and will be performed in cooperation between laboratories of bioorganic chemistry, chemical physics and molecular genetics at NICPB. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Anu Aaspõllu | Institute of Chemical Physics and Biophysics | teadur | |
| 2. | Maaja Ivask | Institute of Chemical Physics and Biophysics | magistrant | |
| 3. | Merike Kelve | Institute of Chemical Physics and Biophysics | van.teadur | |
| 4. | Tõnu Kesvatera | Institute of Chemical Physics and Biophysics | van.teadur | |
| 5. | Anne Kuusksalu | Institute of Chemical Physics and Biophysics | teadur | |
| 6. | Kalju Laurik | Institute of Chemical Physics and Biophysics | mehhaanik | |
| 7. | Annika Lopp | Institute of Chemical Physics and Biophysics | van.teadur | |
| 8. | Marta Mererand | Institute of Chemical Physics and Biophysics | laborant | |
| 9. | Mailis Päri | Institute of Chemical Physics and Biophysics | insener | |
| 10. | Mati Rannala | Institute of Chemical Physics and Biophysics | insener | |
| 11. | Eveli Raudvere | Institute of Chemical Physics and Biophysics | insener/magistr. | |
| 12. | Tõnu Reintamm | Institute of Chemical Physics and Biophysics | teadur | |
| 13. | Tiiu Roovere | Institute of Chemical Physics and Biophysics | magistrant | |
| 14. | Mari Samel | Institute of Chemical Physics and Biophysics | teadur | |
| 15. | Ene Siigur | Institute of Chemical Physics and Biophysics | van.teadur | |
| 16. | Jüri Siigur | Institute of Chemical Physics and Biophysics | van. teadur | |
| 17. | Ingrid Sumeri | Institute of Chemical Physics and Biophysics | van.insener | |
| 18. | Indrek Tammiste | Institute of Chemical Physics and Biophysics | insener | |
| 19. | Ain Toim | Institute of Chemical Physics and Biophysics | vaneminsener | |
| 20. | Katrin Trummal | Institute of Chemical Physics and Biophysics | teadur | |
| 21. | Külli Tõnismägi | Institute of Chemical Physics and Biophysics | teadur | |
| 22. | Vello Tõugu | Institute of Chemical Physics and Biophysics | van.teadur | |
| 23. | Ants Uus | Institute of Chemical Physics and Biophysics | vaneminsener | |
| 24. | Heiki Vija | Institute of Chemical Physics and Biophysics | teadur | |