| title: | Prostatitis: epidemiology in Estonia, etiological factors, mechanisms of pathogenesis and novel treatment strategies. |
|---|---|
| reg no: | ETF5701 |
| project type: | Estonian Science Foundation research grant |
| subject: |
3.1. Basic Medicine 3.4. Health Sciences |
| status: | accepted |
| institution: | TU Faculty of Medicine |
| head of project: | Reet Mändar |
| duration: | 01.01.2004 - 31.12.2007 |
| description: | Main purposes of the project: 1. To clarify the epidemiology of chronic prostatitis in general population of Estonia and find out regional, age- and habits-related and social-economic features of the possible risk factors. Hypothesis: Expected prevalence can be about 10¿14% due to previous data of Finland and Canada. 2a. To clarify the prevalence of asymptomatic inflammatory prostatitis in Estonian young men. Hypothesis: although no data about young preferably healthy men are available, some prevalence (1¿15%) of this syndrome can be expected by previous infertility-related studies. The results could give valuable information for deciding the necessity of fertility-related prophylactic screening of young men. 2b. To detect the causative agents in case of asymptomatic inflammatory prostatitis using extended microbiological analysis. Hypothesis: quantitative anaerobic investigation of seminal microflora may be necessary in detecting the causative agent of infection. 2c. To clarify the changes of male genital tract microflora during sexual debut. Hypothesis: microflora may change more rich, the occurrence of opportunistic microorganisms will increase. 3a. To clarify the role of oxidative stress in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome. Hypothesis: complex evaluation of oxidative stress parameters and antioxidant system may give significant information about pathogenesis mechanisms of prostatitis. 3b. To clarify the influence of an antioxidative probiotic (Lactobacillus fermentum ME-3) to prostatitis patients. Hypothesis: antioxidant therapy may relieve the complaints of prostatitis and influence the oxidative stress markers. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Kadri Kermes | TÜK ühendlabor | arst | |
| 2. | Paul Korrovits | TÜ mikro-bioloogia instituut | arst | |
| 3. | Tiiu Kullisaar | University of Tartu | vanemteadur | |
| 4. | Krista Lõivukene | TÜK ühendlabor | arst-mikrobioloog | |
| 5. | Reet Mändar | TU Faculty of Medicine | associate professor | |
| 6. | Margus Punab | TÜK androloogia kabinet | arst | |