| title: | Role of CYLD protein in hedgehog signaling and skin tumorigenesis |
|---|---|
| reg no: | ETF5933 |
| project type: | Estonian Science Foundation research grant |
| subject: |
1.8. Molecular Biology 1.15. Zoology |
| status: | accepted |
| institution: | Institute of Chemical Physics and Biophysics |
| head of project: | Priit Kogerman |
| duration: | 01.01.2004 - 31.12.2007 |
| description: | Hedgehog receptor PTCH1 is an important determinant of pattern formation during development of higher eukaryotes and is mutated in the majority of Basal Cell Carcinomas (BCC) as well as in several other tumor types. CYLD is a tumor suppressor gene mutations in which lead to a distinct tumor type of the skin, cylindroma. Our preliminary data indicate that CYLD protein has a function in the PTCH-GLI pathway. Understanding the signal transduction pathways from these tumor suppressor proteins will give us important insights into the developmental programs leading to the formation of multicellular organisms and help us understand how faults in these programs will lead to developmental abnormalities and tumorigenesis. This information may be used in the future to create novel treatment strategies for human disease conditions including cancer. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Lembi Kogerman | KBFI | teadur | |
| 2. | Priit Kogerman | Institute of Chemical Physics and Biophysics | Head of laboratory | |
| 3. | Priit Kogerman | KBFI | ||
| 4. | Alla Maloverjan | KBFI | teadur | |
| 5. | Piret Michelson | KBFI | teadur, doktorand | |
| 6. | Olga Njunkova | KBFI | teadur, doktorand | |
| 7. | Piret Tiigimägi | KBFI | teadur | |