| title: | Associations between markers of chronic inflammation and lipoprotein parameters in patients of type II Diabetes Mellitus |
|---|---|
| reg no: | ETF5956 |
| project type: | Estonian Science Foundation research grant |
| subject: |
3.1. Basic Medicine |
| status: | accepted |
| institution: | Estonian Institute of Cardiology |
| head of project: | Katrin Aasvee |
| duration: | 01.01.2004 - 31.12.2007 |
| description: | Relevant high-risk group for coronary heart disease (CHD) are the patients of type II Diabetes Mellitus (DM2). Progression of atherosclerosis is in DM2 patients very intensive, an important cause for it is characteristic dyslipidemia. During recent years more attention has been paid to HDL when predicting the risk for CHD. HDL is recognized anti-atherogenic in normal physiological context, but changes to pro-atherogenic during inflammation, when acute-phase reactants are partly substituting apolipoprotein (apo) A-I in HDL, generating pro-oxidant and pro-inflammatory HDL particles. In generation of these particles a relevant role has been paid to phospholipid transfer protein (PLTP).The markers of systemic chronic inflammation are in DM2-subjects increased, atherogenic lipid profile in these patients is potentiated by unfavourable apo E phenotype. There are contradicting results on relation of apo E polymorphism to inflammatory process. Aims: 1. To reveal associations of PLTP activity and markers of inflammation with lipoprotein parameters and diabetic state. 2.To clear out possible associations between apo E polymorphism and markers of systemic chronic inflammation. 3. To evaluate the relevance of above-named factors in incidence of myocardial infarction among DM2 patients. Te results of the project 1) will give new knowledge on the associations of HDL-fraction with markers of systemic chronic inflammation; 2) make possible to evaluate the role of PLTP, apo E phenotype and disorder in glucose metabolism in generation of characteristic dyslipidemia in DM2 patients; 3) make possible to evaluate the role of above-mentioned factors in formation of cardiovascular complications in DM2 patients. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Katrin Aasvee | Estonian Institute of Cardiology | senior researcher | |
| 2. | Anu Hedman | Ida-Tallinna Keskhaigla | arst-resident | |
| 3. | Elvira Kurvinen | EKARDI | vanemteadur | |
| 4. | Tiiu Roovere | Tallinn Technical University | magistrant | |